Gene 82977.m00080 (T.vaginalis)

82977.m00080

Species: T.vaginalis
Alias: 82977.m00080, TvagK0162
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
82977.m00080.AA Protein None 250 None Fasta, JSON
82977.m00080.kin_dom Protein Kinase Domain None 191 None Fasta, JSON

Protein domain

Protein domains of 82977.m00080.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 82977.m00080.AA CAMK 2-188 17 1.1e-32 102.07 In-house 94-418 (425) Show / Hide 
Range on Protein: 2-188
Range on HMM: 94-418/425
Sequence Identity: 17% (57 aa)

QLEHPNILRIVNYFN------------EGNK--------FFIIS---EDCVHG----NVKEYLDQT----------------NISTTERIEFCTDLIRGL
.| ||||...  ..               .|        ....    | |  |     . .|. .                  ..  |   .   .. ..
KLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAV

NYLHSKGITRNHLKLENILVDKS-----------------CKVKIADYGLPYFIDESDE--------------------------KFGGPKYFLA-PEVL
.|.||..|    ||.||||.|..                 ...||.| |.  ..|....                           | |  .. | ||||
HYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVL

QK-------------LNVNTFKADVWALGIILYYVAYKELPFGDE----------------ELWNDFTQYGLARIPHF---------------ISEE---
..                 ..|.|.|..|.|||     ..|| ..                ||.   ..     .|..               ||.|   
NGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH

-----FMRTLKLALQVNPEKRPTPQE
      .  ..  |||.||||.| ..
FVSQECKDLIRKMLQVDPEKRMTIEQ
Kinase 82977.m00080.AA Ciliate-E2 2-191 19 1.3e-31 105.79 In-house 88-361 (365) Show / Hide 
Range on Protein: 2-191
Range on HMM: 88-361/365
Sequence Identity: 19% (56 aa)

QLEHPNILRIVNYFN--EGNKFFIISEDCVHGNVKEYLDQT------------NISTTERIEFCTDLIR---------------GLNYLHSKG-ITRNHL
|| ||||.... .|     |..... | | .|. ..|. .             ...  |.... . ...               .|.|||||. |    .
QLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDI

KLENILVDKSCKVKIADYGLPYFIDESDEK----------------------------------FGGPKYFLAPEVLQKLNVNT--------FKADVWAL
|.||||.     .||.| ||  ..|.. ..                                  . |  ...|||.|.. . ..        .|.|.|.|
KPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSL

GIILYYVAYKELPFGDEELWND-FTQYGLAR-------------IPHFISEEFMRTLKL----ALQVNPEKRPT-PQELFK
|.|||.  ....||  ..   .   ..  .              ... .|.| .  .|      ||..||||.| ......
GVILYEMLFGKPPF--QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 82977.m00080.AA Ciliate-E2-Unclassified 1-191 21 1.6e-31 106.63 In-house 71-348 (352) Show / Hide 
Range on Protein: 1-191
Range on HMM: 71-348/352
Sequence Identity: 21% (60 aa)

MQ-----LEHPNILRIVNYFNEGNKFFIISEDCVHGNVKEYLDQT------------------NISTTERI-----EFCTDLIRGLNYLHSKG-ITRNHL
||     . ||.|.. . .|.  ....|. | | .|. ..|. .                    ..  . .      ..  .. ||.|||.|. |    .
MQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDI

KLENILVDKSC---KVKIADYGLPYFIDES------------------DEKFGGPKYFL----APEVLQKLNVNT---FKADVWALGIILYYVAYKELPF
|.||||.|...   ..||.|.|. ......                     | |  ...    ||||||. | ..   .|.|.|.||.|||.  . ..||
KPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPF

GDEELWN---------------DFTQYGLAR-----------IPHFISEEFM----RTLKLALQVNPEKRPTPQELFK
.|.                    . |  ...           ||. .|.|      . |.  |..||.||.|......
YDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN
Kinase 82977.m00080.AA CAMKL 1-189 24 1.2e-29 91.64 In-house 67-291 (297) Show / Hide 
Range on Protein: 1-189
Range on HMM: 67-291/297
Sequence Identity: 24% (56 aa)

MQLE---HPNILRIVNYFNEGNK------FFIISEDCVHGN--VKEYLDQTN-----ISTTERIEFCTDLIRGLNYLHSKGITRNHLKLENILVDKSC--
..|    |||| ..   .   ..      .... | |  |.    .|...       ..  |   . . .. ..||.||.||    .|.||||.|..   
KMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN

KVKIADYGLP-YFID----ESD--EKFGGPKYFLAPEVLQK--LNVNTFKADVWALGIILYYVAYKELPFGDEE-----------LWNDFTQYGLARIPH
..||.| |.  ....    . .  . | |   . |||..|.     . .|.|.|..|.|||   . .||| |.            .| . .. .  .|. 
NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWY

FISEEFMRTLKLALQVNPEKRPTPQEL
..| .  . ..  |||||||||| ...
HVS-DCRDLIRKMLQVNPEKRPTIHQI
Kinase 82977.m00080.AA Pkinase 3-193 25 7e-29 103.19 Pfam 57-293 (293) Show / Hide 
Range on Protein: 3-193
Range on HMM: 57-293/293
Sequence Identity: 25% (61 aa)

LEHPNILRIVNYFNEGNKFFIISEDCVHG----NVKEYLD---QTNI--STTERIEFCTDLIRGLNYLHSKGITRNHLKLENILVDKSCKV----KIADY
| ||||.|.  .| ....  .. | | .|      ..|.    ....  |  | . ... ..|||.|.||.||    ||.||||.|. . .    ||.| 
LNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF

GLP----YFIDESDEKFGGPKYFLAPEVLQKLNVNTFKADVWALGIILYYVAYKELPFGDEELWNDFTQYGLARIPHFIS--------------------
||     |  ..    | |  ...||||... .  . |.|.|..|.|||... ...|| ..  | |     ...|    .                    
GLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRH

-----------EEFMRTLKLALQVNPEKRPTPQELFKV--M
           ||.   .|  |...|.||||......   .
WHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 82977.m00080.AA TKL 3-193 20 5e-28 98.01 In-house 82-364 (364) Show / Hide 
Range on Protein: 3-193
Range on HMM: 82-364/364
Sequence Identity: 20% (60 aa)

LEHPNILRIVNYFNEGNK-------------FFIISEDCVHGN-VKEYLDQTNISTTERIEFCTDLIRGLNYLHS--------KGITRNHLKLENILVDK
| ||||.... | .....             ..|. | | .|.    ..         |. .. |  ||.|||||        ..|    || .|||||.
LRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDE

SCK--------------VKIADYGLPYFIDESDE----------------------KFGGPKYFLAPEVLQKLNVNT---------------FKADVWAL
  .              .||.|.||  |...| .                      . .| ....|||||.. . .|                |.||.. 
NWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSF

GIILYYVAYKELPFGDEE-----------LWNDFTQYGLAR--IP------------HFISEEFMRTLKLALQVNPEKRPTPQELFKVM
||.|. ..  ..|. |.            ..     .   |  ||            . . ... . ..   . .|||||. ||. | .
GIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 82977.m00080.AA PLK1 2-195 26 1.4e-23 74.13 In-house 55-253 (253) Show / Hide 
Range on Protein: 2-195
Range on HMM: 55-253/253
Sequence Identity: 26% (53 aa)

QLEHPNILRIVNYFNEGNKFFIISEDCVHGNVKEYLDQ-TNISTTERIEFCTDLIRGLNYLHSKGITRNHLKLENILVDKSCKVKIADYGLPYFIDESDE
||.|..| .. ..| . .  .|. | | .  . |   .   |   |   .   ...|  ||| . |    ||| |. ..   .||| |.||  ..... |
QLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPECRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGE

K---FGGPKYFLAPEVLQKLNVNTFKADVWALGIILYYVAYKELPFGDEELWNDFTQYGLA--RIPHFISEEFMRTLKLALQVNPEKRPTPQELFKVMNN
.    .|   ..|||||.|    .|  |.|..| |.| . . . ||  . | . . .   .  |||. ||.   . ..  |. .|..||| ... .    
RKKTLCGTPNYIAPEVLNK-KGHSFEVDIWSIGCIMYILLFGQPPFETKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase 82977.m00080.AA TK 1-193 13 2.4e-23 74.45 In-house 95-486 (486) Show / Hide 
Range on Protein: 1-193
Range on HMM: 95-486/486
Sequence Identity: 13% (55 aa)

MQ---LEHPNILRIVNYFNEG------------NKFFIISEDCVHGN----VKEYLDQT-----------------------------------------
|.   ..||||.|.. .  .|              . |. | . ||.     ..|| .                                          
MCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC

------------------------------------NISTTERIEFCTDLIRGLNYLHSK------GITRNHLKLENILVDKSCK-----------VKIA
                                    .... ... .| .. .|. |||||      ..    |   |.||... .           .|||
PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIA

DYGLP--------YFIDESDEKFGGPKYF-----------------------------LAPEVLQK--------LNVNTFKADVWALGIILYYVAYKE-L
|.||           |...|.      |                              .|||.|..         .. | | |||..|. .. .      
DFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQE

PFGD-------------EELWNDFTQ---------------YGLARIPHFIS-------------EEFMRTLKLALQVNPEKRPTPQELFKVM
|..              .|. .  ..               . ... ||  .             ||... ..   . .||.||| ..| . .
PYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 82977.m00080.AA MELK 2-195 27 2.4e-23 76.37 In-house 53-254 (254) Show / Hide 
Range on Protein: 2-195
Range on HMM: 53-254/254
Sequence Identity: 27% (56 aa)

QLEHPNILRIVNYFNEGNKFFIISEDCVHGNVKEYL-DQTNISTTERIEFCTDLIRGLNYLHSKGITRNHLKLENILVDKSCKVKIADYGLPYFIDESDE
.|.| .| ..  | .  .|.|.. | |  |.. .|.  |  ..  |   |   ..  . |.||.|     || ||.|.|   ..|. |.||        .
NLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKD

KF-----GGPKYFLAPEVLQKLNVNTFKADVWALGIILYYVAYKELPFGDEELWNDFT--QYGLARIPHFISEEFMRTLKLALQVNPEKRPTPQELFKVM
.       |   . |||..| ..     ||||..||.|| .    ||| |. .   .   . |    |...| |  . |.  |||.|.||   ..| .  
YHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHP

NN
  
WV
Kinase 82977.m00080.AA SAK 2-183 31 2.7e-21 69.06 In-house 55-242 (254) Show / Hide 
Range on Protein: 2-183
Range on HMM: 55-242/254
Sequence Identity: 31% (59 aa)

QLEHPNILRIVNYFNEGNKFFIISEDCVHGNVKEYLDQT--NISTTERIEFCTDLIRGLNYLHSKGITRNHLKLENILVDKSCKVKIADYGLPYFIDESD
|| || || . |||.. |  ... | |  | .. |...     . .|  .|  ... |. |||| ||    | | |||. .  ..||||.||   .   .
QLKHPSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRPFTEEEARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPH

EKF----GGPKYFLAPEVLQKLNVNTFKADVWALGIILYYVAYKELPFGDEELWNDFTQYGLA--RIPHFISEEFMRTLKLALQVNPEKR
||     | | | ..||.  .      ..|||.|| .|| .     ||  .   |   .  .|   .| ..| |    ..  |. ||. |
EKHYTMCGTPNY-ISPEIATR-TAHGLQSDVWSLGCMLYTLLIGRPPFDTDAVKNTLNKVMMAEYIMPAHLSMEAQDLIHKMLRKNPHER
Kinase 82977.m00080.AA ULK 5-143 25 1.1e-20 69.02 In-house 77-256 (329) Show / Hide 
Range on Protein: 5-143
Range on HMM: 77-256/329
Sequence Identity: 25% (46 aa)

HPNILRIVNYFNEG--NKFFIISEDCVHGNVKEYLDQT-----------NISTTERIEFCTDLIRGLNYLHSKGITRNHLKLENILVDK-SCK-------
|||| .   .|..   | ..|| | | .|. ..|. .            ..|  | |.|. ... |. .||...|    .|..|||...   |       
HPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVH

----VKIADYGLPYFIDES------DEKFG------GPKYFLAPEVLQ----KLNVNTFKADVWALGIILYYVAYKELPF
    .|||| |.  ..|..         .       |  .. ||..||    . . ...|.|.| ||.|.|.  | . ||
PNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPF
Kinase 82977.m00080.AA S_TKc 1-193 23 5.5e-15 42.87 SMART 19-231 (231) Show / Hide 
Range on Protein: 1-193
Range on HMM: 19-231/231
Sequence Identity: 23% (55 aa)

MQLE------------------------HPNILRIVNYFNEGNKFFIISEDCVH--GNVKEYLDQTN-------ISTTERIEFCTDLIRGLNYLHSKGIT
   .                        |||| ..  .| . ...... | | .  |....|... .       ..  .   ..  ....|.|.||.|| 
RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGII

RNH--LKLENILVDKSCKVKIADYGLPYFIDESDEKFGGPKYFLAPEVLQKLNVNTFKADVWALGIILYYVAYKELPFGDEELWNDFTQYGLARIPHFIS
  |  || ||||.|.   .||.| ||  ..      | |  ...|||||     ...|.|.|..|.|||  .. . ||      .... . . .     |
--HRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-----S

EEFMRTLKLALQVNPEKRPTPQELFK---------VM
.|.   ..  ||..||||||  |...          .
PEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 82977.m00080.AA TyrKc 1-193 19 5.8e-10 -61.63 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-193
Range on HMM: 1-280/280
Sequence Identity: 19% (56 aa)

M--------------------------------------------QL--EHPNILRIVNYFNEG-------NKFFIISEDCVHGNVKEYLDQTN--ISTT
                                             .|  .||||.|.. .  ..          .|. | . ||. |.||  .   ... 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

ERIEFCTDLIRGLNYLHSKGITRNHLKLENILVDKSCKVKIADYGLPYFIDES-------DEKFG----GPK-----YFLAPEVLQKLNVNTFKADVWAL
. ..||..  .| .|||||..    |   |.||..   |||.| ||  .|..        | .      | |       .|||.. . .. |.| |||. 
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKSDVWSF

GIILY------YVAYKEL---PFGDEELWNDFTQYGLARIPHF--------ISEEFMRTLKLALQVNPEKRPTPQELFKVM
|. ..         | .    .  ..|. ..  | .  ..|.          ..|  .  |   . .||.||| .|. . .
GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 82977.m00080.AA Pkinase_Tyr 1-66 26 0.000559 14.1 Pfam 58-132 (270) Show / Hide 
Range on Protein: 1-66
Range on HMM: 58-132/270
Sequence Identity: 26% (20 aa)

MQL-EHPNILRIVNYFN-EGNK--FFIISEDCVHGNVKEYLDQT-----NISTTERIEFCTDLIRGLNYLHSKGI
.||  ||||.| .     .|     .|. | . ||. ..|| .      .... . ...|..  .|..||.||..
KQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNC
Kinase 82977.m00080.AA Pkinase_Tyr 75-134 30 0.00348 11.41 Pfam 141-205 (270) Show / Hide 
Range on Protein: 75-134
Range on HMM: 141-205/270
Sequence Identity: 30% (20 aa)

NILVDKSCKVKIADYGLPYFI-DESDE-KFGGPKYF----LAPEVLQKLNVNTFKADVWALGIILY
|.||... .|||.| ||   | ...   . .|   .    .|||...     | | |||. |. ..
NCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKSDVWSFGVLMW