Gene 90487.m00107 (T.vaginalis)

90487.m00107

Species: T.vaginalis
Alias: 90487.m00107, TvagK0793
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
90487.m00107.AA Protein None 2158 None Fasta, JSON
90487.m00107.kin_dom Protein Kinase Domain None 272 None Fasta, JSON

Protein domain

Protein domains of 90487.m00107.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Rapamycin_bind 90487.m00107.AA Rapamycin_bind 1700-1719 50 8e-06 19.95 Pfam 1-20 (100) Show / Hide 
Range on Protein: 1700-1719
Range on HMM: 1-20/100
Sequence Identity: 50% (10 aa)

ELIRIAVLWWDSWYSTLDNA
||||.|.||.  |.  |. |
ELIRVAILWHEMWHEGLEEA
Rapamycin_bind 90487.m00107.AA Rapamycin_bind 1741-1795 16 0.310135 5.49 Pfam 46-100 (100) Show / Hide 
Range on Protein: 1741-1795
Range on HMM: 46-100/100
Sequence Identity: 16% (9 aa)

RPPETANEVSFIRSLGPYVHDVIDALDAFDKNRSHENKSHLWRQLVTVYNMVKPI
..||| .|.||. . |   ..  ... .. .... ..    |  ...|.. ... 
KGPETMREISFVQQFGRDLQEAHEWCQKYKRTGDENCLNQAWDIYYQVFRRIRKQ
Kinase 90487.m00107.AA PIKK 1832-2093 38 3.3e-101 342.54 In-house 1-290 (290) Show / Hide 
Range on Protein: 1832-2093
Range on HMM: 1-290/290
Sequence Identity: 38% (111 aa)

KISKIENRVKIMASKQKPRRIVIVGTNGNIYPFLLKGHEDTRLDERVMQLFKFLNSVVNDE-------LRVTPYEVMPLTRDVGLIGWVPNCTTIFELVK
 |  .  .| .||.||||..|.| | .| .||.|.||||| |.|.|||||| ..|     .       |  . | | |..   |||.||.||.|..|. |
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

NFRTQNNVNIEEE-----------------------CLESMRGVDYNNLYLDEKVAAFKRGLKKTAGDDLKRILFIRSLDTTHWLERRKTYTASLASTSI
. . . .   | |                       ... .  ..|. . |.|||..|   . .|..|..|...  ...| . |.|||. || |.|. ..
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQC--MMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCM

FGYILGLGDRHMSNIMMDENTAKLIHIDFGDCFEVAQHRKLFPETVPFRLTRMLVNALEPTGYDGAFRSLCVTLMEVCRKNRTKISGLLEAF
 |||||||||| .||| |. |....|||||.|||.|  |  .||.|||||||..|||..|.| .| ||. |.. |.. |..| .. ...|.|
VGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 90487.m00107.AA FRAP 1862-2103 48 3.5e-99 335.8 In-house 2-251 (251) Show / Hide 
Range on Protein: 1862-2103
Range on HMM: 2-251/251
Sequence Identity: 48% (121 aa)

YPFLLKGHEDTRLDERVMQLFKFLNSVVNDE-------LRVTPYEVMPLTRDVGLIGWVPNCTTIFELVKNFRTQNNV--NIEEECLESMRGVDYNNLYL
| |||||||| | ||||||||  .|   . .       | .. | ..||  . ||||||..| |.  |....| . ..  ||| . ...|   ||. | |
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMC-NDYDHLPL

DEKVAAFKRGLKKTAGDDLKRILFIRSLDTTHWLERRKTYTASLASTSIFGYILGLGDRHMSNIMMDENTAKLIHIDFGDCFEVAQHRKLFPETVPFRLT
 .||  |.  .. |.|.|||..| ..|     |.|||  || |||  |. |||||||||| ||||..  | |..|||||||||||  |  ||| .|||||
MNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLT

RMLVNALEPTGYDGAFRSLCVTLMEVCRKNRTKISGLLEAFVYDPLLQWLN
||||||.| .| .| .|  | . |.| | ..  .   |||||||||. |  
RMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase 90487.m00107.AA PI3_PI4_kinase 1861-2103 26 2.3e-68 238.23 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1861-2103
Range on HMM: 1-300/300
Sequence Identity: 26% (83 aa)

IYPFLLKGHEDTR--LDERVMQLF-----------------------KFLNSVVNDE---LR----VTPYEVMPLTRDVGLIGWVPNCTTIFELVKNFRT
.|||..||..| |   |.|.||..                       .. | .   .   .|    ..|| ..|.  . |.|.|||||||. |. .....
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

QNNVNI-----------EEECLESMRGVDYNNLYLDEKVAAFKRGLKKTAGDDLKRILFIRSLDT-THWLERRKTYTASLASTSIFGYILGLGDRHMSNI
. .  .           . .... |         . .||  | . ..|| ...| . .   . |  . |.|.|.... |.|  ....||||.|||| .||
KCKHKHFNKEHKMWMKMWPDWWHLM---------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNI

MM--DENTAKLIHIDFGDCFE-VAQHRKLFPETVPFRLTR------MLVNAL------EPTGYDGAFRSLCVTLMEVCRKNRTKISGLL-------EAFV
|.  |. | .|.|||||.||. .....  .||.||||.|.      ..|.|.      .|.|..| ||..|.......|.. . .  ||       |..|
MVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMV

YDPLLQWLN
.|.|. |  
HDGLPMWRS
Kinase 90487.m00107.AA PI3Kc 1863-2154 24 3.2e-64 220.57 SMART 1-336 (336) Show / Hide 
Range on Protein: 1863-2154
Range on HMM: 1-336/336
Sequence Identity: 24% (85 aa)

PFLLKGHEDTRLDERVMQLFKFLNSVVNDE-------LRVTPYEVMPLTRDVGLIGWVPNCTTIFELVKNFRTQNN--VNIEEECLESMRGV--------
....|...| | |.|.||.|.  | .   .       |...|| ..|.  . |.|.|||||.|. .. |..... .   ....     |  |        
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQKNMY

-------------DYNNLYLDEKVAAFKRGLKKTAGDDLKRILFIRSLDT-THWLERRKTYTASLASTSIFGYILGLGDRHMSNIMMDENTAKLIHIDFG
             .| .. ..|... |   .... ...|.  .  .. |    | |.|...| |.|  ....||||.|||| .|||.|..| ...|||||
MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG

DCFEVAQHRKLFP----ETVPFRLTRMLVNALE----PTGYDGAFRSLCVTLMEVCRKNRTKISGLLEAFVYDPLLQWLNNENQAGGIVARIDQKLSGSD
..|. .. . .|.    |.||||||...|.. .    |.||.| ||..|.. ... ||.. .|  |.|..||||.. ... .   .  .. . |..  ..
HIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM---EKDIKYLRQRFRLDH

FGVRMSEAQQVNM--------LIEEA-----TSNKNLCQMFRGW
    .|. .  ..        |||.      |  ... . ... 
----LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 90487.m00107.AA ATR 1831-2093 27 5.2e-41 137.22 In-house 1-267 (267) Show / Hide 
Range on Protein: 1831-2093
Range on HMM: 1-267/267
Sequence Identity: 27% (75 aa)

VKISKIENRVKIMASKQKPRRIVIVGTNGNIYPFLLKGHEDTRLDERVMQLFKFLNSVV-------NDELRVTPYEVMPLTRDVGLIGWVPNCTTIFELV
  |. ... |.|.|| |||..| . |..| .|  . | ..| | | | |.  . .| .          .. .  | |.||  . ..| || |  |.  ..
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL

KNFRTQNNVNIEEECLESMRGVDYNNLYLDEKVAAFKRGLKKTAGDDLKRILFIRSLDTTHWLERRKTYTASLASTSIFGYILGLGDRHMSNIMMDENTA
.       .  .   |      |     . ||  .|.  |        .     | .| . |   |. |  | |. .. |||.||||||  ||..|. . 
DKLWKEKKQYMQFYQLRQC--MDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKING

KLIHIDFGDCFEVAQHRKLFPETVPFRLTRMLVNALEPTGYDGAFRSLCVTLMEVCRKNRTKISGLLEAF
 ..|.|.   |   .  .  ||.||||||. .|... | . .| ||  |.  | . |..|  | .....|
ECVHVDYNCIFNSGEQFEV-PEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase 90487.m00107.AA ATM 1980-2104 49 3.6e-39 122.54 In-house 128-251 (304) Show / Hide 
Range on Protein: 1980-2104
Range on HMM: 128-251/304
Sequence Identity: 49% (62 aa)

LDTTHWLERRKTYTASLASTSIFGYILGLGDRHMSNIMMDENTAKLIHIDFGDCFEVAQHRKL-FPETVPFRLTRMLVNALEPTGYDGAFRSLCVTLMEV
||   | |.|  || | |  || ||||||||||. ||.. |  | |.||| |  ||  | . |  |||||||||| .|  .  || .| ||  |   |||
LDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFE--QGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEV

CRKNRTKISGLLEAFVYDPLLQWLNN
 |     .  . |  .||||  |  |
MRNSQETLLTIVEVLLYDPLFDWTMN
Kinase 90487.m00107.AA DNAPK 2003-2103 35 2.2e-21 74.46 In-house 201-301 (301) Show / Hide 
Range on Protein: 2003-2103
Range on HMM: 201-301/301
Sequence Identity: 35% (36 aa)

GYILGLGDRHMSNIMMDENTAKLIHIDFGDCFEVAQHRKLFPETVPFRLTRMLVNALEPTGYDGAFRSLCVTLMEVCRKNRTKISGLLEAFVYDPLLQWL
..||| ||||. | |    .   | ||||  |  |      ||  ||||||  .| . | .  | ...  .  |   || |       . |. ||.. | 
HWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWK

N
|
N
Kinase 90487.m00107.AA FATC 2126-2158 57 1.1e-19 66.08 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2126-2158
Range on HMM: 1-33/33
Sequence Identity: 57% (19 aa)

VRMSEAQQVNMLIEEATSNKNLCQMFRGWYPWW
. .|  |||..||.|||...|||||. || |||
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 90487.m00107.AA DNAPK 1831-1925 36 7.6e-19 65.06 In-house 2-103 (301) Show / Hide 
Range on Protein: 1831-1925
Range on HMM: 2-103/301
Sequence Identity: 36% (37 aa)

VKISKIENRVKIMASKQKPRRIVIVGTNGNIYPFLLKGHEDTRLDERVMQLFKFLNSVVND-------ELRVTPYEVMPLTRDVGLIGWVPNCTTIFELV
|.|   . || .|||  .|.||.| |      ||. || || |.| |. |||  .| .          ||    | . |.|   ||| || |  .  .. 
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDIL

KN
 |
NN
Kinase 90487.m00107.AA SMG1 1840-1924 39 2.1e-15 47.33 In-house 1-92 (242) Show / Hide 
Range on Protein: 1840-1924
Range on HMM: 1-92/242
Sequence Identity: 39% (36 aa)

VKIMASKQKPRRIVIVGTNGNIYPFLLKGHEDTRLDERVMQLFKFLNSVVNDELRV-TP------YEVMPLTRDVGLIGWVPNCTTIFELVK
. |.  | ||.... .|  |  ||.| || ||  ||||.||     | .     |  ||      | | ||    ||| ||   | .| | |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYK
Kinase 90487.m00107.AA SMG1 1985-2035 45 3.4e-11 33.17 In-house 183-233 (242) Show / Hide 
Range on Protein: 1985-2035
Range on HMM: 183-233/242
Sequence Identity: 45% (23 aa)

WLERRKTYTASLASTSIFGYILGLGDRHMSNIMMDENTAKLIHIDFGDCFE
|    . |  | |  |. |||.||||||. |...|  |   .|||.  |||
WWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFE