Gene 85805.m00060 (T.vaginalis)
85805.m00060
Species: T.vaginalis
Alias: 85805.m00060, TvagK0183
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 85805.m00060.AA | Protein | None | 169 | None | Fasta, JSON |
| 85805.m00060.kin_dom | Protein Kinase Domain | None | 168 | None | Fasta, JSON |
Protein domains of 85805.m00060.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 85805.m00060.AA | CAMK | 1-164 | 18 | 8e-35 | 109.11 | In-house | 136-414 (425) | Show / Hide |
Range on Protein: 1-164
Range on HMM: 136-414/425
Sequence Identity: 18% (52 aa)
M---EYCPFD------LERIVLSNRN--------------MQPAEIKKYCREAVLCIKACHDMNIAHCDIKPANFMTDEY-----------------GRL
| |||. ...|| .. .. .| ..| | . .. ||..||.|.|.|| | . |. . .
MEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNI
KIGDFGLATIFKDSH------------------------VRNIYSGTKIMMA-PEIYEQ-------------NGYDAMAADIWALGCTLYFIATGRYPFF
|| |||.|..|.... . . || || ||. .. . |. ..|.|..|. ||. .|..||
KIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFY
VV-------------DPRELVQLISLAKYD-GSLIKDK-----------------------LLRDVIARCLRIEPKDRL
...|| . | .||| . .. .| | ..|. .|..|.
GDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRM
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| Pkinase | 85805.m00060.AA | Pkinase | 1-165 | 25 | 1.5e-33 | 119.66 | Pfam | 79-283 (293) | Show / Hide |
Range on Protein: 1-165 Range on HMM: 79-283/293 Sequence Identity: 25% (53 aa) MEYCPF-----DLERIVL--SNRNM--QPAEIKKYCREAVLCIKACHDMNIAHCDIKPANFMTDEYGRL----KIGDFGLATI--FKDSHVRNIYSGTKI ||||. || ... ..... .. |.|.|... . .. ||.|.| |.|.||.|.. |. | . ||.||||| .. . . || MEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW MMAPEIYE-QNGYDAMAADIWALGCTLYFIATGRYPFFVV------DPRELVQLISLAKYDGSLIKD---------------------KLLRDVIARCLR ||||. ...|. ..|.|..||.|| ..|| || |.......| .... . .. . ..|.| .||. YMAPEVIRGGQYYGP-KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC IEPKDRLG ||.|.. KDPKKRPT |
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| Kinase | 85805.m00060.AA | CAMKL | 1-121 | 32 | 7.3e-29 | 89.12 | In-house | 100-236 (297) | Show / Hide |
Range on Protein: 1-121 Range on HMM: 100-236/297 Sequence Identity: 32% (45 aa) MEYCP---FDLERIVLSNRN----MQPAEIKKYCREAVLCIKACHDMNIAHCDIKPANFMTDEYG--RLKIGDFGLATIFKD-----SHVRNIYSGTKIM ||||. || . .... |.. | ..| | | .. ||...|.| |||| | . || | .|| |||....... . .. |. MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY MAPEIYEQ--NGYDAMAADIWALGCTLYFIATGRYPF |||||.. ||. ..|||..| .||.. .|..|| MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPF |
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| Kinase | 85805.m00060.AA | MARK | 37-163 | 40 | 1.2e-27 | 87.54 | In-house | 120-250 (262) | Show / Hide |
Range on Protein: 37-163 Range on HMM: 120-250/262 Sequence Identity: 40% (53 aa) CHDMNIAHCDIKPANFMTDEYG--RLKIGDFGLATIFKDSHVRNIYSGTKIMMAPEIYEQNGYDAMAADIWALGCTLYFIATGRYPFF--VVDPRELVQL ||..||.|.|||| | . || | || |||...... |. ||. ||||| .. ||. ..|||.|| |||. .|..|| .| || . CHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKK ISLAKYDGSLIKDKLLRDVIARCLRIEPKDR | ||| | .|. | | | . |..| ILRGKYDIPCHVSKECRNLIQRLLTVNPEER |
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| Kinase | 85805.m00060.AA | ULK | 1-163 | 24 | 4.7e-26 | 88.0 | In-house | 99-317 (329) | Show / Hide |
Range on Protein: 1-163 Range on HMM: 99-317/329 Sequence Identity: 24% (54 aa) MEYCPF-DLERIVLSNRN----------MQPAEIKKYCREAVLCIKACHDMNIAHCDIKPANFMTDEY------------GRLKIGDFGLATIFKDS--- ||||. ||| . |.. |...... . |. |..|| |.||||.| . .. |.|||.|||.| . .. MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME -HVRNIYS------GTKIMMAPEIYEQNG----YDAMAADIWALGCTLYFIATGRYPFFVVDPRELV-----QLISL------------AKYD---GSLI . .. || . |||.| ...| |. .||| ||| .| . .|..||. ..... .|| . ... . . QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQ KDKLLRDVIARCLRIEPKDR . ..| | |.| ...||| ISPECKDLIRRMLQYDEKDR |
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| Kinase | 85805.m00060.AA | STE | 1-163 | 23 | 2e-25 | 86.84 | In-house | 116-345 (359) | Show / Hide |
Range on Protein: 1-163
Range on HMM: 116-345/359
Sequence Identity: 23% (55 aa)
MEYCPF-DLERIVLSNRNMQP--------------AEIKKYCREAVLC-IKACHDMNIAHCDIKPANFMTDEYGRLKIGDFGLATIFKDSH---------
|||.. |. |. .. .. .|...||. . . |...| | |||||| . |. |||..... ||.
MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNII
--------VRNIYSGTKIMMAPEIYEQ------NGYDAMAADIWALGCTLYFIATGRYPFFVVDPRELVQLISLAK-------------YDGSLIKD---
|| || ||||. .| .|||. .||| ||||. |||..|.. | . .| . . ..|
DCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDT-KCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLS
-------------------KLLRDVIARCLRIEPKDR
. ..| |..||...|..|
QNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKR
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| Kinase | 85805.m00060.AA | Ciliate-E2-Unclassified | 1-165 | 20 | 3e-25 | 84.57 | In-house | 100-342 (352) | Show / Hide |
Range on Protein: 1-165
Range on HMM: 100-342/352
Sequence Identity: 20% (51 aa)
MEYCP-FDLERIVLS------------NRNMQ-----PAEIK-----KYCREAVLCIKACHDMN-IAHCDIKPANFMTDEYG---RLKIGDFGLATIFK-
||||. ||. . . ....| ..| .|... ..... .| | | | |||| | . |. | ..|| |||.. .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ
----DSHV---------RNIY---SGTKIMM----APEIYEQNGYDAM---AADIWALGCTLYFIATGRYPFFVVDPRE---------------LVQLIS
| . .... .|| . | |||......|| . ..|||.||. ||.. .|.|||. . . .. .
NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI
LAK-------------YDGSLIKDKLLRDVIARCLRIEPKDRLG
..| .. | ...| . ..| |. |..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRIT
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| Kinase | 85805.m00060.AA | Ciliate-E2 | 26-165 | 22 | 5.1e-25 | 82.82 | In-house | 165-354 (365) | Show / Hide |
Range on Protein: 26-165 Range on HMM: 165-354/365 Sequence Identity: 22% (46 aa) YCREAVLCIKACHDMN-IAHCDIKPANFMTDEYGRLKIGDFGLATIFKDSHVRNIY--------------------------------SGTKIMMAPEIY |... .|... .| | | | |||| | . .|| ||||.....|.. .... || |||||. YIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEIL EQNGYDA--------MAADIWALGCTLYFIATGRYPFFVVDPRELVQLISLAKYDGSLIK------------------DKLLRDVIAR----CLRIEPKD . .|| ..|||.||..||. .|..|| | | |.| . . .. | | . .| .|. NGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEK RLG |.. RIT |
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| Kinase | 85805.m00060.AA | CAMKK | 24-122 | 28 | 6.7e-25 | 75.59 | In-house | 179-327 (396) | Show / Hide |
Range on Protein: 24-122 Range on HMM: 179-327/396 Sequence Identity: 28% (43 aa) KKYCREAVLCIKACH-DMN-------------------IAHCDIKPANFMTDEYG---RLKIGDFGLATIFKDSHVRNIY------------SGTKIMMA .|| |. .. .. .| . . | | |||| | || | ..|| ||| ..||.... ... ||. || WKYFRDCIKGLEYLHNYQKACSYIIIYINEFIIDHFQDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMA PEIYEQ-NG--------------YDAMAADIWALGCTLYFIATGRYPFF || . |. |. ||||||||.||| . .|. ||. PELCSKENQKENYNGYKYRFRFIYCGKAADIWALGVTLYCFVFGKCPFW |
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| Kinase | 85805.m00060.AA | ULK | 1-163 | 25 | 1.1e-23 | 80.94 | In-house | 96-312 (324) | Show / Hide |
Range on Protein: 1-163 Range on HMM: 96-312/324 Sequence Identity: 25% (56 aa) MEYCPF-DLERIVLSNRN---------MQPAEIKKYCREAVLCIKACHDMNIAHCDIKPANFMTDEY------------GRLKIGDFGLATIFKDS---- ||||. ||| . |.. |...... . |. |..|| |.||||.| . . |.|||.|||.| .. . MEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQ HVRNIYS------GTKIMMAPEIYEQNG----YDAMAADIWALGCTLYFIATGRYPFFVVDPRELV----QLISL------AKYDGSLIKD--------- .. . || . |||.| ...| |. .||| ||| .| . .|.|||| ..... .|| .. . .. QMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKIS KLLRDVIARCLRIEPKDR . ..| | |.| ...||| PECKDLIRRMLQYDEKDR |
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| Kinase | 85805.m00060.AA | CAMKK-Unclassified | 24-129 | 24 | 4.6e-23 | 71.7 | In-house | 181-341 (392) | Show / Hide |
Range on Protein: 24-129 Range on HMM: 181-341/392 Sequence Identity: 24% (40 aa) KKYCREAVLCIKACHDMN---------------------IAHCDIKPANFMTDEYGR-----LKIGDFGLATIFKDSHVR--NIYSGTKIMMAPEIYEQN ||| |. . .. .|. | | | |||| | |. .. .|| |||...|..... . . ||. |||| . . KKYFRQCCKGLQYMHNFNQACSYIIIYINEFDKIDHFQDIIHRDIKPQNILIDHEDNDKGEHFKIADFGISVIMEHEQQKKLKNNAGTYCFMAPEFWSKE --GYDAMA-------------------------ADIWALGCTLYFIATGRYPFFVVDPREL .|| . ||||.|| |.| ..... ||. .. || NFKYDYNDYSFLPGTFNPLRKTYRIERICFYKKADIWSLGVTFYCMVYHSLPFWHKNLQEL |
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| Kinase | 85805.m00060.AA | S_TKc | 1-169 | 18 | 3e-14 | 32.07 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1-169
Range on HMM: 1-231/231
Sequence Identity: 18% (47 aa)
M-----------------------------------------------------------------EYCPF---DLERIVLSNRN------MQPAEIKKY
|||. || .. ... . . ....|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY
CREAVLCIKACHDMNIAHCDIKPANFMTDEYGRLKIGDFGLATIFKDSHVRNIYSGTKIMMAPEIYEQNGYDAMAADIWALGCTLYFIATGRYPFFVVDP
... .. .. ||...| |.|.||.| . || ..||.|||||... . . || ||||. ||. ..|.|..||.|| ..|. || ..
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QM
RELVQLISLAKYDGSLIKDKLLRDVIARCLRIEPKDRLG------------DAIL
.. ..| .. ..| | .||. .|..|.. . .
QMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
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