Gene 86498.m00623 (T.vaginalis)

86498.m00623

Species: T.vaginalis
Alias: 86498.m00623, TvagK0658
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: YAK

Sequence

Name Sequence Type Origin Length Description Download
86498.m00623.AA Protein None 249 None Fasta, JSON
86498.m00623.kin_dom Protein Kinase Domain None 241 None Fasta, JSON

Protein domain

Protein domains of 86498.m00623.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 86498.m00623.AA DYRK 2-241 29 1.3e-56 194.44 In-house 81-320 (320) Show / Hide 
Range on Protein: 2-241
Range on HMM: 81-320/320
Sequence Identity: 29% (73 aa)

DLLGPSVYQLLLDKKLEGM-PLKTIQNIMKSVLITLDDISSI-GVIHMDIRPENILQSAN-DPNKFIVVDYHCAGLEGRTNPVYVQSRFYRAPEVLLRLE
.||  . |..|   .  |  .|. .. . ...|  |. ...    || |. ||||.     ...   |.|   .. |...   |.||||||||||.|.. 
ELLSMNLYEFLKNNHFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCP

YGCKIDIWSLGVAAFEMMVGVPLFPGNTEVQMLYIINSMVGPFPQHMIEKS--SRRLSFFLHDGTMKSAERLAEENMENIEDWKNCLIYKTIAENILTYR
|. .||.||||.   |.  | |||||..|. .|. |  . |..|..||.|.  .|.  ||          .  .|. . .   .   ..|.. ... ..|
YCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC-----FMYCECDEWTKQNKITDHYMTPKCHPTKRGQRR

YPDLNELPPEVREQRLMFIDLLMKCVTIDPEKRISAAEALRHPFI
.|.   . |. . ....|.|...|| ..||.|||....||.||..
PPGRRNWDPRHQCDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase 86498.m00623.AA CMGC 75-241 22 3.5e-44 142.51 In-house 278-513 (513) Show / Hide 
Range on Protein: 75-241
Range on HMM: 278-513/513
Sequence Identity: 22% (56 aa)

EGRTNPVYVQSRFYRAPEVLLRLE----------YGCKIDIWSLGVAAFEMMVG--------VPLFPGNTE-----------VQMLYIINSMVGPFPQHM
..|..  ||..|.|||||.||. .          |...||.||.|   .||. |         |||||..|           . .|. |  . |... .|
PNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WM

IEKSSRRLSFFLHDGTMKSAERLAEENMENIEDWKNCLI-------------------YKTIAENIL-------TYRYPDLNELPPEVRE----------
|.|.  |  |              . . .. |.| |..                    ..  | | .       .........| |  ..          
IQKGK-RH-F--------------N-FCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMV

----------------------QRLMFIDLLMKCVTIDPEKRISAAEALRHPFI
                      .   .||||.|. ..||.|||.|..||.||..
FNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 86498.m00623.AA DYRK1 1-241 29 4.8e-33 113.11 In-house 80-321 (321) Show / Hide 
Range on Protein: 1-241
Range on HMM: 80-321/321
Sequence Identity: 29% (71 aa)

MDLLGPSVYQLLLDKKLEGMPLKTIQNIMKSVLITLDDISS--IGVIHMDIRPENILQSANDPNKFIVVDYHCAGLEGRTNPVYVQSRFYRAPEVLLRLE
..||   .| ||   .  |. |  .. . . .. .|  .|.  . .|| |..|||||       .  ..|.  .   |.    |.||||||.||||| .|
FELLSYNLYDLLRNTHFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIE

YGCKIDIWSLGVAAFEMMVGVPLFPGNTEVQMLYIINSMVGPFPQHMIEKSSRRLSFFLHDGTMKSAERLAEENMENIEDWKNCLIYKTIAENILTYRYP
|  .||.||||    || .| ||| |  ||  .  |  ..|  |.|||... .   .| .|     . .  ..   . ..     . . .  .       
YDMAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDKKKHYKEPCTRKLHEILGVETGGPGGR

DLNELPPEVREQRLMFIDLLMKCVTIDPEKRISAAEALRHPFI
 ..| |    |  | | ||. . .  ||..||.  .||.|.|.
RKGE-PGHSVEDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase 86498.m00623.AA HIPK 2-241 28 1.5e-31 96.24 In-house 80-329 (329) Show / Hide 
Range on Protein: 2-241
Range on HMM: 80-329/329
Sequence Identity: 28% (73 aa)

DLLGPSVYQLLLDKKLEGMPLKTIQNIMKSVLITLDDISSIGVIHMDIRPENIL--QSANDPNKFIVVDYHCAGLEGRTNPV---YVQSRFYRAPEVLLR
..|    |. . . |   .||| |  |.. ||  |  . ..|.|| |..||||.       | .  |.|.  |    ..  |   |.|||.|||||..| 
EMLEQNLYDFQKQNKFMPLPLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKV--VCNTYLQSRYYRAPEIILG

LEYGCKIDIWSLGVAAFEMMVGVPLFPGNTEVQMLYIINSMVGPFPQHMIEKSSRRLSFFLHDGTMKSA--------ERLAEENMENIEDWKNCLIYKTI
| .  ..|.||||    | . | ||.||. |      |    .   .|.... ..   || .|  .|          | ...  .   |  |  ..    
LPFCENHDMWSLGCVIAELFLGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQSKFRPWRLKHIEEHEQQTSVKSKEARKYIFNCLDD

AENILTYRYPDLNELPPEVREQRLMFIDLLMKCVTIDPEKRISAAEALRHPFI
  .  .   |.  ..  |.   |  |...| | .|.|..|||. .|||.|||.
MPEVNMLVDPERQDYRVEKIDRR-EFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase 86498.m00623.AA DyrkP 25-241 31 6.3e-30 95.21 In-house 108-323 (323) Show / Hide 
Range on Protein: 25-241
Range on HMM: 108-323/323
Sequence Identity: 31% (68 aa)

IQNIMKSVLITLDDISSIGVIHMDIRPENILQSANDPNKFIVVDYHCAGLEGRTNPVYVQSRFYRAPEVLLRLEYGCKIDIWSLGVAAFEMMVGVPLFPG
.| | . .||.|| | |. .|| |..|||||  .    .  ..|.  .         ||||| ||||||..   |  .||.||||    |.  |  ||  
LQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLFQN

NTEVQMLYIINSMVGPFPQHMIEKSSRRLSFFLHDGTMKSAERLAEENMENIEDWKNCLIYKTIAENILTYRYPDLNELPPEVREQRLMFIDLLMKCVTI
 .   .|  .  ..||||  |..       || ..  .        ..  ||.| .     .  .  |     |    |   .| . .||||   .|. |
DNIQGLLARVIGIIGPFPEWMMQEGRLVQNFFTRKRLLYMDVFEEADQSQNINDQQDMQRQRQKTGKIQIL-VPKHSNLRARLRTDDHMFIDFVRQCLQI

DPEKRISAAEALRHPFI
|  .| .| |||.||..
DFTRRPTAKEALQHPWF
Kinase 86498.m00623.AA DYRK2 2-156 32 2.4e-28 89.01 In-house 81-241 (318) Show / Hide 
Range on Protein: 2-156
Range on HMM: 81-241/318
Sequence Identity: 32% (52 aa)

DLLGPSVYQLLLDKKLEGMPLKTIQNIMKSVLITLDDISSIGVIHMDIRPENILQSANDPNKFIVVDYHCAGLEGR-TNPVYVQSRFYRAPEVLLRLEYG
.||. ..| ..  ..  |  |. .    .|.|  |.  .   .|| |  |||||     ..   |.|      | .    .|.|||||||||| |.. ||
ELLSMNLYEYIKKNHFQGFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYG

CKIDIWSLGVAAFEMMVGVPLFPGNTEVQMLYIINSMVGPFPQHMIEKS-----SRRLSFF
  ||.||.|  . |.  |.|||||  |.  .. .    |  |.......     .||  ||
MAIDMWSFGCIMAELYTGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFF
Kinase 86498.m00623.AA Pkinase 1-241 19 3.3e-24 86.69 Pfam 79-293 (293) Show / Hide 
Range on Protein: 1-241
Range on HMM: 79-293/293
Sequence Identity: 19% (51 aa)

MDLLGP-----SVYQLLL---DKKLEGMPLKTIQNIMKSVLITLDDISSIGVIHMDIRPENILQSANDPNK---FIVVDYHCA----GLEGRTNPVYVQS
|....      . . ..    ....  .. ......|. .|  |. . | |.|| |. ||||| . |...    . . |  .|       .. . ... .
MEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGT

RFYRAPEVLL-RLEYGCKIDIWSLGVAAFEMMVGVPLFPGN----TEVQMLYIINSMVG-PFPQHMIEKSSRRLSFFLHDGTMKSAERLAEENMENIEDW
..|.||||.. . .|| |.|.||.|.  .||. | |.|||     . . ....|.   | |.. .  ...|....| . . . .                
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----------------

KNCLIYKTIAENILTYRYPDLNELPPEVREQRLMFIDLLMKCVTIDPEKRISAAEALRHPFI
                       . .   ..   ..|.. .| . ||.||..|...| ||..
---------------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 86498.m00623.AA YAK 3-148 30 4.5e-22 71.45 In-house 86-231 (347) Show / Hide 
Range on Protein: 3-148
Range on HMM: 86-231/347
Sequence Identity: 30% (45 aa)

LLGPSVYQLLLDKKLEGMPLKTIQNIMKSVLITLDDISSIGVIHMDIRPENILQSANDPNKFIVVDYHCAGLEGRTNPVYVQSRFYRAPEVLLRLEYGCK
.|  . | .|   |  |.    |.   |..|  .    .  .|| |  ||||.  . .     ..|.  .  | ..   |.|.|.||.||...   |   
MLSNNLYEYLKQNKFCGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTS

IDIWSLGVAAFEMMVGVPLFPGNTEVQMLYIINSMVGPFPQHMIEK
|| ||||    |   |.|.|||| |   .  |  | | .|  ||..
IDMWSLGCIVAELFLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQ
Kinase 86498.m00623.AA PRP4 82-156 38 2.4e-17 60.09 In-house 165-239 (320) Show / Hide 
Range on Protein: 82-156
Range on HMM: 165-239/320
Sequence Identity: 38% (29 aa)

YVQSRFYRAPEVLLRLEYGCKIDIWSLGVAAFEMMVGVPLFPGNTEVQMLYIINSMVGPFPQHMIEKSSRRLSFF
| .||||||||...  .|   ||.|| |.  .|.  |  .||| |  .||  .  . | .|. || |.  .  .|
YLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQFKDNHF
Kinase 86498.m00623.AA CDKL 82-147 41 9e-17 53.87 In-house 159-225 (286) Show / Hide 
Range on Protein: 82-147
Range on HMM: 159-225/286
Sequence Identity: 41% (28 aa)

YVQSRFYRAPEVLLR-LEYGCKIDIWSLGVAAFEMMVGVPLFPGNTEVQMLYIINSMVGPFPQHMIE
||  | ||||| |.   .||  .|||..|    ||. | ||.||  ..  || |  ..||. .. .|
YVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLWPGQSDIDQLYHIQKCLGPLIPRHQE
Kinase 86498.m00623.AA RCK 82-128 47 5.8e-16 46.87 In-house 173-220 (298) Show / Hide 
Range on Protein: 82-128
Range on HMM: 173-220/298
Sequence Identity: 47% (23 aa)

YVQSRFYRAPEVLLRL-EYGCKIDIWSLGVAAFEMMVGVPLFPGNTEV
|| .| |||||.|||   |  ..|||..|  ..| ..  |||||. |.
YVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEI
Kinase 86498.m00623.AA RCK 215-241 48 3.3e-15 44.42 In-house 272-298 (298) Show / Hide 
Range on Protein: 215-241
Range on HMM: 272-298/298
Sequence Identity: 48% (13 aa)

IDLLMKCVTIDPEKRISAAEALRHPFI
|.|..|....||.|||.|..||.||..
IELMEKMLQWDPQKRITAQQALQHPYF
Kinase 86498.m00623.AA S_TKc 1-241 17 1.4e-13 22.07 SMART 19-231 (231) Show / Hide 
Range on Protein: 1-241
Range on HMM: 19-231/231
Sequence Identity: 17% (52 aa)

MDLL------------------------------------------------G--PSVYQLLLDKKLEG----MPLKTIQNIMKSVLITLDDISSIGVIH
 .                                                  |   ...... ... .|    .|  ... .|. ..  |. . | |.||
RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIH

MDIRPENILQSANDPNKFIVVDYHCAGLEGRTNPVYVQSRFYRAPEVLLRLEYGC-KIDIWSLGVAAFEMMVGVPLFPGNTEVQMLYIINSMVGPFPQHM
 |. ||||| .        . |   | .       .. ...|.|||||    ||. |.|.||.|.  .||..| |.||  .. .|. .|           
RDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------

IEKSSRRLSFFLHDGTMKSAERLAEENMENIEDWKNCLIYKTIAENILTYRYPDLNELPPEVREQRLMFIDLLMKCVTIDPEKRISAAEALR-------H
                                                                    ..|...|| . |||||..| |||.       |
-----------------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

PFI
|..
PWF
Kinase 86498.m00623.AA PRP4 203-241 48 7.2e-11 36.09 In-house 282-320 (320) Show / Hide 
Range on Protein: 203-241
Range on HMM: 282-320/320
Sequence Identity: 48% (19 aa)

LPPEVREQRLMFIDLLMKCVTIDPEKRISAAEALRHPFI
.| . ... . | ||| ||   ||.|||.  |||.||||
IPEDQMKKVHQFKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase 86498.m00623.AA DYRK2 214-241 42 1.1e-10 30.6 In-house 291-318 (318) Show / Hide 
Range on Protein: 214-241
Range on HMM: 291-318/318
Sequence Identity: 42% (12 aa)

FIDLLMKCVTIDPEKRISAAEALRHPFI
||| ...| . ||..|.....||.||.|
FIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase 86498.m00623.AA CDKL 215-241 29 6.9e-08 23.06 In-house 260-286 (286) Show / Hide 
Range on Protein: 215-241
Range on HMM: 260-286/286
Sequence Identity: 29% (8 aa)

IDLLMKCVTIDPEKRISAAEALRHPFI
.|.. ||  .|| .|........||. 
LDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 86498.m00623.AA YAK 210-241 34 1.6e-07 21.25 In-house 316-347 (347) Show / Hide 
Range on Protein: 210-241
Range on HMM: 316-347/347
Sequence Identity: 34% (11 aa)

QRLMFIDLLMKCVTIDPEKRISAAEALRHPFI
.| .|||..      .| .| ..  |  ||||
HRDCFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase 86498.m00623.AA CMGC 1-55 17 2e-06 15.87 In-house 134-216 (513) Show / Hide 
Range on Protein: 1-55
Range on HMM: 134-216/513
Sequence Identity: 17% (15 aa)

MDLLGPSVYQLLLDKK-------LEGMPLKT------------IQNIM------KSVLITLD--DISSIG--VIHMDIRPENIL
..... . ||.. ...         ...               |...|      . .|  |.   . | .  .|| |. |||||
FEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENIL
Kinase 86498.m00623.AA CDKL 12-60 28 0.000986 8.64 In-house 87-136 (286) Show / Hide 
Range on Protein: 12-60
Range on HMM: 87-136/286
Sequence Identity: 28% (14 aa)

LLDKKLEGMPLKTIQNIMKSVLITLDDISSIGVIHMDIRPENILQS-AND
.|... .| . . ....|  .|  ..   .  .|| || ||||| . .|.
ELEEYPNGVDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNG