Gene 90487.m00099 (T.vaginalis)
90487.m00099
Species: T.vaginalis
Alias: 90487.m00099, TvagK0311
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 90487.m00099.AA | Protein | None | 808 | None | Fasta, JSON |
| 90487.m00099.kin_dom | Protein Kinase Domain | None | 262 | None | Fasta, JSON |
Protein domains of 90487.m00099.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 90487.m00099.AA | TKL | 188-273 | 20 | 1.3e-15 | 52.73 | In-house | 241-364 (364) | Show / Hide |
Range on Protein: 188-273 Range on HMM: 241-364/364 Sequence Identity: 20% (25 aa) APETLKDN----------------TYTSKSDIFSLAFIFYEFSEGINPFA-NKNDKEI------AELINNPSKFLQ---------------FSSSPAELQ ||| |... .|. |.|..| . ...| . |.. .... .| .... . .|.|. .. | .. APEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMK KLILDCWDQNPKKRPEAIKIFEMF ||. ||||..|.||| . .| . . KLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | 90487.m00099.AA | Abl | 39-273 | 21 | 6e-15 | 45.82 | In-house | 15-252 (252) | Show / Hide |
Range on Protein: 39-273 Range on HMM: 15-252/252 Sequence Identity: 21% (53 aa) IYHGIDSKSNQEVSIKEFTADTLTKEDELRYVTEIYLQRKCNHRFISQILGFTTKK-PFAIITEFFKNGVMAEKLYRNNNKIAFSGTHLSTIALALTHSL .| |. . .. | .| ||. .. .. | . .. |. . |.|| |. || ||||| .| . . | |.... . | .| .. .. VYEGVWKRHDCTVAVKTLKEDTMEVHE---FLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYL-RECDREELPAVVLLYMATQIASGM SYMHNIGISHANISANTISLDDKNISRLNFFDFAKTGKMQLNSEQ-----PIISNAPETLKDNTYTSKSDIFSLAFIFYEFSE-GINPFANKNDKEIAEL ||. . | . | . ...| .. | |. | . . || ||| | |.. ||||.. . .| |. |. . ... .. SYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYPGIDLSHVYHK INNPSKFLQFSSSPAELQKLILDCWDQNPKKRPEAIKIFEMF ... . . | . .|.. ||. .. ||. .| ... LEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM |
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| Kinase | 90487.m00099.AA | Pkinase | 188-273 | 22 | 3.9e-14 | 51.06 | Pfam | 179-293 (293) | Show / Hide |
Range on Protein: 188-273 Range on HMM: 179-293/293 Sequence Identity: 22% (26 aa) APETLK-DNTYTSKSDIFSLAFIFYEFSEGINPFANK------NDKEIAELINNPSKFLQFSSS--------------------PAELQKLILDCWDQNP ||| .. .. |..|.|..|. |.||. | || .. ..... ..| | ... . . |....| .|....| APEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP KKRPEAIKIFEM--F |||| | |.. | KKRPTAEQILQHPWF |
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| Kinase | 90487.m00099.AA | TKL-Unique | 188-273 | 22 | 1e-13 | 44.91 | In-house | 194-290 (290) | Show / Hide |
Range on Protein: 188-273 Range on HMM: 194-290/290 Sequence Identity: 22% (22 aa) APETLKD--NTYTSKSDIFSLAFIFYEFSEGIN------PFANKNDKEIAELINN--PSKFLQF-SSSPAELQKLILDCWDQNPKKRPEAIKIFEMF ||| |.. ..|. |||..| ... .| .. |. . ......|.. .. . .. | |...|| .||...| .|| . | . APEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
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| Kinase | 90487.m00099.AA | Fer | 188-274 | 21 | 1.3e-13 | 42.82 | In-house | 186-283 (283) | Show / Hide |
Range on Protein: 188-274 Range on HMM: 186-283/283 Sequence Identity: 21% (21 aa) APETLKDNTYTSKSDIFSLAFIFYEFSE-GINPFAN-----KNDKE----IAELINNPSKFLQFS-SSPAELQKLIL-DCWDQNPKKRPEAIKIFEMFS ||||... .|..|.|..| .|. . | |... |. .. |.. ..... . | |. .... .||...|..|| . .| ... APETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKK-GYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
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| Kinase | 90487.m00099.AA | TKL-ciliate1 | 188-273 | 24 | 3.7e-12 | 37.92 | In-house | 182-279 (279) | Show / Hide |
Range on Protein: 188-273 Range on HMM: 182-279/279 Sequence Identity: 24% (24 aa) APETLK-----DNTYTSKSDIFSLAFIFYEFSEGINPFANKND--KEIAELINNP------SKFLQFSSSPAELQKLILDCWDQNPKKRPEAIKIFEMF |||.. . .. | ||.... . |.. || .| .. | .|. | |... .|. .||.|||.|||.. | . APEQMDPHIFPNYPINEKIDIYAYGIVMYILCFRKTPFQQKMSVINIMCYWCEFPGRPNLGPQFIHF-DCPQNFHNLMMRCWCQNPNKRPNFNEIIQIL |
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| Kinase | 90487.m00099.AA | Src-Echino1 | 25-273 | 21 | 3.8e-12 | 37.96 | In-house | 1-252 (252) | Show / Hide |
Range on Protein: 25-273 Range on HMM: 1-252/252 Sequence Identity: 21% (55 aa) IKKDNTIKETKRYVIYHGIDSKSNQEVSIKEFTADTLTKEDELRYVTEIYLQRKCNHRFISQILGFTTKK-PFAIITEFFKNGVMAEKLYRNNNK-IAFS . |. | . . ...|. . | .| .| |... | .. | . .|| |. | || | | |.|| .|| . . | |.. | . . LRMDKKIGKGHCGEVWKGV-WNGNTPVAVKTLKEKTMSPAD---FLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKM- GTHLSTIALALTHSLSYMHNIGISHANISANTISLDDKNISRLNFFDFAKTGKMQLNSEQ-----PIISNAPETLKDNTYTSKSDIFSLAFIFYEFSE-G | | . . . |. . | ...| . ... |. .. | |. . . || ||| .| |||..| .. |. | -TTLIDMGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFG INPFANKNDKEIAELINNPSKFLQFSSSPAELQKL-ILDCWDQNPKKRPEAIKIFEMF |. . ..|. . ... . . | | .. .. || ..|..|| . . | RYPYPGMMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF |
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| Kinase | 90487.m00099.AA | Dicty4-Unclassified | 188-273 | 28 | 1.6e-11 | 35.65 | In-house | 176-263 (263) | Show / Hide |
Range on Protein: 188-273 Range on HMM: 176-263/263 Sequence Identity: 28% (26 aa) APETLKDNTYTSKSDIFSLAFIFYEFSEGINPFANKN-DKEIAELINNPSKFLQ---FSSSPAELQKLILDCWDQNPKKRPEAIKIFEMF .|| |. |..|||..| | . || | |. ..| .. .| |. .. . ..||| .|| |.||| .| . SPECLMHESYNQKSDVYSYAMMLYELATGDEPYQEIQSIMNAARSVC--DKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL |
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| Kinase | 90487.m00099.AA | TK-Unique | 188-273 | 30 | 2.1e-11 | 35.7 | In-house | 204-294 (294) | Show / Hide |
Range on Protein: 188-273 Range on HMM: 204-294/294 Sequence Identity: 30% (28 aa) APETLK--DNTY-TSKSDIFSLAFIFYE-FSEGINPFANKNDKEIAELINNPSKFLQFSSS-PAELQKLILDCWDQNPKKRPEAIKIFEMF ||| || ...| |.|||. |.. . .| |. | |. . .|.| |.| . . .|.... . |. .|. || .|..|| .| .. APESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | 90487.m00099.AA | S_TKc | 32-273 | 19 | 3.5e-11 | -12.89 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 32-273 Range on HMM: 1-231/231 Sequence Identity: 19% (51 aa) KETKRY-------VIYHGIDSKSNQEVSIKEFTADTLTKEDELRYVTEIYLQRKCNHRFISQILGFTTKKPFAIITEFFKN--GVMAEKLYRNNNK---I | | . | ... |....| ||. . || . .| .| .| ..... . . ...|. . | . . . ... . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF AFSGTHLSTIALALTHSLSYMHNIGISHANISANTISLDDKNISRLNFFDFAKTGKMQLNSEQPIISN----APETLKDNTYTS-KSDIFSLAFIFYEFS |. | .. . | |.|. || | . | ||. . | .|. .. ||| | |. |.|. |. |.||. PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML EGINPFANKNDKEIAELINNPSKFLQFSSSPAELQKLILDCWDQNPKKRPEAIKIFE---------MF | || ..... ..| . |. .| |.. .|.||| | .... | CGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 90487.m00099.AA | MLK | 188-273 | 25 | 4.1e-11 | 34.91 | In-house | 201-291 (291) | Show / Hide |
Range on Protein: 188-273 Range on HMM: 201-291/291 Sequence Identity: 25% (23 aa) APETL---KDNTYTSKSDIFSLAFIFYEFSEGINPFANKND--KEIAELINNPSKFLQFSSSPAELQKLILDCWDQNPKKRPEAIKIFEMF ||| . . ..|. |.|..| . ...| . |... .| ... ..| |. |. . ||. .||.|.|.||| | . . APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | 90487.m00099.AA | TyrKc | 31-273 | 18 | 1.6e-10 | -52.48 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 31-273 Range on HMM: 1-280/280 Sequence Identity: 18% (54 aa) IKETKRY------VIYHGIDSKSNQEVSIKEFTADTLTKEDELRYVTEIYLQRKC--NHRFISQILGFTTK--------KPFAIITEFFKNGVMAEKLYR |. | ..|.|. . ..| .| .|. . |. . .| .| | ...| |. .| |..|. ..| . | . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK NNNKIAFSGTHLSTIALALTHSLSYMHNIGISHANISANTISLDDKN--------ISRLNFFD-FA----KTGKMQL--NSE--QPIISNAPETLKDNTY . .| .. .| ... .| | .. | . | . ..... || | . .. ... .. || |||....... HRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF TSKSDIFSLAFIFYE-FSEGINPFAN-----KNDKEIAELINNPSKFLQFSS--------SPAELQKLILDCWDQNPKKRPEAIKIFEMF |.|||..| .| |. | | . ....|. |.. . | . |.|. .....||. .|..|| | | | TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 90487.m00099.AA | LRRK | 245-275 | 38 | 2e-09 | 29.47 | In-house | 321-351 (351) | Show / Hide |
Range on Protein: 245-275 Range on HMM: 321-351/351 Sequence Identity: 38% (12 aa) PAELQKLILDCWDQNPKKRPEAIKIFEMFSN . ..|.|| .||...||||| ...|.. | WHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
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| Kinase | 90487.m00099.AA | Pkinase | 38-147 | 16 | 9.4e-07 | 24.96 | Pfam | 14-131 (293) | Show / Hide |
Range on Protein: 38-147 Range on HMM: 14-131/293 Sequence Identity: 16% (20 aa) VIYHGIDSKSNQEVSIKEFTADTLTKEDELRYVT---EIYLQRKCNHRFISQILGFT-TKKPFAIITEFFKNG----VMAEKLY-RNNNKIAFSGTHLST . |.... .....| .|.. . .|...... . ||.. ...|| .| ..... .|. ...|. .| .. . ...... || .. CVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKF IALALTHSLSYMHNIGISH ... . | |.|. || | YMYQILRGLEYCHSMGIIH |
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| Kinase | 90487.m00099.AA | TKL | 39-106 | 13 | 0.000355 | 10.95 | In-house | 13-123 (364) | Show / Hide |
Range on Protein: 39-106 Range on HMM: 13-123/364 Sequence Identity: 13% (15 aa) IYHGID----SKSNQEVSIKEFTADTLTKEDE-------------------------LRYVTEIYLQRKCNHRFISQILGFTTKKP-------------- ...|.. | ....| .| | . .... . . || . ....| | |..|. . | KWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQ FAIITEFFKNG ..|..|. ..| LCIVMEYCPGG |
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| Kinase | 90487.m00099.AA | LRRK | 188-212 | 39 | 0.000569 | 9.92 | In-house | 247-274 (351) | Show / Hide |
Range on Protein: 188-212 Range on HMM: 247-274/351 Sequence Identity: 39% (11 aa) APETLKDN---TYTSKSDIFSLAFIFYE |||....| .|| |.|..| . | .| APEIMRYNGEEEYTEKVDCYSFGMILWE |
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| Kinase | 90487.m00099.AA | Pkinase_Tyr | 245-273 | 34 | 0.001704 | 12.46 | Pfam | 242-270 (270) | Show / Hide |
Range on Protein: 245-273 Range on HMM: 242-270/270 Sequence Identity: 34% (10 aa) PAELQKLILDCWDQNPKKRPEAIKIFEMF |.|. .|...||...|..|| | |.. PDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | 90487.m00099.AA | Pkinase_Tyr | 188-205 | 44 | 0.003649 | 11.34 | Pfam | 182-199 (270) | Show / Hide |
Range on Protein: 188-205 Range on HMM: 182-199/270 Sequence Identity: 44% (8 aa) APETLKDNTYTSKSDIFS ||| .... .|.|||. | APECINYGKFTTKSDVWS |
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| Kinase | 90487.m00099.AA | TKL-Unique | 80-150 | 18 | 0.068209 | 2.68 | In-house | 53-138 (290) | Show / Hide |
Range on Protein: 80-150 Range on HMM: 53-138/290 Sequence Identity: 18% (16 aa) N-HRFISQILGFTT----KKP-FAIITEFFKNGVMAEKLYR-------NNNKIAFSGTHLSTIALALTHSLSYMHNIG--ISHANI . | .| .. |... . | . |..|.. | . | . |||.. .. ..|. . | |. . | | .. HYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDL |
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| Kinase | 90487.m00099.AA | MLK | 48-142 | 18 | 0.141954 | 1.39 | In-house | 22-142 (291) | Show / Hide |
Range on Protein: 48-142 Range on HMM: 22-142/291 Sequence Identity: 18% (22 aa) NQE-----VSIKEFTADT----LTKEDELRYVTEIYLQRKCNHRF----ISQILGFTTKK-P-FAIITEFFKNGVMAEKLYRNNNKIA-----------F |.. | .|...|.. | . .|... |. .|. | |..| .. . |.|..|. .| ... |. ...|.. NKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVY SGTHLSTIALALTHSLSYMHN . |. ..|| . ..| |. DHDHAMNWALQCARGMHYLHS |
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