Gene 95240.m00157 (T.vaginalis)
95240.m00157
Species: T.vaginalis
Alias: 95240.m00157, TvagK0639
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 95240.m00157.AA | Protein | None | 2159 | None | Fasta, JSON |
| 95240.m00157.kin_dom | Protein Kinase Domain | None | 179 | None | Fasta, JSON |
Protein domains of 95240.m00157.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 95240.m00157.AA | PIKK | 1809-2082 | 34 | 3.8e-76 | 259.27 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 1809-2082 Range on HMM: 1-290/290 Sequence Identity: 34% (99 aa) LVSHVHHILKTMPSAQHPRKMSIVGTDGITYKYLLKGGVDLRLDLHVMQLFSLINSILVEDKFGDEMHSLIHLYGVTPLSRQSGLISWAEGGKTLYSLIK . . |.. | |.|..| | || | ||.||. |||.| |||||.|.| .| |. | | | |.|.| ..||| | .. || ..| RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK WYRKLRKFPLTAESKV---------------YMDFLPKGKESSL-LLTRIQRLEIFNELVEAAPSDQLRQVLWLKSPCAESWLIQATNFARSTSLMSFVG ... . |. |.... . . .. .... ...|.|.|.... | | .. .|.|.| .|.|. .|..||. .|..|| QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG YIIGLGDRHPSNILVMEKRGNVVHIDLSEVFEKAALRKTAREVVPFRLTRMIVDALGPSGVHGVFSITARNVMNALRRNQSTILAFLDIF ||.|||||||.||.. . | .||||. ||.| | . | |||||||..|.|.|| || ||| . || ..|... |...... | YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
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| Kinase | 95240.m00157.AA | FRAP | 1839-2092 | 37 | 3.3e-65 | 222.93 | In-house | 2-251 (251) | Show / Hide |
Range on Protein: 1839-2092 Range on HMM: 2-251/251 Sequence Identity: 37% (94 aa) YKYLLKGGVDLRLDLHVMQLFSLINSILVEDKFGDEMHSLIHLYGVTPLSRQSGLISWAEGGKTLYSLIKWYRKLRKFPLTAESKVYMDFLPKGKESSLL | .|||| |.| | ||||| ||| .| . | | . ||| ..||| | . || ||. ||| . . .| ... . . YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMCNDYDH---- LTRIQRLEIFNELVEAAPSDQLRQVLWLKSPCAESWLIQATNFARSTSLMSFVGYIIGLGDRHPSNILVMEKRGNVVHIDLSEVFEKAALRKTAREVVPF |. ... ||| .. ..|. .|||||| | |. ||. || || .|||.||||||||||. | .|||| || | | | .|| LPLMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPF RLTRMIVDALGPSGVHGVFSITARNVMNALRRNQSTILAFLDIFTKENIVDMIW |||||.| |. |. | . .| ||. .| . ..| |. | . . RLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL |
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| Kinase | 95240.m00157.AA | PI3_PI4_kinase | 1838-2089 | 24 | 3.2e-51 | 181.29 | Pfam | 1-297 (300) | Show / Hide |
Range on Protein: 1838-2089 Range on HMM: 1-297/300 Sequence Identity: 24% (72 aa) TYKYLLKGGVDLR--LDLHVMQLF-----------------------SLINSILVEDKFGDEMHSLIHLYGVTPLSRQSGLISWAEGGKTLYSLIKWYRK .|....||| ||| | ..||.. .|.| ... |. . . .. | . |.. ..|.| | . |. ... |.. WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV LRKFPLTAESKVYMDFLPKGKESSLLLTRIQRLEIFNELVEAAPSDQLRQVLWLKSPCA-ESWLIQATNFARSTSLMSFVGYIIGLGDRHPSNILV--ME .|.. .. ... . . ... . |.|..|.|.. | . |.|..| ..| | | |. .||.|| |. |.||.|.||||..||.| .. KCKHKHFNKEHKMWMKMWPDWWHLM---RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDK KRGNVVHIDLSEVFE-KAALRKTAREVVPFRLTR------MIVDAL------GPSGVHGVFSITARNVMNALRRNQSTILAFL-------DIFTKENIVD ..|...||| |. . . .| ||||.|. ..|.|. .||| | | . ...||||.. ....| ... . .... TTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPM |
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| Kinase | 95240.m00157.AA | PI3Kc | 1840-2148 | 22 | 5.5e-50 | 173.3 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 1840-2148
Range on HMM: 1-336/336
Sequence Identity: 22% (78 aa)
KYLLKGGVDLRLDLHVMQLFSLINSILVED--KFGDEMHSLIHLYGVTPLSRQSGLISWAEGGKTLYSLIKWYRKLRKFPLTAESKVYMD----------
..|.| ||| | ..||.|.|.| |. .| ... .| . |.. |.. ..|.| | .|| .. | |.| .|.|.. . .. |
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLH--MRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNM
-------FLPKGKESSLLLTRIQRLEIFNELVEAAPSDQLRQVLWLKSPCA-ESWLIQATNFARSTSLMSFVGYIIGLGDRHPSNILVMEKRGNVVHIDL
.. ... .. .|....|. | . . . . . |.. .| ..| . |.| .||.||. .. |.|| |.||||..||.. .| |...|||.
YMMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDF
SEVFEKAALRKTA----REVVPFRLTRMIVDALG----PSGVHGVFSITARNVMNALRRNQSTILAFLDIFTKENI-VDMIWYQNDDNDDADKEKSSLKK
|... .. . ||.||||||...|.. | |||. | | .. ...|.|... .|.. . .. . .| . . .| .......
GHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM----EKDIKYLRQRFRL
AISKLEDKLNFREFGE-----ENPDT-DEHVSKLISIATDPMNL
| |.. .. | ... ... .... .. . ...
DH--LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| Kinase | 95240.m00157.AA | ATR | 1809-2082 | 27 | 4.8e-39 | 130.41 | In-house | 2-267 (267) | Show / Hide |
Range on Protein: 1809-2082 Range on HMM: 2-267/267 Sequence Identity: 27% (75 aa) LVSHVHHILKTMPSAQHPRKMSIVGTDGITYKYLLKGGVDLRLDLHVMQLFSLINSILVEDKFGDEMHSLIHLYGVTPLSRQSGLISWAEGGKTLYSLIK .. ... . | |.|.|.|. |.|| | . | ||| | |. .||| .. | . | | || |...| | . || .... YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD WYRKLRKFPLTAESKVYMDFLPKGKESSLLLTRIQRLEIFNELVEAAPSDQLRQVLWLKSPCAESWLIQATNFARSTSLMSFVGYIIGLGDRHPSNILVM | .| . .. .. ..| .| . ... .| |.. .. . | ...| |. ||. .. ||||||||||| |||. KLWKEKKQYMQFY-QLRQCMDKKSREEW------EKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILID EKRGNVVHIDLSEVFEK-AALRKTAREVVPFRLTRMIVDALGPSGVHGVFSITARNVMNALRRNQSTILAFLDIF . | .||.| .| . . |.||||||. .| ..|| . .|.| .| .| .. |....| | KINGECVHVDYNCIFNSGEQFE--VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | 95240.m00157.AA | ATM | 1981-2081 | 46 | 1.5e-27 | 84.77 | In-house | 140-239 (304) | Show / Hide |
Range on Protein: 1981-2081 Range on HMM: 140-239/304 Sequence Identity: 46% (47 aa) FARSTSLMSFVGYIIGLGDRHPSNILVMEKRGNVVHIDLSEVFEKAALRKTAREVVPFRLTRMIVDALGPSGVHGVFSITARNVMNALRRNQSTILAFLD . || | ||||.|||||| |||. |. .||||| ||. . | | ||||||| ||| .| || ||| | .| | |.| . YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTP-ETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVE I . V |
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| Kinase | 95240.m00157.AA | SMG1 | 1947-2034 | 43 | 4.5e-19 | 59.68 | In-house | 156-242 (242) | Show / Hide |
Range on Protein: 1947-2034 Range on HMM: 156-242/242 Sequence Identity: 43% (39 aa) IFNELVEAAPSDQLRQVLWLKSPCAESWLIQATNFARSTSLMSFVGYIIGLGDRHPSNILVMEKRGNVVHIDLSEVFEKA-ALRKTARE . ||.|| | . | . || . | .|||| || ||||||||||| |.|. | ||||| ||| .|. . | VLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLN--VPE |
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| Kinase | 95240.m00157.AA | FATC | 2127-2159 | 48 | 6.2e-16 | 54.08 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 2127-2159 Range on HMM: 1-33/33 Sequence Identity: 48% (16 aa) ENPDTDEHVSKLISIATDPMNLSQMYLGWSAYW |. .. ..|..||. |||| ||.||| ||...| EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
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| Kinase | 95240.m00157.AA | DNAPK | 1948-2094 | 26 | 1.6e-15 | 52.82 | In-house | 157-301 (301) | Show / Hide |
Range on Protein: 1948-2094 Range on HMM: 157-301/301 Sequence Identity: 26% (39 aa) FNELVEAAPSDQLRQVLWLKSPCAESWLIQATNFARSTSLMSFVGYIIGLGDRHPSNILVMEKRGNVVHIDLSEVFEKAALRKTAREVVPFRLTRMIVDA |.. . | | .|. . | | .| |.|. . ..| | |||| | .| | .. || | | . | |||||| . FRKQEDKIPRDVFRRAFVRMSTTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINL LGPSGVHGVFSITARNVMNALRRNQSTILAFLDIFTKENIVDMIWYQ . | .. |.. | |.|. . | |.| .. .| | . MSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFD--WKN |
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| Kinase | 95240.m00157.AA | SMG1 | 1817-1908 | 35 | 1.7e-15 | 47.65 | In-house | 1-92 (242) | Show / Hide |
Range on Protein: 1817-1908 Range on HMM: 1-92/242 Sequence Identity: 35% (33 aa) LKTMPSAQHPRKMSIVGTDGITYKYLLKGGVDLRLDLHVMQLFSLINSILVEDKFGDEMHSLIHLYGVTPLSRQSGLISWAEGGKTLYSLIK . .| |.|. .| || | || || || || .|| |..| . . | |||| |||| | .| |. | | ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYK |
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| Kinase | 95240.m00157.AA | DNAPK | 1808-1903 | 26 | 1e-06 | 20.18 | In-house | 2-97 (301) | Show / Hide |
Range on Protein: 1808-1903 Range on HMM: 2-97/301 Sequence Identity: 26% (25 aa) ILVSHVHHILKTMPSAQHPRKMSIVGTDGITYKYLLKGGVDLRLDLHVMQLFSLINSILVEDKFGDEMHSLIHLYGVTPLSRQSGLISWAEGGKTL . . | | |... | | | .. ||. |||.| . ||| | |. | | . |. ||| | . .| VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVL |
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| Kinase | 95240.m00157.AA | ATM | 1840-1899 | 35 | 5e-06 | 14.95 | In-house | 1-60 (304) | Show / Hide |
Range on Protein: 1840-1899 Range on HMM: 1-60/304 Sequence Identity: 35% (21 aa) KYLLKGGVDLRLDLHVMQLFSLINSILVEDKFGDEMHSLIHLYGVTPLSRQSGLISWAEG . | || ||| | . | | . | .| | | | ||| || . | | RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTG |
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