Gene 92477.m00219 (T.vaginalis)
92477.m00219
Species: T.vaginalis
Alias: TvagK0319, 92477.m00219
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 92477.m00219.AA | Protein | None | 430 | None | Fasta, JSON |
| 92477.m00219.kin_dom | Protein Kinase Domain | None | 219 | None | Fasta, JSON |
Protein domains of 92477.m00219.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 92477.m00219.AA | TKL | 213-428 | 23 | 2.2e-68 | 233.49 | In-house | 1-335 (364) | Show / Hide |
Range on Protein: 213-428
Range on HMM: 1-335/364
Sequence Identity: 23% (82 aa)
IGRGASSVVYSGIYKP--------TGEEVAIKKFNCHELSLTEL-------------------------QHFQNEITVLASSSHPTLVQLVGATDSYP--
||.|....|| |... ||..||.|||. |. ..... ... .|| .. . .|| .||..|. . |
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------YCIVTKYIPNGNLFDALHKNNMLSQTDLTIA-LYDIARGMKCIHSSG--------FVHRDLKSPNVLIDQNKR--------------I
.|||. |.|.|.|.. || .... .|||||| ||.. .||||||.|.|.|.| . .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC
KLCDFGISSSSDKND--------------------QSINRAGTAQWMAPEFFNGR---------------YEITEKVDVYSFAIIAYEIASKQIPFDGLD
|.||||.| . ... ..... || .||||| ..| .| .||.|||||.|. .||.. ..|.....
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP
SQKII---------THVAINNLRPHLP------------ASC
. .| |. ..||| .| .|
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDC
|
|||||||||
| Kinase | 92477.m00219.AA | TKL-Unique | 211-428 | 33 | 2.4e-66 | 226.74 | In-house | 3-261 (290) | Show / Hide |
Range on Protein: 211-428
Range on HMM: 3-261/290
Sequence Identity: 33% (87 aa)
EDIGRGASSVVYSGIYKPTGEEVAIKKFNC-HELSLTELQHFQNEITVLASSS-HPTLVQLVGATD----SYP-YCIVTKYIPNGNLFDALHKNNMLS--
. ||.|....|| |... |..||||.|. ..|....| | ||.... || .|...|.. . | .|||. |.| |.| | || || ..
NKIGEGGYGQVYKGKWR--GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN
---QTDLTIALY-----DIARGMKCIHSSG--FVHRDLKSPNVLIDQN-----KRIKLCDFGISSSSDKNDQSINR----------AGTAQWMAPEFFNG
..|. ... |||.|| .|... ||||||.|.|.|.| .||.||||.| ...|.....|. |...||||| ...
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM
R-YEITEKVDVYSFAIIAYEIASKQI------PFDGLDSQKIITHVAI--NNLRPHLPASC
. ..||.|||||.|. .|||. .| |..|.|..... |. |.|| .| .|
NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHC
|
|||||||||
| Kinase | 92477.m00219.AA | LRRK | 207-430 | 27 | 6.6e-53 | 182.08 | In-house | 1-317 (351) | Show / Hide |
Range on Protein: 207-430
Range on HMM: 1-317/351
Sequence Identity: 27% (87 aa)
LIENEDIGRGASS-VVYSGIYK--------------------------PTGEEVAIKKFNC--------------------------------HELSLTE
|...| ||||.. .|| .... ...|||||.| || ...
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA
LQHFQNEITVLASSSHPTLVQLVGATDSYPYCIVTKYIPNGNLFDALHKNN-M-L-----S---QTDLTIALYDIARGMKCIHSSG--FVHRDLKSPNVL
.. |..|.... . || .|.|.| . . |.|.|. |.|.|.| . ||.. . . . .. | ||| .||.||. ||. ..||||||||.|
FREFRHEVWIMSHLNHPNIVSLKGFCIH-PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIAL-QIAKGMEYLHSHNPPIIHRDLKSPNIL
I---D---------QNKRIKLCDFGISS--SSDKNDQSINRAGTAQWMAPEFFN--GRYEITEKVDVYSFAIIAYEIASKQ-IPFDGLD----S--QKII
. . .. .|..|||||. ..... |. .||||| . |. | |||||.|||..| .|. . | .|||..| . . .|
LWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQI
THVAINNLRPHLPAS-CRR
|. ||| .| . |..
EDKIIEGLRPTIPQHYCPP
|
|||||||||
| Kinase | 92477.m00219.AA | Dicty4 | 208-428 | 34 | 1.3e-51 | 170.49 | In-house | 1-244 (277) | Show / Hide |
Range on Protein: 208-428
Range on HMM: 1-244/277
Sequence Identity: 34% (85 aa)
IENED-IGRGASSVVYSGIYKPTGEEVAIKKF--NCHELSLTELQHFQNEITVLASSSHPTLVQLVGATD---SYP--YCIVTKYIPNGNLFDALHK---
| |. ||.|. . || |. . | |||.||. . ... .|. | .|.. ... .|| .... || | | |||| | | |||. ||.
INIEQRIGKGSFGEVYKGTWR--GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS
---NNMLSQ--TDLT---IALYDIARGMKCIHS--SGFVHRDLKSPNVLIDQNKRIKLCDFGISS----SSDKNDQSINRAGTAQWMAPEFFNGRYEITE
. .. . . .|. |.|||| |. . ..|||||| | |.|.|.|.| ||||.| .|..| .||. ||||| .. . .|
EQQQSIKLDWPLIKRAMRMAF-DAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQ-PYNE
KVDVYSFAIIAYEIASKQIPFD--GLDSQKIITHVAINNLRPHLPASC
|.|||||.|. .||. .|.|. . . ... |. ||| .|..|
KADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWC
|
|||||||||
| Kinase | 92477.m00219.AA | Pkinase | 207-430 | 29 | 1.6e-50 | 178.98 | Pfam | 1-245 (293) | Show / Hide |
Range on Protein: 207-430 Range on HMM: 1-245/293 Sequence Identity: 29% (72 aa) LIENEDIGRGASSVVYSGIYKPTGEEVAIKKFNCHELSLTELQHFQN--EITVLASSSHPTLVQLVGAT-DSYPYCIVTKYIPNG----NLFDALH--KN . . ||.|....|| .. | ||..||.|... .. . ..|. . || .... .|| |.| .. |. ...|. | ..| ||| .. .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH NML--SQTDLTIALYDIARGMKCIHSSGFVHRDLKSPNVLIDQNKRI----KLCDFGISSS--SDKNDQSINRAGTAQWMAPEFFNGRYEITEKVDVYSF . . | .. .| |.||.. .|| |..|||||. |.|||.| | |.||||.. .| ..|| .|||| .|. ... |||..|. GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC AIIAYEIASKQIPFDGL------DSQKIITHVAINNLRPHLPASCRR .| || .... ||.| | ...| . |. . | .|.. GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSI |
|||||||||
| Kinase | 92477.m00219.AA | MLK | 207-430 | 28 | 2e-50 | 173.13 | In-house | 1-264 (291) | Show / Hide |
Range on Protein: 207-430 Range on HMM: 1-264/291 Sequence Identity: 28% (76 aa) LIENEDIGRGASSVVYSGIYKPTGEE-----VAIKKFN----CHELSLTELQHFQNEITVLASSSHPT----LVQLVGATDSY-P-YCIVTKYIPNGNLF . . | || |.. .|..| .. ... ||.|... . . .| ..|. |. |. ||| .|..|. .. . .|||. |...| |. IQFHEWIGSGSFGKVWKGRWR--NKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY DALHKNN---------------MLSQTDLTIALYDIARGMKCIHSSGF---VHRDLKSPNVLIDQ------NKRIKLCDFGISSSSDKNDQ-SINRAGTA . || .. . . ...|| ..|||| || .||||||.|.|||. .. | ||||.| . .... ..|||. NVLHGARSKWMDANHNQKNDRVYDHDHAMNWAL-QCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTY QWMAPEFF----NGRYEITEKVDVYSFAIIAYEIASKQIPFD-GLDSQKIITHVAINNLRPHLPASCRR ||||| . ...| .||.||.|.... .|. ....|.. ..|. |. || |.|||..| .| . AWMAPEVIQQFRCEKY--SEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPE |
|||||||||
| Kinase | 92477.m00219.AA | Dicty4-Unclassified | 207-428 | 33 | 3.2e-46 | 156.27 | In-house | 1-234 (263) | Show / Hide |
Range on Protein: 207-428 Range on HMM: 1-234/263 Sequence Identity: 33% (81 aa) LIENEDIGRGASSVVYSGIYKPTGEEVAIKKFNCHELSLT--ELQHFQNEITVLASSSHPTLVQLVGATDSYP------YCIVTKYIPNGNLFDALH--- . ||.|. | |. |. | | .||.|||| . .| | |. .| | .|| ||.. |. | .|||. .. |||| | IQIDQFIGKGHFSKVHKGNWK--GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCIN-PRSHKSTMCIVMEFMHKGNLFEVIHSKP --KNNMLSQTD---LTIALYDIARGMKCIHSSGFVHRDLKSPNVLIDQNKRIKLCDFGISSSSDKNDQSINRAGTAQWMAPEFFNGRYEITEKVDVYSFA .. .. | . .|. |||.|| |. |.|||.|| |.|.| . || ||||| | | ||| | .|| . . | ||||.| SEQQQPIKLDDTLIIKYAF-DIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHE-SYNQKSDVYSYA IIAYEIASKQIPFDGLD-SQKIITHVAINNLRPHLPASC .. || | |. . . |. ||| .| .| MMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNC |
|||||||||
| Kinase | 92477.m00219.AA | Dicty5 | 207-428 | 35 | 1e-41 | 141.38 | In-house | 1-227 (260) | Show / Hide |
Range on Protein: 207-428 Range on HMM: 1-227/260 Sequence Identity: 35% (83 aa) LIENEDIGRGASSVVYSGIYKPTGEEVAIKKFNCHELSLTELQHFQNEITVLASSS--HPTLVQLVGAT---DSYPYCIVTKYIPNGNLFDAL--HKN-- . . | ||| ||.|||| | |||| . ... |. |.|.. . || .. || | ||. .|| |. || ||..| .. VSFHDWIASGASGRVYNGIYK--GMDVAIKVYSQENCMCFDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPF-HVTEYCHNGSLFNYLNDQRKTT --NMLSQTDLTIALYDIARGMKCIHSSGFVHRDLKSPNVLIDQNKRIKLCDFGISSSSDKNDQSINRAGTAQWMAPEFFNGRYEITEKVDVYSFAIIAYE ... . | .|. |||..|. .|| . .|||||| |.|| | ||. |||.| | . || |||.| |||. ..|.|||||.|. .| GQPIAYFQQLHMAI-DIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQ-PYHQKCDVYSFGIVLWE IASKQIPFDGLDSQKIITHVAINNLRPHLPASC . . |.| . . | |. || .|. | MFTRKEPYDNINNWNIPVMVMKGE-RPTIPKDC |
|||||||||
| Kinase | 92477.m00219.AA | STE | 208-403 | 21 | 5.4e-39 | 135.36 | In-house | 1-268 (359) | Show / Hide |
Range on Protein: 208-403
Range on HMM: 1-268/359
Sequence Identity: 21% (58 aa)
IEN-EDIGRGASSVVYSGIYK------PTGEE---------VAIKKFNCHELS---------------LTELQHFQNEITVLASSS--HPTLVQLVGATD
|. | ||.||. .|| .... .|||. .|||. | . . .|.| ...|| .. .. || |. |.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
SYP--------YCIVTKYIPNGNLFDALHKNNMLSQT------------DLTI--ALYDIARG-MKCIHSSGFVHRDLKSPNVLIDQNKRIKLCDFGISS
.|. |...| | | .... . .. | ...| .| .. .|| . .|||.|. |.|. .||||||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG
SSDK----------------ND-QSINRAGTAQWMAPEFFNG-----RYEITEKVDVYSFAIIAYEIASKQIPF
. .. .. .. .|| ||||| .. . . ..|.|..|. . . | | . |.
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW
|
|||||||||
| Kinase | 92477.m00219.AA | TK | 207-428 | 16 | 7.9e-39 | 127.27 | In-house | 1-443 (486) | Show / Hide |
Range on Protein: 207-428
Range on HMM: 1-443/486
Sequence Identity: 16% (73 aa)
LIENEDIGRGASS---VVYSGIYKPTG-------------------------EEVAIKKFNC-HELSLTELQH--------------FQNEITVLAS--S
.. . .|.|. .|| |.... . ..||.| .. | .| . . .|. .. .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
SHPTLVQLVG-ATDS------------YPYCIVTKYIPNGN----LFDALHKNNM---------------------------------------------
|| .|.|.| |.. |..||. | |.|. | | |.|.
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-----------LSQTDLTI-------------------ALYDIARGMKCIHSS------GFVHRDLKSPNVLIDQNKR-----------IKLCDFG----
|...|| ..||.|| .|| .|||||| |.|...|.. .|..|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ
------ISSSSDKNDQSINRAGTAQ-------------------------WMAPEFFNGR--------YEITEKVDVYSFAIIAYEIAS--KQIPFDGLD
||.. . . ||. ||||| .|.| |.| ||.|| . .|| . .. . |..
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS
S---------QKIITHVAIN-------------NLRPHLPASC
. | .. .. .|. |. |
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHC
|
|||||||||
| Kinase | 92477.m00219.AA | S_TKc | 207-429 | 26 | 1.8e-36 | 128.4 | SMART | 1-220 (231) | Show / Hide |
Range on Protein: 207-429
Range on HMM: 1-220/231
Sequence Identity: 26% (64 aa)
LIENEDIGRGASSVVYSGIYKPTGEEVAIKKFNCHELSLTELQHFQNEITVLASSSHPTLVQLVGATDSYPYCIVTKYIPN--GNLFDALHKNNM-----
. ||.|| ..|| .. | ||..||||. . .|...|| .| . || .|.| .. .. ...|. |... |.||| ..|..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF
-LSQTDLTIALYDIARGMKCIHSSGFVHRDLKSPNVLIDQNKRIKLCDFGISSSSDKNDQSINRAGTAQWMAPEFFNGRYEITE-KVDVYSFAIIAYEIA
.. . .| |..... .|| |..||||| |.|.|. .||.||||.. || .|||| . . |.|..|. .| || .
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML
SKQIPFDGLDSQKIITHV-------------AIN-NLRPHLPASCR
. . ||. . |... .. . . || .
CGYPPFP--QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQ
|
|||||||||
| Kinase | 92477.m00219.AA | TKL-ciliate1 | 210-404 | 27 | 1.3e-34 | 115.92 | In-house | 4-220 (279) | Show / Hide |
Range on Protein: 210-404 Range on HMM: 4-220/279 Sequence Identity: 27% (61 aa) NEDIGRGASSVVYSGIYKPTGEEVAIKKFNCHELSL--TELQHFQNEI-TVLASSSHPTLVQLVGATDSY--PYCIVTKYIPNGNLFDALHK--N--NML || | .. ||.| . .|||.. | .. . || || . . | |.||.| . .| . |.. . . | .|| .|. .|. GQKIGSGHFCNVYKGRCN--SYDVAIMNMNYFNSQESFINQKEFQREIQQHIKIKQHINLQQLQG-ISFYDNNFYIIMEHCHKGTMFDICHRKHSQIYMI SQTDLTIALYDIARGMKCIHSSG--FVHRDLKSPNVLIDQNKRIKLCDFGISSS------SDKNDQSI----NRAGTAQWMAPEFFN----GRYEITEKV . ..|||.|| .|. .|||||. | | | . | |.|. . . |.. | .| ||||| . | |.||. KWQHRMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKI DVYSFAIIAYEIASKQIPFD |.|...|..|. ... ||. DIYAYGIVMYILCFRKTPFQ |
|||||||||
| Kinase | 92477.m00219.AA | Pkinase_Tyr | 207-428 | 28 | 9.9e-33 | 111.48 | Pfam | 1-241 (270) | Show / Hide |
Range on Protein: 207-428 Range on HMM: 1-241/270 Sequence Identity: 28% (70 aa) LIENEDIGRGASSVVYSGIYK----PTGEEVAIKKFNCHELSLTE--LQHFQNEITVLASS-SHPTLVQLVGA-T-DSYP--YCIVTKYIPNGNLFDALH .. .. .|.|| .|| |..| |. .||.|. . . . .. | .|. .. . .|| .|.|.|. | .. | ..||. | |.|.| | |. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR K----NNMLSQTDLTIALYDIARGMKCIHSSGFVHRDLKSPNVLIDQNKRIKLCDFGISSSSDKNDQSINRAGT-----AQWMAPE-FFNGRYEITEKVD | .. |. || ..||.|| .| ...|||| |.|.. |. .| |||| . . |. |... ||||| ...|. |.| | KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGK--FTTKSD VYSFAIIAYEIAS-KQIP-FDGLDSQKIITHVAINNLRPHLPASC |.|| . .|| . ..| . |.. . .. ... .. | | | VWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENC |
|||||||||
| Kinase | 92477.m00219.AA | TyrKc | 207-430 | 24 | 3.4e-18 | 67.71 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 207-430 Range on HMM: 1-280/280 Sequence Identity: 24% (71 aa) LIENEDIGRGASSVVYSGIYKPTGEEVAIKKFNCHELSLTELQHFQNEITVLASS--SHPTLVQLVG-ATDS-------YPYCIVTKYIPNGNLFDALHK . .. .|.|| .|| |..| ..||.|. . . .. | .|. .. . .|| .|.|.| .|.. |..||. | |.|.| | |.| ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK NNM-LSQTDLTIALYDIARGMKCIHSSGFVHRDLKSPNVLIDQNKRIKLCDFGISSSSDKN------DQSINRAG--TAQ------WMAPEFF-NGRYEI . |. || ..||.|| .|| ...|||| |.|.. |...| .||| | . .. . .. . ||||| . |.. HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF-- TEKVDVYSFAIIAYEIASK-QIPFDG-----LDSQKIITHVAINNLRPHLPA----------------------------------SCRR |.| ||.|| . .|| . | | | .. | .| .| . .| | . TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||