Gene 97340.m00058 (T.vaginalis)

97340.m00058

Species: T.vaginalis
Alias: 97340.m00058, TvagK0933
External Links:
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: STE7-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
97340.m00058.AA Protein None 348 None Fasta, JSON
97340.m00058.kin_dom Protein Kinase Domain None 253 None Fasta, JSON

Protein domain

Protein domains of 97340.m00058.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc 97340.m00058.AA S_TKc 63-315 30 2.3e-76 260.94 SMART 1-231 (231) Show / Hide 
Range on Protein: 63-315
Range on HMM: 1-231/231
Sequence Identity: 30% (82 aa)

LNVKELIGAGTQGTVSDVIHIPSGREFAMKNIHVIDKTTLQKTIDEIHSLRKLKHTNVVQLFTVFYQKGDIHILMDLVRG--ASLGDYIKVVPV------
  . ..|| |. |.|  ..|. .||..|.| |.       .... ||  |.| .| |.|.|. ||.  ..... |... |   .| ||||  .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

VPEKALGQIAIQCLSGLLFMRKNHILHRDLKPSNVMVALDGSVKIADFGLARQLRATGDLAKSFTGTMSYMSPERIREDNYGL-KSDVWSLGVILYQCAI
 ||     .. | ...| .. ...|.||||||.|...     .||.||||||||       ..| ||  ||.|| .    ||  |.|.||.|.||| .. 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GKFPFGGMKIAFWDVNFDSSDEVDVKLPPECSENMRDFISRCLEVDTNARASIEELVE-------HPWA
|. ||     . ...                |. ..|||..||..| . | .. |. .       ||| 
GYPPFP-QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 97340.m00058.AA STE 63-315 22 3.1e-65 223.05 In-house 1-359 (359) Show / Hide 
Range on Protein: 63-315
Range on HMM: 1-359/359
Sequence Identity: 22% (83 aa)

LNVKELIGAGTQGTVSDVIHI------PSGRE---------FAMKNIHVIDK-----------------TTLQKTIDEIHSLRKLK--HTNVVQLFTVFY
.   | || |. |||   ...      ..|..         .|.| ... ..                 . .|. . ||  ..|..  | |.|. .  ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

QKG-------DIHILMDLVRGASLGDYIK---VV-----------PVVPEKALGQIAIQCLSG-LLFMRKNHILHRDLKPSNVMVALDGSVKIADFGLAR
..|       ...| | .. | || | ||    .            ..||. .. |. |.| | | .  ..|| |||.||.|...     ||..|||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLRA---------------TGD-LAKSFTGTMSYMSPERIRE------DNYGLKSDVWSLGVILYQCAIGKFPFGGMKIA----FWDVNFDSSD------
||                 |..   ..|.||  .|.||.|.       . |. |.|.||||  .   | || |.  |.       .  |. ...      
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---EVDVKLPP-------------------ECSENMRDFISRCLEVDTNARASIEELVE--HPWA
   .   .||.                   ..|....|||..||. | | |.. ..| .  ||. 
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 97340.m00058.AA CAMK 68-315 19 1.8e-64 206.4 In-house 1-425 (425) Show / Hide 
Range on Protein: 68-315
Range on HMM: 1-425/425
Sequence Identity: 19% (83 aa)

LIGAGTQGTVSDVIHIPSG------------REFAMKNIHV----------------IDKT------------TLQKTIDEIHSLRK-------LKHTNV
 .| |. |.|  .||. ..            ...|.| |                  |||.            ....   ||. ..|       |.| |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLFTVFYQKG-------------------DIHILM---DLVRGA----SLGDYIKVV---------------PVVPEKALGQIAIQCLSGLLFMRKNHI
..|. |.  .                    .... |   ... |      | |||.                   ..|.   ..  | .|.. .. ...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDLKPSNVMVALD-----------------GSVKIADFGLARQLRA-----------------------TGDLAKSFTGTMSYMS-PERIR-------
 |||||| |...  .                 . .||.|||.|....                        .|.. | | || .||. || ..       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------EDNYGLKSDVWSLGVILYQCAIGKFPFGGM--------------------KIAFWDVNFDS--------------SDEVDVK-LPPECSENMR
       .. || |.|.||.||||| .  |..|| |                     ||   . .|..               |..     . ..|.  .
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQECK

DFISRCLEVDTNARASIEELVEHPWA
|.|...|.|| . |..||.  .||| 
DLIRKMLQVDPEKRMTIEQCLNHPWM
Pkinase 97340.m00058.AA Pkinase 63-315 29 7.7e-64 223.2 Pfam 1-293 (293) Show / Hide 
Range on Protein: 63-315
Range on HMM: 1-293/293
Sequence Identity: 29% (86 aa)

LNVKELIGAGTQGTVSDVIHIPSGREFAMKNIHVIDKTTLQKTID----EIHSLRKLKHTNVVQLFTVFYQKGDIHILMDLVRGA----SLGDYIK--VV
. ... ||.|. |.|   .|. .|...|.| | . ..   .. ..    ||. ...|.| |.|.|. .|. |..|.. |....|     .| |||.    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

PVV--PEKALGQIAIQCLSGLLFMRKNHILHRDLKPSNVMVALDGSV----KIADFGLARQL-RATGDLAKSFTGTMSYMSPERIR-EDNYGLKSDVWSL
 ..  .|. .  .. | |.|| .. .. |.||||||.|...  .| .    ||.|||||.|.    .  ...|.||  ||.|| ||    || |.|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVILYQCAIGKFPFGGM-----KIAFWDVNFDSSDEVDVKLPPECS-------------------ENMRDFISRCLEVDTNARASIEELVEHPWA
|.|||. . |..|| |          . .. . . ...   | .||                   |...|||..||..| . | ..|....||| 
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 97340.m00058.AA STE7-Unclassified 63-315 31 1.6e-62 214.05 In-house 1-301 (301) Show / Hide 
Range on Protein: 63-315
Range on HMM: 1-301/301
Sequence Identity: 31% (97 aa)

LNVKELIGAGTQGTVSDVIHIP------SGREFAMKNIHVIDK--TTLQKTIDEIHSLRKLK-HTNVVQLFTVFYQKGD---IHILMDLVRGASLG---D
| . . .|.|  |||. . | .      .|  .|.| | ..|   .  .. . |.  |.| . | ..|. .  .|...    |||.| .  . ||    |
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

YIKVV----PV----VPEKALGQIAIQCLSGLLFMRKNH-ILHRDLKPSNVMVALDGSVKIADFGLARQLRATGDLAKSFTGTMSYMSPERIRED-----
  | .    |.    .||. || ||.| . || .  . | | |||.||.|. |  .| |||.||| . || .| | ||...|. .|||||||. .     
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHRP

NYGLKSDVWSLGVILYQCAIGKFPFG------GMKIA-------FWDVNFDSSDEVDVK---LPP-----ECSENMRDFISRCLEVDTNARASIEELVE-
 |..|||.||||  .  ||.||.|..      ..          ||..   .|  |. .   ||        |....||||.|.  ... |..| .| . 
SYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWEL---LSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNE

HPWA
||| 
HPWI
Kinase 97340.m00058.AA CAMKL 63-315 25 2.4e-57 181.52 In-house 1-297 (297) Show / Hide 
Range on Protein: 63-315
Range on HMM: 1-297/297
Sequence Identity: 25% (76 aa)

LNVKELIGAGTQGTVSDVIH-IPSGREFAMKNIHVID--KTTLQKTID----------------EIHSLRKLK---HTNVVQLFTVFYQKGD------IH
 .. . .| |. |.|   .| .  |.. |.|   .||  |...   ..                ||. ...|.   | |...|. |.. .        |.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIK---IIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIY

ILMDLVRGAS--LGDYIKVVP----VVPEKALGQIAIQCLSGLLFMRKNHILHRDLKPSNVMVALDGS--VKIADFGLARQLRA----TGDLAKSFTGTM
. | .. | .  | |||.  .      ||.   ..  | .|.. .. ...| |||.|| |...  .|.  .||.|||.. . |     .|.. | | |. 
LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

SYMSPERIRE--D-NYGLKSDVWSLGVILYQCAIGKFPFG-------GMKIAFWDVNFDSSDEVDVKLPPECSENMRDFISRCLEVDTNARASIEELVEH
.||.|| .    .  .| | |.||.|||||    |..||        |..      . . ..      ... |   ||.|.. |.|. . |..|.....|
PYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

PWA
|| 
PWM
Kinase 97340.m00058.AA Ciliate-E2 63-315 20 3.3e-57 194.93 In-house 1-365 (365) Show / Hide 
Range on Protein: 63-315
Range on HMM: 1-365/365
Sequence Identity: 20% (77 aa)

LNVKELIGAGTQGTVSDVIHIPSGREFA--------------------MKNIHVIDKTTLQKTIDEIHSLR----------------KLKHTNVVQLFTV
 .. ..|| |..|.|  . ..  ...||                    .... .. |  .. .  ||| .|                .|.| |..... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FY--QKGDIHILMDLVRGASLGDYIKVV-----------PVVPEKALGQIAIQCLS---------------GLLFMRKNH-ILHRDLKPSNVMVALDGSV
|.  ..  | . |... | .| ||||                 ||  ..|  | |.               .| .. ... |.|||.||.|...     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIADFGLARQL-----------------------RATG--------DLAKSFTGTMSYMSPERIREDN---------YGLKSDVWSLGVILYQCAIGKFP
||.||||....                       | .|        ...... ||  ||.|| ..  .         |. |.|.||||||||..  ||.|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FGGMKIAFWDVNFDSSDEVDVKLPPE------------------CSENMRDFISR----CLEVDTNARAS-IEELVEHPWA
|           ..   . ....|..                  .|... |.|..    .|..| . | . .|.. .||| 
F-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 97340.m00058.AA Ciliate-E2-Unclassified 64-315 20 2.2e-53 183.55 In-house 2-352 (352) Show / Hide 
Range on Protein: 64-315
Range on HMM: 2-352/352
Sequence Identity: 20% (73 aa)

NVKELIGAGTQGTVSDVIHIPSGREF-----AMKNIHVIDKTTLQ--------KTIDEIH-------------SLRKLKHTNVVQLFTVFYQKGDIHILM
.. . || | .|.|  ..|.  . ..     ..|.... .|  ..        |.. ..              .|. ..| ..| .| .| .|  | | |
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

DLVRGASLGDYIKVVPV-----------------VPEKALG-----QIAIQCLSGLLFMRKNH-ILHRDLKPSNVMVALDG---SVKIADFGLARQLRAT
....| .| .|||  .                  ..|..       ... | |.|| .. ... |.|||.||.|...  .|    .||.|||.....   
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

---------------GDLAKSFTGTMSYM----SPERIREDNYGLK----SDVWSLGVILYQCAIGKFPFGG---------------------MKIAFWD
                .....|.|| .||    .|| ... ||. .    .|.||||||||..  |..||..                     ..  . .
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

--VNFDSSDE--VDVKLPPECSENMRDFISRCLEVDTNARASIEELVEHPWA
  ..|.....  .. ...||. .  .|.....|... | | ..|.. .||| 
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 97340.m00058.AA STE7 63-268 31 3.4e-50 173.06 In-house 1-240 (288) Show / Hide 
Range on Protein: 63-268
Range on HMM: 1-240/288
Sequence Identity: 31% (75 aa)

LNVKELIGAGTQGTVSDVIHIPSGREFAMKNIHVIDK--TTLQKTIDEIHSLRKLK-HTNVVQLFTVFYQKGD--IHILMDLVRGASLGDYIKVV-----
| . . .|.|  |.|  . | |||  .|.| |.. ..  .  .. . |.  |.| . . ..|| .  ||..||  |.| | .  | .|  ..|.|     
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

----PVVPEKALGQIAIQCLSGLLFMRK-NHILHRDLKPSNVMVALDGSVKIADFGLARQLRATGDLAKSFTGTMSYMSPERIRE--DNYGLKSDVWSLG
      .||. || ||.. ..|| ....  .| ||| ||||. |  .| ||..||| . ||  . | |..|.|. .||.||||    . |. .|||||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLG

VIL-YQCAIGKFPFGGMKI----------------AFWDV
. . ...|.|..|... .                 |....
ITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQ
Kinase 97340.m00058.AA ULK 63-315 25 6.2e-50 172.21 In-house 1-329 (329) Show / Hide 
Range on Protein: 63-315
Range on HMM: 1-329/329
Sequence Identity: 25% (84 aa)

LNVKELIGAGTQGTVSDVIHIPS----GREFAMKNIH---VIDKTTLQK-------TIDEIHSLRKLK--------HTNVVQLFTVFYQKGD--IHILMD
 .... .| |. |.|   ... .    .  .| | |     . |  .|         . ||  ..|||        | |.|.|. .|. . .  | | |.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LVRGASLGDYIKVVPVVPEKA----------LGQIAIQCLSGLLFMRKNHILHRDLKPSNVMVALD------------GSVKIADFGLARQLRAT---GD
.  |  | .|||     ||.             |. .| |.|. ...|. | |||.||.|...  .            | .||||||.|...       .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LAKSFT------GTMSYMSPERIRED----NYG-LKSDVWSLGVILYQCAIGKFPFGGMKIAFWDVNFDSS-----DEVD-------------VKLP---
......      ||  ||.|. . .     .|.  |.|.||||.|.|..  || ||      ..  ..|       ....              . |   
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPF------YAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDG

--PECSENMRDFISRCLEVDTNARASIEELVEHPWA
  | .|....|.|.|.|..| . | |.||| .||| 
NDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 97340.m00058.AA ULK 63-315 24 1.1e-49 171.36 In-house 1-324 (324) Show / Hide 
Range on Protein: 63-315
Range on HMM: 1-324/324
Sequence Identity: 24% (80 aa)

LNVKELIGAGTQG-TVSDVIHIPS---GREFAMKNIH---VIDKTTL-------QKTIDEIHSLRKLK---HTN--VVQLFTVFYQKGD--IHILMDLVR
 .... .| |. | .|   ... .   .  .| | |     ..|  .       |. . ||  ..|||   | |  .|.|. .|. . .  | | |..  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GASLGDYIK-----VVPV-----VPEKALGQIAIQCLSGLLFMRKNHILHRDLKPSNVMVALD------------GSVKIADFGLARQLRATG---DLAK
|  | .|||      . .      .|.   |. .| ..|. ...|. | |||.||.| ..  .            | .||||||.|...   .   .. .
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

SFT------GTMSYMSPERIRED----NYG-LKSDVWSLGVILYQCAIGKFPFGGM-KIAFWDVNFDSSDE----------VDVKLP-----PECSENMR
..       ||  ||.|. . .     .|.  |.|.||||.|.|..  || || ..    ..  . .  .             .. |     | .|....
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

DFISRCLEVDTNARASIEELVEHPWA
|.|.|.|..| . | |.||. .||| 
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 97340.m00058.AA NEK 64-250 29 2.9e-47 163.32 In-house 2-216 (286) Show / Hide 
Range on Protein: 64-250
Range on HMM: 2-216/286
Sequence Identity: 29% (64 aa)

NVKELIGAGTQGTVSDVIHIPSGRE-----FAMKNIHVIDK---TTLQKTI-DEIHSLRKLKHTNVVQLFTVFYQKG--DIHILMDLVR-GASLGDY---
 . . || | .|.|  | ..  |..     ...|.|  ...      |...  |.. |..||| |.|  .  |. ..   ..| |.    |  | .    
EIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKIN-MGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IKVVP----VVPEKALGQIAIQCLSGLLFMRKN-----HILHRDLKPSNVMVALDGS----VKIADFGLARQLRATGDLAKS-FTGTMSYMSPERIREDN
||         .|.    . || ...| .| ..     .|||||.||.|..   ...    ||| |||....|  | |.|.. ..||  ||||| ...  
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YGLKSDVWSLGVILYQ
|. |||.||||..||.
YNNKSDIWSLGCVLYE
Kinase 97340.m00058.AA TyrKc 63-313 23 5.3e-16 36.09 SMART 1-280 (280) Show / Hide 
Range on Protein: 63-313
Range on HMM: 1-280/280
Sequence Identity: 23% (66 aa)

LNVKELIGAGTQGTVSDVIHIPSGREFAMKNIHVIDKTTLQKTIDEIHSLRKL--KHTNVVQLFTVFYQK-------GDIHILMDLVRGASLGDYIKVVP
.  .. .| |  |.|   . .   .. | | ..      ..  ..|.  ..||  .| |.|.|. |  |.       . . |.| .. . .| ||..   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

V-VPEKALGQIAIQCLSGLLFMRKNHILHRDLKPSNVMVALDGSVKIADFGLARQLRAT-------GDLAKSF-TGTMS-----YMSPERIREDNYGLKS
  .. | | ....|  .|  .  .... ||||   |..|. .. |||.||||.| .              |.   |. .      |.|| |..  .  ||
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVWSLGVILY-QCAIGKFPFGGM---KIAFWDVNFDSSDEVDVKLPPE--------CSENMRDFISRCLEVDTNARASIEELVEHP
|||| || ..  .  |. |  ||   ..   .|  .  .    . ||.        |.. | . ...| . | . | . .|..|  
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 97340.m00058.AA Pkinase_Tyr 106-249 30 8.1e-11 37.27 Pfam 51-205 (270) Show / Hide 
Range on Protein: 106-249
Range on HMM: 51-205/270
Sequence Identity: 30% (48 aa)

IDEIHSLRKL-KHTNVVQLFTVFY-QKGD--IHILMDLVRGASLGDYIKV----VPVVPEKALGQIAIQCLSGLLFMRKNHILHRDLKPSNVMVALDGSV
. |.  ...| .| |.|.|  | . |..   | | | .. . .| || .      . .. | | |...|  .|. .   ... ||||   |..|. .. |
MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVV

KIADFGLARQLRATGDL-AKSFTGTMSY--MSPERIREDNYGLKSDVWSLGVILY
||.|||||| .  ..    |.  | .    |.|| |..  .  |||||| || ..
KICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMW
Kinase 97340.m00058.AA STE7 279-315 34 1.1e-09 31.77 In-house 252-288 (288) Show / Hide 
Range on Protein: 279-315
Range on HMM: 252-288/288
Sequence Identity: 34% (13 aa)

KLPPECSENMRDFISRCLEVDTNARASIEELVE-HPWA
.|| . |. ..||...||  | | |.....| . ||. 
RLP-KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase 97340.m00058.AA NEK 279-315 25 4.6e-05 14.21 In-house 248-286 (286) Show / Hide 
Range on Protein: 279-315
Range on HMM: 248-286/286
Sequence Identity: 25% (10 aa)

KLPPE--CSENMRDFISRCLEVDTNARASIEELVEHPWA
..|.    |. ....||..| .|   | |.... |.|  
PIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI