Gene 89619.m00116 (T.vaginalis)

89619.m00116

Species: T.vaginalis
Alias: 89619.m00116, TvagK0955
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag3

Sequence

Name Sequence Type Origin Length Description Download
89619.m00116.AA Protein None 545 None Fasta, JSON
89619.m00116.kin_dom Protein Kinase Domain None 148 None Fasta, JSON

Protein domain

Protein domains of 89619.m00116.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 89619.m00116.AA TKL 98-273 17 1.8e-31 110.61 In-house 115-364 (364) Show / Hide 
Range on Protein: 98-273
Range on HMM: 115-364/364
Sequence Identity: 17% (44 aa)

IVSTYASNGFLDDRNIVNANPTKKLLITIGLAAALKFLHNQR--------IFDLNIKPSNILIDKNYY--------------PMITDYNYTRFNNNPHNP
||  |...| | .. .    . ... . .. | .. .||...        |   ..|..|||.|.|.               . |.|.   ||...  | 
IVMEYCPGGSLLHYLH----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNM

CMN--------------------VGTVLYLSPEHITQE---------------YVVSPKSDIFSFAWIIYRLFCHRDPFQMFNDP---------LECVMK
 ..                    .||  ...|| . ..               .  |.|.|..||. ... ... . |.. .. .         .. .| 
NDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMV

FSQGWRPEIP------------NTTAPVIQDIIQQCWSQNPDARPTASALFDML
 . | ||.||            ... | . ...|.||...|..||... . . |
CDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 89619.m00116.AA TKL-Unique 108-265 23 4.8e-23 78.23 In-house 91-282 (290) Show / Hide 
Range on Protein: 108-265
Range on HMM: 91-282/290
Sequence Identity: 23% (46 aa)

LDD--------RNIVNANPTKKLLITIGLAAALKFLHNQR--IFDLNIKPSNILIDKN-----YYPMITDYNYTRFNNNPHNPCMN----------VGTV
|..        .|  . |. ... . |  | .. .||.    |  ...|.||.|.| |     .   | | .  .||..  .   |          .|. 
LHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSF

LYLSPEHITQE-YVVSPKSDIFSFAWIIYRLFCHRD------PFQMFNDP--LECVMKFSQGWRPEIPNTTAPVIQDIIQQCWSQNPDARPT
....|| .... .  | |||..||. . . .. .        |.| ...   .| | .   . ||.|||   . ..|.||||| ..|. ||.
RWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPS
Kinase 89619.m00116.AA Dicty4-Unclassified 122-273 27 8.7e-16 50.52 In-house 112-263 (263) Show / Hide 
Range on Protein: 122-273
Range on HMM: 112-263/263
Sequence Identity: 27% (42 aa)

LLITIGLAAALKFLHNQRIFDLNIKPSNILIDKNYYPMITDYNYTRFNNNPHNPCMNVGTVLYLSPEHITQEYVVSPKSDIFSFAWIIYRLFCHRDPFQM
. . .  |  . .||   .    || ||||.||..   | |    |   .  |     ||.   |||    |   . |||..|.| . | |     |.| 
IKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQ-KSDVYSYAMMLYELATGDEPYQE

FNDPLECVMKF-SQGWRPEIPNTTAPVIQDIIQQCWSQNPDARPTASALFDML
   ...      . . ||.||    . ..  |  ||.  |  |||     . |
IQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase 89619.m00116.AA RIPK 180-265 26 3e-15 48.38 In-house 184-282 (290) Show / Hide 
Range on Protein: 180-265
Range on HMM: 184-282/290
Sequence Identity: 26% (26 aa)

GTVLYLSPEHIT--QEYV---VSPKSDIFSFAWIIYRLFCHRDPFQMFNDPLECVMKFSQGWRPEIPNTTAPVIQD--------IIQQCWSQNPDARPT
||  |. |||.   .      |.||.|. ||| ... ..  . |.     ..  .|. .|| ||...  . .  ..         .|.||.|.|..||.
GTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPC
Kinase 89619.m00116.AA Pkinase 128-273 22 3.6e-14 51.2 Pfam 117-293 (293) Show / Hide 
Range on Protein: 128-273
Range on HMM: 117-293/293
Sequence Identity: 22% (40 aa)

LAAALKFLHNQRIFDLNIKPSNILIDKNYYP----MITDYNYTRF--NNNPHNPCMNVGTVLYLSPEHITQEYVVSPKSDIFSFAWIIYRLFCHRDPFQ-
.. .|...|...|    .||.|||||.|...     |.|    ..  . | . .   .||  |..|| |      .||.|..|.  |.| ..| | ||. 
ILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPG

-----MFNDPLECVMKFSQ-GWRPEIPNTTA-------------------PVIQDIIQQCWSQNPDARPTASALFDM--L
       .|..... .  .  .. ..|..                     .  .|.|  |. ..|  ||||  ..    .
HCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 89619.m00116.AA HH498 149-273 27 5.4e-14 40.36 In-house 154-284 (284) Show / Hide 
Range on Protein: 149-273
Range on HMM: 154-284/284
Sequence Identity: 27% (36 aa)

NILIDKNYYPMITDYNYTRFNNNPHNPCMNV--GTVLYLSPEHITQEYVVSPKSDIFSFAWIIYRLFCHRDPFQMFNDPLECVMKFSQGW-RPEIPNT--
||||...    . |.   || .  |   |    |   . .||  .|    | | |.||.| .|. ..  . ||  .  |     .      || ||.|  
NILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEMHTREVPFHHY-KPAAAAAEMAYHHIRPPIPQTPT

--TAPVIQDIIQQCWSQNPDARPTASALFDML
      .  .||.||...|. ||. .    .|
AQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
S_TKc 89619.m00116.AA S_TKc 17-275 18 1.3e-13 22.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-275
Range on HMM: 1-231/231
Sequence Identity: 18% (53 aa)

YQEIRELPSSGFSRVVLMEEKTTKHQVVFKYAKLMIESASEDDPVTRKMFYN--KVYQSIKQMHPCINPTEGFCPPTKEGIPIIVSTYASN--GFLDDRN
|. .|.. . .|..| .  .| |...|  |  |              .....  .. ..    || |    ...     .   .|  |...  | | |. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK---HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYI

IVN--------ANPTKKLLITIGLAAALKFLHNQRIFDLNIKPSNILIDKNYYPMITDYNYTRFNNNPHNPCMNVGTVLYLSPEHITQEYVVSP-KSDIF
  .         ..     ..  .. ||...|...|    .||.|||.|.    .|.|    |.          .||  |..|| .      .. |.|. 
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWW

SFAWIIYRLFCHRDPFQMFNDPLECVMKFSQGWRPEIPNTTAPVIQDIIQQCWSQNPDARPTASALFD-------MLCM
|.  |.| ..| . ||.     .. ..|              |   |.|..|.  .|. ||||  ..        .  .
SCGCILYEMLCGYPPFP----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 89619.m00116.AA Dicty5 121-281 30 1.6e-13 42.92 In-house 106-260 (260) Show / Hide 
Range on Protein: 121-281
Range on HMM: 106-260/260
Sequence Identity: 30% (49 aa)

KLLITIGLAAALKFLHNQRIFDLNIKPSNILIDKNYYPMITDYNYTRFNNNPHNPCMNVGTVLYLSPEHIT-QEYVVSPKSDIFSFAWIIYRLFCHRDPF
.| . |. | ....||   |    .|  |.|| .|.   | |.   ||  |  .  |.|||  . ..|  . | |    | |..||. . . .|    |.
QLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPY--HQKCDVYSFGIVLWEMFTRKEPY

QMFNDPLECVMKFSQGWRPEIPNTTAPVIQDIIQQCWSQNPDARPTASALFDMLCMNISNII
   |     ||    | ||.|| .    |  .|  || | |  ||.    |   |  .  ||
DNINNWNIPVM-VMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPS----FKEICKYFESII
Kinase 89619.m00116.AA MLK 145-273 26 2.9e-13 42.47 In-house 153-291 (291) Show / Hide 
Range on Protein: 145-273
Range on HMM: 153-291/291
Sequence Identity: 26% (37 aa)

IKPSNILID------KNYYPMITDYNYTRFNNNP-HNPCMNVGTVLYLSPEHI--TQEYVVSPKSDIFSFAWIIYRLFCHRDPFQMFNDPLECVMKF-SQ
.|..|||||      ..    |.|    |. ..   |   | ||. . .|| |   ..  .| |.|..|.. ... ..  . |..  .||... ..    
LKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYN

GWRPEIPNTTAPVIQDIIQQCWSQNPDARPTASALFDML
| || ||.|  . .   ..|||.|.|  ||. .     |
GLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 89619.m00116.AA LRRK 179-275 26 1.3e-12 40.97 In-house 240-351 (351) Show / Hide 
Range on Protein: 179-275
Range on HMM: 240-351/351
Sequence Identity: 26% (30 aa)

VGTVLYLSPEHITQE--YVVSPKSDIFSFAWIIYRLFCHR-DPFQMFN--DPLECVMKFSQ----GWRPEIPNT-TAP-----VIQDIIQQCWSQNPDAR
||. ....|| .  .   . . |.|..||. |.. |   . .||. ..  | ..   ....    | || ||..   |       || ||.||...|. |
VGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKR

PTASALFDMLCM
|..|  .. |  
PHFSQIVKRLSQ
Kinase 89619.m00116.AA TKL-Sp1 117-154 31 6.1e-10 26.83 In-house 96-133 (263) Show / Hide 
Range on Protein: 117-154
Range on HMM: 96-133/263
Sequence Identity: 31% (12 aa)

NPTKKLLITIGLAAALKFLHNQRIFDLNIKPSNILIDK
.. ||. |....  |. |.|  .|  | |||.|.....
DWAKKMQISCEVLQAVTFMHACNILHLDIKPANVMVER
Kinase 89619.m00116.AA NZAK 180-273 26 9.8e-09 24.93 In-house 234-329 (329) Show / Hide 
Range on Protein: 180-273
Range on HMM: 234-329/329
Sequence Identity: 26% (26 aa)

GTVLYLSPEHITQEYVVSPKSDIFSFAWIIYRLFCHRDP--FQMFNDPLECVMKFSQGWRPEIPNTTAPVIQDIIQQCWSQNPDARPTA-SALFDML
||. |. ||   . . .  |||..||  ..  .|    |       .    |    .  .| ||.     . |.|.|||  .|  ||   | . . |
GTHHYMAPE-NKNNHRINEKSDVWSFGCTVWQMFGYNPPNTIYSPKEMASMVSDQKFNYIPQIPFHVPDKMKDFITQCWDIDPKKRPKDFSHMIEKL
TyrKc 89619.m00116.AA TyrKc 17-273 18 1.8e-08 -85.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-273
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

YQEIRELPSSGFSRVVLMEEKTTKHQVVFKYAKLMIESASEDDPVTRKMFYN--KVYQSI-KQMHPCINPTEGFCPPTKE-----GIPIIVSTYASNGFL
 . ...| .  | .|.. . |    ||  |  |             |..|..  ..  .. .  ||.|    | |   ..     . . ||  |...| |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----------REDFMREARIMCKLGG-HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

DDRNIVNA---NPTKKLLITIGLAAALKFLHNQRIFDLNIKPSNILIDKNYYPMITDYNYTRFNNNP--------HNP-----CMN-VGTVLYLSPEHIT
.|.   .    .. ..| . .  |.   .|| ...    .   |.|...|.   |.|   .|.  .                 . . .  .  ..|| | 
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

QEYVVSPKSDIFSFAWIIYRLF--CHRDPFQM---FNDPLECVMKFSQGWRPEIPNT--------TAPVIQDIIQQCWSQNPDARPTASALFDML
.... ..|||..||   .. .|  .   .  |   . .. | . .  || |...|            . . .|..|||  .|. ||| |.. . .
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 89619.m00116.AA Pkinase_Tyr 237-273 35 1e-06 22.87 Pfam 234-270 (270) Show / Hide 
Range on Protein: 237-273
Range on HMM: 234-270/270
Sequence Identity: 35% (13 aa)

RPEIPNTTAPVIQDIIQQCWSQNPDARPTASALFDML
| ..|  . . | |...||| ..|. ||| |..  .|
RMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 89619.m00116.AA NZAK 98-155 20 2.7e-05 13.18 In-house 79-141 (329) Show / Hide 
Range on Protein: 98-155
Range on HMM: 79-141/329
Sequence Identity: 20% (13 aa)

IVSTYAS----NGFL-DDRNIVNANPTKKLLITIGLAAALKFLHNQRIFDLNIKPSNILIDKN
|.. . .      || .|. .   .. .   .   .|  . .|| . |    ||..|.. |.|
IYMEWMEGGNLTQFLMNDKKQLRFKEHRIIKMIADIAETMSYLHKHHIIHRDIKSNNVILDFN
Kinase 89619.m00116.AA TKL-Sp1 237-273 37 7.5e-05 10.63 In-house 227-263 (263) Show / Hide 
Range on Protein: 237-273
Range on HMM: 227-263/263
Sequence Identity: 37% (14 aa)

RPEIPNTTAPVIQDIIQQCWSQNPDARPTASALFDML
.|||     | .| | . |  | |  || |. | |  
KPEILTKVDPKVQKILEPCFDQKPEKRPSAEDLLDQF
Kinase 89619.m00116.AA RIPK 129-156 33 0.018702 4.14 In-house 117-146 (290) Show / Hide 
Range on Protein: 129-156
Range on HMM: 117-146/290
Sequence Identity: 33% (10 aa)

AAALKFLHNQR--IFDLNIKPSNILIDKNY
. .  .||..   |  .  ||.|||.| |.
SCGMCYLHSMNPPIIHRDLKPENILVDNNF
Ank 89619.m00116.AA Ank 423-456 35 3.9e-07 30.01 Pfam 1-33 (33) Show / Hide 
Range on Protein: 423-456
Range on HMM: 1-33/33
Sequence Identity: 35% (12 aa)

NGDTALQVAARKGDLELVKYLIKVNGINLNTTNQ
.|.|.| .|.|.|..| ||.|.. .| ..| .. 
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank 89619.m00116.AA Ank 457-490 38 0.00194 16.66 Pfam 1-33 (33) Show / Hide 
Range on Protein: 457-490
Range on HMM: 1-33/33
Sequence Identity: 38% (13 aa)

KGYSPLHEAVRFSKTEVVYTLVKAPGIEMSIKDK
 |..||| |.|   ||||  |..  | .  ..|.
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD