84561.m00139

Species: T.vaginalis
Alias: 84561.m00139, TvagK0956
External Links:
Annotation:

Classification

Group: CMGC
Family: CLK

Sequence

Name Sequence Type Origin Length Description Download
84561.m00139.AA Protein None 357 None Fasta, JSON
84561.m00139.kin_dom Protein Kinase Domain None 128 None Fasta, JSON

Protein domain

Protein domains of 84561.m00139.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 84561.m00139.AA CMGC 226-353 15 1.4e-16 50.08 In-house 293-513 (513) Show / Hide
Range on Protein: 226-353
Range on HMM: 293-513/513
Sequence Identity: 15% (34 aa)

SPEQLLSTR----------WSYEIDIWQLGILFVELITG--------RKLFT-HNNR----------LLHYALIEKLGGQFPLFLLDESQ--------KS
.|| ||. .          ....||.| .|  | |..||        . ||  |...          . . ..| |. | ..  ... ..        . 
APEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEE

EIPIFRDGKCDIS------------MLDDECRKIYNS---FP-----TLENLIHN-------------------------------------DKALSFAQ
|.| . .    .              ...  |.  .|   ||     ...||. .                                     ..|. . .
EWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLK

ATLCTDPSRRLLPLQLINHPFI
  |. ||..|. . |  .||..
KMLQYDPDKRITAEQALQHPYF

Kinase 84561.m00139.AA Pkinase 226-353 17 4.8e-12 43.67 Pfam 179-293 (293) Show / Hide
Range on Protein: 226-353
Range on HMM: 179-293/293
Sequence Identity: 17% (24 aa)

SPEQLL-STRWSYEIDIWQLGILFVELITGRKLFTHN----NRLLHYALIEKLGG-QFPLFLLDESQKSEIPIFRDGKCDISMLDDECRKIYNSFPTLEN
.|| .. .. .....|.| .|... |...|| .| .     | . ....|.. .| ...     .. .|  . ||. .                 ...  
APEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------------F-HWTF-

LIHNDKALSFAQATLCTDPSRRLLPLQLINHPFI
   .. ...|    || ||..|. . |. .||..
HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 84561.m00139.AA Ciliate-E2 225-353 12 2.8e-11 34.95 In-house 254-365 (365) Show / Hide
Range on Protein: 225-353
Range on HMM: 254-365/365
Sequence Identity: 12% (20 aa)

QSPEQLL---------STRWSYEIDIWQLGILFVELITGRKLFTHNNRLLHYALIEKLGGQFPLFLLDESQKSEIPIFRDGKCDISMLDDECRKIYNSFP
..|| |          .....|..||| ||... |...|.  |                                            ..  . . .. ..
MAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------------------------------------------QQQIKQCKIDFPC

TL-------------ENLIHNDKALSFAQA----TLCTDPSRRLL-PLQLINHPFI
               ... . ...  . .      |. ||. |.  . |..|||..
PEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

S_TKc 84561.m00139.AA S_TKc 46-353 13 4.4e-11 -14.32 SMART 1-231 (231) Show / Hide
Range on Protein: 46-353
Range on HMM: 1-231/231
Sequence Identity: 13% (45 aa)

YKILDLIESTNEYKSYFGIHQRQKFFVLIKFYYKSPTLLRKANIETEALTITNTIDLTHQYFVKYIGRYEYNLCPILIFQALGP---TLTKQMEFFNG--
|.||..| .    | | ..| . .  | ||            .|. |     .     | . ||... ..   .  ...  ..    .| . ..  ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--LTFSLSTIRVFMWHLIHALELLHECKLI----------------------CGNLSTDTVSLLEDYVDQKGYVMKTGERSVQLRINSLSCASNGNIWHV
    |.  ..| .|. .. ||| .|. . |                      .  |                                            
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL-------------------------------------------T

TSLTPERIQSPEQLLSTRWSY-EIDIWQLGILFVELITGRKLFTHNNRLLHYALIEKLGGQFPLFLLDESQKSEIPIFRDGKCDISMLDDECRKIYNSFP
|        .|| |    ... ..|.| .|... |...|. .|       ......|.|                                         
TFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-----------------------------------------

TLENLIHNDKALSFAQATLCTDPSRRLLPLQLIN-------HPFI
        . |..| .  |. ||..|.   .. .       ||..
-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 84561.m00139.AA Ciliate-E2-Unclassified 221-353 20 1.1e-08 26.33 In-house 230-352 (352) Show / Hide
Range on Protein: 221-353
Range on HMM: 230-352/352
Sequence Identity: 20% (29 aa)

PERIQSPEQLLSTRWS----YEIDIWQLGILFVELITGRKLFTHNNRLLHYALIEKLGGQFPLFLLDESQKSEIPIFRDGKCDISMLDDEC-RKIYNSFP
| ....|| | .   .    |..||| ||... |...|.  |  ||.  |. ||..   .               ..     ....| ...  |... ..
P-QYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-N---------------NA-----YRKQLYQNIKQKNIQFPK

TLE-N--LIHNDKALSFAQ----ATLCTDPSRRLLPLQLINHPFI
  . .   . ...|  | .      |  .|. |. . |..|||..
FPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase 84561.m00139.AA CDK 226-258 38 3e-06 15.69 In-house 187-225 (284) Show / Hide
Range on Protein: 226-258
Range on HMM: 187-225/284
Sequence Identity: 38% (15 aa)

SPEQLL-STRWS--YEIDIWQLGILFVELIT---GRKLF
.|| || |.. |   .||.| .|  |.|..|   .. ||
APELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLF

Kinase 84561.m00139.AA DYRK1 226-262 45 4e-06 16.79 In-house 171-207 (321) Show / Hide
Range on Protein: 226-262
Range on HMM: 171-207/321
Sequence Identity: 45% (17 aa)

SPEQLLSTRWSYEIDIWQLGILFVELITGRKLFTHNN
||| || .... .||.| || . ||. ||  ||.  |
SPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLFSGSN

Kinase 84561.m00139.AA Ciliate-D1 240-258 36 1e-05 20.02 In-house 1-19 (19) Show / Hide
Range on Protein: 240-258
Range on HMM: 1-19/19
Sequence Identity: 36% (7 aa)

DIWQLGILFVELITGRKLF
|||..|... |...|.. |
DIWSFGCILYEMLFGQPPF

Kinase 84561.m00139.AA DyrkP 227-262 41 2.9e-05 12.56 In-house 174-209 (323) Show / Hide
Range on Protein: 227-262
Range on HMM: 174-209/323
Sequence Identity: 41% (15 aa)

PEQLLSTRWSYEIDIWQLGILFVELITGRKLFTHNN
|| ..  .. | ||.| || .  || ||  ||   |
PEVIIGCKYDYRIDMWSLGCILAELWTGNVLFQNDN

Kinase 84561.m00139.AA CLK 235-278 35 4e-05 10.54 In-house 224-268 (350) Show / Hide
Range on Protein: 235-278
Range on HMM: 224-268/350
Sequence Identity: 35% (16 aa)

WSYEIDIWQLGILFVELITGRKLFTHNNRLLHYALIEKLGG-QFP
||.  |.|  |   .|| ||  ||  .. . | |..|.. | ..|
WSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIP

Kinase 84561.m00139.AA CDKL 321-353 39 0.000154 11.44 In-house 254-286 (286) Show / Hide
Range on Protein: 321-353
Range on HMM: 254-286/286
Sequence Identity: 39% (13 aa)

IHNDKALSFAQATLCTDPSRRLLPLQLINHPFI
..| |||.|... |  ||..|.   || .||. 
KSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF

Kinase 84561.m00139.AA DYRK2 226-258 39 0.000258 9.57 In-house 170-202 (318) Show / Hide
Range on Protein: 226-258
Range on HMM: 170-202/318
Sequence Identity: 39% (13 aa)

SPEQLLSTRWSYEIDIWQLGILFVELITGRKLF
.||  | .. . .||.| .|   .|| ||  ||
APEVILGGKYGMAIDMWSFGCIMAELYTGYPLF

Kinase 84561.m00139.AA DYRK2 337-353 52 0.001297 7.25 In-house 302-318 (318) Show / Hide
Range on Protein: 337-353
Range on HMM: 302-318/318
Sequence Identity: 52% (9 aa)

DPSRRLLPLQLINHPFI
||| |. | |  .||.|
DPSERMTPSQALKHPWI

Kinase 84561.m00139.AA CDKL 226-258 35 0.001303 8.22 In-house 167-200 (286) Show / Hide
Range on Protein: 226-258
Range on HMM: 167-200/286
Sequence Identity: 35% (12 aa)

SPEQLLS-TRWSYEIDIWQLGILFVELITGRKLF
.|| |.  |  . ..||| .| .. |.|.|  |.
APELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLW

Kinase 84561.m00139.AA DYRK1 337-353 35 0.016106 4.09 In-house 305-321 (321) Show / Hide
Range on Protein: 337-353
Range on HMM: 305-321/321
Sequence Identity: 35% (6 aa)

DPSRRLLPLQLINHPFI
|| .|. |.. . |.|.
DPKQRITPYYALQHSFF

Kinase 84561.m00139.AA DYRK2 143-168 34 0.05936 1.76 In-house 99-124 (318) Show / Hide
Range on Protein: 143-168
Range on HMM: 99-124/318
Sequence Identity: 34% (9 aa)

FSLSTIRVFMWHLIHALELLHECKLI
|||. .| |   ....|..||. ..|
FSLQLVRRFAHSILQCLRFLHKNNII

Kinase 84561.m00139.AA CLK 143-168 30 0.096107 0.19 In-house 111-136 (350) Show / Hide
Range on Protein: 143-168
Range on HMM: 111-136/350
Sequence Identity: 30% (8 aa)

FSLSTIRVFMWHLIHALELLHECKLI
. ...||.. . |..|.. ||. ||.
YPIDHIRHMAYQLCEAVKFLHDMKLT