Gene 88273.m00300 (T.vaginalis)
88273.m00300
Species: T.vaginalis
Alias: 88273.m00300, TvagK0791
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 88273.m00300.AA | Protein | None | 2192 | None | Fasta, JSON |
| 88273.m00300.kin_dom | Protein Kinase Domain | None | 279 | None | Fasta, JSON |
Protein domains of 88273.m00300.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Rapamycin_bind | 88273.m00300.AA | Rapamycin_bind | 1712-1811 | 33 | 4e-50 | 160.07 | Pfam | 1-100 (100) | Show / Hide |
Range on Protein: 1712-1811 Range on HMM: 1-100/100 Sequence Identity: 33% (33 aa) EMMRVSVSWFELAYQCIDESSHEFCPDVNKQMMLKFLDPLKEILSKKCETCMESKFFAQNYSHLKIAFGLLKKYEENDDLGSLNEVWDHFSTVFNKLRNV |..||...|.|.......|.|. .. | |...|...|.|| |.|.|..||..|..| .| ...|. |.....||....|...||..||.. .||...|.. ELIRVAILWHEMWHEGLEEASRQYFGDHNIEKMFNILEPLHEMLEKGPETMREISFVQQFGRDLQEAHEWCQKYKRTGDENCLNQAWDIYYQVFRRIRKQ |
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| Kinase | 88273.m00300.AA | PIKK | 1849-2118 | 38 | 5.70000000001e-110 | 371.64 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 1849-2118 Range on HMM: 1-290/290 Sequence Identity: 38% (111 aa) YISSFKNVIKIINSKQRPRKICITGSDGNKYKFLLKAHEDTRLDERVMQLFDFINTLVDNSVLRMKNFLGMTTYRVVPITGEVGLIGWVNDCGTLHEAVK .| .. .. .. .||.|.|| | |.|| | .|.| ||| |.|.|||||| ..||. . | .| ..||.|.| . . |||.||..| ||.| | RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK ESRRKRGMKIQAEMQS--------------------TINYAPNYDTLKLDDKLIAFKKGLQATDGLDVRRILLASAPSTATWLTRRTTYASSMAIISMAG . . | . . | |. ....|. . |..|...| . .|.| . . ..... ..|. ..|..||. |..| | ..|.| QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG YILGLGDRHFSNIMIGKTTAKLVHIDFGDCFEVAMHRERFPEKVPFRLTRMLVNALEVSKIEGTFRTCCEDSLDLMRQNGRQILSLLEAF ||||||||| .|||| ..|...||||||.|||.|| |...||||||||||..|||... ..|| || |||... .|||. .....|.| YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
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| Kinase | 88273.m00300.AA | FRAP | 1878-2128 | 47 | 6e-104 | 351.65 | In-house | 1-251 (251) | Show / Hide |
Range on Protein: 1878-2128 Range on HMM: 1-251/251 Sequence Identity: 47% (120 aa) KYKFLLKAHEDTRLDERVMQLFDFINTLVDNSVLRMKNFLGMTTYRVVPITGEVGLIGWVNDCGTLHEAVKESRRKRGMKIQAEMQSTINYAPNYDTLKL | |||| ||| | |||||||| ||.| | | | .. | ..|. . ||||||..| ||| ... |.| .. .| . ...|| | | EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMCNDYDHLPL DDKLIAFKKGLQATDGLDVRRILLASAPSTATWLTRRTTYASSMAIISMAGYILGLGDRHFSNIMIGKTTAKLVHIDFGDCFEVAMHRERFPEKVPFRLT .| |. .. | | | ...| |. |. ||| | |.|..||||||||||||| ||||. . | |.||||||||||||| ||.||||.||||| MNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLT RMLVNALEVSKIEGTFRTCCEDSLDLMRQNGRQILSLLEAFIHDPLLQRQT ||||||.|. |||..| || .. .| . .. ||||. |||. RMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL |
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| Kinase | 88273.m00300.AA | PI3_PI4_kinase | 1878-2128 | 26 | 1.8e-71 | 248.55 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 1878-2128 Range on HMM: 1-300/300 Sequence Identity: 26% (79 aa) KYKFLLKAHEDTR--LDERVMQLF-----------------------DFINTLVDNSVLRMKNFLGMTTYRVVPITGEVGLIGWVNDCGTLHEAVKESRR |.|..| ..| | |.|.||.. ..|.. .. . . ..|..||..| . |.|.||..| |.|| .. . WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV KRGMKIQA-EMQSTINYAPNYDTLKLDDKLIAFKKGLQATDGLDVRRILLASAPST-ATWLTRRTTYASSMAIISMAGYILGLGDRHFSNIMI--GKTTA |...|.. | . ..|....|.. .|.. | . . | . . .. .. . |. .|...|.....|.| .....||||.|||| .|||. ||| KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG KLVHIDFGDCFE-VAMHRERFPEKVPFRLTR------MLVNAL------EVSKIEGTFRTCCEDSLDLMRQNGRQILSLL-------EAFIHDPLLQRQT .|.|||||.||. ..|... .||.||||.|. ..|.|. ..|. .|.||..|.. . ..|.... ...|| |...||.|. HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
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| Kinase | 88273.m00300.AA | PI3Kc | 1880-2181 | 22 | 8.2e-63 | 215.91 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 1880-2181
Range on HMM: 1-336/336
Sequence Identity: 22% (76 aa)
KFLLKAHEDTRLDERVMQLFDFINTLVDNSVLRMKNFLGMTTYRVVPITGEVGLIGWVNDCGTLHEAVKESRRKRGMKIQAEMQSTINY-----------
...|...| | |.|.||.| .|.. . . | |..|...|. . |.|.||..| |||. |... ...| . . .
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
----------APNYDTLKLDDKLIAFKKGLQATDGLDVRRILLASAPST-ATWLTRRTTYASSMAIISMAGYILGLGDRHFSNIMIGKTTAKLVHIDFGD
.. |...... .|. | . . .. . . . .. |. | ..|.....|.| .|..||||.|||| .|||. ..| ...|||||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
CFEVAMHRERFP----EKVPFRLTRMLVNALE----VSKIEGTFRTCCEDSLDLMRQNGRQILSLLEAFIHDPL-LQRQTNHSGSSNVDDAVSAVKRISD
.|. .. .. |. |.||||||...|.. . .|. .| |||||. . .||.. .|..|.|....||. . . . . .. . . ||
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-EKDIKYLRQRFRLDHLSD
KLSGNDFEG----MQGNLKVSDQVELLIAQAMDEKNL
... . |. . .. . .. .... ...
EEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| Kinase | 88273.m00300.AA | ATR | 1848-2118 | 30 | 4.4e-52 | 175.57 | In-house | 1-267 (267) | Show / Hide |
Range on Protein: 1848-2118 Range on HMM: 1-267/267 Sequence Identity: 30% (83 aa) VYISSFKNVIKIINSKQRPRKICITGSDGNKYKFLLKAHEDTRLDERVMQLFDFINTLVDNSVLRMKNFLGMTTYRVVPITGEVGLIGWVNDCGTLHEAV ||. | ....|. | |.|.|| . |||| | . | ..| | | | |. . || . . |. | || |.|. . ..| |||. ||. . AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL KESRRKRGMKIQAEMQSTINYAPNYDTLKLDDKLIAFKKGLQATDGLDVRRILLASAPSTATWLTRRTTYASSMAIISMAGYILGLGDRHFSNIMIGKTT .. . .... | . .. .|. .|.. | . . | | . | | |.|...| |||.|||||| ||.| | . DKLWKEKKQYMQFYQ---LRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKIN AKLVHIDFGDCFEVAMHRERFPEKVPFRLTRMLVNALEVSKIEGTFRTCCEDSLDLMRQNGRQILSLLEAF .||.|. | | || ||||||. .|... | .| || ||. . .||.. .|.|....| GECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | 88273.m00300.AA | ATM | 2008-2123 | 45 | 2e-34 | 107.11 | In-house | 131-245 (304) | Show / Hide |
Range on Protein: 2008-2123 Range on HMM: 131-245/304 Sequence Identity: 45% (53 aa) ATWLTRRTTYASSMAIISMAGYILGLGDRHFSNIMIGKTTAKLVHIDFGDCFEVAMHRERFPEKVPFRLTRMLVNALEVSKIEGTFRTCCEDSLDLMRQN | | .| | |.| |. |||||||||| ||.| | ||||| | || || ||||||| .| . . .|| || ||| .. || AIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT-PETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNS GRQILSLLEAFIHDPL .| . | . ||| QETLLTIVEVLLYDPL |
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| Kinase | 88273.m00300.AA | FATC | 2160-2192 | 57 | 3.7e-20 | 67.63 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 2160-2192 Range on HMM: 1-33/33 Sequence Identity: 57% (19 aa) GNLKVSDQVELLIAQAMDEKNLCQMFSGWCPWW .| |..||. ||..|.|..|||||..|||||| EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
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| Kinase | 88273.m00300.AA | DNAPK | 2004-2128 | 30 | 1.2e-17 | 60.71 | In-house | 177-301 (301) | Show / Hide |
Range on Protein: 2004-2128 Range on HMM: 177-301/301 Sequence Identity: 30% (38 aa) APSTATWLTRRTTYASSMAIISMAGYILGLGDRHFSNIMIGKTTAKLVHIDFGDCFEVAMHRERFPEKVPFRLTRMLVNALEVSKIEGTFRTCCEDSLDL . . |.| | .... |.| ..||| |||| | |. . . |||| | | || |||||| .| . || | .. |. STTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMA MRQNGRQILSLLEAFIHDPLLQRQT .|. . . || ||.. FRKDRNILTNFCDVFINDPSFDWKN |
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| Kinase | 88273.m00300.AA | DNAPK | 1848-1945 | 32 | 7e-16 | 54.11 | In-house | 2-99 (301) | Show / Hide |
Range on Protein: 1848-1945 Range on HMM: 2-99/301 Sequence Identity: 32% (32 aa) VYISSFKNVIKIINSKQRPRKICITGSDGNKYKFLLKAHEDTRLDERVMQLFDFINTLVDNSVLRMKNFLGMTTYRVVPITGEVGLIGWVNDCGTLHE | | | . .. | ||..| | | | |. | || |.| |. ||| | . | . || ..| | ||| ||. .| . VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKD |
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| Kinase | 88273.m00300.AA | SMG1 | 2017-2070 | 51 | 2e-15 | 47.39 | In-house | 190-242 (242) | Show / Hide |
Range on Protein: 2017-2070 Range on HMM: 190-242/242 Sequence Identity: 51% (28 aa) YASSMAIISMAGYILGLGDRHFSNIMIGKTTAKLVHIDFGDCFEVAMHRERFPE || | |..|| |||.|||||| |..| || ||||. ||| . || YARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKG-KKLNVPE |
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| Kinase | 88273.m00300.AA | SMG1 | 1857-1937 | 37 | 2.8e-14 | 43.58 | In-house | 1-81 (242) | Show / Hide |
Range on Protein: 1857-1937 Range on HMM: 1-81/242 Sequence Identity: 37% (30 aa) IKIINSKQRPRKICITGSDGNKYKFLLKAHEDTRLDERVMQLFDFINTLVDNSVLRMKNFLGMTTYRVVPITGEVGLIGWV | |. | .|.|. |||| | .| | || ||||.|| .||. | | |. ||| || ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWV |
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| Kinase | 88273.m00300.AA | ATM | 1880-1936 | 33 | 2e-06 | 16.33 | In-house | 1-57 (304) | Show / Hide |
Range on Protein: 1880-1936 Range on HMM: 1-57/304 Sequence Identity: 33% (19 aa) KFLLKAHEDTRLDERVMQLFDFINTLVDNSVLRMKNFLGMTTYRVVPITGEVGLIGW . | | .| | | . | | |||. | | . ||.|||. | . | RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW |
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