Gene 96421.m00005 (T.vaginalis)

96421.m00005

Species: T.vaginalis
Alias: TvagK0349, 96421.m00005
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Unique

Sequence

Name Sequence Type Origin Length Description Download
96421.m00005.AA Protein None 220 None Fasta, JSON
96421.m00005.kin_dom Protein Kinase Domain None 125 None Fasta, JSON

Protein domain

Protein domains of 96421.m00005.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 96421.m00005.AA Dicty5 10-138 35 3.5e-31 104.55 In-house 120-260 (260) Show / Hide 
Range on Protein: 10-138
Range on HMM: 120-260/260
Sequence Identity: 35% (50 aa)

LHEMGLIHRDLKSPNILLDQRLLPYICDFGIAR--QTGDRMTKDI--------EM-DSRHYDNKVNVYSYGCILYEMLVHKYPYQDCTSYKAAANIMSGK
|| |. ||||||| |.|.  ..   | |||. |       || ..        |.  .. |..|. |||.| .|.||.  | || . ..   .  .|.| 
LHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIPVMVMKGE

RPELPNH-DSQICSLISKCWAQDPEKRPPMRNIFKAFCKLK
||..|    . |  || ||| | | .||    | | | .. 
RPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase 96421.m00005.AA TKL 10-134 23 6.8e-30 104.83 In-house 148-364 (364) Show / Hide 
Range on Protein: 10-134
Range on HMM: 148-364/364
Sequence Identity: 23% (50 aa)

LHEMG--------LIHRDLKSPNILLDQRLL--------------PYICDFGIARQTG-----------------------DRMTKD----------IEM
|| |.        .|||||||.|||.|. .               . |||||..|                           .||.           ...
LHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRG

D--------------SRHYDNKVNVYSYGCILYEMLVHKYPYQDCTSY----------KAAANIMSGKRPELP-----------NHDS--QICSLISKCW
.              .. |. |. |||.| .|.|.|  . ||.|  ..           .. ..  |.||..|           ..|   ....|. .||
QMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCW

AQDPEKRPPMRNIFKAF
..|||||| .  | | .
DHDPEKRPSFQEILKRL
Kinase 96421.m00005.AA TKL-Unique 10-134 24 4.2e-26 89.15 In-house 126-290 (290) Show / Hide 
Range on Protein: 10-134
Range on HMM: 126-290/290
Sequence Identity: 24% (40 aa)

LHEMG--LIHRDLKSPNILLDQR-----LLPYICDFGIARQTGDRMTKDIE---------------------MDS--RHYDNKVNVYSYGCILYEMLVHK
||  .   |||||||.|.|.|..     .   |||||...    .... .                      . .   .|..|. |||.| .|.|.. .|
LHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRK

Y------PYQDCTSYKAAANIMS---GKRPEL-PNHDSQICSLISKCWAQDPEKRPPMRNIFKAF
       |||...... .. . .   ..||.. ..   ..  || .||..||..||   .| .  
ITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 96421.m00005.AA MLK 10-134 32 4.5e-26 87.53 In-house 140-291 (291) Show / Hide 
Range on Protein: 10-134
Range on HMM: 140-291/291
Sequence Identity: 32% (49 aa)

LHEMG---LIHRDLKSPNILLDQ------RLLPYICDFGIARQTGDR---MTKDI--------EM----DSRHYDNKVNVYSYGCILYEMLVHKYPYQ-D
||.|    .|||||||.|||.|.       .   |||||..|   ..   |.. .        |.     .  |. |. |.|.| .|.|||  . ||. .
LHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQH

CT-SYKAAANIMSGKRPELPNH-DSQICSLISKCWAQDPEKRPPMRNIFKAF
   .. |. ... |.|| .|.  .  ...|...|| |||.||| .| | . .
YDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 96421.m00005.AA HH498 10-134 29 7.8e-23 68.87 In-house 137-284 (284) Show / Hide 
Range on Protein: 10-134
Range on HMM: 137-284/284
Sequence Identity: 29% (43 aa)

LHE---MGLIHRDLKSPNILLDQRLLPYICDFGIARQTGDR----MTK----------DIEMDSRHYDNKVNVYSYGCILYEMLVHKYPYQDCTSYKAAA
||.      ||||| | |||...     . |||. |   |.    |||           .   .  |. || |.||. ...||.  . |. .     |||
LHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAA

NIMSGK-RPELPNH-----DSQICSLISKCWAQDPEKRPPMRNIFKAF
 .   . || .|.      . .. .||  || . || ||    |    
EMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase 96421.m00005.AA STE 10-135 24 5.7e-19 63.72 In-house 168-359 (359) Show / Hide 
Range on Protein: 10-135
Range on HMM: 168-359/359
Sequence Identity: 24% (48 aa)

LHEMGLIHRDLKSPNILLDQRLLPYICDFGIARQTGDRMT----------------KD-------------IEMDSRH----YDNKVNVYSYGCILYEML
||... ||||.|. ||||       .||||.. |  | |.                |              |. ....    || |. ..| || . ||.
LHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTPWMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA

VHKYPYQDCTSYKAAANIMSG---------------KRPELPNHDS--------------------QICSLISKCWAQDPEKRPPMRNIFK---AFC
  |.|. | .  .|  .|. .               . | ||.| |                      .  |.||   ||.|||      |    | 
TGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 96421.m00005.AA LRRK 59-136 30 2.5e-16 54.26 In-house 259-351 (351) Show / Hide 
Range on Protein: 59-136
Range on HMM: 259-351/351
Sequence Identity: 30% (28 aa)

YDNKVNVYSYGCILYEMLVHK-YPYQDCT-------SYKAAANIMSGKRPELPNH-DSQ------ICSLISKCWAQDPEKRPPMRNIFKAFCK
|. || .||.| ||.| |  .  |... .        ..   .|..| || .|.|   .       ..|| .||..||.||| .  |.|    
YTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 96421.m00005.AA Dicty4-Unclassified 59-134 40 8.2e-15 47.12 In-house 185-263 (263) Show / Hide 
Range on Protein: 59-134
Range on HMM: 185-263/263
Sequence Identity: 40% (32 aa)

YDNKVNVYSYGCILYEMLVHKYPYQDCTSYKAAANIMSGK--RPELP-NHDSQICSLISKCWAQDPEKRPPMRNIFKAF
|  |  ||||. .|||..    |||.  |   ||     |  ||..| | |  . .||  ||  || ||| |  | .  
YNQKSDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase 96421.m00005.AA Pkinase 55-134 22 2.7e-13 48.09 Pfam 185-293 (293) Show / Hide 
Range on Protein: 55-134
Range on HMM: 185-293/293
Sequence Identity: 22% (24 aa)

DSRHYDNKVNVYSYGCILYEMLVHKYPYQDC------TSYKAAANIMSGKRPELPNHD---------------------SQICSLISKCWAQDPEKRPPM
....|. || ..|.||||||||  . |....      . ..  ..||... ..    .                     .  ...|..|...||.|||  
GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA

RNIFKA--F
. |..   |
EQILQHPWF
Kinase 96421.m00005.AA RAF 65-134 25 3.4e-12 38.06 In-house 200-275 (275) Show / Hide 
Range on Protein: 65-134
Range on HMM: 200-275/275
Sequence Identity: 25% (19 aa)

VYSYGCILYEMLVHKYPYQ-DCTSYKAAANIMSGK-RPELP----NHDSQICSLISKCWAQDPEKRPPMRNIFKAF
||..|...||..    ||| ..   .  . . .|. |. ..    . .. .  |.. ||...||.||  . | |  
VYAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI
Kinase 96421.m00005.AA RIPK 65-134 27 1.1e-11 36.13 In-house 211-290 (290) Show / Hide 
Range on Protein: 65-134
Range on HMM: 211-290/290
Sequence Identity: 27% (22 aa)

VYSYGCILYEMLVHKYPYQD-CTSYKAAANIMSGKRPELP----NHD-----SQICSLISKCWAQDPEKRPPMRNIFKAF
|||.. ...| |  | || |  ..    . . .|.||.|.    . .     .|. .|. .||.|||..||  . .   .
VYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase 96421.m00005.AA Pkinase 10-43 52 1.6e-11 41.81 Pfam 124-161 (293) Show / Hide 
Range on Protein: 10-43
Range on HMM: 124-161/293
Sequence Identity: 52% (20 aa)

LHEMGLIHRDLKSPNILLDQRLLP----YICDFGIARQ
.|.|| ||||||. |||.|..  .     |||||.|.|
CHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQ
Kinase 96421.m00005.AA Dicty4-Unclassified 10-44 51 8.8e-09 26.16 In-house 125-159 (263) Show / Hide 
Range on Protein: 10-44
Range on HMM: 125-159/263
Sequence Identity: 51% (18 aa)

LHEMGLIHRDLKSPNILLDQRLLPYICDFGIARQT
||   .||||.|| |||.|      | ||||.| .
LHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVI
Kinase 96421.m00005.AA RIPK 10-41 52 1.2e-07 22.04 In-house 123-156 (290) Show / Hide 
Range on Protein: 10-41
Range on HMM: 123-156/290
Sequence Identity: 52% (18 aa)

LHEMG--LIHRDLKSPNILLDQRLLPYICDFGIA
|| |.  .||||||  |||.|  .   | ||| |
LHSMNPPIIHRDLKPENILVDNNFHVKIADFGLA
TyrKc 96421.m00005.AA TyrKc 3-134 12 2.2e-07 -103.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 3-134
Range on HMM: 1-280/280
Sequence Identity: 12% (35 aa)

VSYD---------------------------------------LMKL-----------------------------------------------------
.. .                                       ..||                                                     
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

----------------HEMGLIHRDLKSPNILLDQRLLPYICDFGIARQTGDR--------MTKD----IEM-------------DSRHYDNKVNVYSYG
                |....|||||   |.|.. ..   |.||| .|  .|         . .      .              . . .  |  |.|.|
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFG

CILYEMLVH-KYPYQD-----CTSYKAAANIMSGKRPELPNH---------DSQICSLISKCWAQDPEKRPPMRNIFKAF
  ..|..   . || .     .. . . .....|.|.. | .          . . .....||. |||.|| ...| . |
VCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
S_TKc 96421.m00005.AA S_TKc 1-136 18 2.9e-07 -70.29 SMART 19-231 (231) Show / Hide 
Range on Protein: 1-136
Range on HMM: 19-231/231
Sequence Identity: 18% (44 aa)

MGVS------------------------------------------------Y---DLMK-------------------------------LHEMGLIHR
  ..                                                    ||..                               .|..| |||
RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYMYQICCALEYCHSHGIIHR

DLKSPNILLDQRLLPYICDFGIARQTGDRMTKDIEMDSR------------HYDN-KVNVYSYGCILYEMLVHKYPYQDCTSYKAAANIMSGKRPELPNH
|||  |||||.     |||||.|||           ..             .|.  |. ..| ||||||||. . |..    ...  ...          
DLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG---------

DSQICSLISKCWAQDPEKRPPMRNIFK-------AFCK
... ...|.||.  ||||||    ...           
SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 96421.m00005.AA Pkinase_Tyr 65-134 27 7e-07 23.93 Pfam 197-270 (270) Show / Hide 
Range on Protein: 65-134
Range on HMM: 197-270/270
Sequence Identity: 27% (20 aa)

VYSYGCILYEMLV-HKYP-YQDCTSYKAAANI-MSGKRPELPNH-DSQICSLISKCWAQDPEKRPPMRNIFKAF
|.|.|  ..|..   . | |.... .   . |  .| | . | .    | .|. .||..|||.|| .. |   .
VWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 96421.m00005.AA LRRK 9-44 40 3e-06 18.06 In-house 179-230 (351) Show / Hide 
Range on Protein: 9-44
Range on HMM: 179-230/351
Sequence Identity: 40% (21 aa)

KLHEMG--LIHRDLKSPNILL---D---------QRLLPYICDFGIAR--QT
.||     .||||||||||||   .         .     |.|||| |  |.
YLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQC
Kinase 96421.m00005.AA RAF 10-41 50 1e-05 15.62 In-house 116-147 (275) Show / Hide 
Range on Protein: 10-41
Range on HMM: 116-147/275
Sequence Identity: 50% (16 aa)

LHEMGLIHRDLKSPNILLDQRLLPYICDFGIA
||  . ||||||| ||.|.  .   | |||..
LHAKNIIHRDLKSKNIFLHNGKVVVITDFGLF
Kinase 96421.m00005.AA Pkinase_Tyr 10-42 45 0.014312 9.33 Pfam 127-159 (270) Show / Hide 
Range on Protein: 10-42
Range on HMM: 127-159/270
Sequence Identity: 45% (15 aa)

LHEMGLIHRDLKSPNILLDQRLLPYICDFGIAR
|.....|||||   |.|..  .   ||||| ||
LESKNCIHRDLAARNCLVTENNVVKICDFGLAR