Gene 93865.m00227 (T.vaginalis)
93865.m00227
Species: T.vaginalis
Alias: TvagK0794, 93865.m00227
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 93865.m00227.AA | Protein | None | 2167 | None | Fasta, JSON |
| 93865.m00227.kin_dom | Protein Kinase Domain | None | 209 | None | Fasta, JSON |
Protein domains of 93865.m00227.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| HEAT | 93865.m00227.AA | HEAT | 197-227 | 25 | 1.234655 | 6.06 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 197-227 Range on HMM: 1-31/31 Sequence Identity: 25% (8 aa) VQSSILSSLQHEDKQVRAAGCHTLEIALTLS . . .|. |...| .||.| | .| . . ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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| HEAT | 93865.m00227.AA | HEAT | 530-560 | 16 | 0.00258 | 15.34 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 530-560 Range on HMM: 1-31/31 Sequence Identity: 16% (5 aa) FVPLVYSMCHDTNIDICISAIKVLCNLSDTL ..|.. ....|.. .. .|.. |..|.. . ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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| Rapamycin_bind | 93865.m00227.AA | Rapamycin_bind | 1695-1795 | 28 | 6.3e-44 | 140.47 | Pfam | 1-100 (100) | Show / Hide |
Range on Protein: 1695-1795 Range on HMM: 1-100/100 Sequence Identity: 28% (29 aa) ELVRVASSWFEIWCYAIDESSRLYLHQNDPKSAAKLLLQHHDKISNPPQSFLELSFKAQFAATLSKAHTLTQCYFEGKSGIESFHLAWQFYTGIYTSLQN ||.||| .|.|.|.....|.||.|....... ...|...|......|... | ||..|| .|..|| . |.| . .. ..... ||..|.... ... ELIRVAILWHEMWHEGLEEASRQYFGDHNIEKMFNILEPLHEMLEKGPETMREISFVQQFGRDLQEAHEWCQKYKRTGD-ENCLNQAWDIYYQVFRRIRK Q | Q |
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| Kinase | 93865.m00227.AA | FRAP | 1862-2107 | 46 | 3.7e-95 | 322.46 | In-house | 1-251 (251) | Show / Hide |
Range on Protein: 1862-2107 Range on HMM: 1-251/251 Sequence Identity: 46% (116 aa) KYKFLLKANEDTRLDQRVVQLLTFVNTIMASAMAG-----NLTTYSILPLAPNVGLIGWVRDSTTIYELMRDYRERRKIPLNVEINNTLQMCPNFEQLPA | |||| || | | || || .|.... ... |||.|| | ||||||.. |. |.||||.. .| .|.| | ..||.....|| EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMCNDYDHLPL IERKESFEFGLSKTKGDDLQQIILVNSSDSSNWVSRRLVYTESLAATSMVGYILGLGDRHPGNIMMCVKTGKLLHIDFGDCFEVAQHREHYPETVPFRLT ... | |.. . |||.||. .. | | | || || ||| ||.||||||||||| |||. |||..||||||||||| || .|| .||||| MNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLT RVFVNALEIAKVEGTLRQCSINVMNLLRLHKDTISGLLETFVHDPLLMGTA | |||.|.. .||. | . ||. .| ||. . || || |||. RMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL |
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| Kinase | 93865.m00227.AA | PIKK | 1834-2097 | 35 | 1.3e-92 | 313.97 | In-house | 2-290 (290) | Show / Hide |
Range on Protein: 1834-2097 Range on HMM: 2-290/290 Sequence Identity: 35% (104 aa) INSFDPVMNVFTSKQRPRAVSINATDGNKYKFLLKANEDTRLDQRVVQLLTFVNTIMASA-----MAGNLTTYSILPLAPNVGLIGWVRDSTTIYELMRD | ..|.. | ..||.|. .| || | .|.| || |.|||| ||. ..||. . . ...|||. |. .. |||.|| ...|. |. .. IRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYKQ YRERRKIPLNVEINN--------------------TLQMCPNFEQLPAIERKESFEFGLSKTKGDDLQQIILVNSSDSSNWVSRRLVYTESLAATSMVGY .... .| . |. .|.|.. .| |..|.|. ...|..|... . . ..|. | .|| || |.| .|||| WCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVGY ILGLGDRHPGNIMMCVKTGKLLHIDFGDCFEVAQHREHYPETVPFRLTRVFVNALEIAKVEGTLRQCSINVMNLLRLHKDTISGLLETF ||||||||| ||| . ||...|||||.|||.| |. ||.||||||| .|||... .||| .|.| . || ..| |..|. ...|.| ILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
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| Kinase | 93865.m00227.AA | PI3_PI4_kinase | 1862-2107 | 28 | 1.6e-70 | 245.41 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 1862-2107 Range on HMM: 1-300/300 Sequence Identity: 28% (84 aa) KYKFLLKANEDTR--LDQRVVQLL-----------------------TFVNTIMASAMAGNL-----TTYSILPLAPNVGLIGWVRDSTTIYELMRDYRE |.|..| ..| | |.|..|.. ...|.. . . . ..|...|..|. |.|.|| ..||. |. | |.. WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV RRK-IPLNVEINNTLQMCPNFEQLPAIERKESFEFGLSKTKGDDLQQIILVNSSDS-SNWVSRRLVYTESLAATSMVGYILGLGDRHPGNIMM--CVKTG ..| ...| | . ..| |. ..| .....| || ..||....| | . .. | .| ..| ...|.| ..|.||||.||||..|||. . .|| KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG KLLHIDFGDCFE-VAQHREHYPETVPFRLTR------VFVNAL------EIAKVEGTLRQCSINVMNLLRLHKDTISGLL-------ETFVHDPLLMGTA .| |||||.||. ......| ||.||||.|. .|.|. . . .|..|.. ....|| |.. . || |..|||.|.| . HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
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| Kinase | 93865.m00227.AA | PI3Kc | 1864-2156 | 23 | 1.4e-68 | 235.09 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 1864-2156
Range on HMM: 1-336/336
Sequence Identity: 23% (79 aa)
KFLLKANEDTRLDQRVVQLLTFVNTIMASA-----MAGNLTTYSILPLAPNVGLIGWVRDSTTIYELMRDYRERRKIPLNVEINNTLQM-----------
...|...| | |.|. |.. .|.| .. . ...|...|. |. |.|.|| ...|. .... |.. .|.|..... ..|
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
----------CPNFEQLPAIERKESFEFGLSKTKGDDLQQIILVNSSDSS-NWVSRRLVYTESLAATSMVGYILGLGDRHPGNIMMCVKTGKLLHIDFGD
.. ... .|....||. ....|...|.. . .. |.. .|...| .| |.|. .||.||||.||||..|||.. |||...|||||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
CFEVAQHREHYP----ETVPFRLTRVFVNALE----IAKVEGTLRQCSINVMNLLRLHKDTISGLLETFVHDPLLMGTAKMSEEKQPDVLIRRIVAK-LT
.|. .. ..... |.||||||. .|.. . .....| |.| .....| |...| |.|..|.||.. .| || ...| |. |.
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM--EKDIKYLRQRFRLDHLS
GDDFPDKG---------NLCVEQQVDTLISEATSTLNI
.. . . ..| . ... .. ..
DEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| Kinase | 93865.m00227.AA | ATR | 1834-2097 | 28 | 2.5e-42 | 141.76 | In-house | 3-267 (267) | Show / Hide |
Range on Protein: 1834-2097 Range on HMM: 3-267/267 Sequence Identity: 28% (77 aa) INSFDPVMNVFTSKQRPRAVSINATDGNKYKFLLKANEDTRLD---QRVVQLLTFVNTIMASAMAGNL--TTYSILPLAPNVGLIGWVRDSTTIYELMRD | || ......| |.|. .|. .|| | . | .| | | .|. .|. |.| . . . . ||...|| . ..| || . |. .. IAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILDK -YRERRKIPLNVEINNTLQMCPNFEQLPAIERKESF-EFGLSKTKGDDLQQIILVNSSDSSNWVSRRLVYTESLAATSMVGYILGLGDRHPGNIMMCVKT ..|... . |..| |.. .| || | . . .. . |. .| | | | | |. .|||||.|||||| ||.. . LWKEKKQYMQFYQ----LRQCMDKKSREEWEKQKVFREFLLPR-HPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKIN GKLLHIDFGDCFEVAQHREHYPETVPFRLTRVFVNALEIAKVEGTLRQCSINVMNLLRLHKDTISGLLETF | . |.|. | . | ||.||||||. |... | .| |. . .| ..| |.| | .....| GECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | 93865.m00227.AA | ATM | 1989-2102 | 45 | 9.1e-32 | 98.48 | In-house | 133-245 (304) | Show / Hide |
Range on Protein: 1989-2102 Range on HMM: 133-245/304 Sequence Identity: 45% (52 aa) WVSRRLVYTESLAATSMVGYILGLGDRHPGNIMMCVKTGKLLHIDFGDCFEVAQHREHYPETVPFRLTRVFVNALEIAKVEGTLRQCSINVMNLLRLHKD | .|| || | | |.||||||||||| ||.. . | ||| | || . |||||||||| | . | ||| | | | .| .. WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT-PETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE TISGLLETFVHDPL |. . | . ||| TLLTIVEVLLYDPL |
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| Kinase | 93865.m00227.AA | FATC | 2135-2167 | 60 | 1.1e-18 | 62.93 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 2135-2167 Range on HMM: 1-33/33 Sequence Identity: 60% (20 aa) GNLCVEQQVDTLISEATSTLNICMMFKGWRPWW .| |||||| ||.|||.. |.|.|. || ||| EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
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| Kinase | 93865.m00227.AA | DNAPK | 2007-2107 | 34 | 6.8e-17 | 57.85 | In-house | 201-301 (301) | Show / Hide |
Range on Protein: 2007-2107 Range on HMM: 201-301/301 Sequence Identity: 34% (35 aa) GYILGLGDRHPGNIMMCVKTGKLLHIDFGDCFEVAQHREHYPETVPFRLTRVFVNALEIAKVEGTLRQCSINVMNLLRLHKDTISGLLETFVHDPLLMGT ..||| |||| | | .| |||| | | || |||||| |.| . |. | ..| | | .| . . |. ||.. HWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWK A N |
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| Kinase | 93865.m00227.AA | DNAPK | 1832-1926 | 31 | 6.9e-14 | 46.76 | In-house | 2-101 (301) | Show / Hide |
Range on Protein: 1832-1926 Range on HMM: 2-101/301 Sequence Identity: 31% (31 aa) IGINSFDPVMNVFTSKQRPRAVSINATDGNKYKFLLKANEDTRLDQRVVQLLTFVNTIMA-----SAMAGNLTTYSILPLAPNVGLIGWVRDSTTIYELM . | || . | | ||. . | | |. | || |.|||. || | |.. . . .| ||.| |. ||| || . ... VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDIL |
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| Kinase | 93865.m00227.AA | SMG1 | 1996-2039 | 54 | 2.6e-12 | 36.94 | In-house | 190-233 (242) | Show / Hide |
Range on Protein: 1996-2039 Range on HMM: 190-233/242 Sequence Identity: 54% (24 aa) YTESLAATSMVGYILGLGDRHPGNIMMCVKTGKLLHIDFGDCFE | | | ||||||.|||||| |... . || |||. ||| YARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFE |
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| Kinase | 93865.m00227.AA | SMG1 | 1841-1932 | 30 | 5.8e-10 | 29.04 | In-house | 1-97 (242) | Show / Hide |
Range on Protein: 1841-1932 Range on HMM: 1-97/242 Sequence Identity: 30% (30 aa) MNVFTSKQRPRAVSINATDGNKYKFLLKANEDTRLDQRVVQLLTFVNTIMASAMAGNLTT-----YSILPLAPNVGLIGWVRDSTTIYELMRDYRER . . | .|. . || | .| | || || |..| | |||. | ||. || ||| || | .. | . . | ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQR |
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