Gene 94173.m00177 (T.vaginalis)

94173.m00177

Species: T.vaginalis
Alias: TvagK0887, 94173.m00177
External Links:
Annotation:

Classification

Group: Other
Family: WEE
Subfamily: WEE-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
94173.m00177.AA Protein None 290 None Fasta, JSON
94173.m00177.kin_dom Protein Kinase Domain None 229 None Fasta, JSON

Protein domain

Protein domains of 94173.m00177.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 94173.m00177.AA WEE 118-290 26 5e-37 121.79 In-house 85-297 (297) Show / Hide 
Range on Protein: 118-290
Range on HMM: 85-297/297
Sequence Identity: 26% (59 aa)

ELCELG------DI-----SNYTFTEDDIWKMIHDIGTALKHLHSQ-GWIHLDVSPGNILITNDC---------------------FKLADFGTLTKIG-
|.|. |      .|     .|  ..|. ||. . || ..|.|.||. | .|.|. |.||.|....                     .|..||| .|..  
EYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTDMNS

---EFEEGNEGAGPFVSPEALAFPCTDFEVGPP--TDIFSFGVVLFECASQQAAPRGGCPGYSKIRNG-------EILLGQGSYPCEHSQELIDLINMML
   .... .|| ... .|| |       . ..    ||||.| ...| |...  |. | ..  .||.|       .|   . . ..  |||| .|| .|.
NNNNPHQEQEGDSRYMAPEILQG---YYHYTHLYKADIFSLGITIYELACNMDLPKNG-DWWHQIRQGDLSFDKNQIPFPEFDNII--SQELKQLIKWMM

AVDPAERPTAEQLVQATGM
  ||  |||..||.|   .
HPDPEQRPTCQQLLQHPVL
Kinase 94173.m00177.AA Pkinase 57-287 20 4.3e-26 93.35 Pfam 11-290 (293) Show / Hide 
Range on Protein: 57-287
Range on HMM: 11-290/293
Sequence Identity: 20% (60 aa)

SNSVVFSAESVNGNEQYAIKITPHKHRVHEE--YDKR-------NLVTDSPYIVKTISLSESPTKALLKIELCELG----DIS-------NYTF--TEDD
| ..|. .  .. ....|.|| . .|. ...  .. |       . . ..|.||...   |....  .  |.|| |    | .       . .|  .|..
SFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWE

IWKMIHDIGTALKHLHSQGWIHLDVSPGNILIT--NDC---FKLADFGT--L--TKIGEFEEGNEGAGPFVSPEALAFPCTDFEVGPPTDIFSFGVVLFE
. ...  |  .|...||.| || |. | ||||   ...   .|..|||   .  .  ..   .  |  ....|| .    .. . ||. |..|.|..|.|
CKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPKVDMWSCGCILYE

CASQQAAPRGG----CPGYSKIRNGEILLGQGSYPCEHS---------------------QELIDLINMMLAVDPAERPTAEQLVQA
 .. .   .|          . .  .|. .. ..... .                     .|..|.|. .|..||..||||||..| 
MLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH
Kinase 94173.m00177.AA Ciliate-E2 96-286 21 6.6e-20 65.01 In-house 90-361 (365) Show / Hide 
Range on Protein: 96-286
Range on HMM: 90-361/365
Sequence Identity: 21% (60 aa)

DSPYIVKTISLSE--SPTKALLKIELCELGDISNYT----------------FTEDDIWKMIHDIGT---------------ALKHLHSQG-WIHLDVSP
..|.|.| .   .  . ..  |  |.|. ||   |                 |||  | ...  |                 ||..|||..  || |  |
NHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKP

GNILITNDCFKLADFGTLTKIGEF--------------EEGNE---------------------GAGPFVSPEALAFPCTD-----FEVGPPTDIFSFGV
 |||.     |..|||. .|. ..              . .|.                     |  ....|| |     |      . .   ||.|.||
ENILF----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV

VLFECASQQAAPRGGCPGYSKIRNGEILLGQGSY-------------PCEHSQELIDLINM----MLAVDPAERPT-AEQLVQ
.|.|. . .         . .| ...| . .  .             . ..||| .|||.     || .|| .|.| .||. .
ILYEMLFGKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 94173.m00177.AA TKL 118-288 16 1e-19 67.69 In-house 118-364 (364) Show / Hide 
Range on Protein: 118-288
Range on HMM: 118-364/364
Sequence Identity: 16% (40 aa)

ELCELGD-ISNYTFTEDDIWKMIHDIGTALKHLHSQG--------WIHLDVSPGNILITND---------------CFKLADFGTLTKIGEFEEGNEG--
|.|. |.  ....   . . ....||  .. .|||..         || |  . |||. ..               | |..|||. . . . .. | .  
EYCPGGSLLHYLH--WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMT

-----------------AG---PFVSPEALAFP------------CTDFEVGPPTDIFSFGVVLFECASQQAAPRGGCPGYSKIR-------NGEILLG-
                  .    . .||.|               |  ||  . .|..|||.||.|... .   ..  .   ...        . .. | 
TMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGL

QGSYP------------CEHSQELIDLINMMLAVDPAERPTAEQLVQAT
.   |                .....|. .  . || .||.......  
RPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
S_TKc 94173.m00177.AA S_TKc 47-290 21 3.9e-19 70.82 SMART 1-231 (231) Show / Hide 
Range on Protein: 47-290
Range on HMM: 1-231/231
Sequence Identity: 21% (56 aa)

LASSTPLRCTSNSVVFSAESVNGNEQYAIKITPHKHRVHEEYDKRNLVTDSPYIVKTISLSESPTKALLKIELCEL--GDISN-----------YTFTED
     ..   . ..|. .  .. ....|||| .   ..  | .      . |.||| .   .. ..  .  |.|.   ||              . |.| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

DIWKMIHDIGTALKHLHSQGWIHLDVSPGNILITNDCFKLADFGTLTKIGEFEEGNEGAGPFVSPEALAFPCTDFEVGP-PTDIFSFGVVLFECASQQAA
....... |  ||...||.| || |. | |||... . |..|||  ...        |   ...|| |         |. . |. |.|..|.|...    
HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL----TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCILYEMLC-GYP

PRGGCPGYSKIRNGEILLGQGSYPCEHSQELIDLINMMLAVDPAERPTAEQLVQ-------ATGM
|          .  ....         |.|..|.|. .| .||..|||| .. |          .
PFP-----QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 94173.m00177.AA Ciliate-E2-Unclassified 57-286 18 9.9e-18 58.1 In-house 11-348 (352) Show / Hide 
Range on Protein: 57-286
Range on HMM: 11-348/352
Sequence Identity: 18% (62 aa)

SNSVVFSAESVNGNEQYAIKITPHKHRVH--------------EEYDKRN---------------LVTDSPYIVKTISLSESPTKALLKIELCELGDISN
....|. ..  . ...||.|.   .. ..              .|  ...               |  ..|.||| .   ..  .  .  |.|| || ..
GFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQ

YT----------------------FTEDDIW-----KMIHDIGTALKHLHSQG-WIHLDVSPGNILITND----CFKLADFGTLTKIGEF--EEGNE---
|                       |||  .      ...  |  .|..||...  || |  | |||..|.    . |..|||   |....  .. ..   
YIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQ

--------------GAGPFV----SPEALAFPCTD----FEVGPPTDIFSFGVVLFECASQQAAPRGG--CPG----------------YSKIRNGEILL
              |   .     .|| |     |    ...    ||.|.||.|.|.  ..  | ..  |                  . .. .  .. 
KMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKC----DIWSLGVILYEMLFGY-YPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQ

GQGSYP----CEHSQELIDLIN----MMLAVDPAERPTAEQLVQ
 . . .    .  |.| .|.||     || ..| .|.|.||. .
FPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN
Kinase 94173.m00177.AA CAMK 52-224 14 9.9e-11 30.07 In-house 1-325 (425) Show / Hide 
Range on Protein: 52-224
Range on HMM: 1-325/425
Sequence Identity: 14% (49 aa)

PLRCTSNSVVFSAESVNGN------------EQYAIKI---------------------------------TPHKHRVHEEYDKRNLV------TDSPYI
 |   | ..|. ..  | .            ...||||                                    ...|  |..  ...       | | |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKTISLSES-------------------PTKALLKI---ELCELG----DISNYT--------------------FTEDDIWKMIHDIGTALKHLHSQGW
.| .   |.                   ...  .     |.|. |    |. .|                     |||..  .... |  |....||.. 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHLDVSPGNILITND------------------CFKLADFGTLTKIGE---------FEEGNEGAG-------------------PFVS-PEALAF-PCT
.|.|  | |||....                    |..|||  .|. .         ...|.                       .... || |   .. 
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

DFE---------VGPPTDIFSFGVVLF
...         .||..|. | ||.|.
NMQNATDEEKPYYGPKCDMWSCGVILY
Kinase 94173.m00177.AA NAK 259-288 40 1.4e-10 31.41 In-house 270-299 (299) Show / Hide 
Range on Protein: 259-288
Range on HMM: 270-299/299
Sequence Identity: 40% (12 aa)

HSQELIDLINMMLAVDPAERPTAEQLVQAT
.||...||| .|| .|| .||. .|... .
YSQQMHDLIRYMLTPDPEQRPNIYQVLNQL
Kinase 94173.m00177.AA DCAMKL 98-177 31 4.4e-10 27.0 In-house 75-164 (279) Show / Hide 
Range on Protein: 98-177
Range on HMM: 75-164/279
Sequence Identity: 31% (28 aa)

PYIVKTISLSESPTKALLKIELCELGD-----ISNYTFTEDDIWKMIHDIGTALKHLHSQGWIHLDVSPGNILITN-----DCFKLADFG
|.|.. .   . .|.  |  |. . ||     ..|  ||| |   |..... |||.||. . .| |. | | |.          ||.|||
PHIIQLYEHWDTETHYYLVMEYVQGGDLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDFG
Kinase 94173.m00177.AA CMGC 146-177 30 1.7e-09 26.4 In-house 195-249 (513) Show / Hide 
Range on Protein: 146-177
Range on HMM: 195-249/513
Sequence Identity: 30% (17 aa)

LKHLHSQG--WIHLDVSPGNILITNDCF---------------------KLADFG
||..||..   || |  | ||||...|                      |..|||
LKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFG
Kinase 94173.m00177.AA ULK 60-177 21 3.8e-09 28.66 In-house 15-183 (324) Show / Hide 
Range on Protein: 60-177
Range on HMM: 15-183/324
Sequence Identity: 21% (37 aa)

VVFSAE-SVNG--NEQYAIKITP-----HKHRVHE-EYDKRNLV--------TD---SPY--IVKTISLSESP--TKALLKIELCELGDISNY-------
.|. ..   ..  |...|.|. .      |    | .| . .|          .   .|.  ||| .  .|..  .   .  |.|. || ..|       
KVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKL

-------TFTEDDIWKMIHDIGTALKHLHSQGWIHLDVSPGNILITND-------------CFKLADFG
       ...|. . . ...|  ..|.||... || |  | ||||.|.             ..|.||||
PETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFG
Kinase 94173.m00177.AA TyrKc 60-288 15 5.1e-09 -76.9 SMART 14-280 (280) Show / Hide 
Range on Protein: 60-288
Range on HMM: 14-280/280
Sequence Identity: 15% (45 aa)

VVFSAESVNGNEQYAIKITPHKHRVHEEYDKRNLVT----------DSPYIVKTISLSESP-------TKALLKIELCELGDISNYT------FTEDDIW
.|. ..     .| |.|   . .       .. .            . | ||. .    ..          ..  |....||  .|       .. .|  
EVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLL

KMIHDIGTALKHLHSQGWIHLDVSPGNILITNDC-FKLADFGTLTKIGEFE--------EGNEG---AGPFV------SPEALAFPCTDFEVGPPTDIFS
.. ..|     .|||.. || |    |.|....   | .||| |.. .. .                 | ..      .||..     . .  . .|..|
SFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG-LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NYGKFTTKSDVWS

FGVVLFECASQQAAPRGG-----CPG---YSKIRNGEILLGQGS-YPCE-----HSQELIDLINMMLAVDPAERPTAEQLVQAT
|||...|  .  . |  |     ..    . ....|. .    . |  .      ..|. ... .  . ||..||| .....  
FGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 94173.m00177.AA RCK 257-286 43 1.8e-08 22.66 In-house 265-294 (298) Show / Hide 
Range on Protein: 257-286
Range on HMM: 265-294/298
Sequence Identity: 43% (13 aa)

CEHSQELIDLINMMLAVDPAERPTAEQLVQ
.  ||..|.|...||. || .|.||.|. |
PNCSQDCIELMEKMLQWDPQKRITAQQALQ
Kinase 94173.m00177.AA RCK 145-177 37 2.5e-08 22.25 In-house 117-159 (298) Show / Hide 
Range on Protein: 145-177
Range on HMM: 117-159/298
Sequence Identity: 37% (16 aa)

ALKHLHSQGWIHLDVSPGNILIT----------NDCFKLADFG
.|.|.|..|  | |..| ||..|          .|  |.||||
GLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFG
Kinase 94173.m00177.AA CAMK 260-286 55 3.9e-07 18.26 In-house 395-421 (425) Show / Hide 
Range on Protein: 260-286
Range on HMM: 395-421/425
Sequence Identity: 55% (15 aa)

SQELIDLINMMLAVDPAERPTAEQLVQ
||| .|||. || ||| .|.|.||  .
SQECKDLIRKMLQVDPEKRMTIEQCLN
Kinase 94173.m00177.AA NAK 130-177 32 6.4e-07 19.04 In-house 116-171 (299) Show / Hide 
Range on Protein: 130-177
Range on HMM: 116-171/299
Sequence Identity: 32% (18 aa)

FTEDDIWKMIHDIGTALKHLHSQG----WIHLDVSPGNILIT----NDCFKLADFG
|||| |.. . |.  .....|..      || |  ..|||.     .. .|| |||
FTEDEILQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSESHHDGNYKLCDFG
Kinase 94173.m00177.AA CMGC 260-286 48 1e-05 13.86 In-house 483-509 (513) Show / Hide 
Range on Protein: 260-286
Range on HMM: 483-509/513
Sequence Identity: 48% (13 aa)

SQELIDLINMMLAVDPAERPTAEQLVQ
....|||.. ||  ||..|.||||  |
DPQAIDLLKKMLQYDPDKRITAEQALQ
Kinase 94173.m00177.AA ULK 214-278 23 2.1e-05 15.21 In-house 233-312 (324) Show / Hide 
Range on Protein: 214-278
Range on HMM: 233-312/324
Sequence Identity: 23% (19 aa)

TDIFSFGVVLFECASQQAAPRGG-CPGY----SKIRNG---EILLGQGSYPCE------H-SQELIDLINMMLAVDPAER
.||.|.|....|.   .  ...  .. |    . |.||   .|.  .   ..       . |.|..|||  || .|. .|
CDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDR
Kinase 94173.m00177.AA DCAMKL 265-283 68 3.1e-05 11.63 In-house 254-272 (279) Show / Hide 
Range on Protein: 265-283
Range on HMM: 254-272/279
Sequence Identity: 68% (13 aa)

DLINMMLAVDPAERPTAEQ
|||..|| |||  |.||||
DLISHMLQVDPEKRYTAEQ