Gene 92757.m00247 (T.vaginalis)

92757.m00247

Species: T.vaginalis
Alias: TvagK0634, 92757.m00247
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
92757.m00247.AA Protein None 2255 None Fasta, JSON
92757.m00247.kin_dom Protein Kinase Domain None 249 None Fasta, JSON

Protein domain

Protein domains of 92757.m00247.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FAT 92757.m00247.AA FAT 1565-1657 17 0.000608 13.43 Pfam 298-408 (408) Show / Hide 
Range on Protein: 1565-1657
Range on HMM: 298-408/408
Sequence Identity: 17% (20 aa)

A-KLYMLKAKWKIWL-----IKGDSPEVMHEVRNLLSEAIKYRPMHYM-TNNMWAWSNMKLASLVK-----------EERVDRAIDAIIAFAHCVLISPK
| . | ....| . |      .   .|   |. .  ..|... |..|    ..||  |... .. .           ... . .. |.  | |..  | .
AMRCYHKQGMWQWKLYEEQYMN-WNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCFFHSIALSQG

-NCFADLLQLSS
 |.. |.| | .
SNSRQDTLRLLW
Kinase 92757.m00247.AA PIKK 1902-2166 37 6.7e-99 334.88 In-house 1-290 (290) Show / Hide 
Range on Protein: 1902-2166
Range on HMM: 1-290/290
Sequence Identity: 37% (109 aa)

TILRFGRELNILNSKRRPRQLKIVGSDHVTYKFLLKGHEDLRQDQRVMQFFELVNSISHNV------HTRIAILSITPLSPRVGLIQWLPGCDTMSELID
 |  . | . .. .|..|. . | |.|   | .|.||||||||||||||.| |.| . ..       |  |   |..|.|.| |||.|...|.|  |...
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

DYRSISSIKINVESKM-------------------LEEYTIPDYDSLQPIQRYEYLIEVDKNTSPDDLKNIMWLKAPDAEAWVNHTSHFSRSTALMSIVG
....   |. . |. |                   ...   ..|...   ...| . |.  || ||..|.. |.|.||.|.|   .... ||.|.|..||
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YIIGLGDRHPSNIMIQRYSGSVIHIDFGDCFEVTAKRAQLAETIPFRLTRMIVKALGQCGVNGSFRRVCQDTLQTLRGNREAVMAVLEIF
||.|||||||.||||....| ..|||||.|||.  .|    |..||||||..| |.| .||.| ||| | ...  .| .|| .|.|.| |
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 92757.m00247.AA FRAP 1932-2176 48 1.6e-97 330.3 In-house 2-251 (251) Show / Hide 
Range on Protein: 1932-2176
Range on HMM: 2-251/251
Sequence Identity: 48% (121 aa)

YKFLLKGHEDLRQDQRVMQFFELVNSISHNVHT------RIAILSITPLSPRVGLIQWLPGCDTMSELIDDYRSISSIKINVESKMLEEYTIPDYDSLQP
| ||||||||.||| |||| | |.| . ||  .       |   || ||| . ||| | . |||.  || |||    |. |.| .....  ..||| |  
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDR-MCNDYDHLPL

IQRYEYLIEVDKNTSPDDLKNIMWLKAPDAEAWVNHTSHFSRSTALMSIVGYIIGLGDRHPSNIMIQRYSGSVIHIDFGDCFEVTAKRAQLAETIPFRLT
... |    . .||  .||| ..||| |  | | .    . || | ||..|||.|||||||||||.|||.| ..||||||||||  .| .. | ||||||
MNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLT

RMIVKALGQCGVNGSFRRVCQDTLQTLRGNREAVMAVLEIFFREPLSSGRL
||.| |.  ||..| .| .|.  .. .| ..| |||||| |   ||   ||
RMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase 92757.m00247.AA PI3_PI4_kinase 1931-2176 27 1.3e-66 232.43 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1931-2176
Range on HMM: 1-300/300
Sequence Identity: 27% (83 aa)

TYKFLLKGHEDLR--QDQRVMQFF-----------------------ELVNSI--SHNVHTR----IAILSITPLSPRVGLIQWLPGCDTMSELIDDYRS
.|.|..||..|||  ||.|.||..                       .|.| .  ....  |    ... .. |..|. |.|.|.| |.|..|... |. 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

ISSIKINVESKMLEEYTIPDYDSLQPIQRYEYLIEVDKNTSPDDLKNIMWLKAPDA-EAWVNHTSHFSRSTALMSIVGYIIGLGDRHPSNIMI--QRYSG
  ..|..  ... .    ||...|  .|. |.  .. ..| ...| .  | . ||| |.| .  ..| || | |..|.||.|.||||..|||.   . .|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

SVIHIDFGDCFE-VTAKRAQLAETIPFRLTR------MIVKAL------GQCGVNGSFRRVCQDTLQTLRGNREAVMAVL-------EIFFREPLSSGRL
 ..|||||.||. .  |.    |..|||.|.      ..|.|.      .. |  | ||..| .... || . ...|..|       |.... .| . | 
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
Kinase 92757.m00247.AA PI3Kc 1933-2232 22 4.3e-56 193.6 SMART 1-336 (336) Show / Hide 
Range on Protein: 1933-2232
Range on HMM: 1-336/336
Sequence Identity: 22% (76 aa)

KFLLKGHEDLRQDQRVMQFFELVNSISHNV------HTRIAILSITPLSPRVGLIQWLPGCDTMSELIDDYRSISSIKINVE--SKMLEEYT--------
 ...|...|||||.|.||.|.|.| | ..       . .. . .. |..|. |.|.| | |.|. .. . |.   .. ....   .   . .        
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQKNMY

-----------IPDYDSLQPIQRYEYLIEVDKNTSPDDLKNIMWLKAPDA-EAWVNHTSHFSRSTALMSIVGYIIGLGDRHPSNIMIQRYSGSVIHIDFG
           ...|. .  ... .|  .. ... |..|.. .| . ||. |.|..  ..| ||.| ...|.|| |.||||..|||. . .| ..|||||
MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG

DCFEVTAKRAQLA----ETIPFRLTRMIVKALG----QCGVNGSFRRVCQDTLQTLRGNREAVMAVLEIFFREPL-SSGRLF-ESKEMNENIVAGSLNNN
..|.   |.        |. |||||...| . |    . |. | ||. |  ... .| .....|...|.. . |.  . | . ..... ..    .    
HIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDH---

MDSLSRKNLAEIMTR-----ISDKVRGTDNNNTVPMTVHEQVD
   || .. |. ...     .  . ... .. .. |  . .  
---LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 92757.m00247.AA ATR 2053-2166 36 7.8e-36 119.3 In-house 155-267 (267) Show / Hide 
Range on Protein: 2053-2166
Range on HMM: 155-267/267
Sequence Identity: 36% (42 aa)

PDAEAWVNHTSHFSRSTALMSIVGYIIGLGDRHPSNIMIQRYSGSVIHIDFGDCFEVTAKRAQLAETIPFRLTRMIVKALGQCGVNGSFRRVCQDTLQTL
||.. |    . . ||.| ...|||||||||||  ||.|..  | ..|.|.  |     .. .  |..|||||. .| ..|  . .| ||| |..... .
PDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDY-NCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCM

RGNREAVMAVLEIF
| .|. .|.|.. |
RDHRDDIMSVWDCF
Kinase 92757.m00247.AA ATM 2054-2171 44 2.6e-32 100.27 In-house 129-245 (304) Show / Hide 
Range on Protein: 2054-2171
Range on HMM: 129-245/304
Sequence Identity: 44% (52 aa)

DAEAWVNHTSHFSRSTALMSIVGYIIGLGDRHPSNIMIQRYSGSVIHIDFGDCFEVTAKRAQLAETIPFRLTRMIVKALGQCGVNGSFRRVCQDTLQTLR
|   |      . || |  ||||||.||||||  ||.|   |  ..||| |  ||   |     ||.|||||| ||  .|  || | ||| |  |.  .|
DPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFE-QGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMR

GNREAVMAVLEIFFREPL
   | .. . |.   .||
NSQETLLTIVEVLLYDPL
Kinase 92757.m00247.AA SMG1 2032-2118 42 1.1e-17 55.08 In-house 157-242 (242) Show / Hide 
Range on Protein: 2032-2118
Range on HMM: 157-242/242
Sequence Identity: 42% (37 aa)

LIEVDKNTSPDDLKNIMWLKAPDAEAWVNHTSHFSRSTALMSIVGYIIGLGDRHPSNIMIQRYSGSVIHIDFGDCFEVTAKRAQLAE
| |.   | |. |   .|      . |   |  . |||| ||.|||||||||||  |..|    | |.|||.  |||   |  .  |
LEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFE-KGKKLNVPE
Kinase 92757.m00247.AA FATC 2223-2255 45 1.2e-15 53.11 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2223-2255
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

VPMTVHEQVDWLIKSARDMYNLSCLFRGWNPLW
.|..|..||| ||..| | .||. .. || | |
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 92757.m00247.AA SMG1 1910-1986 41 2.3e-15 47.19 In-house 1-83 (242) Show / Hide 
Range on Protein: 1910-1986
Range on HMM: 1-83/242
Sequence Identity: 41% (35 aa)

LNILNSKRRPRQLKIVGSDHVTYKFLLKGHEDLRQDQRVMQFFELVNSISHNV--------HTRIAILSITPLSPRVGLIQWLPG
. ||  | .|..|  .|||   | .| || |||  | |.|||  .|| .   .        | |    |.|||  | |||||  |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHAR--HYSVTPLGTRSGLIQWVDG
Kinase 92757.m00247.AA DNAPK 2056-2171 29 2.9e-15 51.82 In-house 181-296 (301) Show / Hide 
Range on Protein: 2056-2171
Range on HMM: 181-296/301
Sequence Identity: 29% (34 aa)

EAWVNHTSHFSRSTALMSIVGYIIGLGDRHPSNIMIQRYSGSVIHIDFGDCFEVTAKRAQLAETIPFRLTRMIVKALGQCGVNGSFRRVCQDTLQTLRGN
|..    .|| |. |.  | ..| | ||||  | |.    | .| ||||  |          |  ||||||  .  .   ..|| .. .    .  .|  
ETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKD

REAVMAVLEIFFREPL
|   .   ..| ..|.
RNILTNFCDVFINDPS
Kinase 92757.m00247.AA DNAPK 1901-1958 41 5.1e-12 39.85 In-house 2-59 (301) Show / Hide 
Range on Protein: 1901-1958
Range on HMM: 2-59/301
Sequence Identity: 41% (24 aa)

TTILRFGRELNILNSKRRPRQLKIVGSDHVTYKFLLKGHEDLRQDQRVMQFFELVNSI
  |  |     .. | |||. . | | |     |. || ||||||||. | |   | |
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNI
Kinase 92757.m00247.AA ATR 1901-1958 36 7.8e-08 22.32 In-house 1-58 (267) Show / Hide 
Range on Protein: 1901-1958
Range on HMM: 1-58/267
Sequence Identity: 36% (21 aa)

TTILRFGRELNILNSKRRPRQLKIVGSDHVTYKFLLKGHEDLRQDQRVMQFFELVNSI
. |  |   ..|| | ..|... . |||   |  . | ..|||.| | |.| ||.| .
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFC
Kinase 92757.m00247.AA ATM 1933-1986 36 1.1e-05 13.73 In-house 1-60 (304) Show / Hide 
Range on Protein: 1933-1986
Range on HMM: 1-60/304
Sequence Identity: 36% (22 aa)

KFLLKGHEDLRQDQRVMQFFELVNS-ISHNVHTR-----IAILSITPLSPRVGLIQWLPG
. | || .|||||  . | | . |  .  |  ||     |    . ||| | | . |  |
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTG