Gene 96452.m00077 (T.vaginalis)

96452.m00077

Species: T.vaginalis
Alias: 96452.m00077, TvagK0932
External Links:
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: STE7-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
96452.m00077.AA Protein None 362 None Fasta, JSON
96452.m00077.kin_dom Protein Kinase Domain None 253 None Fasta, JSON

Protein domain

Protein domains of 96452.m00077.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc 96452.m00077.AA S_TKc 72-324 31 1.1e-77 265.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 72-324
Range on HMM: 1-231/231
Sequence Identity: 31% (84 aa)

LKFHEQLGHGVQGTVYRCTHIPSGKEFAVKSIKYQDKSQLQKTVDEIHSLRILRHPNVVHLFSAFAQKGSIHILMDLVNG--ASLGDYLKYSPI------
 ......|.|  |.||.|.|. .|...|.| ||       ...  ||  |.  .|||.|.|. .|   ..... |....|   .| ||.|  .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

IPEPALHEITVQMIAGLRFCCKNHIIHRDIKPSNVMLSLDGRIQIADFGLARQLRDTGDFAQSVIGTTCYMSPERIRGQSYGL-KSDVWSLGLILYQSCI
.||     .. |.. .| .| ...|||||.||.|..|.   .| |.||||||||        ...||  ||.|| .   .||  |.|.||.| |||  . 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GRYPFGENKTHFWDLNFETQNDIIVDLGPNYSPLLLDFIEKCLVMEQDDRATFEELNA-------HEWI
|. ||          . ..  ..|.      || ..|||.|||... ..| |  |. .       |.|.
GYPPFP---------QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase 96452.m00077.AA Pkinase 72-324 30 1.7e-70 245.29 Pfam 1-293 (293) Show / Hide 
Range on Protein: 72-324
Range on HMM: 1-293/293
Sequence Identity: 30% (89 aa)

LKFHEQLGHGVQGTVYRCTHIPSGKEFAVKSIKYQDKSQLQKTVD----EIHSLRILRHPNVVHLFSAFAQKGSIHILMDLVNGA----SLGDYLK--YS
.......| |  |.||.|.|. .||..||| ||.....  ..  .    ||. .. |.|||.| |. .|  |..|.. |....|     .| ||..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

PII--PEPALHEITVQMIAGLRFCCKNHIIHRDIKPSNVMLSLDGRI----QIADFGLARQL-RDTGDFAQSVIGTTCYMSPERIR-GQSYGLKSDVWSL
  .  .|  .  .  |.. || .| .. |||||.||.|.... .| |     |.|||||.|.    .  .... ||  ||.|| || || || |.|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GLILYQSCIGRYPFGEN---------KTHFWDLNFETQNDIIVD----------------LGPNYSPLLLDFIEKCLVMEQDDRATFEELNAHEWI
|.|||. . || || .          . .. ..  ..  |.  .                . .| |. ..|||..|| .   .| |.|..  |.|.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 96452.m00077.AA STE7-Unclassified 72-324 33 9.1e-67 228.13 In-house 1-301 (301) Show / Hide 
Range on Protein: 72-324
Range on HMM: 1-301/301
Sequence Identity: 33% (101 aa)

LKFHEQLGHGVQGTVYRCTHIP------SGKEFAVKSIKYQDK--SQLQKTVDEIHSLRILR-HPNVVHLFSAFAQKGS---IHILMDLVNGASLG---D
|.. . ||||  |||. | | .      .|| .| |.|. .|   .  .. . |.  |..   ||..|| . |. ....   |||.| .  . ||    |
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

YLKYS----PI----IPEPALHEITVQMIAGLRFCCKNH-IIHRDIKPSNVMLSLDGRIQIADFGLARQLRDTGDFAQSVIGTTCYMSPERIRGQ-----
 .| .    ||    |||| |  |. | | ||..  . | ||||||||.|. .. .|.. |.||| . || .| | |.. .|.. |||||||.||     
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHRP

SYGLKSDVWSLGLILYQSCIGRYPFG--------ENKTH-----FWDL--NFETQNDIIVDLGP---NYSPLLLDFIEKCLVMEQDDRATFEELNA-HEW
||..|||.||||| .    .|.||..        ...       ||.|  ....    . .  |   ..|. . |||.||.  .. .|... .|   |.|
SYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHPW

I
|
I
Kinase 96452.m00077.AA STE 72-324 21 2.1e-65 223.61 In-house 1-359 (359) Show / Hide 
Range on Protein: 72-324
Range on HMM: 1-359/359
Sequence Identity: 21% (80 aa)

LKFHEQLGHGVQGTVYRCTHI------PSGKE---------FAVKSIKYQDK-----------------SQLQKTVDEIHSLRILR--HPNVVHLFSAFA
... |..|.|  ||||.. ..      ..|..         .|.| ......                 ...|.   ||  .. ..  |||.|. . .. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

QKG-------SIHILMDLVNGASLGDYLK--YSP------------IIPEPALHEITVQMIAG-LRFCCKNHIIHRDIKPSNVMLSLDGRIQIADFGLAR
..|       ...| | ...| || | .|  |..             .||. .  |..| . | | .  ..|||||||||.|..|     . ..|||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLRD---------------TGD-FAQSVIGTTCYMSPERIRG------QSYGLKSDVWSLGLILYQSCIGRYPFGENKTH----FWDLNFETQN------
|| |               |..   ....||  .|.||.|..      . |. |.|.||||. .   . |..|. . . .     .  |.  |.      
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----DIIVDLGP------------------NYSPLLLDFIEKCLVMEQDDRATFEELNA--HEWI
    ..     .                  ..|| . |||.|||... ..|.| ..|    |..|
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 96452.m00077.AA STE7 72-324 33 3e-61 209.8 In-house 1-288 (288) Show / Hide 
Range on Protein: 72-324
Range on HMM: 1-288/288
Sequence Identity: 33% (96 aa)

LKFHEQLGHGVQGTVYRCTHIPSGKEFAVKSIKYQDK--SQLQKTVDEIHSLRILR-HPNVVHLFSAFAQKGS--IHILMDLVNGASLGDYLKYS-----
|.. ..||||  |.|| . | |||| .||| |.....  .  .. . |.  |.    .|..|. . || ..|.  |.| | .  | .|  ..|.      
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

----PIIPEPALHEITVQMIAGLRFCCK-NHIIHRDIKPSNVMLSLDGRIQIADFGLARQLRDTGDFAQSVIGTTCYMSPERIRG--QSYGLKSDVWSLG
     .|||. |  |.|. | ||..  .  .|||||.||||. .  .|.. ..||| . || |. | |.. .|.  ||.|||| |  |.|. .|||||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLG

LIL-YQSCIGRYPFGENKTH-----FWDLNFE------TQNDIIVDL-G----PNYSPLLLDFIEKCLVMEQDDRATFEELNA-HEWI
. . ..  .||||.....||       ...|       .| ..||.       |..|| . ||..|||  ....|.....| . |..|
ITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLPKFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase 96452.m00077.AA CAMK 77-324 16 5.9e-60 191.56 In-house 1-425 (425) Show / Hide 
Range on Protein: 77-324
Range on HMM: 1-425/425
Sequence Identity: 16% (72 aa)

QLGHGVQGTVYRCTHIPSG------------KEFAVKSIKYQ----------------------------DKSQLQKTVDEIHSLRI-------LRHPNV
.||.|  |.|..|.|. ..            ...|.| |. .                            . . ...   ||. ..        |.|||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VHLFSAFAQKGS-------------------IHILM---DLVNGA----SLGDYLKYS---------------PIIPEPALHEITVQMIAGLRFCCKNHI
..|. ..  .                     ... |   ... |      | ||..                   ..|   . .  |.. ....| ...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKPSNVMLSLD-----------------GRIQIADFGLARQLRD-----------------------TGDFAQSVIGTTCYMS-PERIRGQS----
.|||.|| |..|. .                 . | |.|||.|.....                       .|.  . . || .||. || ..|..    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YGLKSDVWSLGLILYQSCIGRYPFGE--------------NKTHFWDLNFETQNDII----------------------VDLGPNYSPLL
          || |.|.||.| |||    |..|| .              |    .    . . | .                           . |.  
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEF-HH-FVSQEC

LDFIEKCLVMEQDDRATFEELNAHEWI
 |.| |.|. . ..|.| |.  .|.|.
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 96452.m00077.AA Ciliate-E2 72-324 21 1.6e-57 196.03 In-house 1-365 (365) Show / Hide 
Range on Protein: 72-324
Range on HMM: 1-365/365
Sequence Identity: 21% (81 aa)

LKFHEQLGHGVQGTVYRCTHIPSGKEFA--------------------VKSIKYQDKSQLQKTVDEIHSLR----------------ILRHPNVVHLFSA
 ||....| | .|.||.|...  .|.||                     . .|.. |.|.. .  ||| .|                .| |||.. .. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FA--QKGSIHILMDLVNGASLGDYLKYSPIIP-----------EPALHEITVQMIA---------------GLRFCCKNH-IIHRDIKPSNVMLSLDGRI
|   .. .| . |....| .| ||.| ...             |    .|. | .                .|... ... ||||||||.|...     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

QIADFGLAR----------------QLRDTG----------------DFAQSVIGTTCYMSPERIRGQS---------YGLKSDVWSLGLILYQSCIGRY
 |.||||..                 . . .                . .....||  ||.|| ..|..         |. |.|.|||| |||. . |..
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFGENKTHFWDLNFETQNDIIVD----------------LGPNYSPLLLDFIEK----CLVMEQDDRAT-FEELNAHEWI
||         ..   |..|  .                   . |.   |.| |    .|. ... | | .|..  |.|.
PF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 96452.m00077.AA Ciliate-E2-Unclassified 73-324 23 4.6e-55 189.25 In-house 2-352 (352) Show / Hide 
Range on Protein: 73-324
Range on HMM: 2-352/352
Sequence Identity: 23% (83 aa)

KFHEQLGHGVQGTVYRCTHIPSGKEF-----AVKSIKYQDKSQLQ--------KTVDEIH-------------SLRILRHPNVVHLFSAFAQKGSIHILM
|...|.|.| .|.||.| |.  . ..     . |...| .|....        |.. ..              .|. . ||..|..| .| .|  | | |
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

DLVNGASLGDYLKYSP-----------------IIPEPALH-----EITVQMIAGLRFCCKNH-IIHRDIKPSNVMLSLDG---RIQIADFGLARQLRD-
....| .| .|.| ..                 |..| .        .. | . || ...... ||||||||.|.... .|   .| |.|||..... . 
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

---TGDF------------AQSVIGTTCYM----SPERIRGQSYGLK----SDVWSLGLILYQSCIGRYPF-GENKTH-----------FWDLNFETQND
   . ..            .....|| .||    .|| ..|| |. .    .|.|||| |||. . |.||| ..|..            .   ... ...
NNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNA--YRKQLYQN

II---VDLGP--------NYSPLLLDFIE----KCLVMEQDDRATFEELNAHEWI
|.   ..  .        . ||   |||.    |.|.  .. | |||..  | |.
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 96452.m00077.AA ULK 72-324 25 3.6e-52 179.63 In-house 1-324 (324) Show / Hide 
Range on Protein: 72-324
Range on HMM: 1-324/324
Sequence Identity: 25% (82 aa)

LKFHEQLGHGVQG-TVYRCTHIPS---GKEFAVKSIK---YQDKSQL-------QKTVDEIHSLRILR---HPN--VVHLFSAFAQKGS--IHILMDLVN
   ...||.|  | .||. ... .   .. .|.| |     ..|...       |.   ||  ...|    |||  .| |.  |  . .  | | |.. |
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GASLGDYLK---YSP------IIPEPALHEITVQMIAGLRFCCKNHIIHRDIKPSNVMLSLD------------GRIQIADFGLARQLRDTG---DFAQS
|  | .|.|   ..|      ...|.   ..  | ..|...  |. ||||||||.| ... .            |.. |||||.|... . .   .  |.
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

VI------GTTCYMSPERIR----GQSYG-LKSDVWSLGLILYQSCIGRYPFGEN-KTHFW---DL---------NFETQNDIIVD--LGPNYSPLLLDF
        ||  ||.|. .     .. |.  |.|.|||| |.|.   |.||| ..  . ..   .|           ..|.  . .   .|. || . |.
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDL

IEKCLVMEQDDRATFEELNAHEWI
| ..|. ...|| ..||. .|.|.
IRRMLQYDEKDRISWEEIFNHPWF
Kinase 96452.m00077.AA NEK 76-259 28 1.1e-51 177.97 In-house 5-216 (286) Show / Hide 
Range on Protein: 76-259
Range on HMM: 5-216/286
Sequence Identity: 28% (61 aa)

EQLGHGVQGTVYRCTHIPSGKE-----FAVKSIKYQ--DKSQLQKTV-DEIHSLRILRHPNVVHLFSAFAQKG--SIHILMDLVN-GASLGDY---LKYS
...| | .|.||.. ..  ||.     .. | |...  .  . |...  |.. |. |.|||.|  . .|  ..  ...| |.  . |  | .    .|  
KKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQ

P----IIPEPALHEITVQMIAGLRFCCKN-----HIIHRDIKPSNVMLSLDGR----IQIADFGLARQLRDTGDFAQS-VIGTTCYMSPERIRGQSYGLK
      ..|    .. .||. .|... ..     .|.||||||.|..|. ...    . | |||....| .| |.|.. ..|| .||||| .....|. |
KQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNK

SDVWSLGLILYQ
||.|||| .||.
SDIWSLGCVLYE
Kinase 96452.m00077.AA ULK 72-324 24 4e-50 172.84 In-house 1-329 (329) Show / Hide 
Range on Protein: 72-324
Range on HMM: 1-329/329
Sequence Identity: 24% (81 aa)

LKFHEQLGHGVQGTVYRCTHIPS----GKEFAVKSIK---YQDKSQLQK-------TVDEIHSLRILR--------HPNVVHLFSAFAQKGS--IHILMD
   ...||.|  |.||. ... .    .. .|.| |     . |...|           ||  .. |         |||.| |.  |  . .  | | |.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LVNGASLGDYLK----------YSPIIPEPALHEITVQMIAGLRFCCKNHIIHRDIKPSNVMLSLD------------GRIQIADFGLARQLRDT---GD
. ||  | .|.|          .  ...|.   ..  | ..|...  |. ||||||||.|.... .            |.. |||||.|... .     .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

FAQSVI------GTTCYMSPERIR----GQSYG-LKSDVWSLGLILYQSCIGRYPFGENKTHFWDLNFETQNDIIVDL----------------------
 ...        ||  ||.|. .     .. |.  |.|.|||| |.|.   |..||      ..  ...... || .|                      
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPF------YAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDG

-GPNYSPLLLDFIEKCLVMEQDDRATFEELNAHEWI
 .|. || . |.| ..|. ...|| ..||| .|.|.
NDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 96452.m00077.AA STE20 72-254 28 2.8e-44 153.44 In-house 1-214 (288) Show / Hide 
Range on Protein: 72-254
Range on HMM: 1-214/288
Sequence Identity: 28% (62 aa)

LKFHEQLGHGVQGTVYRCTHIPSGKE----FAVKSIKYQDK----SQLQKTVDEIHSLRILRHPNVVHLFSAFAQK----GSIHILMDLVNGASLGDYLK
 .. |..|.|  |.||...|.|.|..     |.| ... ..     ...  . ||  .. ..|||.|. . ..  .     .. |.|.. .| || | .|
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

YSPIIP---------EPALHEITVQMIAGLRFCCKNHIIHRDIKPSNVMLSLDGRIQIADFGLARQLRD----TGDFA-QSVIGTTCYMSPERIRG----
 . ..          |.    |. ..  || .  .|||||||||  |..|. ||....||||.. || .    | .|  ....|| ..|.|| |..    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-QSYGLKSDVWSLG
 . |. |.|.||||
DKGYDYKCDIWSLG
Kinase 96452.m00077.AA TyrKc 72-324 21 6e-17 51.36 SMART 1-280 (280) Show / Hide 
Range on Protein: 72-324
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

LKFHEQLGHGVQGTVYRCTHIPSGKEFAVKSIKYQDKSQLQKTVDEIHSLRIL--RHPNVVHLFSAFAQK-------GSIHILMDLVNGASLGDYLKYSP
... ..||.|  |.||..| .    . |||..|      ..   .|.  .. |  .|||.| |. .  |.       . . |.| .. . .| |||... 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

I-IPEPALHEITVQMIAGLRFCCKNHIIHRDIKPSNVMLSLDGRIQIADFGLARQLRDT-------GDFAQ----SVI--GTTCYMSPERIRGQSYGLKS
  .. . |... .|  .| ..  ....||||.   |.... .... |.||||.| . |            .    .         |.|| |.   .  ||
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVWSLGLILY--QSCIGRYPFGENK--THFWDLNFETQNDIIVDLGPN--------YSPLLLDFIEKCLVMEQDDRATFEELNAHEWI
|||| |  ..   .  .  . |. .      ..    ..    .  ||         .. . . ...|   . .|| ||.|.  || .
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 96452.m00077.AA Pkinase_Tyr 72-254 26 1.7e-15 53.08 Pfam 1-201 (270) Show / Hide 
Range on Protein: 72-254
Range on HMM: 1-201/270
Sequence Identity: 26% (54 aa)

LKFHEQLGHGVQGTVYRCTHI----PSGKEFAVKSIKYQDKSQ---LQKTVDEIHSLRIL-RHPNVVHLFSAFA-QKGS--IHILMDLVNGASLGDYLKY
..| ..||.|  |.||..|        . . |||..| .  ..   ...   |.  .. | .|||.| |  .   |...  | | | .. . .| |||. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----SPIIPEPALHEITVQMIAGLRFCCKNHIIHRDIKPSNVMLSLDGRIQIADFGLARQLRDTGDFAQSVIGT-----TCYMSPERIRGQSYGLKSDVW
     . .. . | .. .|  .|. .   ...||||.   |.... .. . |.|||||| .    |   .. ..        |.|| |.   .  |||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SLG
| |
SFG
Kinase 96452.m00077.AA STE20 292-324 36 1.1e-08 28.17 In-house 256-288 (288) Show / Hide 
Range on Protein: 292-324
Range on HMM: 256-288/288
Sequence Identity: 36% (12 aa)

NYSPLLLDFIEKCLVMEQDDRATFEELNAHEWI
..|| . ||..|||... ..|.| ..|  |..|
KWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI