Gene 93986.m00181 (T.vaginalis)

93986.m00181

Species: T.vaginalis
Alias: 93986.m00181, TvagK0332
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
93986.m00181.AA Protein None 781 None Fasta, JSON
93986.m00181.kin_dom Protein Kinase Domain None 203 None Fasta, JSON

Protein domain

Protein domains of 93986.m00181.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 93986.m00181.AA TKL 1-202 23 1.8e-49 170.65 In-house 79-364 (364) Show / Hide 
Range on Protein: 1-202
Range on HMM: 79-364/364
Sequence Identity: 23% (69 aa)

MGRTKNRFIIPFVGYTVEKP--------------FCIITEYMPNGALNNYLRKEWRAKPIFSGTHLTM-IAMGLICAIRYCHVQR--------IIHRDIK
| |..   |..|.||  . |              .||..||.|.| | .||             |... .|..  ... | | ..        |||||.|
MSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLK

AANLLLDHHFL--------------PKLCDFGISRFIATR---------------------AMTDGIGTASHMAPEIFVST----------------KYN
 .|.|.| ..               .|.||||.|||. ..                     .    .||  .||||..  .                .|.
SKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYS

IKVDVFAYGATLFEMLEKKNPYVGHPVEEVI---------SNFR-KGKRPIFR-----------NKEIPDGLKDLLNRCWSQSPKNRPTPAEIYLEF
 |.||...|  |.|.|  . || ..| ...|         .    ||.||              .. .|...|.|. .||.. |..||.  ||  ..
EKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 93986.m00181.AA Pkinase 22-202 25 1.2e-42 151.87 Pfam 76-293 (293) Show / Hide 
Range on Protein: 22-202
Range on HMM: 76-293/293
Sequence Identity: 25% (57 aa)

CIITEYMPNG----ALNNYLRKEWRAKPI-FSGTHLTMIAMGLICAIRYCHVQRIIHRDIKAANLLLDHHFLP----KLCDFGISR---FIATRAMTDGI
....||...|     |  |..  || ... ||  .. ...  ..... ||| ..|||||.| .|.|.|..  .    |.||||...       . ||.  
YMVMEYCEGGLYVMDLFDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFC

GTASHMAPEIFV-STKYNIKVDVFAYGATLFEMLEKKNPYVGH----PVEEVISNFRKGKRPIFRNKEI----------------------PDGLKDLLN
||   ||||.   ...|  |||....| .|.||| .. |. ||    .  . .  ... ..|...  .                       .. .||...
GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK

RCWSQSPKNRPTPAEIYLE--F
.|. . || |||...|     |
WCLCKDPKKRPTAEQILQHPWF
Kinase 93986.m00181.AA MLK 9-202 30 1.9e-42 145.11 In-house 71-291 (291) Show / Hide 
Range on Protein: 9-202
Range on HMM: 71-291/291
Sequence Identity: 30% (69 aa)

IIPFVGYTVEK-P-FCIITEYMPNGALNNYL---RKEWRAKP-------IFSGTHLTMIAMGLICAIRYCHV-QR--IIHRDIKAANLLLDH------HF
||.|.|   .  . |||..||...| |.|.|   |..| .         . .  |.  .|.    .. | |  ..  |||||.|  |.|.|.      | 
IIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHG

LPKLCDFGISRFIATR-A-MTDGIGTASHMAPEIF---VSTKYNIKVDVFAYGATLFEMLEKKNPYV-GHP-VEEVISNFRKGKR-PIFRNKEIPDGLKD
  | ||||.||.. .. . |.. .||.  ||||..    ..||..|.||. .|  | ||| .. ||  ..   .  . .  .|.| ||  .  .|...| 
TLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPST--CPEHWKK

LLNRCWSQSPKNRPTPAEIYLEF
|...||.| |..||. ..|  ..
LMKQCWNQDPHKRPSFRQIVQHL
Kinase 93986.m00181.AA Dicty5 23-206 36 5.1e-38 128.45 In-house 76-260 (260) Show / Hide 
Range on Protein: 23-206
Range on HMM: 76-260/260
Sequence Identity: 36% (69 aa)

IITEYMPNGALNNYLRKEWR--AKPIFSGTHLTMIAMGLICAIRYCHVQRIIHRDIKAANLLLDHHFLPKLCDFGISRFIATR-AMTDGIGTASHMAPEI
..|||  || | |||.   .   .||  .. | | |..   ..|. |   |||||.|  | |.   .  |. |||.|||.. |  ||  .||   ||.|.
HVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHM-AIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACEL

FVSTKYNIKVDVFAYGATLFEMLEKKNPYVGHPVEEVISNFRKGKRPIFRNKEIPDGLKDLLNRCWSQSPKNRPTPAEIYLEFASGK
| .  |  |.||...|  |.||. .| ||      .      || ||    | .|     |   || | |.|||.  ||   | |  
FNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIPVMVMKGERPTI-PKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase 93986.m00181.AA Dicty4 9-202 30 7.9e-34 110.33 In-house 60-277 (277) Show / Hide 
Range on Protein: 9-202
Range on HMM: 60-277/277
Sequence Identity: 30% (67 aa)

IIPFVGYTV---EKP--FCIITEYMPNGALNNYLRK----EWRAKPIFSGTHLTMIAMGLICA--IRYCHV--QRIIHRDIKAANLLLDHHFLPKLCDFG
|. | |.      .|  .|| ||||| | | . |..        ... ... .  . |.. .|  . . |    .|||||.|..||| | ..  | ||||
ICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFG

ISR----FIATRA-MTDGIGTASHMAPEIFVSTKYNIKVDVFAYGATLFEMLEKKNPYV--GHPVEE-VISNFRKGKRPIFRNKEIPDGLKDLLNRCWSQ
.|.     .   . ..  .||.  ||||. ..  || |.||. .|  |.|.| .. ||   . | .. |..  .|. ||.   .  |. .|.|...||. 
LSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPI-PDWCPPSWKHLIQWCWDH

SPKNRPTPAEI--Y--LEF
.|..||. .||  .  || 
DPQHRPSFEEIIQRRILEH
Kinase 93986.m00181.AA TK 9-202 15 5.9e-33 107.24 In-house 105-486 (486) Show / Hide 
Range on Protein: 9-202
Range on HMM: 105-486/486
Sequence Identity: 15% (59 aa)

IIPFVGYTVEK-------------PFCIITEYMPNGA----LNNYLRKE---------------------------------------------------
|. ..|. ...             |..|..||||.|     | .||||                                                    
IVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDL

-WRAKPIFSGTHLTM-------------------IAMGLICAIRYCHVQ------RIIHRDIKAANLLLDHHFL-----------PKLCDFGISRF----
 . . | .. ..|                     ... . |. .| | .      ...|||. | | |....              |..||| ||     
IKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGV

IATRAMTDGIGTASH--------------------------------MAPEIFVSTK---------YNIKVDVFAYGATLFEMLE--KKNPYVGHPV---
 | .   |.  ....                                |||| . . .         . .| ||...| ...|..   .. .| |..    
LARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDV

------EEVISNFRKGKRP----------IFRNK---EIP--------------DGLKDLLNRCWSQSPKNRPTPAEIYLEF
      .||. . |.| |.           .| .     |              . . ||. .||.  |. ||| .... ..
WKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 93986.m00181.AA UTK 16-202 25 8e-33 109.62 In-house 80-296 (296) Show / Hide 
Range on Protein: 16-202
Range on HMM: 80-296/296
Sequence Identity: 25% (55 aa)

TVEKPFCIITEYMPNGALNNYLRKEWRAKP----IFSGTHLTMIAMGLICAIRYCHVQRIIHRDIKAANLLLDHH-------FLPKLCDFG---ISRFIA
| |.|..|.||||.|| | .|||.  .. |    ... ....  |.   ..  | | ....|||. | | |...|        . |..|||    || ..
TQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVN

T-------------RAMTDGIGTASHMAPEIFVST-KYNIKVDVFAYGATLFEMLEK-KNPYVGHPVEEVISNFRKGK-RPIFRNKEIPDGLKDLLNRCW
|             .|  ... .   ||||....  .. .| ||...| ...|..   . || |.  ..|. ....|  .  ..... |. . .|..|||
TFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCW

SQSPKNRPTPAEIYLEF
 ..| .||.. ... ..
HYDPQERPDFEDLVQQM
Kinase 93986.m00181.AA Dicty4-Unclassified 21-200 32 1.8e-32 108.48 In-house 77-263 (263) Show / Hide 
Range on Protein: 21-200
Range on HMM: 77-263/263
Sequence Identity: 32% (61 aa)

FCIITEYMPNGALNNYLR--KEWRAKPI-FSGTHLTMIAMGLICAIRYCHVQRIIHRDIKAANLLLDHHFLPKLCDFGISRFIA-TRAMTDGIGTASHMA
.||..| |. | |          . .||    |    .|.     . . |   .||||||..|.|.| ||  |  |||||| |  .  ||   ||    .
MCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWES

PEIFVSTKYNIKVDVFAYGATLFEMLEKKNPYVGHP--VEEVISNFRKGKRPIFRNKEIPDGLKDLLNRCWSQSPKNRPTPAEI--YL
||.     || | ||. |.  |.|..    || . .  ..  .|   |. ||      ..  .| |   ||. .|. |||  .|  ||
PECLMHESYNQKSDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPD-NCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase 93986.m00181.AA Ciliate-E2 21-198 19 6.3e-32 106.87 In-house 109-359 (365) Show / Hide 
Range on Protein: 21-198
Range on HMM: 109-359/365
Sequence Identity: 19% (51 aa)

FCIITEYMPNGALNNYLRKE---------------WRAKPIFSGTHLT-------MIAMGLICAIRYCHVQR-IIHRDIKAANLLLDHHFLPKLCDFGIS
. ...||   | |  |...                ..    ..   |        ...  .|.|..|.| .  |||||||  |.|.     .|..|||.|
IYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLS

RFIATR-----------AMTDGI-----------------------GTASHMAPEIFVSTK---------YNIKVDVFAYGATLFEMLEKKNPYVGHPVE
... .             ...                         ||.  |||||. . |         |. |.|... | .|.||| .| |.      
KKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------

EVISNFRKGKRPIFRN----------------KEIPDGLKDLLNR----CWSQSPKNRPT-PAEI
  . .  ..|  .. .                |....  |||...    .    |..|.| . .|
--QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI
Kinase 93986.m00181.AA LRRK 19-204 26 4.8e-30 103.47 In-house 128-351 (351) Show / Hide 
Range on Protein: 19-204
Range on HMM: 128-351/351
Sequence Identity: 26% (59 aa)

KPFCIITEYMPNGALNNYLRKEWRAK-----PIFSGTHLTMIAMGLICAIRYCHVQR--IIHRDIKAANLLL---D---------HHFLPKLCDFGISR-
.|.|...||.|.|.|. .|... . .     . .| . .  ||.    ...| | ..  ||||| |  | ||   .          |   |..|||||| 
HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRM

-FIATRA-MTDGIGTASHMAPEIFVST---KYNIKVDVFAYGATLFEMLEKK-NPYVGHP-------VEEVISNFRKGKRPIFR---NKE--IPDGLKDL
 .. . .   .  |.   |||||   .    |. |||....|  |.| |  .  |. .|.        |..  .  .| || .    ...   .  ..||
FQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDL

LNRCWSQSPKNRPTPAEIYLEFAS
.. ||.. ||.||.. .|     .
IQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 93986.m00181.AA Pkinase_Tyr 1-202 28 2e-29 100.3 Pfam 57-270 (270) Show / Hide 
Range on Protein: 1-202
Range on HMM: 57-270/270
Sequence Identity: 28% (63 aa)

MGRT-KNRFIIPFVGYTV--EKP--FCIITEYMPNGALNNYLRKEWRAKPIFSGTHLTMIAMGLICAIRYCHVQRIIHRDIKAANLLLDHHFLPKLCDFG
|    ..  |. ..|  .  ..|   .|..||||.| | .||||    |. ..  .|  ...   ..  | . ...||||. | | |... .  | ||||
MKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG

ISRFIATRAMTDGIG-TASH--------MAPEIFVSTKYNIKVDVFAYGATLFEMLE-KKNP-YVGHPVEEVISNF-RKGKRPIFRNKEIPDGLKDLLNR
 .| |    . |.   ....        |||| .   |...| || ..| ...|..   . | | | . |||.  . ..| |   . .  || . ||. .
LARDI----YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR-MPCPENCPDEIYDLMKQ

CWSQSPKNRPTPAEIYLEF
|| . |..||| .||. ..
CWHYDPEDRPTFSEIHEQL
Kinase 93986.m00181.AA TKL-Unique 71-202 30 1.8e-28 97.59 In-house 133-290 (290) Show / Hide 
Range on Protein: 71-202
Range on HMM: 133-290/290
Sequence Identity: 30% (48 aa)

IIHRDIKAANLLLDHH-----FLPKLCDFGISRFIATR-AMTDG----------IGTASHMAPEIFVS--TKYNIKVDVFAYGATLFEMLEKKN------
|||||.|  |.|.| .     .  |.||||.|.| ... .|| .          .|..  ||||.. .  ..|..|.||...|. | |... |       
IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKK

PYVGHPVEEVISNFRK---GKRPIFRNKEIPDGLKDLLNRCWSQSPKNRPTPAEIYLEF
|| |   |....  ..   ..||   | ..|  ..||...|| . | .||.  ||. . 
PYQGMDQEQWCEMVHYMEENYRPPIPN-HCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 93986.m00181.AA S_TKc 1-203 23 1.1e-19 72.7 SMART 19-231 (231) Show / Hide 
Range on Protein: 1-203
Range on HMM: 19-231/231
Sequence Identity: 23% (57 aa)

MGRT-----------------------KNRFIIPFVGYTVEKPFCIITEYMPN--GALNNYLRKEWRAKPI--FSGTHLTMIAMGLICAIRYCHVQRIIH
  .                        .  .|. . .. ... .....||...  | |  |..|  | ..   |.  |   ..  ..||. ||| ..|||
RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIH

RDIKAANLLLDHHFLPKLCDFGISRFIATRAMTDGIGTASHMAPEIFVSTKYNI-KVDVFAYGATLFEMLEKKNPYVGHPVEEVISNFRKGKRPIFRNKE
||.| .|.|||.    |.||||..|..     |  .||   ||||..   .|.  |.|. . | .|.|||  . |.      ..   |.| .        
RDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG--------

IPDGLKDLLNRCWSQSPKNRPTPAEIYL--------EFA
 .. .||....|.   |..|||  |.          .. 
-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 93986.m00181.AA TyrKc 1-202 22 1.2e-16 46.31 SMART 3-280 (280) Show / Hide 
Range on Protein: 1-202
Range on HMM: 3-280/280
Sequence Identity: 22% (63 aa)

MGRT-------------------------------------------KNRFIIPFVGYTVE--------KPFCIITEYMPNGALNNYLRKEWRAKPIFSG
.|..                                           ..  |. ..|. ..        .| .|..||||.|.|..||||  .    .. 
LGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---LCM

THLTMIAMGLICAIRYCHVQRIIHRDIKAANLLLDHHFLPKLCDFGISRFIATR----AMTDGIGT----ASH-------MAPEIFVSTKYNIKVDVFAY
 .|  ..    |  .| | ...||||. | | |... .  | .||| ||.|       . .| . .     ..       |||| .   |...| ||...
KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSF

GATLFEMLEK-KNPYVG-----HPVEEVISNFRKGKRPIFRNK-------EIPDGLKDLLNRCWSQSPKNRPTPAEIYLEF
| ...|..   . || |      . .||| . ..|.|.            . || . ..  .||   |..||| .||. .|
GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 93986.m00181.AA TKL-Unique 8-37 34 0.000144 12.23 In-house 57-91 (290) Show / Hide 
Range on Protein: 8-37
Range on HMM: 57-91/290
Sequence Identity: 34% (12 aa)

FIIPFVGYTV----EKP-FCIITEYMPNGALNNYL
.|  ..||..      | .||..||.| | |...|
NIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVL