Gene 81864.m00355 (T.vaginalis)

81864.m00355

Species: T.vaginalis
Alias: TvagK0269, 81864.m00355
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
81864.m00355.AA Protein None 806 None Fasta, JSON
81864.m00355.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of 81864.m00355.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 81864.m00355.AA TKL 31-278 23 4.3e-72 245.82 In-house 1-364 (364) Show / Hide 
Range on Protein: 31-278
Range on HMM: 1-364/364
Sequence Identity: 23% (86 aa)

IGKGGYAEVWLVTDEEGN--------SKGALKQLYSE-----------------------CITEKDIVNFTREVQTLAASN--HPFFVKFLG--FSPQF-
||.||..||.  .    .           | |.. |.                       . .|    .|..|....  |.  ||  |.|.|  ..|.. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------PLSILTEYIPNGSLFKLMRSESKSKILTGSKKTVIAMGVANAMHFLHLQG--------IIHRDLKSMNVLLDSKYY-------------
            | | .||.|.|||. ..           ...  .|...| .|..|| ..        |||||||| |.|.|...              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-PRICDFGIARIYRETPQ-------------------IMTVNIGTPHWMAPEALNGE----------------KYGFPFDVYSYGMLLYELLTEKIPWEN
 . |||||..|   .. .                        .||| |||||.|.|.                .|    ||||.|..|.|.|| ..|...
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

VNQEVVM---------RLVMIEGKRPQIP------------QKTPQQLKDLIEKCWAQNPDERPTFEYIYEQF
 . . ..          .|  .|.|| ||              .|...|.|...||...|..||.|. | ...
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase 81864.m00355.AA Pkinase 25-278 23 2.1e-64 225.05 Pfam 1-293 (293) Show / Hide 
Range on Protein: 25-278
Range on HMM: 1-293/293
Sequence Identity: 23% (70 aa)

LKKTKLIGKGGYAEVWLVTDEEGNSKGALKQLYSECITEKDIVNFTR--EVQTLAASNHPFFVKFLGFS--PQFPLSILTEYIPNG----SLFKLMRSES
... . ||.|....|.. ..   . . |.|..  . . ..  .. .|  |.| ..  |||. |.....   .. .  . .|| ..|    .|| ...  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYIST-W

KSKIL--TGSKKTVIAMGVANAMHFLHLQGIIHRDLKSMNVLLDSKYYP----RICDFGIARIY-RETPQIMTVNIGTPHWMAPEALN-GEKYGFPFDVY
... .  .      ..  .. .. ..| .||||||||. |.|.|.....    .|||||.|. .     . ||.  |||..|||| .. |..|| . |..
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SYGMLLYELLTEKIPWENV------NQEVVMRLVMIEGKRPQIPQKTP-------------------QQLKDLIEKCWAQNPDERPTFEYIYEQ--F
|.| .|||.|. . |. .       .| ......|    . ..|.. .                   . .||.|..|....| .|||.| | .   |
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 81864.m00355.AA TKL-Unique 27-278 29 4.3e-62 212.59 In-house 1-290 (290) Show / Hide 
Range on Protein: 27-278
Range on HMM: 1-290/290
Sequence Identity: 29% (85 aa)

KTKLIGKGGYAEVWLVTDEEG-NSKGALKQLY-SECITEKDIVNFTREVQTLAASN-HPFFVKFLGFSP----QFP-LSILTEYIPNGSLFKLMR-----
  ..|| |||..|  .   ..  .. |.||.   | .  . . .| .|| ..   . ||. |.. |..     . | ..| .||.| ||| ..       
FWNKIGEGGYGQVYKG---KWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNN

--SESKSKILTGSKKTVIAMGVANAMHFLHLQG--IIHRDLKSMNVLLDSK-----YYPRICDFGIARIYR---ETPQIMT------VNIGTPHWMAPEA
    .... |. ...  .|  .| .|..||  .  |||||||| |.|.|..     .  .|||||....     ... ..       ...|.. ||||| 
NNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

LNG--EKYGFPFDVYSYGMLLYELLTEKI------PWENVNQEVVMRLVMI--EGKRPQIPQKTPQQLKDLIEKCWAQNPDERPTFEYIYEQF
|..  ..|    ||||.|. |.|..| ||      | ....|| .  .|    |..|| ||.  |....|||..||...|..||.|. |..  
LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 81864.m00355.AA Dicty5 65-282 36 5.7e-57 194.61 In-house 39-260 (260) Show / Hide 
Range on Protein: 65-282
Range on HMM: 39-260/260
Sequence Identity: 36% (83 aa)

DIVNFTREVQTLAASN--HPFFVKFLGFSPQFPLS--ILTEYIPNGSLFKLMRSESK--SKILTGSKKTVIAMGVANAMHFLHLQGIIHRDLKSMNVLLD
|.. | |||  . ..   || |....|   .      ..|||. ||||| . .   |   . .    .  .|...|..| .||  .||||||||||.|. 
DWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLIT

SKYYPRICDFGIAR-IYRETPQIMTVNIGTPHWMAPEALNGEKYGFPFDVYSYGMLLYELLTEKIPWENVNQEVVMRLVMIEGKRPQIPQKTPQQLKDLI
  .   | |||. | .  .    ||...||. |||.|  ||  |  . ||||.|  |.|..| | | .|.|.     .||  | || ||   |     ||
ENWKIKIIDFGTSRFV--DNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIPVMVM-KGERPTIPKDCPTEISNLI

EKCWAQNPDERPTFEYIYEQFASGN
.||| | |  ||.|  | . | |  
KKCWQQKPHNRPSFKEICKYFESII
Kinase 81864.m00355.AA MLK 80-278 33 5.1e-56 192.42 In-house 67-291 (291) Show / Hide 
Range on Protein: 80-278
Range on HMM: 67-291/291
Sequence Identity: 33% (75 aa)

NHPFFVKFLGFSPQF-P-LSILTEYIPNGSLFKLMRS-ESKSK----------ILTGSKKTVIAMGVANAMHFLHLQG---IIHRDLKSMNVLLDS----
||| ...|.| . |  . . |..||...|||. . .. .||.           . . . .  .|. .|..||.|| .    |||||||| |.|.|     
NHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHD

--KYYPRICDFGIAR-IYRETPQIMTVNIGTPHWMAPEAL---NGEKYGFPFDVYSYGMLLYELLTEKIPWE-NVNQEVVMRLVMIEGKRPQIPQKTPQQ
  .   .|||||..| ... . . |. |.||. |||||..    .|||    ||.|.|..|.|.|| ..| .  ...  .   |  .|.|| ||.  |  
MHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEH

LKDLIEKCWAQNPDERPTFEYIYEQF
.| |...|| |.| .||.| .| ...
WKKLMKQCWNQDPHKRPSFRQIVQHL
S_TKc 81864.m00355.AA S_TKc 25-279 26 6.1e-56 193.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-279
Range on HMM: 1-231/231
Sequence Identity: 26% (70 aa)

LKKTKLIGKGGYAEVWLVTDEEGNSKGALKQLYSECITEKDIVNFTREVQTLAASNHPFFVKFLGFSPQFPLSILTEYIPN--GSLFKLMRSESKS---K
 .. ..||||....|..... . . . |.|..           .. ||.| |   .||. ||....     | . .||...  |.||.....  .    .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

ILTGSKKTVIAMGVANAMHFLHLQGIIHRDLKSMNVLLDSKYYPRICDFGIARIYRETPQIMTVNIGTPHWMAPEALNGEKYGF-PFDVYSYGMLLYELL
 ..      ..  ...|. ..| .||||||||  |.|||.     |||||.||..       |  .|||..|||| |   .||. . |..| | .|||.|
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

TEKIPWENVNQEVVMRLVMIEGKRPQIPQKTPQQLKDLIEKCWAQNPDERPTFEYIYE--------QFA
. . |..  ..........            ....||.|.||.  .|..|||   . .        .. 
CGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 81864.m00355.AA LRRK 80-280 31 1.6e-50 174.17 In-house 115-351 (351) Show / Hide 
Range on Protein: 80-280
Range on HMM: 115-351/351
Sequence Identity: 31% (76 aa)

NHPFFVKFLGFSPQFPLSILTEYIPNGSLFKLMRSESKSKI------LTGSKKTVIAMGVANAMHFLHLQG--IIHRDLKSMNVLL-DSK----------
|||  |. .||.   || . .||.|.|.| ...........      .. . |  ||. .| .| .|| .   |||||||| |.||  |.          
NHPNIVSLKGFC-IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNA

-YYPRICDFGIARIYRETPQ--IMTVNIGTPHWMAPEALNGE---KYGFPFDVYSYGMLLYELLTEK-IPWENVN-Q-----EVVMRLVMIEGKRPQIPQ
 .   |.|||| |..  ..   ....  |.| ||||| ....    |  . |.||.||.|.|||| . .| .. .       .   .. .||| || |||
HVCAKIADFGISRMFQCFHMGVAKGC-VGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQ

K-TPQ-----QLKDLIEKCWAQNPDERPTFEYIYEQFAS
   |.      ..|||..||...|..||.|..| ..  .
HYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 81864.m00355.AA Dicty4 25-280 31 2.1e-49 163.04 In-house 1-277 (277) Show / Hide 
Range on Protein: 25-280
Range on HMM: 1-277/277
Sequence Identity: 31% (89 aa)

LKKTKLIGKGGYAEVWLVTDEEGNSKG---ALKQLYSECIT--EKDIVNFTREVQTLAASNHPFFVKFLGFSP---QFP--LSILTEYIPNGSLFKLMRS
......||||...|| .     |. .|   | | | .  ..  |. .  | .||  ..   ||  ..|.| .      |  ..| ||| | |.|..| ..
INIEQRIGKGSFGEVYK-----GTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHD

------ESKSKILTGSKK-TVIAMGVANAMHFLHL--QGIIHRDLKSMNVLLDSKYYPRICDFGIAR-IYRET--PQ-IMTVNIGTPHWMAPEALNGEKY
      .|... ..  |.   .|  .|  |  ||     |||||||| | | |  .   .||||... . ...   .  ||. .||| ||||| . .. |
KPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTA-CGTPCWMAPEVMMHQPY

GFPFDVYSYGMLLYELLTEKIPWE--NVNQEVVMRLVMIEGKRPQIPQKTPQQLKDLIEKCWAQNPDERPTFEYIYEQ--FAS
    ||||.|..|.|.|| ..|      . . . |.|  .. || ||. .|  .|.||..||  .|  ||.|| | ..    .
NEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Pkinase_Tyr 81864.m00355.AA Pkinase_Tyr 25-278 29 2.2e-49 167.88 Pfam 1-270 (270) Show / Hide 
Range on Protein: 25-278
Range on HMM: 1-270/270
Sequence Identity: 29% (81 aa)

LKKTKLIGKGGYAEVWLVTDE----EGNSKGALKQLYSECITEKD--IVNFTREVQTLAAS-NHPFFVKFLGFSP--QFP--LSILTEYIPNGSLFKLMR
... | .|.| . ||.. |      ... . | | |  |  ....  .  | ||....    .||  |...|     . |  . | .|| |.|.| .  |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SE-SKSKILTGSKKTVIAMGVANAMHFLHLQGIIHRDLKSMNVLLDSKYYPRICDFGIAR-I-----Y-RETPQIMTVNIGTPHWMAPEALNGEKYGFPF
.  .  . || . .  ... .|..| .|. ...|||||   |.|....   .||||| || |     | | .   . . |    |||||..|  |.    
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPI---KWMAPECINYGKFTTKS

DVYSYGMLLYELLT-EKIP-WENVNQEVVMRLVMIEGKRPQIPQKTPQQLKDLIEKCWAQNPDERPTFEYIYEQF
||.|.| |..|..|  ..| ....  | |....  .| |  .|...|. . ||. .||...|..||||..|.||.
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 81864.m00355.AA Dicty4-Unclassified 25-278 32 5.7e-48 162.37 In-house 1-263 (263) Show / Hide 
Range on Protein: 25-278
Range on HMM: 1-263/263
Sequence Identity: 32% (89 aa)

LKKTKLIGKGGYAEVWLVTDEEGNSKG---ALKQLYSECITEK--DIVNFTREVQTLAASNHPFFVKFLGFSPQFP------LSILTEYIPNGSLFKLMR
..  . ||||  ..|       || ||   | | . .         | .| .||  |    ||  ||  | .   |      . | .| .. | || .  
IQIDQFIGKGHFSKVH-----KGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCIN-PRSHKSTMCIVMEFMHKGNLFEVIH

---SESKSKILTGS-KKTVIAMGVANAMHFLHLQGIIHRDLKSMNVLLDSKYYPRICDFGIARIYRETPQIMTVNIGTPHWMAPEALNGEKYGFPFDVYS
   || .  |   .     .|. .|  | .||   .||||.|| |.|.|  .  .| ||||.|    . . ||   ||| | .|| | .| |    ||||
SKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFN-FNMTTIAGTPKWESPECLMHESYNQKSDVYS

YGMLLYELLTEKIPWENVN-QEVVMRLVMIEGKRPQIPQKTPQQLKDLIEKCWAQNPDERPTFEYIYEQF
|.|.||||.|   |.  .     . |.|   . ||.||   .  .| ||  ||   |  |||.. | .  
YAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase 81864.m00355.AA TK 25-278 15 3.2e-45 149.08 In-house 1-486 (486) Show / Hide 
Range on Protein: 25-278
Range on HMM: 1-486/486
Sequence Identity: 15% (76 aa)

LKKTKLIGKGGYA---EVWLV-------------------------TDEEGNSKGALKQLYSEC-ITEKDIVN--------------FTREVQTLA--AS
..  | .|.| .    ||..                            |.|. . | |.| ...  ....                 . .| . .   . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

NHPFFVKFLG--FSPQ-----------FPLSILTEYIPNGS----LFKLMRSESKSKI------------------------------------------
.||  |...|  . ..            |. |..|| |.|.    | .  |. .. ..                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LTGSKKTVIAMGVANAMHFLHLQ------GIIHRDLKSMNVLLDSKYY-----------PRICDFGIAR
                               ||   .  ... .|..| .|| .      ...||||   |.|.....             .|.||| .|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

---------IYRETPQIMTVNIGTPH-------------------------WMAPEALNGEK---------YGFPFDVYSYGMLLYELLT--EKIPWENV
         ||...    . . ||.                          |||||.||. .         .    ||.|.| |..|..|  .. . ...
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

N----------QEVVMRLVMI------------EGKRPQIPQKTP--------------QQLKDLIEKCWAQNPDERPTFEYIYEQF
.          |||. .|..             .. |.  |.  |              . . ||. .||. .|..||||. ..||.
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 81864.m00355.AA LISK 30-223 28 2.6e-44 141.75 In-house 1-238 (296) Show / Hide 
Range on Protein: 30-223
Range on HMM: 1-238/296
Sequence Identity: 28% (68 aa)

LIGKGGYAEVWLVTDEEGNSKGALKQLYS---ECITEKDIVNFTREVQTLAASNHPFFVKFLGFSPQ--FPLSILTEYIPNGSLFKLMRSES-KSKILTG
 ||||....|  .|  . ..  |.|.. .     . .  . .. ||||..    ||. |.| | . .    | |.||||  | |. . .... ... |. 
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

SKKTVIAMGVANAMHFLHLQGIIHRDLKSMNVLLDSK----YYPRICDFGIARIYRETP-----------------------------------QIMTVN
...  || ..| .| .|| ..||||||||.|.|.. .    .  ..|||| ||.  ...                                   . ||. 
PQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRMTI-

IGTPHWMAPEALNGEKYGFPFDVYSYGMLLYELLTEKIP
 ||| ||||| |.|..|    ||.|.|..| |. |.. .
CGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKA
Kinase 81864.m00355.AA STE 25-272 20 9.3e-41 141.65 In-house 1-349 (359) Show / Hide 
Range on Protein: 25-272
Range on HMM: 1-349/359
Sequence Identity: 20% (74 aa)

LKKTKLIGKGGYAEVWLVTDE------EGNSK---------GALKQLY---------------SECITEKDIVNFTREVQTLAASN--HPFFVKFLGFSP
... . ||||.. .| .  .       . . .          | ||.                 | . .... .. .|....  .|  ||. ||..|   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

QFP--------LSILTEYIPNGSLFKLMRSE-SKSKILT----------GSKKTVIAMGVANA-MHFLHLQGIIHRDLKSMNVLLDSKYYPRICDFGIAR
.          | |  ||...||| .....  .. | |.           |   .|.  .  . ...|| ..|||||.|. |.||       .||||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

IYRE---------------TPQIMT-VNIGTPHWMAPEALNG------EKYGFPFDVYSYGMLLYELLTEKIPWENVNQEVVMRLVMIE-----------
.  .               | | ..   .||| ||||| ...       .|..  |..| | .. |..| | || . .   .| . ...           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---GKRPQIPQKTP-------------------QQLKDLIEKCWAQNPDERPTFE
   |. |..|...                    . .|| |.||   .|..||| .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTAS
Kinase 81864.m00355.AA TyrKc 25-278 25 1e-38 135.89 SMART 1-280 (280) Show / Hide 
Range on Protein: 25-278
Range on HMM: 1-280/280
Sequence Identity: 25% (74 aa)

LKKTKLIGKGGYAEVWLVTDEEGNSKGALKQLYSECITEKDIVNFTREVQTLAAS--NHPFFVKFLGFSPQF--------PLSILTEYIPNGSLFKLMRS
... | .| | . ||.. |      . | | | ...     .  | || . .     .||  |...|   |         || |..|| |.|.| .  |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

ESKSKILTGSKKTVIAMGVANAMHFLHLQGIIHRDLKSMNVLLDSKYYPRICDFGIARIYRET------PQIMTVN--IGTP-----HWMAPEALNGEKY
  .   |. ...  ..  .|. | .|| ...|||||   |.|.....  .|.||| .|   .        .  ..    |.       |||||..|  |.
HRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

GFPFDVYSYGMLLYELLTE-KIPWEN-----VNQEVVMRLVMIEGKRPQIPQK--------TPQQLKDLIEKCWAQNPDERPTFEYIYEQF
 .  ||.|.| ...|..|  . |...     .. . |...|. .|.|. .|.          |. . .....||. .|..||||. |.|.|
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK-QGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 81864.m00355.AA LISK 242-278 26 9.3e-05 11.17 In-house 259-296 (296) Show / Hide 
Range on Protein: 242-278
Range on HMM: 259-296/296
Sequence Identity: 26% (10 aa)

RPQIPQK-TPQQLKDLIEKCWAQNPDERPTFEYIYEQF
...|.    | .. ||  .|   .|..||.|. | ...
WQKICPDDCPPPFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase 81864.m00355.AA LRRK 25-39 43 0.030628 3.71 In-house 1-16 (351) Show / Hide 
Range on Protein: 25-39
Range on HMM: 1-16/351
Sequence Identity: 43% (7 aa)

LKKTKLIGKGGYA-EV
||. ..||.||.. .|
LKIEEQIGRGGFGTFV