TVAG_123200

Species: T.vaginalis
Alias: TvagK1046, TVAG_123200
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Unique

Sequence

Name Sequence Type Origin Length Description Download
TVAG_123200.AA Protein None 940 None Fasta, JSON
TVAG_123200.kin_dom Protein Kinase Domain None 228 None Fasta, JSON

Protein domain

Protein domains of TVAG_123200.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TVAG_123200.AA TKL 58-287 11 1.2e-13 45.47 In-house 31-364 (364) Show / Hide
Range on Protein: 58-287
Range on HMM: 31-364/364
Sequence Identity: 11% (41 aa)

VQTINTDLSQKSNSSL-----------------------FFKEVQNLSSSK--YPTILPFEGFTISNSY---------NCDKPAIVYDCYTGLK-LSEIL
| ..... ........                       ||.|.. .. |.   | |..| |. .....         .. ...||.. . |   |. ..
VKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH

EIEDDENALENWNLTTKIRSLIGVAFALDHIHGLN--------IAHGNINAESVVYGGDYW--------------PYLANLSFENFFNEEKVKNLVP---
             .  ..|  ...| .... |  |        |.| ... . .    ..               . .. . .  |..... .|      
-------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTM

------------SYFET---TWKAPELTGTTKKTLPG----------------DIYSFGMLILLLFVGQDEFEDIVE-------------SYTEEES-EL
            .. .     | |||.   . ..                   |.||||...  .. ..  ..|. .             ..  ...  .
MESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRP

EIP------------DSVPSQISEIIQSCCNPNPQERPVISTVLQEL
.||            ...| ......| |....|..||  ...|..|
PIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase TVAG_123200.AA TKL-Unique 245-287 30 4e-12 39.23 In-house 248-290 (290) Show / Hide
Range on Protein: 245-287
Range on HMM: 248-290/290
Sequence Identity: 30% (13 aa)

YTEEESELEIPDSVPSQISEIIQSCCNPNPQERPVISTVLQEL
|.||.. ..||.. | .....|| |....|..||  .... .|
YMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL

Kinase TVAG_123200.AA UTK 252-287 25 3.6e-08 24.07 In-house 261-296 (296) Show / Hide
Range on Protein: 252-287
Range on HMM: 261-296/296
Sequence Identity: 25% (9 aa)

LEIPDSVPSQISEIIQSCCNPNPQERPVISTVLQEL
.. |...| .. .. ..|....||||| . ...|..
MPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM

Kinase TVAG_123200.AA Fer 220-288 19 1.3e-07 22.15 In-house 200-283 (283) Show / Hide
Range on Protein: 220-288
Range on HMM: 200-283/283
Sequence Identity: 19% (16 aa)

DIYSFGMLILLLFV-GQDEFED---------I----VESYTEEESELEIPDSVPSQISEIIQ-SCCNPNPQERPVISTVLQELQ
|..||| ..   |  |.. ...         .    .. .....  . .|...|. | .|.  .|.. .| .||  ... |.| 
DVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK

Kinase TVAG_123200.AA TK-Unique 252-287 21 2.3e-07 21.58 In-house 258-294 (294) Show / Hide
Range on Protein: 252-287
Range on HMM: 258-294/294
Sequence Identity: 21% (8 aa)

LEIPDSV-PSQISEIIQSCCNPNPQERPVISTVLQEL
.. |... . .. ....|| . .|.||| .......|
MPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL

Kinase TVAG_123200.AA MLK 252-287 38 3.4e-07 19.59 In-house 245-280 (280) Show / Hide
Range on Protein: 252-287
Range on HMM: 245-280/280
Sequence Identity: 38% (14 aa)

LEIPDSVPSQISEIIQSCCNPNPQERPVISTVLQEL
| ||.. | . . ..|.| |..| .||  |..||.|
LPIPSTCPEPWAKLMQDCWNQDPHKRPKFSEILQQL

Kinase TVAG_123200.AA PLK1 206-289 28 1e-06 17.31 In-house 167-253 (253) Show / Hide
Range on Protein: 206-289
Range on HMM: 167-253/253
Sequence Identity: 28% (25 aa)

APELTGTTKKTLPGDIYSFGMLILLLFVGQDEFE--DIVESYTE-EESELEIPDSVPSQISEIIQSCCNPNPQERPVISTVLQELQD
|||.   .  .   ||.| | .. .| .||  ||   . | |    . |  ||...    ...|..  .|.|..|| |. ||..   
APEVLNKKGHSFEVDIWSIGCIMYILLFGQPPFETKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF

Kinase TVAG_123200.AA HH498 254-287 31 1e-06 16.54 In-house 247-284 (284) Show / Hide
Range on Protein: 254-287
Range on HMM: 247-284/284
Sequence Identity: 31% (12 aa)

IPDS----VPSQISEIIQSCCNPNPQERPVISTVLQEL
|| .    .| ..| .|| | .|.| .||  . ..  |
IPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL

S_TKc TVAG_123200.AA S_TKc 34-291 12 3e-06 -86.22 SMART 1-231 (231) Show / Hide
Range on Protein: 34-291
Range on HMM: 1-231/231
Sequence Identity: 12% (36 aa)

LVLETPLGNIS-----KMKNKNSDRSQYLVQTINTDLSQKSNSSLFFKEVQNLSSSKYPTILPFEGFTISNSYNCDKPAIVYDCYTG--LKLSEILEIED
  .  ..|  .     | ..|. .  .. .  |.           . .|.| |.. . | |  . ..  .     |.  .| ..  |    | ....   
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRG

DENALENWNLTTKIRSLIGVAFALDHIHGLNIAHGNINAESVVYGGDYWPY-------LANLSFENFFNEEKVKNLVPSYFETTWKAPELTGTTKKTL-P
 .      .  .  . .  .. ||...| ..| |  .  | .                || .           . .. . .   . |||.    . .  .
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----------TTFCGTPW---YMAPEVL---GYGKCK

GDIYSFGMLILLLFVGQDEFEDIVESYTEEESELEIPDSVPSQISEIIQSCCNPNPQERPVISTVLQ-----ELQDSI
 |..|.| ..  ...|.  |.       ...  ...    ...  ..|. |.. .|..|| .  .||      .   .
CDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase TVAG_123200.AA TK 255-287 19 4e-06 15.62 In-house 440-486 (486) Show / Hide
Range on Protein: 255-287
Range on HMM: 440-486/486
Sequence Identity: 19% (9 aa)

PDSVP--------------SQISEIIQSCCNPNPQERPVISTVLQEL
|.  |                . ...|.|....|..||  |.....|
PPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase TVAG_123200.AA RAF 259-287 24 4e-06 16.9 In-house 247-275 (275) Show / Hide
Range on Protein: 259-287
Range on HMM: 247-275/275
Sequence Identity: 24% (7 aa)

PSQISEIIQSCCNPNPQERPVISTVLQEL
|. ..|....| . .|.|||. . .. ..
PKEMKELLMECWSYQPEERPSFQQIMKMI

TyrKc TVAG_123200.AA TyrKc 34-287 14 2.4e-05 -136.31 SMART 1-280 (280) Show / Hide
Range on Protein: 34-287
Range on HMM: 1-280/280
Sequence Identity: 14% (47 aa)

LVLETPLGN-------ISKMKNKNSDRSQYLVQ----TINTDLSQKSNSSLFFKEVQNLSSS--KYPTILPFEGFTISNSYNC---DKPAIVYDCYTGLK
..|.  ||.         ..|          .|    ... |         | .| . ...   . | |. . |  .. . |    . . ||     .  
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD

LSEILEIEDDENALENWNLTTKIRSLIGVAFALDHIHGLNIAHGNINAESVVYGGDYWPYLANLSFENFFNEEKVK--------NLVPS--------YF-
| . |    ..      .. ...   . .|   ...|  |. |  . |  . .| ..                 ||        ..           |  
LKDYLRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----------------TVKISDFGLSRDIYDDDQQGESKDYYR

-----ETT------WKAPE--LTG-TTKKTLPGDIYSFGMLI--LLLFVGQDEFE--------DIVESYTEEESELEIPDS--------VPSQISEIIQS
      .       | |||   .|  | |.   |..||| ..  .. . .|   .        . |  | ..   ...|..         |. . .|...
KKEHKGGKTMLPIRWMAPECINYGKFTTKS---DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQ

CCNPNPQERPVISTVLQEL
|.. .| .||  |.. ...
CWHEDPEDRPTFSEIHECF

Kinase TVAG_123200.AA Pkinase_Tyr 252-287 25 0.000602 13.99 Pfam 235-270 (270) Show / Hide
Range on Protein: 252-287
Range on HMM: 235-270/270
Sequence Identity: 25% (9 aa)

LEIPDSVPSQISEIIQSCCNPNPQERPVISTVLQEL
...|.  |  | .....| ...|..||  | ....|
MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase TVAG_123200.AA HH498 204-228 34 0.105651 0.72 In-house 191-216 (284) Show / Hide
Range on Protein: 204-228
Range on HMM: 191-216/284
Sequence Identity: 34% (9 aa)

WKAPELTG-TTKKTLPGDIYSFGMLI
| ||| .   .| .   |..|..| |
WMAPEVFSQCQKYSIKVDVFSYAMCI

TTL TVAG_123200.AA TTL 441-741 29 2.1e-70 245.01 Pfam 1-323 (323) Show / Hide
Range on Protein: 441-741
Range on HMM: 1-323/323
Sequence Identity: 29% (96 aa)

LSLQP-----WQFINHIPGTYVISRKVELARNIERIQKYFPKI------YTFHPLSFAVPAQSLDLQQYMMNAPL--KDRTFIIKPDLGAQGKGIYLIQN
 ....     .| .|| |. |.|.||  |..||.| .. |..       . | | .|  |..  .. .| .. ..   ....|.||. ...|.||... .
MRIDMHYRMMHQMCNHFPNSYWITRKDRLWMNIKRMMCDFGWKHDPYIHFDFMPRTFMLPTDYQEFVDYWEDHEWWGQHNWWIVKPWNSCRGRGIWIMNK

PDDVLD-------ITETSIAQQYINS-HLIDG--YKFDLRIYVLVSSVSPLRIYTFNEGMARFCTEPYKKPRQGNLDQIYRHLTNYSVNKKNSKFEQPTD
... ..        ... ..|.||    ||||  .|||.|.|||| |. ||||| ..|| .|||...|..    |||  . |||||...|..| ..   .
WSQIPKWVFDSQHQDRPWVVQKYIERPLLIDGMHHKFDIRCYVLVTSFNPLRIYVYREGWCRFCSVKYHP-SMSNLDNKCMHLTNYCIQKHYSNYS-CNR

DDASNDGFKRSFSSVLHEMKSEGVDTDKLLKDMHQLIVLTILAVYSYIKHSVKTAFRVDDGKSRCFEIMGYDILI--DKKNKPWLLEVNHSPSLQCDSPF
|.    | ... ..     ...|.|.|.. .. . .|. ||.|  .   | |...... .    |||..|.|..|  | . ||||||||.||.. |..| 
DYNECHGHMWTIQNFWNYLENMGIDWDNIWSQICDIIMKTIVAAWN---HCVEACRMNMQPRYNCFELYGFDFMIQWDENLKPWLLEVNISPDMHCTCPL

DKTLKDNVISGAMK--IMDLNPNFKKIV
|..|....|.   .       |.. |. 
DAHLCHQLIDDVLNCAGCHVPPDCMKDC