Gene 97193.m00079 (T.vaginalis)
97193.m00079
Species: T.vaginalis
Alias: 97193.m00079, TvagK0642
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 97193.m00079.AA | Protein | None | 2116 | None | Fasta, JSON |
| 97193.m00079.kin_dom | Protein Kinase Domain | None | 245 | None | Fasta, JSON |
Protein domains of 97193.m00079.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 97193.m00079.AA | PIKK | 1761-2025 | 34 | 6.8e-87 | 294.99 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 1761-2025 Range on HMM: 1-290/290 Sequence Identity: 34% (99 aa) TISLVGRSMEVLRSKQHPKRLCVKGSNGLEYWFLLKGHEDLRLDQRAMQIFDLINALFGGQ------VQHIVTYHVMPISLGAGLISWINGSDTIAKVVR | |. .|. .|| ||.. .|..| || .|.|||||||.||| || | |.| .. || || | | | ||| | ....|. . RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK DYRTNRGIPVDEESRL-------------------VSEETIPQIDSLLPIQRYEALVDVANKTSDTVLSDAIWFNSTTSEKWLQKTKTFCQTAAVMSIAG ... .| . |. . .. . ... ...|.. .....| .. .. | ....| |. ... .. . |||...| QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG YMLGLGDRHPSNIMISQLTGTVVHIDLGDCFEVAKTRVMFPELIPFRLTRFMVRALGPCGVDGAFKTASKAVIKTIRGRRESIMAILEIF | ||||||||.|||| ..|| .||||.|.|||.|..| .||..|||||| || |.||.||.| | . .| . .| ||..|...| | YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
|||||||||
| Kinase | 97193.m00079.AA | FRAP | 1790-2030 | 43 | 1e-80 | 274.49 | In-house | 1-246 (251) | Show / Hide |
Range on Protein: 1790-2030 Range on HMM: 1-246/251 Sequence Identity: 43% (108 aa) EYWFLLKGHEDLRLDQRAMQIFDLINALFGGQVQ------HIVTYHVMPISLGAGLISWINGSDTIAKVVRDYRTNRGIPVDEESRLVSEETIPQIDSLL || ||||||||.| | | ||.| ||| | . . | | ..|.|. .||| |.. ||. .|||| | . | .. .. .. | | EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIM-DRMCNDYDHLP PIQRYEALVDVANKTSDTVLSDAIWFNSTTSEKWLQKTKTFCQTAAVMSIAGYMLGLGDRHPSNIMISQLTGTVVHIDLGDCFEVAKTRVMFPELIPFRL ... | . | | | .| | || |... . |.||.|||.||||||||||||. .|| .|||| ||||||| .| |||.||||| LMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRL TRFMVRALGPCGVDGAFKTASKAVIKTIRGRRESIMAILEIFVHSPL || .| |. ||..| .. .. |.| || .||.||.|| || || TRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPL |
|||||||||
| Kinase | 97193.m00079.AA | PI3Kc | 1792-2079 | 22 | 1e-50 | 175.76 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 1792-2079
Range on HMM: 1-336/336
Sequence Identity: 22% (75 aa)
WFLLKGHEDLRLDQRAMQIFDLINALF--G----GQVQHIVTYHVMPISLGAGLISWINGSDTIAKVVRDYRTNRGIPVDEESRLV--------------
...|...||| |.|.||.| |.| . .. |. .|...|.. . |.| |.. ..|.... . |......| | . .
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
------SEETIPQIDSLLPIQRYEALVDVANKTSDTVLSDAIWFNSTTS-EKWLQKTKTFCQTAAVMSIAGYMLGLGDRHPSNIMISQLTGTVVHIDLGD
. .. . . ... . ..... . || | | ..... |.| . ..|.. |......|.||.||||..|||. || ..|||.|.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
CFEVAKTRVMFP----ELIPFRLTRFMVRALG----PCGVDGAFKTASKAVIKTIRGRRESIMAILEIFVHSPL--SSEFS--KIKREEPSISVF-LDDV
.|. ..... |. |. |||||. || . | | |..| |.| . . . .| ...||...|..|..|. . .. .|| .. .. . | |
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE
EAIAE-KR------SEEE-SSSLRTVRRIADKLGGL
||. .. |.. .| . .. ..... ..
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
|
|||||||||
| Kinase | 97193.m00079.AA | PI3_PI4_kinase | 1790-2035 | 24 | 2.4e-47 | 168.39 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 1790-2035 Range on HMM: 1-300/300 Sequence Identity: 24% (74 aa) EYWFLLKGHEDLR--LDQRAMQIF-----------------------DLINALF--GGQVQH----IVTYHVMPISLGAGLISWINGSDTIAKVVRDYRT .| |..||..||| |.| ||.. |.| . | . .| ..| . . |.| |.. ..|.... | |.. WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV NRGIPVDEESRLVSEETIPQIDSLLPIQRYEALVDVANKTSDTVLSDAIWFNSTTS-EKWLQKTKTFCQTAAVMSIAGYMLGLGDRHPSNIMI--SQLTG ..... .. .. .. | ..|. .|. | ...|| .| . | .... | |.. ..|. |.|....|.||.||||..|||. || KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG TVVHIDLGDCFE-VAKTRVMFPELIPFRLTR------FMVRAL------GPCGVDGAFKTASKAVIKTIRGRRESIMAIL-------EIFVHSPLSSEFS ..||| |.||. .. . ..||..|||.|. || |. .| | .| |.. . .| ...|. | |..||..| . | HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
|||||||||
| Kinase | 97193.m00079.AA | ATR | 1908-2025 | 35 | 1.2e-34 | 115.14 | In-house | 149-267 (267) | Show / Hide |
Range on Protein: 1908-2025 Range on HMM: 149-267/267 Sequence Identity: 35% (42 aa) WFNST--TSEKWLQKTKTFCQTAAVMSIAGYMLGLGDRHPSNIMISQLTGTVVHIDLGDCFEVAKTRVMFPELIPFRLTRFMVRALGPCGVDGAFKTASK ||| . ...| . .| . ||... ||..|||||| ||.| ...| .||.| | .. . ||..|||||. || ..|| . .| |. | WFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQ-FEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACE AVIKTIRGRRESIMAILEIF ... .| .|. ||.... | VIMMCMRDHRDDIMSVWDCF |
|||||||||
| Kinase | 97193.m00079.AA | ATM | 1917-2030 | 40 | 8.6e-26 | 79.06 | In-house | 133-245 (304) | Show / Hide |
Range on Protein: 1917-2030 Range on HMM: 133-245/304 Sequence Identity: 40% (46 aa) WLQKTKTFCQTAAVMSIAGYMLGLGDRHPSNIMISQLTGTVVHIDLGDCFEVAKTRVMFPELIPFRLTRFMVRALGPCGVDGAFKTASKAVIKTIRGRRE | | . | || ||.||||||| ||.| .|||||| || | . || .|||||| .| .| ||.| |. . .| | WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKI-LPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE SIMAILEIFVHSPL .. | |. . || TLLTIVEVLLYDPL |
|||||||||
| Kinase | 97193.m00079.AA | SMG1 | 1902-1977 | 43 | 5.3e-18 | 56.09 | In-house | 168-242 (242) | Show / Hide |
Range on Protein: 1902-1977 Range on HMM: 168-242/242 Sequence Identity: 43% (33 aa) VLSDAIWFNSTTSEKWLQKTKTFCQTAAVMSIAGYMLGLGDRHPSNIMISQLTGTVVHIDLGDCFEVAKTRVMFPE .| .| || . | |. . ||||. ||..|||||| |..| || ||||| ||| | . || LLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGK-KLNVPE |
|||||||||
| Kinase | 97193.m00079.AA | DNAPK | 1911-2030 | 31 | 1e-16 | 57.24 | In-house | 177-296 (301) | Show / Hide |
Range on Protein: 1911-2030 Range on HMM: 177-296/301 Sequence Identity: 31% (38 aa) STTSEKWLQKTKTFCQTAAVMSIAGYMLGLGDRHPSNIMISQLTGTVVHIDLGDCFEVAKTRVMFPELIPFRLTRFMVRALGPCGVDGAFKTASKAVIKT ||| | .| | . || | .. || |||| | |. .| .. || | | | ||| |||||| . . | .. | .. .. STTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMA IRGRRESIMAILEIFVHSPL .| | . ..|. |. FRKDRNILTNFCDVFINDPS |
|||||||||
| Kinase | 97193.m00079.AA | SMG1 | 1769-1845 | 37 | 1.1e-13 | 41.52 | In-house | 1-83 (242) | Show / Hide |
Range on Protein: 1769-1845 Range on HMM: 1-83/242 Sequence Identity: 37% (31 aa) MEVLRSKQHPKRLCVKGSNGLEYWFLLKGHEDLRLDQRAMQIFDLINALFGGQVQ------HIVTYHVMPISLGAGLISWING . .| | ||.| || | | .| || ||| || | || ..| .| | | | |. .||| |. | ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDG |
|||||||||
| Kinase | 97193.m00079.AA | ATR | 1761-1844 | 33 | 1.2e-11 | 35.56 | In-house | 2-91 (267) | Show / Hide |
Range on Protein: 1761-1844 Range on HMM: 2-91/267 Sequence Identity: 33% (30 aa) TISLVGRSMEVLRSKQHPKRLCVKGSNGLEYWFLLKGHEDLRLDQRAMQIFDLINALFGGQVQ------HIVTYHVMPISLGAGLISWIN |. .|.| | |.||.. .|||.| | . | ..||| | | |.. .||| . . . |. || |.|. ...| |.| YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVN |
|||||||||
| Kinase | 97193.m00079.AA | DNAPK | 1760-1818 | 37 | 2.2e-10 | 33.82 | In-house | 2-60 (301) | Show / Hide |
Range on Protein: 1760-1818 Range on HMM: 2-60/301 Sequence Identity: 37% (22 aa) ITISLVGRSMEVLRSKQHPKRLCVKGSNGLEYWFLLKGHEDLRLDQRAMQIFDLINALF . | . |. | |||. ..| | |. || ||||.||| | | | | VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIF |
|||||||||
| Kinase | 97193.m00079.AA | ATM | 1794-1845 | 34 | 8.3e-05 | 10.85 | In-house | 3-60 (304) | Show / Hide |
Range on Protein: 1794-1845 Range on HMM: 3-60/304 Sequence Identity: 34% (20 aa) LLKGHEDLRLDQRAMQIFDLINALFGGQVQ------HIVTYHVMPISLGAGLISWING | || .||| | |.| . | | | || |.|.| .| . | | LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTG |
|||||||||
| FATC | 97193.m00079.AA | FATC | 2084-2116 | 57 | 5e-17 | 57.59 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 2084-2116 Range on HMM: 1-33/33 Sequence Identity: 57% (19 aa) EKLSCEMQVDKLIEEATDYYNFAHLYRGWNPLW |.||.| |||.||.|||| .| ...| || | | EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
|||||||||