Gene 88546.m00256 (T.vaginalis)
88546.m00256
Species: T.vaginalis
Alias: TvagK0816, 88546.m00256
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 88546.m00256.AA | Protein | None | 802 | None | Fasta, JSON |
| 88546.m00256.kin_dom | Protein Kinase Domain | None | 245 | None | Fasta, JSON |
Protein domains of 88546.m00256.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PI3Ka | 88546.m00256.AA | PI3Ka | 286-463 | 20 | 1.1e-08 | 26.35 | SMART | 1-232 (232) | Show / Hide |
Range on Protein: 286-463
Range on HMM: 1-232/232
Sequence Identity: 20% (48 aa)
SSSFKD---PKATKQLEKIKSYGPFAELQPMDVNCLHNNMRECF-KDQALMP-----ALFRAIKWENEDERAKIEKKLIDR--ETIDVEYALEFFTDLYN
. .|. .. .||| | .| | || . . . ... . .| ..|...|...|| .. . . . ||.| |||.. ..
DYDLKPRWNEEERDQLEDIMKYPPTYELTEEEKDLIWKFRHYYLTNHPKALPSMCFPKFLRCVNWSWADEVKQAYQLMHQWWWPPIDPEDALELLDPKFP
I---KCVRQFAVRSCRKMSHQQILLYLPQILQATKCQ---------------------------YTEG-LDDILVFHALEDPIFASYLYWNAQVEK----
|||.||.. ..|| ..|.||.|. || | | .. | . |. ||..| .....||. ..|
DYNCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNPRIGHFFYWYLKSEMYDHC
--------TAFASLLQKLTTQITGEVKQQLED
|..||. . ...|. .. | .
QLHDPHYCQRFGMLLEMYCRGCCGHHMRHLFK
|
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| PI3Ka | 88546.m00256.AA | PI3Ka | 333-406 | 30 | 9.3e-07 | 24.79 | Pfam | 56-135 (211) | Show / Hide |
Range on Protein: 333-406 Range on HMM: 56-135/211 Sequence Identity: 30% (24 aa) PALFR-AIKWENEDERAKIEKKLID--RETIDVEYALEFFTDLYNI--KCVRQFAVRSCRK-MSHQQILLYLPQILQATK | ... .|| ..|..|. . . ..||.. ||| . . |||.||.. .. || .|.||.|. ||.| PKFLQLCVKWHDYDQVAQAYQLMDCRVWPPIDPCDALELLDCNFPDNCPMVRQYAVKCLESYMSDDELLCYLLQLVQALK |
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| Kinase | 88546.m00256.AA | PI3Kc | 550-794 | 20 | 9.6e-41 | 142.59 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 550-794
Range on HMM: 1-336/336
Sequence Identity: 20% (68 aa)
RVIFKIGDDMRQDQLILQLFEVMDHIFKSA----SMQLNITAYMTLAFSETFGCCQFIENSRAILDIAK-------------------------------
.|||| |||.|||....|.|..|..| .. . | .. | .. .. | ... |. . | |
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
-----------------------------------DGMNILQFLANPDG-IVDKSKIDIFTESLAAYSVMTYVLKIGDRHDNNILVT-KDGRLLHIDYGF
. .. .|| .. . .| || |.|.|...||.| ||||| .||... |.| ..|||.|.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
ILGDVTKPFTP--------PLKLSKEMIETIG-----ANGMQKLCDWACPAFNSLRKRARLILVLIELMFTAPL-ECFQNNPKRRLQQVENCLLLK-CTE
|.| |.... | .| ..|.. .| . .. . .| |.. .|| . ||. |.|.| .|. |.. . . ....... . | ..
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-EKDIKYLRQRFRLDHLSD
IEASNSLQA----TFAQSL-NSKMQVFWDAVHTVAVS
||.. .. . ... .|. . . |..|
EEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| Kinase | 88546.m00256.AA | PI3_PI4_kinase | 638-743 | 24 | 1.9e-25 | 95.66 | Pfam | 167-300 (300) | Show / Hide |
Range on Protein: 638-743 Range on HMM: 167-300/300 Sequence Identity: 24% (33 aa) FTESLAAYSVMTYVLKIGDRHDNNILV---TKDGRLLHIDYGFILG-----DVTKPFTPPLKLSK------EMIETI------GANGMQKLCDWACP-AF |..|.| ..|..|.| .|||| .||.| ...| | |||.|.... ||...| .. . .|.. . . |. . | |. FVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAY NSLRKRARLILVLI-------ELMFTAPLECFQN ..||. ..|.. |. |.|....| .. RALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
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| Kinase | 88546.m00256.AA | ATR | 641-734 | 26 | 4.8e-10 | 29.99 | In-house | 170-267 (267) | Show / Hide |
Range on Protein: 641-734 Range on HMM: 170-267/267 Sequence Identity: 26% (26 aa) SLAAYSVMTYVLKIGDRHDNNILVTK-DGRLLHIDYGFILGD---VTKPFTPPLKLSKEMIETIGANGMQKLCDWACPAFNSLRKRARLILVLIELMF | |..... |.. .|||| .|||. | | . |.|| | . . | . | .| . |. ..|. . . | || . . | .. . | SYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | 88546.m00256.AA | PI3_PI4_kinase | 548-588 | 20 | 1.4e-09 | 37.14 | Pfam | 1-70 (300) | Show / Hide |
Range on Protein: 548-588 Range on HMM: 1-70/300 Sequence Identity: 20% (14 aa) IYRVIFKIGDDMR--QDQLILQLF-----------------------EVMDHIFKSASMQLN----ITAY .|..||| |||.| ||....|.. ..|. . |. .. .. ...| WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPY |
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| Kinase | 88546.m00256.AA | PIKK | 638-684 | 33 | 3.4e-08 | 26.3 | In-house | 189-236 (290) | Show / Hide |
Range on Protein: 638-684 Range on HMM: 189-236/290 Sequence Identity: 33% (16 aa) FTESLAAYSVMTYVLKIGDRHDNNILVTKD-GRLLHIDYGFILGDVTK .| |.| .. |.| .|||| .||.. .. | ..|||.|.. .. .. YTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQ |
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| Kinase | 88546.m00256.AA | FRAP | 638-676 | 45 | 3.1e-07 | 22.81 | In-house | 140-179 (251) | Show / Hide |
Range on Protein: 638-676 Range on HMM: 140-179/251 Sequence Identity: 45% (18 aa) FTESLAAYSVMTYVLKIGDRHDNNILVTKD-GRLLHIDYG .| ||| |. |.| .|||| ||. . |...|||.| YTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG |
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| Kinase | 88546.m00256.AA | ATM | 638-676 | 45 | 4e-06 | 15.14 | In-house | 140-179 (304) | Show / Hide |
Range on Protein: 638-676 Range on HMM: 140-179/304 Sequence Identity: 45% (18 aa) FTESLAAYSVMTYVLKIGDRHDNNILVTKDG-RLLHIDYG .| | | |.. |.| .|||| |||. | ||| | YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG |
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| Kinase | 88546.m00256.AA | PIKK | 518-576 | 28 | 0.000897 | 10.05 | In-house | 1-58 (290) | Show / Hide |
Range on Protein: 518-576 Range on HMM: 1-58/290 Sequence Identity: 28% (17 aa) FVVGIDVTDVKVFKSKLCPVCLAFKLQKGGIYRVIFKIGDDMRQDQLILQLFEVMDHIF . ..| | | ..| | . .. | .|. .| ..| |||| ..||| .| .. RIRFMDRM-VTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCL |
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| Kinase | 88546.m00256.AA | DNAPK | 552-576 | 56 | 0.002119 | 8.02 | In-house | 36-60 (301) | Show / Hide |
Range on Protein: 552-576 Range on HMM: 36-60/301 Sequence Identity: 56% (14 aa) IFKIGDDMRQDQLILQLFEVMDHIF ..| . |.|||| | ||| || || CYKGIEDLRQDQRIEQLFQVMNNIF |
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| Kinase | 88546.m00256.AA | DNAPK | 650-680 | 43 | 0.011055 | 5.37 | In-house | 202-233 (301) | Show / Hide |
Range on Protein: 650-680 Range on HMM: 202-233/301 Sequence Identity: 43% (14 aa) YVLKIGDRHDNNILVT-KDGRLLHIDYGFILG ..| ||||| || .| | ||.|. | WILGIGDRHLNNFMVNMENGDIISIDFGHSFG |
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| Kinase | 88546.m00256.AA | ATM | 550-569 | 45 | 0.12729 | 0.49 | In-house | 1-20 (304) | Show / Hide |
Range on Protein: 550-569 Range on HMM: 1-20/304 Sequence Identity: 45% (9 aa) RVIFKIGDDMRQDQLILQLF | . | ||.||| . | | RQLVKGRDDLRQDAVMQQVF |
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| Kinase | 88546.m00256.AA | FRAP | 549-569 | 42 | 0.148875 | 1.66 | In-house | 2-22 (251) | Show / Hide |
Range on Protein: 549-569 Range on HMM: 2-22/251 Sequence Identity: 42% (9 aa) YRVIFKIGDDMRQDQLILQLF | . | .|.||| ..||| YHFLLKGHEDIRQDERVMQLF |
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