Gene TVAG_123200 (T.vaginalis)
TVAG_123200
Species: T.vaginalis
Alias: TvagK1046, TVAG_123200
External Links:
Annotation:
Group:
TKL
Family:
TKL-Unique
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| TVAG_123200.AA | Protein | None | 940 | None | Fasta, JSON |
| TVAG_123200.kin_dom | Protein Kinase Domain | None | 228 | None | Fasta, JSON |
Protein domains of TVAG_123200.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | TVAG_123200.AA | TKL | 58-287 | 11 | 1.2e-13 | 45.47 | In-house | 31-364 (364) | Show / Hide |
Range on Protein: 58-287
Range on HMM: 31-364/364
Sequence Identity: 11% (41 aa)
VQTINTDLSQKSNSSL-----------------------FFKEVQNLSSSK--YPTILPFEGFTISNSY---------NCDKPAIVYDCYTGLK-LSEIL
| ..... ........ ||.|.. .. |. | |..| |. ..... .. ...||.. . | |. ..
VKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH
EIEDDENALENWNLTTKIRSLIGVAFALDHIHGLN--------IAHGNINAESVVYGGDYW--------------PYLANLSFENFFNEEKVKNLVP---
. ..| ...| .... | | |.| ... . . .. . .. . . |..... .|
-------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTM
------------SYFET---TWKAPELTGTTKKTLPG----------------DIYSFGMLILLLFVGQDEFEDIVE-------------SYTEEES-EL
.. . | |||. . .. |.||||... .. .. ..|. . .. ... .
MESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRP
EIP------------DSVPSQISEIIQSCCNPNPQERPVISTVLQEL
.|| ...| ......| |....|..|| ...|..|
PIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | TVAG_123200.AA | TKL-Unique | 245-287 | 30 | 4e-12 | 39.23 | In-house | 248-290 (290) | Show / Hide |
Range on Protein: 245-287 Range on HMM: 248-290/290 Sequence Identity: 30% (13 aa) YTEEESELEIPDSVPSQISEIIQSCCNPNPQERPVISTVLQEL |.||.. ..||.. | .....|| |....|..|| .... .| YMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
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| Kinase | TVAG_123200.AA | UTK | 252-287 | 25 | 3.6e-08 | 24.07 | In-house | 261-296 (296) | Show / Hide |
Range on Protein: 252-287 Range on HMM: 261-296/296 Sequence Identity: 25% (9 aa) LEIPDSVPSQISEIIQSCCNPNPQERPVISTVLQEL .. |...| .. .. ..|....||||| . ...|.. MPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
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| Kinase | TVAG_123200.AA | Fer | 220-288 | 19 | 1.3e-07 | 22.15 | In-house | 200-283 (283) | Show / Hide |
Range on Protein: 220-288 Range on HMM: 200-283/283 Sequence Identity: 19% (16 aa) DIYSFGMLILLLFV-GQDEFED---------I----VESYTEEESELEIPDSVPSQISEIIQ-SCCNPNPQERPVISTVLQELQ |..||| .. | |.. ... . .. ..... . .|...|. | .|. .|.. .| .|| ... |.| DVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
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| Kinase | TVAG_123200.AA | TK-Unique | 252-287 | 21 | 2.3e-07 | 21.58 | In-house | 258-294 (294) | Show / Hide |
Range on Protein: 252-287 Range on HMM: 258-294/294 Sequence Identity: 21% (8 aa) LEIPDSV-PSQISEIIQSCCNPNPQERPVISTVLQEL .. |... . .. ....|| . .|.||| .......| MPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | TVAG_123200.AA | MLK | 252-287 | 38 | 3.4e-07 | 19.59 | In-house | 245-280 (280) | Show / Hide |
Range on Protein: 252-287 Range on HMM: 245-280/280 Sequence Identity: 38% (14 aa) LEIPDSVPSQISEIIQSCCNPNPQERPVISTVLQEL | ||.. | . . ..|.| |..| .|| |..||.| LPIPSTCPEPWAKLMQDCWNQDPHKRPKFSEILQQL |
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| Kinase | TVAG_123200.AA | PLK1 | 206-289 | 28 | 1e-06 | 17.31 | In-house | 167-253 (253) | Show / Hide |
Range on Protein: 206-289 Range on HMM: 167-253/253 Sequence Identity: 28% (25 aa) APELTGTTKKTLPGDIYSFGMLILLLFVGQDEFE--DIVESYTE-EESELEIPDSVPSQISEIIQSCCNPNPQERPVISTVLQELQD |||. . . ||.| | .. .| .|| || . | | . | ||... ...|.. .|.|..|| |. ||.. APEVLNKKGHSFEVDIWSIGCIMYILLFGQPPFETKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF |
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| Kinase | TVAG_123200.AA | HH498 | 254-287 | 31 | 1e-06 | 16.54 | In-house | 247-284 (284) | Show / Hide |
Range on Protein: 254-287 Range on HMM: 247-284/284 Sequence Identity: 31% (12 aa) IPDS----VPSQISEIIQSCCNPNPQERPVISTVLQEL || . .| ..| .|| | .|.| .|| . .. | IPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL |
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| S_TKc | TVAG_123200.AA | S_TKc | 34-291 | 12 | 3e-06 | -86.22 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 34-291 Range on HMM: 1-231/231 Sequence Identity: 12% (36 aa) LVLETPLGNIS-----KMKNKNSDRSQYLVQTINTDLSQKSNSSLFFKEVQNLSSSKYPTILPFEGFTISNSYNCDKPAIVYDCYTG--LKLSEILEIED . ..| . | ..|. . .. . |. . .|.| |.. . | | . .. . |. .| .. | | .... YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRG DENALENWNLTTKIRSLIGVAFALDHIHGLNIAHGNINAESVVYGGDYWPY-------LANLSFENFFNEEKVKNLVPSYFETTWKAPELTGTTKKTL-P . . . . . .. ||...| ..| | . | . || . . .. . . . |||. . . . RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----------TTFCGTPW---YMAPEVL---GYGKCK GDIYSFGMLILLLFVGQDEFEDIVESYTEEESELEIPDSVPSQISEIIQSCCNPNPQERPVISTVLQ-----ELQDSI |..|.| .. ...|. |. ... ... ... ..|. |.. .|..|| . .|| . . CDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | TVAG_123200.AA | TK | 255-287 | 19 | 4e-06 | 15.62 | In-house | 440-486 (486) | Show / Hide |
Range on Protein: 255-287 Range on HMM: 440-486/486 Sequence Identity: 19% (9 aa) PDSVP--------------SQISEIIQSCCNPNPQERPVISTVLQEL |. | . ...|.|....|..|| |.....| PPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL |
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| Kinase | TVAG_123200.AA | RAF | 259-287 | 24 | 4e-06 | 16.9 | In-house | 247-275 (275) | Show / Hide |
Range on Protein: 259-287 Range on HMM: 247-275/275 Sequence Identity: 24% (7 aa) PSQISEIIQSCCNPNPQERPVISTVLQEL |. ..|....| . .|.|||. . .. .. PKEMKELLMECWSYQPEERPSFQQIMKMI |
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| TyrKc | TVAG_123200.AA | TyrKc | 34-287 | 14 | 2.4e-05 | -136.31 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 34-287
Range on HMM: 1-280/280
Sequence Identity: 14% (47 aa)
LVLETPLGN-------ISKMKNKNSDRSQYLVQ----TINTDLSQKSNSSLFFKEVQNLSSS--KYPTILPFEGFTISNSYNC---DKPAIVYDCYTGLK
..|. ||. ..| .| ... | | .| . ... . | |. . | .. . | . . || .
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD
LSEILEIEDDENALENWNLTTKIRSLIGVAFALDHIHGLNIAHGNINAESVVYGGDYWPYLANLSFENFFNEEKVK--------NLVPS--------YF-
| . | .. .. ... . .| ...| |. | . | . .| .. || .. |
LKDYLRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----------------TVKISDFGLSRDIYDDDQQGESKDYYR
-----ETT------WKAPE--LTG-TTKKTLPGDIYSFGMLI--LLLFVGQDEFE--------DIVESYTEEESELEIPDS--------VPSQISEIIQS
. | ||| .| | |. |..||| .. .. . .| . . | | .. ...|.. |. . .|...
KKEHKGGKTMLPIRWMAPECINYGKFTTKS---DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQ
CCNPNPQERPVISTVLQEL
|.. .| .|| |.. ...
CWHEDPEDRPTFSEIHECF
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| Kinase | TVAG_123200.AA | Pkinase_Tyr | 252-287 | 25 | 0.000602 | 13.99 | Pfam | 235-270 (270) | Show / Hide |
Range on Protein: 252-287 Range on HMM: 235-270/270 Sequence Identity: 25% (9 aa) LEIPDSVPSQISEIIQSCCNPNPQERPVISTVLQEL ...|. | | .....| ...|..|| | ....| MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | TVAG_123200.AA | HH498 | 204-228 | 34 | 0.105651 | 0.72 | In-house | 191-216 (284) | Show / Hide |
Range on Protein: 204-228 Range on HMM: 191-216/284 Sequence Identity: 34% (9 aa) WKAPELTG-TTKKTLPGDIYSFGMLI | ||| . .| . |..|..| | WMAPEVFSQCQKYSIKVDVFSYAMCI |
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| TTL | TVAG_123200.AA | TTL | 441-741 | 29 | 2.1e-70 | 245.01 | Pfam | 1-323 (323) | Show / Hide |
Range on Protein: 441-741 Range on HMM: 1-323/323 Sequence Identity: 29% (96 aa) LSLQP-----WQFINHIPGTYVISRKVELARNIERIQKYFPKI------YTFHPLSFAVPAQSLDLQQYMMNAPL--KDRTFIIKPDLGAQGKGIYLIQN .... .| .|| |. |.|.|| |..||.| .. |.. . | | .| |.. .. .| .. .. ....|.||. ...|.||... . MRIDMHYRMMHQMCNHFPNSYWITRKDRLWMNIKRMMCDFGWKHDPYIHFDFMPRTFMLPTDYQEFVDYWEDHEWWGQHNWWIVKPWNSCRGRGIWIMNK PDDVLD-------ITETSIAQQYINS-HLIDG--YKFDLRIYVLVSSVSPLRIYTFNEGMARFCTEPYKKPRQGNLDQIYRHLTNYSVNKKNSKFEQPTD ... .. ... ..|.|| |||| .|||.|.|||| |. ||||| ..|| .|||...|.. ||| . |||||...|..| .. . WSQIPKWVFDSQHQDRPWVVQKYIERPLLIDGMHHKFDIRCYVLVTSFNPLRIYVYREGWCRFCSVKYHP-SMSNLDNKCMHLTNYCIQKHYSNYS-CNR DDASNDGFKRSFSSVLHEMKSEGVDTDKLLKDMHQLIVLTILAVYSYIKHSVKTAFRVDDGKSRCFEIMGYDILI--DKKNKPWLLEVNHSPSLQCDSPF |. | ... .. ...|.|.|.. .. . .|. ||.| . | |...... . |||..|.|..| | . ||||||||.||.. |..| DYNECHGHMWTIQNFWNYLENMGIDWDNIWSQICDIIMKTIVAAWN---HCVEACRMNMQPRYNCFELYGFDFMIQWDENLKPWLLEVNISPDMHCTCPL DKTLKDNVISGAMK--IMDLNPNFKKIV |..|....|. . |.. |. DAHLCHQLIDDVLNCAGCHVPPDCMKDC |
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