Gene 82872.m00053 (T.vaginalis)

82872.m00053

Species: T.vaginalis
Alias: TvagK0756, 82872.m00053
External Links:
Annotation:

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
82872.m00053.AA Protein None 296 None Fasta, JSON
82872.m00053.kin_dom Protein Kinase Domain None 277 None Fasta, JSON

Protein domain

Protein domains of 82872.m00053.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 82872.m00053.AA GSK 4-278 35 3e-114 350.47 In-house 8-328 (328) Show / Hide 
Range on Protein: 4-278
Range on HMM: 8-328/328
Sequence Identity: 35% (114 aa)

GQGAFGTVISALDQ----DGQMI-----AIKTIKIDPKFQ-NREADIMKKL---DHQNCIKLKSVYRKK---ADEGEVFQY-IVMEYMPTSLGKFLGNCK
|.|.||.|  | ..    . . |     ||| .  |.... ||| .|||.|   ||.|...||  . ..   .||..|..  .||||||  | ...    
GHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLYQVIRHYV

TTKRPMIKQSIKHYAQQLFKGLEYIHSLGICHRDLKPDNVLIDPKAHTLKLCDFGSAKNIKE--GDKSTADIGSRFYRAPEILLGCTHYDFSIDIWSAGC
. |..|  . || |. |.|.|| |.||.||||||.||.|.|.||. ..||.||||||| ...  . .... | ||.||||| ..|||.|. .||.||.||
KNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQIDVWSCGC

VIAQMLLDGNVIFAGDDNNDQVVKIMNIMGCPSEEDA-----NS--FEHP-----LPWPTAERTTDLT---------------LLFPPNTESK-LIDLLT
|.| ||. | ..|.||. .|| | | ...| |..|.      ..  |..|        |. ... |..               ...  .|... .|||..
VMAEMLK-GQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQDWIDLIS

AIFSYNPKDRPTATECLKSPYF
... |.|| |... |....|.|
KCLVYDPKKRLSPLEACAHPFF
Kinase 82872.m00053.AA CMGC 4-278 20 8.3e-101 332.04 In-house 8-513 (513) Show / Hide 
Range on Protein: 4-278
Range on HMM: 8-513/513
Sequence Identity: 20% (104 aa)

GQGAFGTVISALD---------------QDGQMIAIKTIKIDPKFQN----------------READIMKKL-----------------DHQNCIKLKSV
|.|..|.| .. |               ......||| || .. ...                ||  |.|.|                 .| |..||. .
GEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDI

YRKKADEGEVFQ------------YIVMEYMPTSLGKFLGNCKT------------------------TKRPMIKQSIKHYAQQLFKGLE--YIHSLG--
.. | ..|. .             |.|.|||...| ... |...                        ... ..   |. |..|...||.  |.|| .  
FYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGN

ICHRDLKPDNVLIDPKA-------------------HTLKLCDFGSAKNIKEGDK----------------------STADIGSRFYRAPEILLGC----
|.|||||| |.||...                     .||.||||.|. . . ..                       | .. .|.|||||||||.    
IIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYT

-----THYDFSIDIWSAGCVIAQMLLD-------GNVIFAGDDN-----------NDQVVKIMNIMGCP----------------SEEDANSFEHP----
     .||. .||.||.||..| |..        |  .| |...            ||  ||....| |                .||. |  . |    
NHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNK

---------------------------LPWPTAERTTDLTLLFPP-------------------------------NTESKLIDLLTAIFSYNPKDRPTA
                           .||.     ..|   .|.                               .  ...||||  .. |.|..|.||
FPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITA

TECLKSPYF
 ..|. |||
EQALQHPYF
S_TKc 82872.m00053.AA S_TKc 1-278 28 1e-78 268.74 SMART 5-231 (231) Show / Hide 
Range on Protein: 1-278
Range on HMM: 5-231/231
Sequence Identity: 28% (82 aa)

MQMGQGAFGTVISALDQD-GQMIAIKTIKIDPKFQNREADIMKKLDHQNCIKLKSVYRKKADEGEVFQYIVMEYMPT---SLGKFLGNCKT--TKRPMIK
 . |.||||.|  . . . |.  ||| ||   .   || .|.|| .| | .||. |..        . |.||||...   .| ... ....  ...|.  
RKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

QSIKHYAQQLFKGLEYIHSLGICHRDLKPDNVLIDPKAHTLKLCDFGSAKNIKEGDKSTADIGSRFYRAPEILLGCTHYDF-SIDIWSAGCVIAQMLLDG
  ...|..|....|||.||.||.||||||.|.|.|    ..|.||||.|. .      |  .|...|.|||.|    .|.. ..|.|| ||... ||  |
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLC-G

NVIFAGDDNNDQVVKIMNIMGCPSEEDANSFEHPLPWPTAERTTDLTLLFPPNTESKLIDLLTAIFSYNPKDRPTATECLK-------SPYF
   |       |. ......|                                  . ..|..  .. ..|..|||| |.|.        |.|
YPPFP------QMQMMFKKIG---------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 82872.m00053.AA CDK 4-278 31 2e-77 247.26 In-house 8-284 (284) Show / Hide 
Range on Protein: 4-278
Range on HMM: 8-284/284
Sequence Identity: 31% (100 aa)

GQGAFGTVISALDQD-G-----QMIAIKTIKIDP--------KFQN---READIMKKLDHQNCIKLKSVYRKK--ADEGEVFQ-----YIVMEYMPTSLG
|.|..|.|  | |.. |     |..|.| |...          |     ||  ..|.| |.| .||. |.  |  ....  ..     |.|.|||.. | 
GEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFEYMDHDLK

KFLGNCKTTKRPMIKQSIKHYAQQLFKGLEYIHSLGICHRDLKPDNVLIDPKAH----TLKLCDFGSAKNIK-------EGDKSTADIGSRFYRAPEILL
|..              ||.| .|| .||.|.|| .| |||||| | ||. . .    .||. ||| |.          .  . |  .  . |||||.||
KYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLL

GCTHYD--FSIDIWSAGCVIAQMLLD--GNVIFAGDDNNDQVVKIMNIMGCPSEEDANSFEHPLPWPTAERTTDLTLLFPPNTESKLIDLLTAIFSYNPK
|..||.   .||.||.||..| |..|  .  .| ||   ||  || .|.|.|.|..  .... ||.                      |||   . |.||
GSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTK-LPDY---------------------DLLNKMLCYDPK

DRPTATECLKSPYF
 | .|...|..|||
KRISAEQALQHPYF
Pkinase 82872.m00053.AA Pkinase 2-278 29 8.8e-73 252.9 Pfam 6-293 (293) Show / Hide 
Range on Protein: 2-278
Range on HMM: 6-293/293
Sequence Identity: 29% (92 aa)

QMGQGAFGTVISALDQDGQM-IAIKTIKIDPKFQNR--------EADIMKKLDHQNCIKLKSVYRKKADEGEVFQYIVMEYMPTSLGKFLGNC----KTT
. |.|.||.|  . ... .   |.|.|| . .  .         |. |||.|.| | ..|. ...      .   |.||||..  |   .  .       
KIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLY-VMDLFDYISTWR

KRPM--IKQSIKHYAQQLFKGLEYIHSLGICHRDLKPDNVLIDPKAHT---LKLCDFGSAKN--IKEGDKSTADIGSRFYRAPEILLGCTHYDFSIDIWS
....    . .|.|. |...||||.|| ||.||||||.|.||| . |.   .|.||||.||   .  .   |   |...|.|||...|...|. ..|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

AGCVIAQMLLDGNVIFAGD----DNNDQVVKIMNIMGCPSEED-------ANSFEHPLPWPTAERTTDLTLLFPPNTESKLIDLLTAIFSYNPKDRPTAT
.||....||. |. .| |.    . .|| ..| .|||.| ..|        ..|  .  | .     . . .| .|... ..|... .. ..||.||||.
CGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-----F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE

ECLKSPYF
..|..|.|
QILQHPWF
Kinase 82872.m00053.AA MAPK 2-278 31 1e-57 198.06 In-house 6-328 (328) Show / Hide 
Range on Protein: 2-278
Range on HMM: 6-328/328
Sequence Identity: 31% (104 aa)

QMGQGAFGTVISALDQD-------GQMIAIKTIK---IDPKFQN---READIMKKL-DHQNCIKLKSVYRKK----ADEGEVFQ--YIVMEYMPTSLGKF
. ||||.|.| || |.        |. .||| |     .| ..    ||  ... . .| | |||. ... .    ... | |.  |||||.| | | . 
PIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQI

LGNCKTTKRPMIKQSIKHYAQQLFKG--LEYIHSLGICHRDLKPDNVLIDPKAHTLKLCDFGSAKNIKEGDKS---------------TADIGSRFYRAP
.   .    |.  . |.    |. .|  | |||| .. |||||| |.|..    .||.|||| |  |   ..                |  .  |.||||
IKSQQ----PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENC-DLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EILLG--CTHYDFSIDIWSAGCVIAQMLLDGNVIFAGDDNNDQVVKIMNIMGCPSEEDANSFE-HPLPW--------PTAERTTDLTLLFPP---NTESK
||.|.   .||. ..|.||.||  | || |. ..| |.|  ||  .||...| ||||. .  .  . ..        ..     ... .||    |. ..
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

LIDLLTAIFSYNPKDRPTATECLKSPYF
 ||||      .|..| |. |.|  |||
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 82872.m00053.AA RCK 2-278 30 3.1e-54 170.33 In-house 6-298 (298) Show / Hide 
Range on Protein: 2-278
Range on HMM: 6-298/298
Sequence Identity: 30% (92 aa)

QMGQGAFGTVISALDQD-GQMIAIKTIKIDPKFQN-------READIMKKLD-HQNCIKLKSVYRKKA-DEGEVFQYIVMEYMPTSLGKFLGNCKTTKRP
| | |..|.|. | . . |. .|||. |   || .       ||   ..||  | | |||| | | .   ..    |.|.||| . | ... . |  ...
QLGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQL----YFVFEYMDMNLYQMMKDFKERRKY

MIKQS--IKHYAQQLFKGLEYIHSLGICHRDLKPDNVLIDPK--------AHTLKLCDFGSAKNIKEGDKSTADIGSRFYRAPEILLGCTHYDFSIDIWS
.  .   ||..  |...||...|. |. |||||| | .. ..          ..|..|||... |      |. ...| |||||.|| ||.|.  .|||.
LPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWA

AGCVIAQMLLDGNVIFAGDDNNDQVVKIMNIMGCPSEEDANSFE-----HPLPWPTAERTTDLTLLFPPNTESKLIDLLTAIFSYNPKDRPTATECLKSP
 ||...      .  |.| .  ||  || ..|| |. .| . .        . .|  .  . |  |.|    . .|.|..    ..|. |.|| ..|. |
VGCIMYELYM-LRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCK-GMPLKQLIPN-CSQDCIELMEKMLQWDPQKRITAQQALQHP

YF
||
YF
Kinase 82872.m00053.AA CDC2 4-220 34 6.8e-54 163.76 In-house 8-232 (301) Show / Hide 
Range on Protein: 4-220
Range on HMM: 8-232/301
Sequence Identity: 34% (80 aa)

GQGAFGTVISALD-QDGQMIAIKTIKIDPKFQN--------READIMKKLD-HQNCIKLKSVYRKKADEGEVFQYIVMEYMPTSLGKFLGNCKTTKRPMI
| | .| |. . | |..|..|.| |...             ||  ..|.|. |.| .||. |. .         |.| ||.   | |.. . . .. .| 
GEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ------NKLYMVFEYLDMDLKKYMDMSIPKNKHMP

KQSIKHYAQQLFKGLEYIHSLGICHRDLKPDNVLIDPKAHTLKLCDFGSAKNIKE-GDKST--ADIGSRFYRAPEILLGCTHYDFSIDIWSAGCVIAQML
 | .| |. |. .|... |. .| ||||||.| ||| |.  .|. ||| |...    .. |   ..  . |||||||||| .|....|.|| ||..| | 
PQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-IKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMF

LD--GNVIFAGDDNNDQVVKIMNIMGCPSEED
.|     .|.||   ||  ||  |.| |.|..
MDVTKKPLFHGDSEIDQLFKIFRILGTPNEQT
Kinase 82872.m00053.AA Ciliate-E2 2-278 19 5.1e-50 169.88 In-house 6-365 (365) Show / Hide 
Range on Protein: 2-278
Range on HMM: 6-365/365
Sequence Identity: 19% (78 aa)

QMGQGAFGTVISALD------------------------QDGQMIAIKTI-KIDPKFQNREADIMK----------------KLDHQNCIKLKSVYRKKA
. |||.||.|  . .                        ......|.|.. | . .....| .||.                .|.| | ||.. ..  | 
KIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKD

DEGEVFQYIVMEYMPT-SLGKFLGNCKT---------------TKRPMIKQSIK-------HYAQQLFKGLEYIHSLG-ICHRDLKPDNVLIDPKAHTLK
|.     |.||||    .| ... |.|.                 . ..|| ..       .|. .. ..|||.|| . |.|||.||.|.|.      .|
DN---NIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IK

LCDFGSAKNIKEGDKSTAD--------------------------------IGSRFYRAPEILLGCT--------HYDFSIDIWSAGCVIAQMLLDGNVI
..||| .|....  . . .                                .|.  | ||||| |          .||...||||.| ||  ..| |.  
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG-VILYEMLFGKPP

FAGDDNNDQVVKIMNIMGCPSEEDANSFEHPLPWPTAERTTDLTLLFPPN------------------TESKLIDLLTA----IFSYNPKDRPT-ATECL
|                                    .   .  . ||..                   . . .||.      .. ..|. |.| . ..|
F-----------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL

KSPYF
. |.|
NHPWF
Kinase 82872.m00053.AA CDK-Unclassified 3-278 24 1.4e-49 161.17 In-house 7-324 (324) Show / Hide 
Range on Protein: 3-278
Range on HMM: 7-324/324
Sequence Identity: 24% (82 aa)

MGQGAFGTVISALDQDGQMI-AIKTIKIDPKF----------------QNREADIMKKLDHQNCIKLKSVYRKKADEG--------EVFQYIVMEYMPTS
.|.|.|| |  |.|.. | . ||| | .  |.                 .||  ... . | | ||.  .. .                 |.||||||  
YGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMVMEYMPY-

LGKFLGNCKTTKRPMIKQSIKHYAQQLFKGLEYIHSLGICHRDLKPDNVLIDPKA----HTLKLCDFGSAKNIK-------------EGDKSTADIGSRF
  .. .  .    .  .. |. .. |...|. |.|. .| |||.|| |..|. .       ||. |||.|                 .... . ..  | 
--TWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQVSTRW

YRAPEILLGCTHYDFSIDIWSAGCVIAQMLLDGNVIFAGDDNNDQVVKIMNIMGCPSEEDANSFEHPLPWPTAERTTDLTLLFPPNTESKL---------
|||||.|.|   ||  .||||.||..|.. . |  ||.|    .|  .|  ..| |.|..         || .    |  ..| .. . .          
YRAPELLFGSKCYDTGVDIWSFGCIYAEW-FQGKPIFQGRTEIEQMHHIFKMLGTPCEDM---------WPDWRYMPDYCKIFFKYKQKFHWWNRFPKCK

----IDLLTAIFSYNPKDRPTATECLKSPYF
    ....    .|.|. |... | |..|.|
HASENNCEFQMVMYQPYNRWKCMEILQHPWF
Kinase 82872.m00053.AA CAMK 2-185 20 1.2e-48 154.43 In-house 1-323 (425) Show / Hide 
Range on Protein: 2-185
Range on HMM: 1-323/425
Sequence Identity: 20% (68 aa)

QMGQGAFGTVISALDQ-DG------------QMIAIKTIKI--------------------------------DPKFQNREADIMKK-------LDHQNC
. |.|.||.|  . .  ..            |  ||| |.                                 | |.  || .||||       ||| | 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLKSVYRKK------ADEG---------EVFQYIVM---EYMPTS------LGKFLGNCK----------TTKRPMI-KQSIKHYAQQLFKGLEYIHSL
|||  ||  .       | .         . . |.||   ||..        . .   . .            .|  .  .  ..| .|.  ...|.||.
IKLYEVYEDPHYFKNTND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH

GICHRDLKPDNVLIDPKA----------------HTLKLCDFGSAKNIKE------------------------GDKSTADIGSRFYRA-PEILLG----
.|.||||||.|.|.| .                 ...|..||| |. ...                        |.| .   |.  | | ||.|.|    
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---------CTHYDFSIDIWSAGCV
          . |....|.||.|..
NMQNATDEEKPYYGPKCDMWSCGVI
Kinase 82872.m00053.AA STE 2-190 25 5.2e-47 162.51 In-house 6-262 (359) Show / Hide 
Range on Protein: 2-190
Range on HMM: 6-262/359
Sequence Identity: 25% (67 aa)

QMGQGAFGTVISALDQD----------------GQMIAIKTIKIDP------------------KFQN---READIMKKLD--HQNCIKLKSVYRKKA--
. |.||||||  |.. .                |...||| .....                  . ..   .| .||||..  |.| .|    | |.   
KIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHN

DEGEVFQYIVMEYMP-TSLGKFLGNCKTTKRPMI----------KQSIKHYAQQLFKG-LEYIHSLGICHRDLKPDNVLIDPKAHTLKLCDFGSAKNIKE
.. .   .|.||||.  || ... ... ...|.            . |.....|. || |.|.||..| |||.||.|.|.       |||||| .... .
HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVCGQLTD

-----------------GDKSTADIGSRFYRAPEILLG---C--THYDFSIDIWSAGCVIAQML
                 . |.. ..|.  . |||....   .   .||.. |||| ||.|  |.
SMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA
Kinase 82872.m00053.AA DYRK 68-219 33 1.1e-40 141.54 In-house 77-226 (320) Show / Hide 
Range on Protein: 68-219
Range on HMM: 77-226/320
Sequence Identity: 33% (53 aa)

YIVMEYMPTSLGKFLGNCKTTKRPM-IKQSIKHYAQQLFKGLEYIHSL-GICHRDLKPDNVLIDP--KAHTLKLCDFGSAKNIKEGDKSTADIGSRFYRA
.|| | . ..|  ||  ... ...    . .. .|||....| ..|..  | | ||||.|...    .  |.|..||||.  ...  . .  | ||||||
CIVFELLSMNLYEFL--KNNHFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQ--RIYTYIQSRFYRA

PEILLGCTHYDFSIDIWSAGCVIAQMLLDGNVIFAGDDNNDQVVKIMNIMGCPSEE
||..|||  |. .||.|| ||..| ... |...|.|....||  .|| ..| |...
PEVILGC-PYCYAIDMWSLGCILAELFT-GWPLFPGENEYDQLACIMEVLGMPPKW
Kinase 82872.m00053.AA TyrKc 2-278 23 1.4e-14 12.82 SMART 6-280 (280) Show / Hide 
Range on Protein: 2-278
Range on HMM: 6-280/280
Sequence Identity: 23% (72 aa)

QMGQGAFGTVISALDQDGQMIAIKTIKIDPKFQN--READIMKKL--DHQNCIKLKSVYRKKADEGEVF-----QYIVMEYMPT-SLGKFLGNCKTTKRP
. | ||||.|  .     .. |.|..| |   .   ||| ||.||  .|.| ..|  | ...      |      .|||||||  .| ..| ... .   
KLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN---FMYIEPLMIVMEYMPHGDLKDYLRKHRPK---

MIKQSIKHYAQQLFKGLEYIHSLGICHRDLKPDNVLIDPKAHTLKLCDFGSAKNIKEG--------DKSTAD-IGSR-----FYRAPEILLGCTH-YDFS
   .   ... |  .| ||.|| .. ||||   |.|.. .  | | .||| ...|...         ....   |..        ||| .   .. . . 
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKFTTK

IDIWSAGCVIAQMLLDGNVIFAG-----DDNND--QVVKIMNIMGCPSE----EDANSFEHPLPWPTAERTTDLTLLFPPNTESKLIDLLTAIFSYNPKD
 |.|| | ..  .. .|     |      .| .  . ||  . | .| .                            | .   ... .. .    ..|.|
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------F-VCCPDEMYQIMKQCWHEDPED

RPTATECLKSPYF
||| .|.    .|
RPTFSEI--HECF
Kinase 82872.m00053.AA Pkinase_Tyr 4-141 32 5.3e-14 48.04 Pfam 8-156 (270) Show / Hide 
Range on Protein: 4-141
Range on HMM: 8-156/270
Sequence Identity: 32% (49 aa)

GQGAFGTVISALDQ-----DGQMIAIKTIKIDPKFQN-------READIMKKL-DHQNCIKLKSVYRKKADEGEVFQYIVMEYMPT-SLGKFLGNCKTTK
|.||||.|  .        ...  |.|..| .   ..       ||| |||.| .|.| ..|  |  .. . .    ||||||||  .| ..| . .. |
GEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYLRKHREDK

RPMIKQSIKHYAQQLFKGLEYIHSLGICHRDLKPDNVLIDPKAHTLKLCDFG
.|   . . ....|  ||.|| .| .. ||||   |.|.. . .. | ||||
QPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT-ENNVVKICDFG
Kinase 82872.m00053.AA CAMK 243-278 20 5.7e-08 21.01 In-house 366-425 (425) Show / Hide 
Range on Protein: 243-278
Range on HMM: 366-425/425
Sequence Identity: 20% (12 aa)

FPPNTESK------------------------LIDLLTAIFSYNPKDRPTATECLKSPYF
|||   |.                         .||.  .  ..|..|.|...||. | .
FPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 82872.m00053.AA CDC2 252-278 48 2e-06 15.04 In-house 275-301 (301) Show / Hide 
Range on Protein: 252-278
Range on HMM: 275-301/301
Sequence Identity: 48% (13 aa)

IDLLTAIFSYNPKDRPTATECLKSPYF
||||  .  |.| .| .| | |. |||
IDLLMQMLQYDPQKRISAKEALQHPYF
Kinase 82872.m00053.AA STE 243-278 17 3.7e-05 14.3 In-house 303-359 (359) Show / Hide 
Range on Protein: 243-278
Range on HMM: 303-359/359
Sequence Identity: 17% (10 aa)

FPPNTE-------------------SKLIDLLTAIFSYNPKDRPTATECLK--SPYF
.|....                   ....| .   . ..|..||||.. ||   | .
LPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 82872.m00053.AA DYRK 4-36 35 7.5e-05 14.39 In-house 8-41 (320) Show / Hide 
Range on Protein: 4-36
Range on HMM: 8-41/320
Sequence Identity: 35% (12 aa)

GQGAFGTVISALDQDGQ-MIAIKTIKIDPKFQNR
|.| || |. . |. .. |.||| |.  ..|...
GKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQ
Kinase 82872.m00053.AA DYRK 249-278 23 0.000172 13.02 In-house 291-320 (320) Show / Hide 
Range on Protein: 249-278
Range on HMM: 291-320/320
Sequence Identity: 23% (7 aa)

SKLIDLLTAIFSYNPKDRPTATECLKSPYF
....|...  . ..|. |.|. . |. | |
HQFKDFIKKCLQWDPHKRITPSQALQHPWF