Gene 81676.m00083 (T.vaginalis)

81676.m00083

Species: T.vaginalis
Alias: TvagK0615, 81676.m00083
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
81676.m00083.AA Protein None 2236 None Fasta, JSON
81676.m00083.kin_dom Protein Kinase Domain None 244 None Fasta, JSON

Protein domain

Protein domains of 81676.m00083.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FAT 81676.m00083.AA FAT 1293-1423 23 5e-09 30.46 Pfam 1-168 (408) Show / Hide 
Range on Protein: 1293-1423
Range on HMM: 1-168/408
Sequence Identity: 23% (40 aa)

APYFANAMMHLRRWDE--LDDALQPAP------------EDSM-----RCFSLKAISAL--HMKKYD--IVDRIIDNAFSLLASRPIT-LWADNQQIHTD
||. |.|. .|  |||  .|. ..  .            |||.     ...  .||..|  | ...|   . | ||.| .||       |     . | .
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRHYP

TMLVAQQLVEILEMKNWQ-LN-----------EEMRPSIEEVWQERLTMA-PRDFELWLKILGNRAAI
.|   |.|.|. |       .           .| . .. . |..|| .   |..| |  || .|. .
VMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHV
Kinase 81676.m00083.AA PIKK 1864-2132 36 1.1e-85 290.95 In-house 1-290 (290) Show / Hide 
Range on Protein: 1864-2132
Range on HMM: 1-290/290
Sequence Identity: 36% (105 aa)

RIQYFVGQFSVYMSKQQPKDVVIRGEDGNFYQYLVKGHEDLRLDERIMQFFRLINNFLKRE--TCFGAQVIQTMSVIPLSITNGLVQWVTGTDTLRSVVE
||. .     |  .|| ||  .||| || .| ||.|||||||.|.|.||.|.|.|. | ..  .   .  |.| ||||.|   ||..||....||.    
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

QYRRLMN---RDPIQE---------------YLLTESLSYVSFDYMMPI-QKYHVISKVMNIVPDTDIANFFYLKANTAEQWHKRTVTFSISAALTSMVG
|..   .   ....|                |. .  ...  .    |  .|. |  ..|. .|  . ...| .|. ..|.|  |.  . .| |. .|||
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YVFGLGDRHPSNLLIDRFTGKLIHIDFGDCFERAAKRKFLPEVVPFRLTRMMCKAMGVTGPDGTFRDAFVNTSRVLRENKRILIMVLAIF
|. |||||||.|..||. ||...|||||.||| | .|   || |||||||.|  |||..| .| || . . . ...|... .|. |.  |
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 81676.m00083.AA FRAP 1894-2142 39 1.6e-74 253.87 In-house 2-251 (251) Show / Hide 
Range on Protein: 1894-2142
Range on HMM: 2-251/251
Sequence Identity: 39% (100 aa)

YQYLVKGHEDLRLDERIMQFFRLINNFLKRETCFGAQ--VIQTMSVIPLSITNGLVQWVTGTDTLRSVVEQYRRLMNRDPIQEYLLTESLSYVSFDYMMP
| .| |||||.| |||.|| | |||  |. ..        ||  |.||||.  ||. ||   |||.  . .||.  .     || . .. .   .| .  
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDR-MCNDYDHLPL

IQKYHVISKVMNIVPDTDIANFFYLKANTAEQWHKRTVTFSISAALTSMVGYVFGLGDRHPSNLLIDRFTGKLIHIDFGDCFERAAKRKFLPEVVPFRLT
..|  .   .||     |..   .||    | |  |   .  | |  ||.||. |||||||||....|.|||..||||||||| | .|  .|| .|||||
MNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLT

RMMCKAMGVTGPDGTFRDAFVNTSRVLRENKRILIMVLAIFVHEPLVDPKE
||.  || ..| .|..| .     .|.||.|  .. ||  ||  ||   . 
RMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase 81676.m00083.AA PI3_PI4_kinase 1893-2142 25 1.6e-60 212.14 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1893-2142
Range on HMM: 1-300/300
Sequence Identity: 25% (78 aa)

FYQYLVKGHEDLR--LDERIMQFF-----------------------RLINNFLKRETCFGAQV----IQTMSVIPLSITNGLVQWVTGTDTLRSVVEQY
 |....||..|||   |.|.||..                       ||.|...| . |         .|. ..||..  .|...||  ..|.. .   |
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGC--DRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTY

R-----RLMNRDPIQEYLL---TESLSYVSFDYMMPIQKYHVISKVMNIVPDTDIANFFYLKANTA-EQWHKRTVTFSISAALTSMVGYVFGLGDRHPSN
.       .| . ......   ...|          .||  | ..... .|  .. ..|. .  .| | | ..  .|  | |  ..|.|..|.||||..|
MVKCKHKHFNKEHKMWMKMWPDWWHLM--------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDN

LLI--DRFTGKLIHIDFGDCFE-RAAKRKFLPEVVPFRLTR------MMCKAM------GVTGPDGTFRDAFVNTSRVLRENKRILIMVL-------AIF
...  |..||.|.|||||.||.  . |. . || ||||.|.      .| .||      ...| .|.|||  . . |.||.........|       ...
IMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECM

VHEPLVDPKE
|| .|.. ..
VHDGLPMWRS
Kinase 81676.m00083.AA PI3Kc 1895-2218 20 3e-53 184.13 SMART 1-336 (336) Show / Hide 
Range on Protein: 1895-2218
Range on HMM: 1-336/336
Sequence Identity: 20% (74 aa)

QYLVKGHEDLRLDERIMQFFRLINNFLKRE-TCFGAQV-IQTMSVIPLSITNGLVQWVTGTDTLRSVVEQYRRLMN------------------RDPIQE
. ..|...||| |.|.||.|||.|. ....  |..  . ......||..   |...||. ..||...   |.  ..                  . .   
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQ-K-NM

YLLTESLSYVSFDYMMPIQKYH-----VISKVMNIVPDTDIANFFYLKANTA-EQWHKRTVTFSISAALTSMVGYVFGLGDRHPSNLLIDRFTGKLIHID
| ... .    .. ||.... |     .. .. . ... .....|. .  .. | | ..  .|  | |  .||.|..|.||||..|...|. ||...|||
Y-MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHID

FGDCFERAAKRKFLP-----EVVPFRLTRMMCKAMG----VTGPDGTFRDAFVNTSRVLRENKRILIMVLAIFVHEPL-VDPKEHRSGSSNTKTDQMSFV
||..|... ..|...     |.||||||..|. .||    ..| .| ||.  . . |..|...  .. .....|. |.  . . .               
FGHIFGHG-PKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM---------------

GMTEVTGSVIDKGRVLLAEPRDKTTNTEMRARVNQ----KLSGTDFNENEALSVEDQATKLIKI
      .  |.. |  . .    ..  | . .. |    || . . ...    . ... .. . 
------EKDIKYLRQRFRLDH--LSDEEAAQYFMQTMCTKLIEHSNESWTTR-MYWMFHNWAQY
Kinase 81676.m00083.AA ATR 2012-2132 33 4.2e-30 99.43 In-house 148-267 (267) Show / Hide 
Range on Protein: 2012-2132
Range on HMM: 148-267/267
Sequence Identity: 33% (41 aa)

NFFYLKANTAEQWHKRTVTFSISAALTSMVGYVFGLGDRHPSNLLIDRFTGKLIHIDFGDCFERAAKRKFLPEVVPFRLTRMMCKAMGVTGPDGTFRDAF
..|  .   ..||      .  | |  .||||. ||||||  |.|||. .| ..|.|.   | .  . .  ||.||||||. |  .||  . .| || | 
DWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRAC

VNTSRVLRENKRILIMVLAIF
. . ...|...  .. |.  |
EVIMMCMRDHRDDIMSVWDCF
Kinase 81676.m00083.AA ATM 2024-2139 40 5.2e-27 83.01 In-house 133-247 (304) Show / Hide 
Range on Protein: 2024-2139
Range on HMM: 133-247/304
Sequence Identity: 40% (47 aa)

WHKRTVTFSISAALTSMVGYVFGLGDRHPSNLLIDRFTGKLIHIDFGDCFERAAKRKFLPEVVPFRLTRMMCKAMGVTGPDGTFRDAFVNTSRVLRENKR
|  . . .  | |  |.|||. ||||||  |.||      |.||| |  ||   |    || ||||||| .   ||.|| .| ||     |  |.|  . 
WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQ-GKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE

ILIMVLAIFVHEPLVD
 |. .  . . .|| |
TLLTIVEVLLYDPLFD
Kinase 81676.m00083.AA FATC 2204-2236 63 8.8e-21 69.61 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2204-2236
Range on HMM: 1-33/33
Sequence Identity: 63% (21 aa)

EALSVEDQATKLIKIATDPYNLAKMYSGWCPFW
| ||||.|. .||. ||||.||..||.||||.|
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 81676.m00083.AA DNAPK 2042-2142 30 6.5e-19 65.33 In-house 201-301 (301) Show / Hide 
Range on Protein: 2042-2142
Range on HMM: 201-301/301
Sequence Identity: 30% (31 aa)

GYVFGLGDRHPSNLLIDRFTGKLIHIDFGDCFERAAKRKFLPEVVPFRLTRMMCKAMGVTGPDGTFRDAFVNTSRVLRENKRILIMVLAIFVHEPLVDPK
... | ||||  | ..   .|  | ||||  |  |      ||  ||||||     |   .  | ..   .   . .|  . ||.    .|. .|..| |
HWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWK

E
 
N
Kinase 81676.m00083.AA SMG1 1997-2084 39 3.4e-16 50.01 In-house 156-242 (242) Show / Hide 
Range on Protein: 1997-2084
Range on HMM: 156-242/242
Sequence Identity: 39% (35 aa)

VISKVMNIVPDTDIANFFYLKANTAEQWHKRTVTFSISAALTSMVGYVFGLGDRHPSNLLIDRFTGKLIHIDFGDCFERAAKRKFLPE
|.  .|   |   .|   .    | . | . |  .  | |  |||||. ||||||  | |||  ||  .|||.  |||.  | .  ||
VLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLN-VPE
Kinase 81676.m00083.AA SMG1 1872-1952 43 1.9e-15 47.53 In-house 1-83 (242) Show / Hide 
Range on Protein: 1872-1952
Range on HMM: 1-83/242
Sequence Identity: 43% (37 aa)

FSVYMSKQQPKDVVIRGEDGNFYQYLVKGHEDLRLDERIMQFFRLINNFL----KRETC-FGAQVIQTMSVIPLSITNGLVQWVTG
  .   | .|| ..  | ||  | || || ||| ||||||||  ..|       . ||  | |      || ||    ||.||| |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARH---YSVTPLGTRSGLIQWVDG
Kinase 81676.m00083.AA ATR 1864-1962 33 2.5e-15 48.27 In-house 2-102 (267) Show / Hide 
Range on Protein: 1864-1962
Range on HMM: 2-102/267
Sequence Identity: 33% (34 aa)

RIQYFVGQFSVYMSKQQPKDVVIRGEDGNFYQYLVKGHEDLRLDERIMQFFRLINNFLKR--ETCFGAQVIQTMSVIPLSITNGLVQWVTGTDTLRSVVE
 |  |     .  | |.|| . ..| || ||  . | ..||| | | |.|  |||  ...  |   .   ..| .||||    ... ||  | |||....
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD

Q
.
K
Kinase 81676.m00083.AA DNAPK 1863-1957 35 2.9e-15 51.86 In-house 2-98 (301) Show / Hide 
Range on Protein: 1863-1957
Range on HMM: 2-98/301
Sequence Identity: 35% (34 aa)

IRIQYFVGQFSVYMSKQQPKDVVIRGEDGNFYQYLVKGHEDLRLDERIMQFFRLINNFLKRETCFGAQVIQ--TMSVIPLSITNGLVQWVTGTDTLR
.||  |     |  |   || ..||| |     ...|| ||||.| || | |   || .        .  |  | ..||.    ||. ||  | .|.
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLK
Kinase 81676.m00083.AA ATM 1895-1953 42 8.1e-10 27.14 In-house 1-61 (304) Show / Hide 
Range on Protein: 1895-1953
Range on HMM: 1-61/304
Sequence Identity: 42% (26 aa)

QYLVKGHEDLRLDERIMQFFRLINNFLKR--ETCFGAQVIQTMSVIPLSITNGLVQWVTGT
  |||| .||| |  . | | . |  |.|  ||      | |  |.|||   | . | |||
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGT