Gene 96301.m00119 (T.vaginalis)
96301.m00119
Species: T.vaginalis
Alias: TvagK0348, 96301.m00119
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 96301.m00119.AA | Protein | None | 783 | None | Fasta, JSON |
| 96301.m00119.kin_dom | Protein Kinase Domain | None | 184 | None | Fasta, JSON |
Protein domains of 96301.m00119.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 96301.m00119.AA | TKL-Unique | 45-267 | 23 | 4.7e-31 | 106.83 | In-house | 20-290 (290) | Show / Hide |
Range on Protein: 45-267 Range on HMM: 20-290/290 Sequence Identity: 23% (65 aa) GSTVAIKRIY-DNKPSKDEIKTYAMEIQAIFATS-TPYSTSLIGYSV----TAP-FIIVTECYEEANLSTLLKQ-----------KKLDFTQLNSILLEL |. ||||.. ...|...... .|. . | . ..||.. ..| ..||.|.... .| .| | .||.. | ... . GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDI AFALKQIHEVN--FIHGNVCPSNIILDKY-----GKTKLVGFGNSRYPSKSPKNVYT-------SGKIKENNWLSPEFLAG--EVFTEKHDVFSFGSLVY | .. .| . ||.. .||. .| . |...|| |. ||. |. .. ...... .|..|| | . . ..|| ||.||| .. AQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLW QFLTGEI------PFNGQSQSEVRSNIVNY----KLPTI----PQQLSKLITDCWDK-PDKRPSIAKILESL .|..| |. | .| .... .| | . |.| |.....||..||. |..||| |...| EIATRKITKTYKKPYQGMDQEQWCE-MVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
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| Kinase | 96301.m00119.AA | TKL | 28-267 | 18 | 4.1e-26 | 91.03 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 28-267
Range on HMM: 1-364/364
Sequence Identity: 18% (67 aa)
FAKGERATFYHGTRMK--------DGSTVAIKRIYDNKPSKDEI-------------------------KTYAMEIQAIFATSTPYSTSLIGYSVTAP--
.| .. |.|. . .| .||.|.. . ..... .. || . .. | ...||. |
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------FIIVTECYEEAN-LSTLLKQKKLDFTQLNSILLELAFALKQIHE--------VNFIHGNVCPSNIILDKYGK--------------TK
. ||.| .. . |..|. . |. .. |. | .. | . || . ..|| .|. .. |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK
LVGFGNSRYPSKSPKNVYTS--------------GKIKEN---NWLSPEFLAGE----------------VFTEKHDVFSFGSLVYQFLTGEIPFNGQSQ
. || || |.| .. |. .... .|..|| | |. ..||.||.||| . . ||...|. ..
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY
SEVR---------SNIVNYKL-----------------PTIPQQLSKLITDCWDK-PDKRPSIAKILESL
... . ... .| |..|....||..|||| |.|||| .||. |
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | 96301.m00119.AA | TK | 22-267 | 13 | 5.4e-22 | 69.85 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 22-267
Range on HMM: 1-486/486
Sequence Identity: 13% (65 aa)
VTQKDEFAKGERA---TFYHGTRMKDG-------------------------STVAIKRIYDN-KPSKDEIKT--------------YAMEIQAIF--AT
.| .. .|. . | |. .. .||.| . . |..| . |.|.. .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
STPYSTSLIGYSVTA-------------PFIIVTECYEEAN----LSTLLKQKK----------------------------------------------
| .|.|... |..||.|. . . | . |....
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------LDFTQLNSILLELAFALKQIHEV------NFIHGNVCPSNIILDKYGK-----------TKLVGFGNS-
|. || . . .| .. .|. ||.|.... |. ... .. |. || |
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-----RYPSKSPKNVYTSGKIKENN--------------------------WLSPEFLAGEV---------FTEKHDVFSFGSLVYQFLT-G-EIPFNGQ
. .. |.. . . . |..|| |.. | ||.| ||.||| |.. .| | | . |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM
SQ---------SEVRSNIVN---------------YKLP---TIP--------------QQLSKLITDCWDK-PDKRPSIAKILESL
| || .... . .| | . . |...||.. |..||. . ..| |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | 96301.m00119.AA | Dicty4-Unclassified | 84-267 | 30 | 4.6e-21 | 68.84 | In-house | 63-263 (263) | Show / Hide |
Range on Protein: 84-267 Range on HMM: 63-263/263 Sequence Identity: 30% (62 aa) LIGYSVTAP------FIIVTECYEEANLSTLLK------QK--KLDFTQLNSILLELAFALKQIHEVNFIHGNVCPSNIILDKYGKTKLVGFGNSRYPSK . ||.. .| ..||.| || . |. ||| | . .. | . | .|||| . ||| .|| | || || . CYGYCI-NPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVID- SPKNVYTSGKIK-ENNWLSPEFLAGEVFTEKHDVFSFGSLVYQFLTGEIPFNG-QSQSEVRSNIVNYKL-PTIPQQ----LSKLITDCW-DKPDKRPSIA . .. | | ||| | .| .. | ||.|.. . | .||. |. . || .. . || | || ..||| .|| . | |||.. ---FNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMN KILESL .| . | QIIQYL |
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| Kinase | 96301.m00119.AA | Dicty4 | 185-269 | 31 | 2e-20 | 64.98 | In-house | 183-277 (277) | Show / Hide |
Range on Protein: 185-269 Range on HMM: 183-277/277 Sequence Identity: 31% (30 aa) WLSPEFLAGEVFTEKHDVFSFGSLVYQFLTGEIPFN--GQSQSEVRSNIVNYKL-PTIPQQ----LSKLITDCWDK-PDKRPSIAKILES--LRS | .|| .... ..|| ||.||| . .. ||...|.. ... ... ..| || | ||.. ...||..|||. | .||| . |.. | . WMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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| Kinase | 96301.m00119.AA | Ciliate-E2-Unclassified | 107-265 | 19 | 5.3e-20 | 66.1 | In-house | 128-348 (352) | Show / Hide |
Range on Protein: 107-265
Range on HMM: 128-348/352
Sequence Identity: 19% (44 aa)
TLLKQKKLDFTQLN-----SILLELAFALKQIHEVN-FIHGNVCPSNIILDKYG---KTKLVGFGNSRYPSKSPKNVYTSG-------KIKENNWL----
.....|... | .. .. .|...|. | .|| . |.||..|. | . |. .||.|... ..... |.. | .. .
NMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTP
-------SPEFLAGEVFT----EKHDVFSFGSLVYQFLTGEIPFNGQSQSE----------------VRSNIVN-----YKLPT--IPQQLSKLITDCWD
.|| | |. .| |..|.| . |..|.|. ||..... . ...|| . | | ||...|. |.
NYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN
---------KPDKRPSIAKILE
.|.||... .||.
DLLQKMLKKNPNKRITFEQILN
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| Kinase | 96301.m00119.AA | LRRK | 185-269 | 27 | 3.4e-19 | 64.53 | In-house | 245-351 (351) | Show / Hide |
Range on Protein: 185-269 Range on HMM: 245-351/351 Sequence Identity: 27% (29 aa) WLSPEFLAGE---VFTEKHDVFSFGSLVYQFLTGE-IPFNGQS-------QSEVRSNIVNYKLPTIP-----Q-----QLSKLITDCWD-KPDKRPSIAK |..|| . .. ..||| |..||| . . ||.. .|| . . ..... .| . |||| . ...||..||. .|.|||. . WMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQ ILESLRS |.. | . IVKRLSQ |
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| Kinase | 96301.m00119.AA | MLK | 185-267 | 30 | 1e-17 | 58.14 | In-house | 199-291 (291) | Show / Hide |
Range on Protein: 185-267 Range on HMM: 199-291/291 Sequence Identity: 30% (28 aa) WLSPEFL---AGEVFTEKHDVFSFGSLVYQFLTGEIPFN-GQSQSEVRSNIVNYKLP-----TIPQQLSKLITDCWD-KPDKRPSIAKILESL | .|| . .| ..|| ||.|.| . .. ||.|.|. ....... ... .| |.| ..||...||. .| |||| . |.. | WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | 96301.m00119.AA | Ciliate-E2 | 95-265 | 15 | 5.6e-16 | 51.31 | In-house | 111-361 (365) | Show / Hide |
Range on Protein: 95-265 Range on HMM: 111-361/365 Sequence Identity: 15% (41 aa) IVTECYEEANLSTLLKQK------------KLDFTQLNSILLELAF---------------ALKQIHEVN-FIHGNVCPSNIILDKYGKTKLVGFGNSRY .|.| .. .| ..|.. ... . | ... ||. .|. | || . |.||.. |.. ||.|.. LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKK PSKSPKN---VYTSGKIKENN----------------------WLSPEFLAGEVFT--------------EKHDVFSFGSLVYQFLTGEIPFNGQSQSEV ... .| ...... . .|...| |.. .| |..|.| . |..|.|. || | . YDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----QQQI RSNIVNYKLPT-------------IPQQLSKLITDCWDK---------PDKRPS-IAKILE . ... | .....|. | | |.||.. . .||. KQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN |
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| Kinase | 96301.m00119.AA | TK-Unique | 83-267 | 20 | 8e-16 | 51.14 | In-house | 68-294 (294) | Show / Hide |
Range on Protein: 83-267
Range on HMM: 68-294/294
Sequence Identity: 20% (46 aa)
SLIGYSV-TA-PFIIVTECYEEANLSTLLKQKK---------------------------LDFTQLNSILLELAFALKQIHE--VNFIHGNVCPSNIILD
...|... . |. |. | .. || ..|.... .. .| ... ..| ... ... ...|...| .|. |
QCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLT
KYGKTKLVGFGNSRYPSKSPKNVYTSG---KIKENNWLSPEFLA--GEVF-TEKHDVFSFGSLVYQFLT-GEIPFNGQSQSEVRSNIVNYKLPTIPQQL-
... |. .|| .|. .. .|| . . . |..|| | .... |.| || ||| | . .| |. |..| ...... .| . . . |..
EDKVCKICDFGMARDVYT--NGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCC
----SKLITDCW-DKPDKRPSIAKILESL
.|. || ..|..|||...|. |
SHEMYNLMKSCWQWEPEERPSFRQIKHRL
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| Kinase | 96301.m00119.AA | Pkinase | 37-267 | 19 | 2.2e-14 | 51.95 | Pfam | 16-293 (293) | Show / Hide |
Range on Protein: 37-267 Range on HMM: 16-293/293 Sequence Identity: 19% (56 aa) YHGTRMKDGSTVAIKRIYDNKPSKDEIKTYAM--EIQAIFATSTPYSTSLIGYSVTAPFII-VTECYEEA----NLSTLLK---QKKL--DFTQLNSILL |.... ..| .||.|.| . .... .| . ||| . |. |... . . | |.|. | |..... .... . .. .... YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY ELAFALKQIHEVNFIHGNVCPSNIILDKYGKT----KLVGFGNSR---YPSKSPKNVYTSGKIKENNWLSPEFLA-GEVFTEKHDVFSFGSLVYQFLTGE ... .|. .|. ..|| . |.|| .|. | . |. || .. | ..| .... ....|| . |. . | |..|.| ..|..|.|. QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP----WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR IPFNGQ------SQSEVRSNIVNYKLPTIP------------------------QQLSKLITDCWDK-PDKRPSIAKILES--L || |. .| .. .| .|. . . ..|..|..| | |||... ||.. . PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 96301.m00119.AA | S_TKc | 22-273 | 19 | 2.8e-14 | 32.46 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 22-273 Range on HMM: 1-231/231 Sequence Identity: 19% (53 aa) VTQKDEFAKGERATFYHGTRMKDGSTVAIKRIYDNKPSKDEIKTYAMEIQAIFATSTPYSTSLIGYSVTAPFIIVTECYEE--ANLSTLLKQKK------ . .. || .. | .. |.| ||||.| .. ||| |. |... .. . .|.|. . .| ...|... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -LDFTQLNSILLELAFALKQIHEVNFIHGNVCPSNIILDKYGKTKLVGFGNSRYPSKSPKNVYTSGKIKEN------NWLSPEFLAGEVFTE-KHDVFSF .. . ... ... ||. .|. ..|| . |.|| ||. |. || .| . ....|| | .. | |. |. PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC GSLVYQFLTGEIPFNGQSQSEVRSNIVNYKLPTIPQQLSKLITDCWD-KPDKRPSIAKILE---SLRSKEIV | ..| .|.|. || . .. .|. .... .| |.. |.|||.. ..|. .. . . GCILYEMLCGYPPFP--QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 96301.m00119.AA | TyrKc | 22-267 | 20 | 4.1e-12 | -26.79 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 22-267 Range on HMM: 1-280/280 Sequence Identity: 20% (61 aa) VTQKDEFAKGE-----RATFYHGTRMKDGSTVAIKRIYDNKPSKDEIKTYAMEIQAIFAT--STPYSTSLIGYSVT--------APFIIVTECYEEANLS .| ... |. ..| . .||.| . ... .. |.. . | |.|. .. | ||.| . .| ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK TLLKQKK--LDFTQLNSILLELAFALKQIHEVNFIHGNVCPSNIILDKYGKTKLVGFGNSRYPSKS-----PKNVYT-----SGK----IKENNWLSPEF |. .. | .| |. . | .|. |.|| |. ... . | || ||. | .|. .|| |. |..|| DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR---WMAPEC LAGEVFTEKHDVFSFGSLVYQFLT-GEIPFNG-----QSQSEVRSNIVNYKLPTIPQQ------------LSKLITDCWDK-PDKRPSIAKILESL . .||.| ||.||| . . .| |. | | | .||. .. . . . .|. . .....||. |..||. . | | . INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 96301.m00119.AA | Pkinase_Tyr | 185-267 | 34 | 7.4e-08 | 27.24 | Pfam | 180-270 (270) | Show / Hide |
Range on Protein: 185-267 Range on HMM: 180-270/270 Sequence Identity: 34% (31 aa) WLSPEFLAGEVFTEKHDVFSFGSLVYQFLT-GEIP-FNGQSQSEVRSNI-VNYKLPTIPQ----QLSKLITDCW-DKPDKRPSIAKILESL |..|| .. .||.| || ||| | . .| ||.| . | | .|| | . .|. . .|...|| .|..||. . |.| | WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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