Gene 92720.m00093 (T.vaginalis)

92720.m00093

Species: T.vaginalis
Alias: 92720.m00093, TvagK0633
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
92720.m00093.AA Protein None 2163 None Fasta, JSON
92720.m00093.kin_dom Protein Kinase Domain None 131 None Fasta, JSON

Protein domain

Protein domains of 92720.m00093.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FAT 92720.m00093.AA FAT 882-900 40 1.140674 2.47 Pfam 389-408 (408) Show / Hide 
Range on Protein: 882-900
Range on HMM: 389-408/408
Sequence Identity: 40% (8 aa)

HARSTSDN-RLFKDTLRLLN
|. . |..   ..|||||| 
HSIALSQGSNSRQDTLRLLW
FAT 92720.m00093.AA FAT 1330-1578 16 9.7e-14 46.23 Pfam 97-403 (408) Show / Hide 
Range on Protein: 1330-1578
Range on HMM: 97-403/408
Sequence Identity: 16% (51 aa)

RASANLACAQHLVELSEVLQVK--------------RGQMTDITEIWKNRLENF-SHESDSWMLTSEIRSLILS--------------PNDHLDSYLKML
|.   . . | |.|| |. | |               . .  . . |..|| .      . |      |....|              |.. ..  .|. 
RHYPVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWIKFA

RVLRQERQWRLAD-----------SHCERFFNEKMPPRVLVEQLKIIWDRGNRKKAVSI-ASLINDKIAGIKNSQDETEENLQFLSNLSVP----VESFN
.. |   .  |.            | ..     ..|| . ...||. |..|....| ..    .. . ..  ... . | | . . ||.|      | |.
NLCRKHGRMQLCEKTLKMLYTYDPSEEDWHP--RAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEIN-GLTYNLEVINNTNLEYFY

KETQS-RLLRLQATWQYRL---YTSKTSGADSLKQICNLFKRANDLRPNDPK-IWSGWAYTSSRALSHFP-----------EQRAKFAEMAMTGFLKAAK
..    |   .|. ||  |     .. .. .. . | . ...|  . |. .|  |  ||.   ....| .           ...  ..  |...|.....
TKLLAMRCYHKQGMWQWKLYEEQYMN-WNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCFFHSIA

LSPS-ESFEYM
|| . .|....
LSQGSNSRQDT
Rapamycin_bind 92720.m00093.AA Rapamycin_bind 1691-1786 28 4.7e-10 33.38 Pfam 2-100 (100) Show / Hide 
Range on Protein: 1691-1786
Range on HMM: 2-100/100
Sequence Identity: 28% (28 aa)

MHRAAVSWNELWLTGLDNASRAN-GIGDIEQSYQVIQGLFDMLEK-PQCQMDHQFIKTMGPQISRAKTMFERAK-TNDENSIKMMWAGFKEIYQSLNDK
. | |..| |.|  ||. |||.  |  .||   .. . | .|||| |.  . ..|... | . ..|. . .. | |.|||.    |  ...... ... 
LIRVAILWHEMWHEGLEEASRQYFGDHNIEKMFNILEPLHEMLEKGPETMREISFVQQFGRDLQEAHEWCQKYKRTGDENCLNQAWDIYYQVFRRIRKQ
Kinase 92720.m00093.AA FRAP 1854-2104 44 9e-87 294.58 In-house 2-251 (251) Show / Hide 
Range on Protein: 1854-2104
Range on HMM: 2-251/251
Sequence Identity: 44% (111 aa)

WKFLLKGNEDLRLDQRIIQFFMLINSMLRSSRATSDLGVSIVEYSIVPFAPNAGFISWVTGADTFQQLVSEYRQNRGSGRNAENEVTNTLVGPLFNSLNA
. ||||| ||.| | |..| | ||| .|.    |   . ||  |||.|   |.| | ||   || . |. .||.      |.| .. .  . . .. |  
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMC-NDYDHLPL

LQRYEIFNHVAEATNANEIREMLWLRSPGASSWIQRSNCFTVSTALMSMAGYVIGLGDRHPSNIMVQRHTGRVIHIDFGFSFEDAMNRTLFPERVQFRLT
... ||| .. . |  .... .|||.||    |..|   .| | | ||||||..||||||||||| || ||...|||||  || || |  |||.. ||||
MNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLT

RMIVNALDGGSVSGLFRKTCEDVMWVLKNGMSSVMSQLEVFVHEPIFYGKE
||.|||..   . | .| ||| || |..    |||  || ||  |.|| . 
RMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase 92720.m00093.AA PIKK 1824-2094 31 2.7e-78 266.42 In-house 1-290 (290) Show / Hide 
Range on Protein: 1824-2094
Range on HMM: 1-290/290
Sequence Identity: 31% (91 aa)

TLRQIDNILGVMSTQQHPRTAWMSDAQGNRWKFLLKGNEDLRLDQRIIQFFMLINSMLRSSRATSDLGVSIVEYSIVPFAPNAGFISWVTGADTFQQLVS
  | .|  . || . | |.   .    |    .|.|| ||||.|||. |.| |.| .|.   ...    .|  ||..|  .. | | ||....| . .  
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

EYRQ------NRGSGR---------------NAENEVTNTLVGPLFNSLNALQRYEIFNHVAEATNANEIREMLWLRSPGASSWIQRSNCFTVSTALMSM
...|      . .. .               .  . ..   ...  ....  ...|.|......| ..  .. .|...| . .|  |   .| |.|.|.|
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMY--QHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCM

AGYVIGLGDRHPSNIMVQRHTGRVIHIDFGFSFEDAMNRTLFPERVQFRLTRMIVNALDGGSVSGLFRKTCEDVMWVLKNGMSSVMSQLEVF
.||..|||||||.|||... || ..|||||..||.|| |  .|| | |||||..|||.    |.|.||..||.|| .....  ..|. .|||
VGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 92720.m00093.AA PI3_PI4_kinase 1853-2104 23 9.9e-54 189.62 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1853-2104
Range on HMM: 1-300/300
Sequence Identity: 23% (73 aa)

RWKFLLKGNEDLR--LDQRIIQFF-----------------------MLINSMLRSSRATSDLGVSIVEYSIVPFAPNAGFISWVTGADTFQQLVSEYRQ
  .|..||..|||   |.|..|..                        |.| .... ...     ..  |...| .|. |.| ||  ..||... ..|. 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

NRG--------------SGRNAENEVTNTLVGPLFNSLNALQRYEIFNHVAEATNANEIREMLWLRSPGA-SSWIQRSNCFTVSTALMSMAGYVIGLGDR
...               ... ...              ..|. |.|....  |  . .....|  .| |   | .. . |. | | |....|..|.|||
KCKHKHFNKEHKMWMKMWPDWWHLM--------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDR

HPSNIMV--QRHTGRVIHIDFGFSFE-DAMNRTLFPERVQFRLTR------MIVNAL------DGGSVSGLFRKTCEDVMWVLKNGMSSVMSQL------
|..||||   . || ..|||||..|.  .|..  .|||| ||.|.      ..|.|.      |  .  |.||..|.... .|   | ..|. |      
HNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMR

-EVFVHEPIFYGKE
 | .|| ...  ..
GECMVHDGLPMWRS
Kinase 92720.m00093.AA PI3Kc 1855-2152 21 1.4e-53 185.21 SMART 1-336 (336) Show / Hide 
Range on Protein: 1855-2152
Range on HMM: 1-336/336
Sequence Identity: 21% (71 aa)

KFLLKGNEDLRLDQRIIQFFMLINSMLRSSRATSDLGVSIVEYSIVPFAPNAGFISWVTGADTFQQLVSEYRQNRG---------------------SGR
 ...|...||| |.|..|.| |.| .... .... . . .  |...|  |. |.| ||. ..|. |. ..|. ...                     .  
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMY-

NAENEVTNTLVGPLFNSLNALQRYEIFNHVAEATNANEIREMLWLRSPGAS-SWIQRSNCFTVSTALMSMAGYVIGLGDRHPSNIMVQRHTGRVIHIDFG
. ..  . .   .    .. ... . | ... ... . ... .| ..|... .| .. . || |.| ..|..|. |.||||..|||. . || ..|||||
MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG

FSFEDAMNRTLFP----ERVQFRLTRMIVNALDGG----SVSGLFRKTCEDVMWVLKNGMSSVMSQLEVFVHEPI---FYGK--EAKPSDAKLRGILERV
. |. .. . .|.    ||| ||||...|..  ||     . |.||..|. .. ...  . ..|. .|..|. ||   . ..    |.  ...| .   .
HIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSD

ASKLSGIDQ----DGEEKDVKAQVDSLIKVAADPKEY
   .  ..|       |... ..   .. .. . ..|
EEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 92720.m00093.AA ATR 1824-2094 22 2.6e-34 114.04 In-house 2-267 (267) Show / Hide 
Range on Protein: 1824-2094
Range on HMM: 2-267/267
Sequence Identity: 22% (62 aa)

TLRQIDNILGVMSTQQHPRTAWMSDAQGNRWKFLLKGNEDLRLDQRIIQFFMLINSMLRSSRATSDLGVSIVEYSIVPFAPNAGFISWVTGADTFQQLVS
 .  .|... .... |.|.   .  ..|  .  . |  .||| | |  .|  ||| ..|           .  |...|   ... | ||    | . .. 
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD

EYRQNRGSGRNAENEVTNTLVGPLFNSLNALQRYEIFNHVAEATNANEIREMLWLRSPGASSWIQRSNCFTVSTALMSMAGYVIGLGDRHPSNIMVQRHT
.  . ..       .  .     .  | .  ..  .|            ..    | | . .|    . .  |.| ..| ||.|||||||  ||.... .
KLWKEKK----QYMQFYQLRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKIN

GRVIHIDFGFSFED--AMNRTLFPERVQFRLTRMIVNALDGGSVSGLFRKTCEDVMWVLKNGMSSVMSQLEVF
| ..|.|.   |     ..    || | ||||. .|...      ||||. ||..| .... .  .|| .. |
GECVHVDYNCIFNSGEQFE---VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase 92720.m00093.AA ATM 1986-2100 38 3e-24 74.03 In-house 133-246 (304) Show / Hide 
Range on Protein: 1986-2100
Range on HMM: 133-246/304
Sequence Identity: 38% (44 aa)

WIQRSNCFTVSTALMSMAGYVIGLGDRHPSNIMVQRHTGRVIHIDFGFSFEDAMNRTLFPERVQFRLTRMIVNALDGGSVSGLFRKTCEDVMWVLKNGMS
|  .   .| | |  |. ||..||||||  ||..      ..||| |  ||        || | ||||| ||  .    | | ||. ||  | |..|   
WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT-PETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE

SVMSQLEVFVHEPIF
 ..   || . .|.|
TLLTIVEVLLYDPLF
Kinase 92720.m00093.AA FATC 2131-2163 54 6.1e-16 54.09 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2131-2163
Range on HMM: 1-33/33
Sequence Identity: 54% (18 aa)

EEKDVKAQVDSLIKVAADPKEYCRHYIGWCPFW
|. .| .||| ||. | ||. .|..||||||.|
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 92720.m00093.AA DNAPK 1993-2104 30 1e-15 53.48 In-house 190-301 (301) Show / Hide 
Range on Protein: 1993-2104
Range on HMM: 190-301/301
Sequence Identity: 30% (34 aa)

FTVSTALMSMAGYVIGLGDRHPSNIMVQRHTGRVIHIDFGFSFEDAMNRTLFPERVQFRLTRMIVNALDGGSVSGLFRKTCEDVMWVLKNGMSSVMSQLE
|  . |.    ... | ||||  | ||   .| .| ||||.||  |      ||   |||||  .| .    . |...      |  ..      .   .
FIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCD

VFVHEPIFYGKE
||. .| |  | 
VFINDPSFDWKN
Kinase 92720.m00093.AA SMG1 1965-2036 43 5e-15 46.09 In-house 162-233 (242) Show / Hide 
Range on Protein: 1965-2036
Range on HMM: 162-233/242
Sequence Identity: 43% (31 aa)

EATNANEIREMLWLRSPGASSWIQRSNCFTVSTALMSMAGYVIGLGDRHPSNIMVQRHTGRVIHIDFGFSFE
|||  | .   ||        |      .  ||| ||| ||.|||||||  |...   || |.|||.   ||
EATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFE
Kinase 92720.m00093.AA SMG1 1832-1915 30 1.4e-10 31.16 In-house 1-84 (242) Show / Hide 
Range on Protein: 1832-1915
Range on HMM: 1-84/242
Sequence Identity: 30% (26 aa)

LGVMSTQQHPRTAWMSDAQGNRWKFLLKGNEDLRLDQRIIQFFMLINSMLRSSRATSDLGVSIVEYSIVPFAPNAGFISWVTGA
. .. |.  |.      . |  . .| || ||| || ||.||  ..| |                ||. |    .| | || ||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGA
Kinase 92720.m00093.AA DNAPK 1856-1912 36 1.5e-08 27.05 In-house 35-91 (301) Show / Hide 
Range on Protein: 1856-1912
Range on HMM: 35-91/301
Sequence Identity: 36% (21 aa)

FLLKGNEDLRLDQRIIQFFMLINSMLRSSRATSDLGVSIVEYSIVPFAPNAGFISWV
|. || ||||.|||| | |   |  .    . .        |.|.|     | | ||
FCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWV
Kinase 92720.m00093.AA ATM 1855-1914 33 1.3e-07 20.0 In-house 1-60 (304) Show / Hide 
Range on Protein: 1855-1914
Range on HMM: 1-60/304
Sequence Identity: 33% (20 aa)

KFLLKGNEDLRLDQRIIQFFMLINSMLRSSRATSDLGVSIVEYSIVPFAPNAGFISWVTG
. | || .||| |  . | | . | .|     |    . |  | .|| .  .| . | ||
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTG