Gene 81877.m00050 (T.vaginalis)

81877.m00050

Species: T.vaginalis
Alias: TvagK0834, 81877.m00050
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK8-like

Sequence

Name Sequence Type Origin Length Description Download
81877.m00050.AA Protein None 336 None Fasta, JSON
81877.m00050.kin_dom Protein Kinase Domain None 202 None Fasta, JSON

Protein domain

Protein domains of 81877.m00050.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 81877.m00050.AA CMGC 7-307 20 5.9e-72 235.47 In-house 1-513 (513) Show / Hide 
Range on Protein: 7-307
Range on HMM: 1-513/513
Sequence Identity: 20% (105 aa)

LKSEKLVGSGTYGEAYRFID---------------EKGDAISVKKSKPIQPEKP----------IPSVIIREICLLSEPK----------------YIH-
 .  | .|.||||. |. .|               | .  . .|| |  . ..           .|. ..||| .| . .                  . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIHAQKVSIQG--------------INSNYSIHFNYEFGAIDVYKLQTKYL-------NRSPSEIV------------AKSIL------FQLLLALN--H
|.. . .                  . .......  |.   | |..  ..        ..  || .             |...      .|.| .|.  .
IVKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHSHG--IIHCDLTPSNLIIMPKAYE---------------RPGILKLIDFGLSRTAEWK--------------------NQEENT-FVVTIWYRSPELL
.|||.  |||.|| |.|. | ..                    |.||..||||.|  .                      ... .|  ||| |||.||.|
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LDDKHYT---------TAVDMWAAGCIFAELLTG--------EILFRSKAKNENSNEFCD--------VQMESILRVMGNFR---------------PSD
| .||||         |..|||..||||||..||        ..||  .  . |     |         |.. | .|.|..                . .
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPN-----DDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEE

LPQYQS-------------------------NFLIP---FQQLNYRPFQSTFDM------------KFSN--------------------IDQTAKDLLR
 |.. .                         |.. .   |.. ...|... |              .| |                    .|. | ||| 
WPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVF-NWIYEEKFKSHKFNHQFKRKCCDPQAIDLLK

SMLTLNPANRISAHDALRHPYF
 ||...|..||.| .||.||||
KMLQYDPDKRITAEQALQHPYF
Kinase 81877.m00050.AA S_TKc 7-307 23 5.3e-66 226.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 7-307
Range on HMM: 1-231/231
Sequence Identity: 23% (75 aa)

LKSEKLVGSGTYGEAYRFIDEK-GDAISVKKSKPIQPEKPIPSVIIREICLLSEPKYIHIIHAQKVSIQGINSNYSIHFNYEFGAIDVYKLQTKYLNRSP
 .  ...|.|..|. |. .. | |    .|. |           |.||| .|.. .  .|..   |         ....  |.   |.  | .   .| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGR

-------SEIVAKSILFQLLLALNHLHSHGIIHCDLTPSNLIIMPKAYERPGILKLIDFGLSRTAEWKNQEENTFVVTIWYRSPELLLDDKHYTT-AVDM
       .| .|.... |...||...|||||||.|| |.|. .          .|..||||.|         .||..| ||..||.|    .|.. ..|.
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDW

WAAGCIFAELLTGEILFRSKAKNENSNEFCDVQMESILRVMGNFRPSDLPQYQSNFLIPFQQLNYRPFQSTFDMKFSNIDQTAKDLLRSMLTLNPANRIS
|. |||..|.|.|. .|.              ||. .....|                                     .. |||..| .|. .|..|..
WSCGCILYEMLCGYPPFP--------------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPT

AHDALR-------HPYF
| .||.       ||.|
A-EALQDEWDIKCHPWF
Kinase 81877.m00050.AA CDK 99-307 33 5.4e-64 203.57 In-house 106-284 (284) Show / Hide 
Range on Protein: 99-307
Range on HMM: 106-284/284
Sequence Identity: 33% (73 aa)

KYLNRSPSEIVAKSILFQLLLALNHLHSHGIIHCDLTPSNLIIMPKAYERPGILKLIDFGLSRTA------EWKNQEENT-FVVTIWYRSPELLLDDKHY
||.         |....||| .|...||..|.| || |.|. |. .  . .| ||. ||||.|        . ... . |  ||| |||.||||| .|||
KYMD-------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMS-EPNRTYTHEVVTLWYRAPELLLGSKHY

T--TAVDMWAAGCIFAELLT---GEILFRSKAKNENSNEFCDVQMESILRVMGNFRPSDLPQYQSNFLIPFQQLNYRPFQSTFDMKFSNIDQTAKDLLRS
.  |..|||..||||||..|   .. ||  .            |.. | |..|   ... |   .  .                           ||| .
SGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSE--------IDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------DLLNK

MLTLNPANRISAHDALRHPYF
||...|..|||| .|| ||||
MLCYDPKKRISAEQALQHPYF
Kinase 81877.m00050.AA Pkinase 106-307 27 4.5e-51 180.79 Pfam 106-293 (293) Show / Hide 
Range on Protein: 106-307
Range on HMM: 106-293/293
Sequence Identity: 27% (57 aa)

SEIVAKSILFQLLLALNHLHSHGIIHCDLTPSNLIIMPKAYERPGILKLIDFGLSRTA-EWKNQEENTFVVTIWYRSPELLLDDKHYTTAVDMWAAGCIF
|| ..|... |.| .|...||.||||.|| |.|. |  . .. . ..|..||||.. . . .|.  .||..|.||..||.......|...||||..|||.
SEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCIL

AELLTGEILFRSK---AKNENSNEFCDVQMESILRVMGNFRPSDLPQYQSNFLIPFQQLNYRPFQSTFDMKFSNIDQTAKDLLRSMLTLNPANRISAHDA
.|.|.|. .|...    .  . ..  .  |. .|.       |  . .  ..  .           .  ..| |.....||.....|...|. |..|...
YEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRHW-H-----------F-HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI

LRHPYF
| ||.|
LQHPWF
Kinase 81877.m00050.AA MAPK 106-307 31 5.9e-47 160.33 In-house 113-328 (328) Show / Hide 
Range on Protein: 106-307
Range on HMM: 113-328/328
Sequence Identity: 31% (72 aa)

SEIVAKSILFQLLLA--LNHLHSHGIIHCDLTPSNLIIMPKAYERPGILKLIDFGLSRTAEWK---NQEENTF-----------VVTIWYRSPELLLDD-
|..  .....|.| .  | ..|| ..||.|| |||. .        . ||. ||||.|... .   .......           |.| |||.||..|   
SDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNEN-----CDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWI

-KHYTTAVDMWAAGCIFAELLT-GEILFRSKAKNENSNEFCDVQMESILRVMGNFRPSDLPQYQ-S----NFLIPF---QQLNYRPFQSTFDM-KFSNID
 .|||.|||||..||||||.|| . .||.   |.         |.. |. |.|.  . .. . . |    |..  .   .. . .|... |    | | .
WMHYTKAVDMWSVGCIFAEMLTDRKPLFP--GKDYID------QWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF-NAN

QTAKDLLRSMLTLNPANRISAHDALRHPYF
  | |||  ||...|  ||.. .||.||||
PQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 81877.m00050.AA ERK7 107-307 32 7.6e-41 137.24 In-house 99-292 (292) Show / Hide 
Range on Protein: 107-307
Range on HMM: 99-292/292
Sequence Identity: 32% (67 aa)

EIVAKSILFQLLLALNHLHSHGIIHCDLTPSNLIIMPKAYERPGILKLIDFGLSRTAEWKN--QEENT----FVVTIWYRSPELLLDDKHYTTAVDMWAA
.|  ..|..||| |. ..||  .|| || |||. .  .       .|. |||| |.   ..  .|.|     .| | |||.|| ||  ..|| .||||  
DIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSEC-----MVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSI

GCIFAELLTGEILFRSKAKNENSNEFCDVQMESILRVMGNFRPSDLPQYQSNFLIPFQQLNYRPFQSTFDMKFSNIDQTAKDLLRSMLTLNPANRISAHD
||| .|.|.|  .|      .        |.| ||.....    |.   .|.. .   . . .  . |.|  . .  . | |||. .| .|| .|..| .
GCILGEMLRGKPMFPGTSTMN--------QIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQ

ALRHPYF
||.||| 
ALQHPYV
Kinase 81877.m00050.AA CDC2 7-214 33 1.3e-40 122.18 In-house 2-209 (301) Show / Hide 
Range on Protein: 7-214
Range on HMM: 2-209/301
Sequence Identity: 33% (74 aa)

LKSEKLVGSGTYGEAYRFID-EKGDAISVKKSKPIQPEKP--IPSVIIREICLLSEPK-YIHIIHAQKVSIQGINSNYSIHFNYEFGAIDVYKLQTKYLN
 | ||. | ||||. |. .| . .. . .|| .  | .    .|| .||||..| | |    |.  . | .|     ...    |.   |  |.. ... 
QKIEKI-GEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-----NKLYMVFEYLDMDLKKYMDMSIP

--RSPSEIVAKSILFQLLLALNHLHSHGIIHCDLTPSNLIIMPKAYERPGILKLIDFGLSRTAEWKNQEENTF--VVTIWYRSPELLLDDKHYTTAVDMW
   . .... ||...|.| .....|...|.| || |.|. |  |.      .|. ||||.|.      .. |   ||| |||.||.|| .|.|.|.||||
KNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-----IKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMW

AAGCIFAEL---LTGEILF
. ||||||.    | . ||
SIGCIFAEMFMDVTKKPLF
Kinase 81877.m00050.AA CDK8 111-239 40 1.3e-40 124.67 In-house 118-253 (329) Show / Hide 
Range on Protein: 111-239
Range on HMM: 118-253/329
Sequence Identity: 40% (56 aa)

KSILFQLLLALNHLHSHGIIHCDLTPSNLIIMPKAYE--RPGILKLIDFGLSR--TAEWKNQEENT-FVVTIWYRSPELLLDDKHYTTAVDMWAAGCIFA
|||..|.|     |||  ..| || |.| ..|    |  . |  |  |.|..|   .  |   ..   |||.|||.|||||  .||| |.| || |||||
KSIMWQILDGIHYLHSNWVLHRDLKPANIMVMGDGPEDMC-GCVKIADMGFARIFHNPLKPLYDLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFA

ELLTGEILFRSKAK---NENSNEFCDVQMESILRVMG
||.| | .|  | .      .| . . |.. |..|||
ELITSEPIFHCKEEKLDIKTQNPYHHDQLDRIFHVMG
Kinase 81877.m00050.AA CDK4 98-307 36 1e-39 133.84 In-house 96-290 (290) Show / Hide 
Range on Protein: 98-307
Range on HMM: 96-290/290
Sequence Identity: 36% (79 aa)

TKYLNRSPS----EIVAKSILFQLLLALNHLHSHGIIHCDLTPSNLIIMPKAYERPGILKLIDFGLSRTAEWKNQEENT-FVVTIWYRSPELLLDDKHYT
. || . |     .  .| . .||| ..  |||| ||| || | |. .      . | .|| ||||.|.    .|   |  |||.|||.|| ||    | 
HTYLDKCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVT-----SDGHVKLADFGLARI--YSFQMALTPVVVTLWYRAPEVLL-QSYYN

TAVDMWAAGCIFAELLTGEILFRSKAKNENSNEFCDVQMESILRVMGNFRPSDLPQYQSNFLIPFQQLNYRPFQSTFDMKFSNIDQTAKDLLRSMLTLNP
| ||||..||||||.     ||. .   .        | . |. |||     | |.  |  .  |.|   |||..        ... ..|||  ||. |.
TPVDMWSVGCIFAEMYCRRPLFCGQSEKD--------QLHKIFDVMGLPPEDDWPRDVSLPWDHFPQRHPRPFKDFCP----HMCKQGDDLLQKMLCYNH

ANRISAHDALRHPYF
. |.||  .| ||||
HKRMSAYQCLQHPYF
Kinase 81877.m00050.AA PITSLRE 111-214 49 2.1e-35 123.96 In-house 109-207 (295) Show / Hide 
Range on Protein: 111-214
Range on HMM: 109-207/295
Sequence Identity: 49% (52 aa)

KSILFQLLLALNHLHSHGIIHCDLTPSNLIIMPKAYERPGILKLIDFGLSRTAEWKNQ-EENT-FVVTIWYRSPELLLDDKHYTTAVDMWAAGCIFAELL
|. . |||..  |.|.. |.| ||  ||| .  |     ||||. |||| |  |.    .  |  ||| |||.|||||. | |.|.||||  ||||||..
KCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHK-----GILKICDFGLAR--EYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEFI

TGEILF
|.. ||
TMKPLF
Kinase 81877.m00050.AA CDKL 109-214 39 2.5e-35 118.21 In-house 99-200 (286) Show / Hide 
Range on Protein: 109-214
Range on HMM: 99-200/286
Sequence Identity: 39% (42 aa)

VAKSILFQLLLALNHLHSHGIIHCDLTPSNLIIMPKAYERPGILKLIDFGLSRTAEWKNQEENTFVVTIWYRSPELLLDDKHYTTAVDMWAAGCIFAELL
| .....|.| |.|..|.| .|| |  | |. | || .    ..|| |||. |. . ..      | | |||.||||..|  | ..||.||.||..||..
VVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNG----QVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMI

TGEILF
.|. |.
DGQPLW
Kinase 81877.m00050.AA CDK5 8-214 37 7e-35 107.3 In-house 3-200 (287) Show / Hide 
Range on Protein: 8-214
Range on HMM: 3-200/287
Sequence Identity: 37% (79 aa)

KSEKLVGSGTYGEAYRFIDEKGDAISVKKSKPIQPE-KPIPSVIIREICLLSEPKYIHIIHAQKVSIQGINSNYSIHFNYEFGAIDVYKLQTKYLNRSPS
| ||. | ||||  |.  . .   |   |   .  |   .||  ||||||| | |   |.    |    | |.  .   .||   |  |   .      .
KMEKI-GEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDV----IHSEKKLTLVFEFCDQDLKKYMDSCNG-EMD

EIVAKSILFQLLLALNHLHSHGIIHCDLTPSNLIIMPKAYERPGILKLIDFGLSRTAEWKNQEENTFVVTIWYRSPELLLDDKHYTTAVDMWAAGCIFAE
  ..||...|||  |   |.| . | || | || |      . |.||| |||| |      .     ||| ||| |  |.  |||.| .||| .||||||
MHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLI-----NKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAE

LL-TGEILF
.  .|  ||
MANAGRPLF
Kinase 81877.m00050.AA CDC2 274-307 52 1.3e-16 47.03 In-house 268-301 (301) Show / Hide 
Range on Protein: 274-307
Range on HMM: 268-301/301
Sequence Identity: 52% (18 aa)

SNIDQTAKDLLRSMLTLNPANRISAHDALRHPYF
| .|... |||..|| ..|..|||| .||.||||
SCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase 81877.m00050.AA CDK5 244-307 39 6e-15 43.19 In-house 228-287 (287) Show / Hide 
Range on Protein: 244-307
Range on HMM: 228-287/287
Sequence Identity: 39% (25 aa)

SDLPQYQSNFLIPFQQLNYRPFQSTFDMKFSNIDQTAKDLLRSMLTLNPANRISAHDALRHPYF
..||.|. |     ||.  .| . ..     . |..  |||  || .||. |||| .||.||||
TKLPDYKPN----HQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 81877.m00050.AA PITSLRE 272-307 53 3.2e-14 48.35 In-house 257-295 (295) Show / Hide 
Range on Protein: 272-307
Range on HMM: 257-295/295
Sequence Identity: 53% (21 aa)

KFS---NIDQTAKDLLRSMLTLNPANRISAHDALRHPYF
.|     | .|. |||  |||.||.|||.| ||| ||.|
RFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase 81877.m00050.AA CDKL 272-307 27 1.1e-10 32.78 In-house 250-286 (286) Show / Hide 
Range on Protein: 272-307
Range on HMM: 250-286/286
Sequence Identity: 27% (10 aa)

KFSNID-QTAKDLLRSMLTLNPANRISAHDALRHPYF
...|.  ..| |.....| ..|. |... ....||||
RYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 81877.m00050.AA CDK8 277-307 48 6.3e-09 23.58 In-house 299-329 (329) Show / Hide 
Range on Protein: 277-307
Range on HMM: 299-329/329
Sequence Identity: 48% (15 aa)

DQTAKDLLRSMLTLNPANRISAHDALRHPYF
|  | .||  |||  |  ||.. .|. ||||
DSHAYHLLYKMLTMDPTKRITCEQAMEHPYF
Kinase 81877.m00050.AA TyrKc 7-307 15 2.4e-05 -136.09 SMART 1-280 (280) Show / Hide 
Range on Protein: 7-307
Range on HMM: 1-280/280
Sequence Identity: 15% (51 aa)

LKSEKLVGSGTYGEAYR-FIDEKGDAISVKKSKPIQPEKPIPSVIIREICLLSEP--KYIHIIHAQKVSIQG-----INSNYSIHFNY-EFGAIDVYKLQ
.. .|  |.| .|| |.   .       ||. |.          ..||. ....   .  .|.    | .|.         . | . | . |. . |   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

TKYLNRSPSEIVAKSILFQLLLALNHLHSHGIIHCDLTPSNLIIMPKAYERPGILKLIDFGLSRTAEWK-----NQEENT--------FVVTIWYRSPEL
..      .     |. .|     ..|||...|| ||   |  .  .      . |  ||||||  . .     ...  .        ... |   .|| 
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

LLDDKHYTTAVDMWAAGCIFAELLTGEILFRSK-AKNENSNEFCDVQMESILRVMGNFRPSDLPQY----QSNFLIPFQQLNYRPFQSTFDMKFSNIDQT
. ... .||. | |. |    |..|      .  ...       ..  . ...   . .  . |..                           |    . 
I-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-------MMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------FVCCPDE

AKDLLRSMLTLNPANRISAHDALRHPYF
  .. ..    .|..| .  .   | .|
MYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 81877.m00050.AA CDK8 11-22 58 0.006401 4.4 In-house 1-12 (329) Show / Hide 
Range on Protein: 11-22
Range on HMM: 1-12/329
Sequence Identity: 58% (7 aa)

KLVGSGTYGEAY
| .|.||||  |
KYIGRGTYGHVY
Kinase 81877.m00050.AA Pkinase 7-23 29 4.995227 1.18 Pfam 1-17 (293) Show / Hide 
Range on Protein: 7-23
Range on HMM: 1-17/293
Sequence Identity: 29% (5 aa)

LKSEKLVGSGTYGEAYR
.. .. .|||..|. |.
YHIGRKIGSGSFGCVYK