Gene 95718.m00005 (T.vaginalis)
95718.m00005
Species: T.vaginalis
Alias: TvagK0251, 95718.m00005
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
95718.m00005.AA | Protein | None | 312 | None | Fasta, JSON |
95718.m00005.kin_dom | Protein Kinase Domain | None | 246 | None | Fasta, JSON |
Protein domains of 95718.m00005.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 95718.m00005.AA | Ciliate-E2-Unclassified | 15-259 | 19 | 2.1e-28 | 95.66 | In-house | 2-352 (352) | Show / Hide |
Range on Protein: 15-259 Range on HMM: 2-352/352 Sequence Identity: 19% (67 aa) RYEKVIARGANGLIYLVYSESQQRKFAMKKYPQFIFKD--------------KDLENI----------------IAINNPHLLKFTQYFKFNDQVYLLME . |.| .|..| .|... ..|. ..||| ... .. | ..|. . ...|...|. .|. . .|. || KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVME YCP-TNLEKLITEP-----------------QMVSKEILR-----NYIYDVVTCVKTCHDNN-ISISDFTLSNFLIDENG---KIKINFLSL-------- ||. .|.. |.. .... . . .|.. .. . . .| .| | | ...| |.|.|| .||| ... YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNN -------KHIVQEQEENAPARFKTMNYF---LPPEVIEQSEYDEM---CSDIWSLGCILYFMASKSLPFNSKDMKS----------------LKDQIKKC . . ..... . | || ..|||... .||.. ..||||||.|||.| .||.... .. |...||.. NCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQK EYNNEKVE--------DLNLREVIS----RCLKIDPNSRTTVGNLLKMKYF .... | . . . . |. ..|| .||.| | .|. .| NIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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Kinase | 95718.m00005.AA | Ciliate-E2 | 14-259 | 18 | 1.6e-27 | 91.55 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 14-259 Range on HMM: 1-365/365 Sequence Identity: 18% (72 aa) LRYEKVIARGANGLIYLV--YSESQQR----------------KFAMKKYPQFIFKDKD---LENIIAIN--------------------NPHLLKFTQY |.| .|. | .|.. ... .| |...|.| |.| .. ....| |. .|...|. . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FK--FNDQVYLLMEYCPT-NLEKLIT-----------------EPQMV--SKEILR-------NYIYDVVTCVKTCHDNN-ISISDFTLSNFLIDENGKI |. .. .|| |||| .|...| | .. .|.||. .|| .. ... .| .| | | ..| |. | FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I KINFLSL-KHIVQEQEENA------PARFKT------------------------MNYFLPPEVIEQSE---------YDEMCSDIWSLGCILYFMASKS || . | | . ...... | . ....||... . ||..| ||||||.|||.| .. KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKC-DIWSLGVILYEMLFGK LPFNSKDMKSLKDQIKKCEYN------------------NEKVEDLNLREVISR----CLKIDPNSRTT-VGNLLKMKYF .|| .|||.|... . | ... |.. .|. ||. | | .|. ..| PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | 95718.m00005.AA | PLK1 | 61-259 | 27 | 7.1e-27 | 85.16 | In-house | 56-253 (253) | Show / Hide |
Range on Protein: 61-259 Range on HMM: 56-253/253 Sequence Identity: 27% (55 aa) INNPHLLKFTQYFKFNDQVYLLMEYCPTN-LEKLITEPQMVSKEILRNYIYDVVTCVKTCHDNNISISDFTLSNFLIDENGKIKINFLSLKHIVQEQEEN .. .|. || ..| .. ||...| | . | | . . | |.| .| .. |.|.| |. | | .... ..|| | .... | LHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPECRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGER APARFKTMNYFLPPEVIEQSEYDEMCSDIWSLGCILYFMASKSLPFNSKDMKSLKDQIKKCEYNNEKVEDLNLREVISRCLKIDPNSRTTVGNLLKMKYF . | || . |||... ||||.|||.| . . || .| .| .|||.|| . ...| . |. ||..| |. ..|....| KKTLCGTPNY-IAPEVLNKKGH-SFEVDIWSIGCIMYILLFGQPPFETKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF |
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S_TKc | 95718.m00005.AA | S_TKc | 14-259 | 23 | 1.9e-26 | 95.08 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 14-259 Range on HMM: 1-231/231 Sequence Identity: 23% (62 aa) LRYEKVIARGANGLIYLVYSESQQRKFAMKKYPQFIFKDKDLENIIAINNPHLLKFTQYFKFNDQVYLLMEYCPT---NLEKLITEPQM------VSKEI . ..| .|| | |... . .|..|.|. . . . .. . |.. |. .| | .|. ||||.. .| ..| . . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H LRNYIYDVVTCVKTCHDNNISISDFTLSNFLIDENGKIKI------NFLSLKHIVQEQEENAPARFKTMNYFLPPEVIEQSEYDEMCSDIWSLGCILYFM | |.| .. .. ||...| | .| |.|| ||| .| | .| ..|||. |. .|.||.||||| | ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWY-MAPEVL---GYGKCKCDWWSCGCILYEM ASKSLPFNSKDMKSLKDQIKKCEYNNEKVEDLNLREVISRCLKIDPNSRTTVGNLLK-------MKYF .. || .|. . ..|. . ... |..||. ||. | |. .|. . .| LCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 95718.m00005.AA | CAMK | 169-259 | 17 | 3.6e-22 | 67.6 | In-house | 284-425 (425) | Show / Hide |
Range on Protein: 169-259 Range on HMM: 284-425/425 Sequence Identity: 17% (25 aa) YFLP-PEVIEQ-------------SEYDEMCSDIWSLGCILYFMASKSLPFNSK-------------DMKSLKDQIKKCEY--NNEKVEDLN-------- .. . |||... .|. .|.||.|.|||.| . .||... ... |. .|.|..| ... .. EYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWW --------------LREVISRCLKIDPNSRTTVGNLLKMKYF . |...|. ||. | |. |. . . DDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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Kinase | 95718.m00005.AA | CAMK-Unique | 173-259 | 25 | 7.1e-21 | 65.47 | In-house | 244-363 (363) | Show / Hide |
Range on Protein: 173-259 Range on HMM: 244-363/363 Sequence Identity: 25% (30 aa) P--------------EVIEQSEYDEMCS---DIWSLGCILYFMASKSLPFNSKDMK--------SLKDQIKKCEY-N-NEKVEDL------NLREVISRC | |||... ||. || |||||| |.|.|.. ..||.. . . .. . |.|..| | .|.... .. .. .| PEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCC LKIDPNSRTTVGNLLKMKYF ...||..| . .||. .. MTVDPDHRWSAKELLEHQWI |
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Kinase | 95718.m00005.AA | Pkinase | 169-259 | 22 | 1.8e-17 | 62.84 | Pfam | 176-293 (293) | Show / Hide |
Range on Protein: 169-259 Range on HMM: 176-293/293 Sequence Identity: 22% (27 aa) YFLPPEVIE-QSEYDEMCSDIWSLGCILYFMASKSLPFNSK------DMKSLKDQIKKCEYNNEKVED---------------------LNLREVISRCL ....|||| ...|. . |.||.||||| |... .|| .. |.. . ..|..... . .. .....|..|| WYMAPEVIRGGQYYGPKV-DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL KIDPNSRTTVGNLLKMKYF . ||..| | .|. ..| CKDPKKRPTAEQILQHPWF |
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Kinase | 95718.m00005.AA | MARK | 170-259 | 32 | 8.8e-17 | 51.55 | In-house | 171-262 (262) | Show / Hide |
Range on Protein: 170-259 Range on HMM: 171-262/262 Sequence Identity: 32% (30 aa) FLPPEVIEQSEYDEMCSDIWSLGCILYFMASKSLPFN--SKDMKSLKDQIKKCEYN-NEKVEDLNLREVISRCLKIDPNSRTTVGNLLKMKYF . .||.... .|| |||||| .|||| . ..|| ..|.| |. .| ...| .| . .| |.| |...|. | |. ...| . . YMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKE-CRNLIQRLLTVNPEERPTIEEIMKHPWM |
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Kinase | 95718.m00005.AA | ULK | 169-259 | 21 | 2.1e-15 | 50.32 | In-house | 216-329 (329) | Show / Hide |
Range on Protein: 169-259 Range on HMM: 216-329/329 Sequence Identity: 21% (25 aa) YFLPPEVIE----QSEYDEMCSDIWSLGCILYFMASKSLP----FNSKD---MKSLKDQ---------IKKCEYN---NEKVEDLNLREVISRCLKIDPN .. |.... | .|.. .||||||||.| | | ||. . ...|... .. ... |... .... |.|.|..|.. LYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEK SRTTVGNLLKMKYF | . |.... | DRISWEELFNHPWF |
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Kinase | 95718.m00005.AA | ULK | 169-259 | 22 | 1.2e-14 | 48.43 | In-house | 212-324 (324) | Show / Hide |
Range on Protein: 169-259 Range on HMM: 212-324/324 Sequence Identity: 22% (25 aa) YFLPPEVIE----QSEYDEMCSDIWSLGCILYFMASKSLP----FNSKD--MKSLKDQ-------IKK--CEYN---NEKVEDLNLREVISRCLKIDPNS .. |.... | .|.. .||||||||.| | . | ||. . ...|... ||. ... .... .... |.|.|..|.. LYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKD RTTVGNLLKMKYF | . ..... | RISWEEIFNHPWF |
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Kinase | 95718.m00005.AA | NEK | 169-259 | 33 | 2.4e-14 | 47.31 | In-house | 189-286 (286) | Show / Hide |
Range on Protein: 169-259 Range on HMM: 189-286/286 Sequence Identity: 33% (33 aa) YFLPPEVIEQSEYDEMCSDIWSLGCILYFMASK--SLPFNSK--DMKSLKDQIKKC-EYN--NEK-VEDLNLREVISRCLKIDPNSRTTVGNLLKMKYF |.. |||... |.. ||||||||.|| |.. ||... .|.|| .|.|. .|. ... . |...||..|. || .| .. .|.| . YYMSPEVCQNKPYNNK-SDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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Kinase | 95718.m00005.AA | STE | 173-259 | 23 | 1.5e-12 | 40.79 | In-house | 231-359 (359) | Show / Hide |
Range on Protein: 173-259 Range on HMM: 231-359/359 Sequence Identity: 23% (31 aa) PEVIEQ------SEYDEMCSDIWSLGCILYFMASKSLPFNS-KDMKSLKDQIKK---CE---------YNNEKVED----------------------LN ||||.| ..||. | ||||||| . || |. ..|. . ... .. . . .| . PEVIQQNGQGRDKGYDTKC-DIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPE LREVISRCLKIDPNSRTTVGNLLK--MKYF ... |..||..||| | |. ||| . . FKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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Kinase | 95718.m00005.AA | CAMK | 19-124 | 11 | 1.1e-08 | 23.35 | In-house | 1-200 (425) | Show / Hide |
Range on Protein: 19-124 Range on HMM: 1-200/425 Sequence Identity: 11% (24 aa) VIARGANGLIYLVYSESQQ------------RKFAMKKYPQF-----------------------------IFKDKDLENIIAI-----------NNPHL .. ||. | .|.. . . .|.|.| .. .. | ... |.| . |.. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI LKFTQYFK------------FNDQ--------VYLLM---EYCPTN------LEKLITEPQ--------------MVSKEILRNYIYDVVTCVKTCHDNN .|. ... . .. .|. | |||. ..... .. .. . | |. .. |. ||..| IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN I | I |
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Kinase | 95718.m00005.AA | Pkinase | 14-144 | 22 | 6.6e-07 | 25.5 | Pfam | 1-153 (293) | Show / Hide |
Range on Protein: 14-144 Range on HMM: 1-153/293 Sequence Identity: 22% (34 aa) LRYEKVIARGANGLIYLVYSESQQRKFAMKKYPQFIFKDKDLENIIA---------INNPHLLKFTQYFKFNDQVYLLMEYCPT-----NLEKLIT---E .. ...| .|. | |. . . ....|.|. . |.. ... . .| |. ... .| .| .|. ||||. | .|. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH PQM-VSKEILRNYIYDVVTCVKTCHDNNISISDFTLSNFLIDENGKI----KI . | . ...|.| .. .. ||...| | ..|.|||.|| | || GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKI |
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Kinase | 95718.m00005.AA | TyrKc | 14-259 | 12 | 1e-06 | -116.49 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 14-259 Range on HMM: 1-280/280 Sequence Identity: 12% (40 aa) LRYEKVIARGANGLIYL-VYSESQQRKFAMKKYPQFIFKDKDLEN----IIAI--NNPHLLKFTQYFKFN-------DQVYLLMEYCPT-NLEKLITEPQ .. .|.. .|| | .|. ... .. | |. .|. . . ..|..... . ......|||.| .| . . ... ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR MVSKEILRNYIYDVVTCVKTCHDNNISISDFT------------------------LSNFLIDENGKIKINFLSLKHIVQEQ-------EENAPA---RF .. .|. | |..||. .|| | . . . .. PK-----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG KT-MNYF-LPPEVIEQSEYDEMCSDIWSLGCILYFMASK-SLPFNS-----KDMKSLKDQIKKCEYNNEKVE---------DLNLREVISRCLKIDPNSR || . . ..||.| ... . ||.|| | .. . . | .. . . ..|. .. . . .....| . ||..| KTMLPIRWMAPECINYGKFTTK-SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR TTVGNLLKMKYF | .. ..| PTFSEI--HECF |
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Kinase | 95718.m00005.AA | STE | 14-106 | 12 | 0.000229 | 11.47 | In-house | 1-162 (359) | Show / Hide |
Range on Protein: 14-106 Range on HMM: 1-162/359 Sequence Identity: 12% (21 aa) LRYEKVIARGANGLIYLVYSE------SQQRK---------FAMKKYP------------------QFIFKD----KDLENIIAIN--NPHLLKFTQYFK .. ..| .|| | |. . . ... .|.|. . .. . |... | |. |. .. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF FN-------DQVYLLMEYCP-TNLEKLIT--------------------EPQM--VSKEILR . |.... |||.. |...| |.| . ..||. KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILK |
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Kinase | 95718.m00005.AA | ULK | 61-113 | 20 | 0.006889 | 6.02 | In-house | 74-140 (329) | Show / Hide |
Range on Protein: 61-113 Range on HMM: 74-140/329 Sequence Identity: 20% (14 aa) IN-NPHLLKFTQYFKFN--DQVYLLMEYCPT-NLEKLIT----------EPQMVSKEILRNYIYDVV .| .|. |. .|. . .|. ||||. .||..| |.. | .. ...... . KNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQIL |
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Kinase | 95718.m00005.AA | ULK | 61-124 | 21 | 0.01989 | 4.5 | In-house | 70-147 (324) | Show / Hide |
Range on Protein: 61-124 Range on HMM: 70-147/324 Sequence Identity: 21% (17 aa) INNPH--LLKFTQYFKFN--DQVYLLMEYCPT-NLEKLIT---------EPQMVSKEILRNYIYDVVTCVKTCHDNNI ...|. |. .|. . .|. ||||. .||..| |.. | .. ...... . | |..|| LKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNI |
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Kinase | 95718.m00005.AA | CAMK-Unique | 64-96 | 18 | 0.084486 | 1.49 | In-house | 76-128 (363) | Show / Hide |
Range on Protein: 64-96 Range on HMM: 76-128/363 Sequence Identity: 18% (10 aa) PHLLKFTQY----FKFND---------------QVYLLMEYCPTN-LEKLITE |...|. .. | . |..||||. . | ..| . PNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQK |
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Kinase | 95718.m00005.AA | MARK | 131-144 | 62 | 0.254693 | 0.27 | In-house | 132-147 (262) | Show / Hide |
Range on Protein: 131-144 Range on HMM: 132-147/262 Sequence Identity: 62% (10 aa) LSNFLIDENG--KIKI . | |||||| .||| PENILIDENGNHNIKI |