Gene 93865.m00187 (T.vaginalis)

93865.m00187

Species: T.vaginalis
Alias: TvagK1026, 93865.m00187
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Unique

Sequence

Name Sequence Type Origin Length Description Download
93865.m00187.AA Protein None 957 None Fasta, JSON
93865.m00187.kin_dom Protein Kinase Domain None 164 None Fasta, JSON

Protein domain

Protein domains of 93865.m00187.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 93865.m00187.AA TKL-Unique 339-426 30 4e-20 67.79 In-house 192-290 (290) Show / Hide 
Range on Protein: 339-426
Range on HMM: 192-290/290
Sequence Identity: 30% (30 aa)

YSAPETIYEP-IFFNEKVDVYSFTIILHEILTNKK------PFSEVDSYSLRQRIML--QDRRPLVPNQLP--LTKILYKGWSRNPNYRPSFDDLVNMM
..||| .  .   ..||.||||| |.| ||.|.|       |....|...... .       || .|| .|  ..... ..| ..|  |||||. ..  
WMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 93865.m00187.AA TKL 281-426 18 7.6e-20 68.15 In-house 137-364 (364) Show / Hide 
Range on Protein: 281-426
Range on HMM: 137-364/364
Sequence Identity: 18% (42 aa)

IILEVARAFQYMHAHR--------FVHCRFTPDCILVRPNGL--------------PLITGLDYVQRTSSKLS-------------------VSIPFC--
..|..||. .|.|...         .|.  ... |||  |.               . |. .   .. | . .                    ... |  
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

-VYSAPETIYEPIFFNEKV---------------DVYSFTIILHEILTNKKPFSEVDSYSLR---------QRIMLQDRRPLVP------------NQLP
  . ||| . . ....|||               ||||| |.| |||| ..|... ....             . .  .||..|            .. |
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCP

--LTKILYKGWSRNPNYRPSFDDLVNMM
  . |.. . |. .|. ||||....  .
PSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 93865.m00187.AA LRRK 338-428 27 3.3e-16 53.84 In-house 244-351 (351) Show / Hide 
Range on Protein: 338-428
Range on HMM: 244-351/351
Sequence Identity: 27% (30 aa)

VYSAPETIYEP--IFFNEKVDVYSFTIILHEILTNK-KPFSE---VDSYSLRQRIML---QDRRPLVP-N-QLP------LTKILYKGWSRNPNYRPSFD
.. |||.. .   . ..||||.||| .||.|.|| .  || |   .| .... .| .     .|| .| . ..|      . . . . |. .|. ||.| 
GWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFS

DLVNMMVK
. |  .  
QIVKRLSQ
Kinase 93865.m00187.AA Shk 351-433 37 8.2e-16 53.35 In-house 183-269 (269) Show / Hide 
Range on Protein: 351-433
Range on HMM: 183-269/269
Sequence Identity: 37% (33 aa)

FNEKVDVYSFTIILHEILTNKKPFS-EVDSY-SLRQRIMLQDRRPLVPNQLP--LTKILYKGWSRNPNYRPSFDDLVNMMVKNEFII
.|||.||||| ||| |||| . |.. . ..|  ..  |     ||  |.  |  | . . | |  ||. ||||   .   . |. .|
YNEKADVYSFGIILWEILTCQEPYPKHHSEYDKFYEAICNKKERPPIPDDCPKSLKHLIQKCWDHNPQRRPSFNEIIQRRILNHILI
Kinase 93865.m00187.AA HH498 353-426 23 5.7e-14 40.29 In-house 205-284 (284) Show / Hide 
Range on Protein: 353-426
Range on HMM: 205-284/284
Sequence Identity: 23% (19 aa)

EKVDVYSFTIILHEILTNKKPFSEVDSYSLRQRIMLQDRRPLVPNQ------LPLTKILYKGWSRNPNYRPSFDDLVNMM
.||||.|. ... |..| . ||.          .  .  || .|..       .   ..  .|. .|. ||.||. | ..
IKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase 93865.m00187.AA TAK1 352-425 26 1.7e-13 41.87 In-house 203-284 (284) Show / Hide 
Range on Protein: 352-425
Range on HMM: 203-284/284
Sequence Identity: 26% (22 aa)

NEKVDVYSFTIILHEILTNKKPFSEVDS----YSLRQRIMLQDRRPLVPN----QLPLTKILYKGWSRNPNYRPSFDDLVNM
|.| |.||. ||. |... |.|... ..    | .   |    |.|.  |      .. .   . |. ||  |||  . |  
NMKCDIYSWGIIMWEVISRKHPYDHIMNPNSAYRIMWAIHNGNRPPMETNRSDCPKRIEQFMKCCWDDNPEKRPSMQECVKY
Kinase 93865.m00187.AA RIPK 351-426 27 5.1e-13 40.67 In-house 205-290 (290) Show / Hide 
Range on Protein: 351-426
Range on HMM: 205-290/290
Sequence Identity: 27% (24 aa)

FNEKVDVYSFTIILHEILTNKKPFSEVDSYSLRQRIMLQDRRPL---VPNQLP-------LTKILYKGWSRNPNYRPSFDDLVNMM
...| ||||| |.. |.||.|.|....  .  .     |. ||    || . |       . . . ..|. .|| ||.| .     
VTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase 93865.m00187.AA Dicty4 351-430 30 5.5e-13 39.81 In-house 194-277 (277) Show / Hide 
Range on Protein: 351-430
Range on HMM: 194-277/277
Sequence Identity: 30% (26 aa)

FNEKVDVYSFTIILHEILTNKKPFS-EVDSY-SLRQRIMLQDRRPLVPNQLP--LTKILYKGWSRNPNYRPSFDDLVNMMVKNE
.|||.||||| |.| |||| . |.. . ..|  ..  .     || .|.. |  ... . . |. .|. ||||   ..  . ..
YNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase 93865.m00187.AA MLK 341-426 29 7.2e-13 41.09 In-house 201-291 (291) Show / Hide 
Range on Protein: 341-426
Range on HMM: 201-291/291
Sequence Identity: 29% (27 aa)

APETI--YEPIFFNEKVDVYSFTIILHEILTNKKPFS-EVDSYSLRQRIMLQDRRPLVPNQLP--LTKILYKGWSRNPNYRPSFDDLVNMM
||| |   .   ..||.||.|. ..| |.|| . |.. ..|.      . .   || .|.. |  . | . . |. .|. ||||.  |   
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 93865.m00187.AA TKL-ciliate2 341-427 30 3.8e-12 36.26 In-house 186-273 (273) Show / Hide 
Range on Protein: 341-427
Range on HMM: 186-273/273
Sequence Identity: 30% (27 aa)

APETIYEPIFFNEKVDVYSFTIILHEILTNKKPFSEVDSYSLRQRIMLQDRRPLVPNQLP--LTKILYKGWSRNPNYRPSFDDLVNMMV
||| | .  .. || ||.|. ||| ||     |. ..      ...| .  || .| . |  .. .. . |  | | ||||....  . 
APEVI-KAFYYTEKADVFSYSIILWEIASREPPYRNKKGDVVAEKVMCNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE
S_TKc 93865.m00187.AA S_TKc 172-433 15 5.1e-10 -29.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 172-433
Range on HMM: 1-231/231
Sequence Identity: 15% (45 aa)

YRRLQ-----------KSLDISSLTVTKIERVSAEKLIISVTEKPKNENLSLEIFPPGASDAPFQHKNSIVSHIEHPSIIKYRSALHYAPYGILSESTDF
|. |.           |  ...        |. | | |                         ..   .| ..  || |.|.  . .    . |   ...
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK----------------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEY

PS-----LTEYLYSGQT------LSPDIYSIIILEVARAFQYMHAHRFVHCRFTPDCILVRPNGLPLITGLDYVQRTSSKLSVSIPFCV---YSAPETIY
 .     | .|. . ..      ...     .. ....| .|.| |...|.   |. ||.       |.      .          ||.   | ||| . 
CDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL-

EPIFFNE-KVDVYSFTIILHEILTNKKPFSEVDSYSLRQRIMLQDRRPLVPNQLPLTKILYKGWSRNPNYRPSFDDLVN--MMVKNEFII
    ..  |.|..|. .|| | |. . ||.  . . . ..|.            ..  .. | . ..|. ||.  .. .  . .|.   .
---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 93865.m00187.AA Pkinase_Tyr 341-426 24 1.6e-08 29.51 Pfam 182-270 (270) Show / Hide 
Range on Protein: 341-426
Range on HMM: 182-270/270
Sequence Identity: 24% (22 aa)

APETIYEPIFFNEKVDVYSFTIILHEILT-NKKP-FSEVDSYSLRQRIMLQDRRPLVPN--QLPLTKILYKGWSRNPNYRPSFDDLVNMM
||| | . . |..| ||.|| . . ||.|  ..| . ... . . ..|  . .|   |     .. ... . |  .|. ||.| ......
APECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
TyrKc 93865.m00187.AA TyrKc 210-426 17 4.5e-08 -92.06 SMART 1-280 (280) Show / Hide 
Range on Protein: 210-426
Range on HMM: 1-280/280
Sequence Identity: 17% (50 aa)

LSLE-----------------------IFPPGASDAPFQHKNSIVSHI--EHPSIIKYRSALHY--------APYGILSESTDFPSLTEYL-YSGQTLSP
..|.                          ..|  . | .  .| ...  .|| |..   .            |. |. |  .  .| .|| ... .|..
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCM

DIYSIIILEVARAFQYMHAHRFVH----CRFTPDCILVRPN-------GLPLITGLD--------YVQRTSSKLSVS-IPFCVYSAPETIYEPIFFNEKV
.    . . .|.  .| | ....|    .|    | . ...       ||    . |        |   ...| . . .|     |||.|     |..| 
KDLLSFCWQIACGMEYLHSKNCIHRDLAAR---NCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR-WMAPECI-NYGKFTTKS

DVYSFTIILHEILTN-KKPFSE-----VDSYSLRQRIMLQDRRPLVPN---------QLPLTKILYKGWSRNPNYRPSFDDLVNMM
||.|| . . ||.|. ..| ..     .. . ......  .|.|  ||            . .|  . | ..|. ||.| ...  .
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 93865.m00187.AA Pkinase 339-426 19 2e-06 23.56 Pfam 177-293 (293) Show / Hide 
Range on Protein: 339-426
Range on HMM: 177-293/293
Sequence Identity: 19% (23 aa)

YSAPETIYEPIFFNEKVDVYSFTIILHEILTNKKPFSEV------DSYSLRQRIML----QDRRPLVPNQ-----------------LPLTKILYKGWSR
| ||| | .      |||..|. .||.| |. . ||..       | . . .|||      |.  . ..                   .. ..... . .
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

NPNYRPSFDDLVNM--M
.|. ||.......   .
DPKKRPTAEQILQHPWF
Kinase 93865.m00187.AA Pkinase 262-300 16 0.022598 9.47 Pfam 90-132 (293) Show / Hide 
Range on Protein: 262-300
Range on HMM: 90-132/293
Sequence Identity: 16% (7 aa)

SLTEYLY--SGQTL--SPDIYSIIILEVARAFQYMHAHRFVHC
.| .|.   .. ..  |..    ......|. .|.|.....|.
DLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHR
Kinase 93865.m00187.AA LRRK 281-300 31 0.047996 3.01 In-house 169-190 (351) Show / Hide 
Range on Protein: 281-300
Range on HMM: 169-190/351
Sequence Identity: 31% (7 aa)

IILEVARAFQYMHAHR--FVHC
| |..|.. .|.| |.  ..|.
IALQIAKGMEYLHSHNPPIIHR
Kinase 93865.m00187.AA MLK 230-295 17 0.048811 3.02 In-house 58-143 (291) Show / Hide 
Range on Protein: 230-295
Range on HMM: 58-143/291
Sequence Identity: 17% (15 aa)

IVSHIEHPS----IIKYRSALHYA-P-YGILSESTDFPSLTEYLYSGQT--------------LSPDIYSIIILEVARAFQYMHAH
..... ||     ||. . . .   . ..|..|  .. || ..|.....               ..|    . | .||. .| |..
HLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSM