89650.m00238

Species: T.vaginalis
Alias: TvagK0547, 89650.m00238
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Tvag2

Sequence

Name Sequence Type Origin Length Description Download
89650.m00238.AA Protein None 231 None Fasta, JSON
89650.m00238.kin_dom Protein Kinase Domain None 172 None Fasta, JSON

Protein domain

Protein domains of 89650.m00238.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase 89650.m00238.AA Pkinase 1-172 30 5.9e-53 187.03 Pfam 79-293 (293) Show / Hide
Range on Protein: 1-172
Range on HMM: 79-293/293
Sequence Identity: 30% (67 aa)

MEYLPNS----DLQTILE--RGVQF--TIYEQVRIFKEIVLGLNYLHKRGISHRDIKPENILFDENYHP----KIIDFGFS----RENCSKLNTYCGTPF
|||...     || ....  |.  |  .  |  .....|. ||.|.|..|| |||.||||||.|.|.|.    ||.|||..      | | ..|.||||.
MEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW

FVAPEVITSDQYDGTKADLWSLAVTMHIMNTGKFPWRYR------SDVQLIKDMQFGRLEIHNEAK---------------------GLIGLIIGKLLTF
..||||| ..||.|.|.| ||. .....| .|..|.. .      .. |.|.    ..|. . . .                          .| ..|..
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

DPADRPTTDDILNM--F
||..||| ..||.   |
DPKKRPTAEQILQHPWF

Kinase 89650.m00238.AA CAMK 1-170 23 1.2e-52 167.59 In-house 136-421 (425) Show / Hide
Range on Protein: 1-170
Range on HMM: 136-421/425
Sequence Identity: 23% (67 aa)

M---EYLPNS----D-LQTILERG--------------VQFTIYEQVRIFKEIVLGLNYLHKRGISHRDIKPENILFDEN-----------------YHP
|   || ..     | .. | |.|                ||  |  |.|. |. ...|.|...| |||.||||||.|.|                 .  
MEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNI

KIIDFGFSRENCS--------------------------KLNTYCGTPFFVA-PEVITS-------------DQYDGTKADLWSLAVTMHIMNTGKFPWR
|||||||...  .                          |..|.|||| ..| |||. .              .|.| |.| ||. | . || .|..|..
KIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFY

YR-------------SDVQLIKDMQFGRLE-IHNEAKG-----------------------LIGLIIGKLLTFDPADRPTTDDILN
               .| .| .  . |. . .. . ..                            | |.|. || .|.| ...||
GDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLN

Kinase 89650.m00238.AA CAMKL 1-170 34 4.9e-51 161.03 In-house 100-293 (297) Show / Hide
Range on Protein: 1-170
Range on HMM: 100-293/297
Sequence Identity: 34% (67 aa)

MEYLPNSD--LQTIL--ERGVQ--FTIYEQVRIFKEIVLGLNYLHKRGISHRDIKPENILFDENY--HPKIIDFGFSRE---N----CSKLNTYCGTPFF
||| .. .  |.  .  ....   ..  |  |.|. || ..||.|..|| ||||||||||.|||     |||||||| .   .      ||.| ||.| .
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

VAPEVITS--DQYDGTKADLWSLAVTMHIMNTGKFPWRYRSD--------VQLIKDMQFGRLE-IHNEAKGLIGLIIGKLLTFDPADRPTTDDILN
 |||.. .  ..||| |.| ||. |..  | .|..|..  ..          . |.|.    . |...       .| |.|. .| .||| ..|.|
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN

Kinase 89650.m00238.AA MARK 26-170 44 4.6e-49 158.62 In-house 108-258 (262) Show / Hide
Range on Protein: 26-170
Range on HMM: 108-258/262
Sequence Identity: 44% (67 aa)

RIFKEIVLGLNYLHKRGISHRDIKPENILFDENY--HPKIIDFGFSREN--CSKLNTYCGTPFFVAPEVITSDQYDGTKADLWSLAVTMHIMNTGKFPWR
|||. || ..||.|...| |||||||||| |||     ||||||||..    .|||| |||| . |||.. .  |||.|.| ||| | . .| .|.||..
RIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFD

YRS--DVQLIKDMQFGRLEIHNEAKGLIGLIIGKLLTFDPADRPTTDDILN
  .  ...| | .. |. .|       .  .| .|||..| .||| ..|..
GDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMK

Kinase 89650.m00238.AA Ciliate-E2 1-170 27 1.2e-43 147.67 In-house 113-361 (365) Show / Hide
Range on Protein: 1-170
Range on HMM: 113-361/365
Sequence Identity: 27% (72 aa)

MEYLPNSDLQTILE------------RGVQFTIYEQVRIFKEIVL---------------GLNYLHKRG-ISHRDIKPENILFDENYHPKIIDFGFSR--
|||.   ||. ...               .||..|  .|.|.|.                .|.|||... | |||||||||||     .||||||.|.  
MEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKY

--ENCSKL------------------------------NTYCGTPFFVAPEVITSDQYDG--------TKADLWSLAVTMHIMNTGKFPWRYRSDVQLIK
  .|. ..                              ||.|||| ..|||.. . .||.        .|.|.||| |....| .||.|.      | ||
DDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----QQQIK

--DMQFG-----------------RLEIHNEAKGLIGLIIGK--LLTFDPADRPT-TDDILN
  . .|                   ... .|.| ||        .|  ||  |.|  ..|||
QCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKK-F-GKRMLQKDPEKRITGWEQILN

Kinase 89650.m00238.AA Ciliate-E2-Unclassified 1-170 27 1.4e-41 142.04 In-house 100-348 (352) Show / Hide
Range on Protein: 1-170
Range on HMM: 100-348/352
Sequence Identity: 27% (68 aa)

MEYLPNSDLQTILER-----------------GVQFTIYEQV-----RIFKEIVLGLNYLHKRG-ISHRDIKPENILFDENY---HPKIIDFGFSRENCS
|||... ||. ...                  . .|| .. .     ..|..|..||.|||. . | ||||||||||||.|    ..||||||.|... .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

K------------------LNTYCGTPFFV----APEVITSDQYDG---TKADLWSLAVTMHIMNTGKFPWRYRSDVQ---------------LIKDMQF
                   ..| |||| .     ||||. . .||.    |.| ||| | .. | .|..|  .... |                ... ..
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

GR-------------LEIHNEAKGLIGLIIGKLLTFDPADRPTTDDILN
 .               ...||| .|  .. |.|  .|  |.| ..|||
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN

Kinase 89650.m00238.AA ULK 25-174 26 7e-39 133.39 In-house 133-329 (329) Show / Hide
Range on Protein: 25-174
Range on HMM: 133-329/329
Sequence Identity: 26% (53 aa)

VRIFKEIVLGLNYLHKRGISHRDIKPENILFDEN------------YHPKIIDFGFSRE-NCS-----KLNTYC------GTPFFVAPEVITSD----QY
. .|| |. |. .|||..| ||||||.||| ...            .. || ||||..  ...      . |.       ||| . ||... .     .|
IQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPY

DGTKADLWSLAVTMHIMNTGKFP---WRYRSDV-----QLIKD-------MQFGRLE---------IHNEAKGLIGLIIGKLLTFDPADRPTTDDILNMF
.  |.|.||| . .. | .|| |   | .....     .||..       ..   |.         | .| | |    | ..|..|. || . ....|..
YDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDL----IRRMLQYDEKDRISWEELFNHP

AE
  
WF

Kinase 89650.m00238.AA ULK 1-174 23 2.1e-37 130.3 In-house 96-324 (324) Show / Hide
Range on Protein: 1-174
Range on HMM: 96-324/324
Sequence Identity: 23% (54 aa)

MEYLPNSDLQTILERGVQFTIYE----------QVRIFKEIVLGLNYLHKRGISHRDIKPENILFDEN------------YHPKIIDFGFSRE-NC----
||| .  ||......   ..  .           . .|| |. |. .|||..| ||||||.|||  ..            .. || ||||..  ..    
MEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNME

-SKLNTYC------GTPFFVAPEVITSD----QYDGTKADLWSLAVTMHIMNTGKFP---WRYRSDV----QLIKD-------MQFGRLEIHN--EAKGL
  .. |..      ||| . ||... .     .|.  |.|.||| . .. | .|| |   | .....    .||.        ..   ... .  ... .
QQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKI

---IGLIIGKLLTFDPADRPTTDDILNMFAE
   .  .| ..|..|. || . ..|.|..  
SPECKDLIRRMLQYDEKDRISWEEIFNHPWF

Kinase 89650.m00238.AA RSK 27-170 33 6.5e-36 125.63 In-house 109-274 (278) Show / Hide
Range on Protein: 27-170
Range on HMM: 109-274/278
Sequence Identity: 33% (57 aa)

IFKEIVLGLNYLHKRGISHRDIKPENILFDE---NYHPKIIDFGFSRE-NCS---KLNTYCGTPFFVAPEVIT---SDQ-YDGTKADLWSLAVTMHIMNT
.. |||| . .||..|| |||.||||||.|.   . | |..||||... .|.   ...|.|.|  ..|||...    .  .|   .|.||| | |. | |
YMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHD-KACDWWSLGVLMYEMLT

GKFPWRY---RSDVQLIKDMQFGR--LEIH------NEAKGLIGLIIGKLLTFDPADRPT-----TDDILN
|. | .     .  ...| .| |.  |..       .||| |    | |.|. ||..|..     ...|..
GCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDL----IRKMLHRDPHKRLGCGPQDAEEIKQ

Kinase 89650.m00238.AA QIK 26-171 35 2.3e-35 123.78 In-house 122-272 (272) Show / Hide
Range on Protein: 26-171
Range on HMM: 122-272/272
Sequence Identity: 35% (54 aa)

RIFKEIVLGLNYLHKRGISHRDIKPENILFDENYHPKIIDFGFS--RENCSKLNTYCGTPFFVAPEVITSDQYDGTKADLWSLAVTMHIMNTGKFPWRYR
|.|..|...  |.|||.| |||.| ||||.|.|   ||.|||||   ..   |.|.||.| . |||.    .||| |.| ||. | . .. .|..|    
RWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGK

SDVQLIKDMQFGRLEIHNEAKGLIGLIIGKLLTFDPADRPTTDDILN---M
.. .| . .  |.  |          .| . |. ||. | |.. |..   |
TLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM

Kinase 89650.m00238.AA MSK 27-174 31 4.7e-33 109.08 In-house 106-277 (277) Show / Hide
Range on Protein: 27-174
Range on HMM: 106-277/277
Sequence Identity: 31% (54 aa)

IFKEIVLGLNYLHKRGISHRDIKPENILFDEN---YHPKIIDFGFSRENCSK----LNTYCGTPFFVAPEVIT----SDQ-YDGTKADLWSLAVTMHIMN
|. |.|. . ..|..|| |||.||||||||..    | |.|||||.|.. .     ....|.|  . |||...    .|  ||    |.||| |..  | 
IMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYD-EACDWWSLGVILYTML

TGKFPWR-YRSDVQ--------LIKDMQFGRLEIH----NEAKGLIGLIIGKLLTFDPADRPTTDDILNMFAE
||. | .   .|.|        . | .. |.  .     ...       |..||| ||..|....|..     
TGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK

Kinase 89650.m00238.AA S_TKc 1-178 22 1.6e-22 82.09 SMART 1-231 (231) Show / Hide
Range on Protein: 1-178
Range on HMM: 1-231/231
Sequence Identity: 22% (57 aa)

M-----------------------------------------------------------------EYLPN--SDLQTILERGVQ------FTIYEQVRI
                                                                  ||...   || .....         |.  .  ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

FKEIVLGLNYLHKRGISHRDIKPENILFDENYHPKIIDFGFSRENCSKLNTYCGTPFFVAPEVITSDQYDGTKADLWSLAVTMHIMNTGKFPWRYRSDVQ
...|...|.|.|..|| |||.||||||.||  | ||.|||..|.     .|.||||...||||.   .|.. |.| ||. ... .| .|. |..   . .
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQM

LIKDMQFGRLEIHNEAKGLIGLIIGKLLTFDPADRPTTDDILN---MFAEHEQI
..| .           . ..  .| |.|..||..|||  ..|.     . |. .
MFKKIG---------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 89650.m00238.AA TyrKc 1-172 19 2e-06 -118.36 SMART 1-280 (280) Show / Hide
Range on Protein: 1-172
Range on HMM: 1-280/280
Sequence Identity: 19% (54 aa)

M-----------------------------------------------------------------------------EYLPNSDLQTIL-ERGVQFTIY
                                                                              || |. ||.  | ... ...  
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

EQVRIFKEIVLGLNYLHKRGISHRDIKPENILFDENYHPKIIDFGFSRENCSK------LNTYC-----GTP-----FFVAPEVITSDQYDGTKADLWSL
. . .   |  | .|||.... |||.   |.| .||.. || ||| ||.  ..        .|      |.         |||.|    .  || | || 
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-TKSDVWSF

AVTMH-IMNTGKFPWRY-----RSDVQLIKDMQFG-RLEIHNE--------AKGLIGLIIGKLLTFDPADRPTTDDILNMF
 |.|  |.  |. |.        |. ..|.. . | |...  .        .   .  |. .   .||.||||  .|   |
GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF