Gene 88200.m00261 (T.vaginalis)
88200.m00261
Species: T.vaginalis
Alias: TvagK0790, 88200.m00261
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 88200.m00261.AA | Protein | None | 2171 | None | Fasta, JSON |
| 88200.m00261.kin_dom | Protein Kinase Domain | None | 279 | None | Fasta, JSON |
Protein domains of 88200.m00261.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Rapamycin_bind | 88200.m00261.AA | Rapamycin_bind | 1693-1792 | 43 | 9.5e-58 | 184.18 | Pfam | 1-100 (100) | Show / Hide |
Range on Protein: 1693-1792 Range on HMM: 1-100/100 Sequence Identity: 43% (43 aa) EMIRVAVTWWEQWFGILDEASRAYLLRNDINEMCELLEPLNEVISKEPSTYFEVSFLAQFGLSLANAHSCIKEYRRTQNEQCVLSAWQTYYSVYQDLKPM |.||||. |.|.|...|.||||.|. ...|..|...||||.|...|.|.|..|.|| .||| .| .||.. . |.||..|.|. .||..||.|....... ELIRVAILWHEMWHEGLEEASRQYFGDHNIEKMFNILEPLHEMLEKGPETMREISFVQQFGRDLQEAHEWCQKYKRTGDENCLNQAWDIYYQVFRRIRKQ |
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| Kinase | 88200.m00261.AA | FRAP | 1859-2109 | 51 | 6e-109 | 368.25 | In-house | 1-251 (251) | Show / Hide |
Range on Protein: 1859-2109 Range on HMM: 1-251/251 Sequence Identity: 51% (130 aa) KYTFLLKAHEDTRLDERVMQLFGFINTLVEHSDIPMKNHLDITTYKVIPLTTSVGLIGWVQGCSTVYDQIKQRREKAGIPLELECQTTYKAAPNYEQLPL | |||| ||| | ||||||||| ||.| . | | |. | .||| . ||||||. | | |.. |.| | . | . . ...|..||| EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMCNDYDHLPL DDKLFAFKRGLNATKGDDLKILLLAQANDSNHWIERRTAYSTSLAMTSMAGYILGLGDRHLCNIMIKQKSAKLVHIDFGDCFEVAQHREKAPEKVPFRLT .| |. .| |||.||| || | |.|||| | ||| |||||||||||||. |||. . |.|||||||||||| ||| |||.||||| MNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLT RILSNALEVSRIEGTFRSCCENVMNLMRSNSETINGILEVFVYDPLQQWIE |.| ||.|. |||..| || ||. .| . | . .|| |||||| |. RMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL |
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| Kinase | 88200.m00261.AA | PIKK | 1830-2099 | 41 | 1.3e-108 | 367.15 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 1830-2099 Range on HMM: 1-290/290 Sequence Identity: 41% (119 aa) TLSSIAPELTVMKSKQRPRRMIMFGDDGKKYTFLLKAHEDTRLDERVMQLFGFINTLVEHSDIPMKNHLDITTYKVIPLTTSVGLIGWVQGCSTVYDQIK .... .|||..||.|..... | ||| | .|.| ||| |.|.||||||...||. . | || |.||.|||... |||.||..|.| . .| RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK QRREKAGIPLELECQT--------------------TYKAAPNYEQLPLDDKLFAFKRGLNATKGDDLKILLLAQANDSNHWIERRTAYSTSLAMTSMAG |...|..| | | | . ...| .||..|. .| ...|..|..| ... . |. | |||..| |.| .|.| QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG YILGLGDRHLCNIMIKQKSAKLVHIDFGDCFEVAQHREKAPEKVPFRLTRILSNALEVSRIEGTFRSCCENVMNLMRSNSETINGILEVF |||||||||. ||||.. ....||||||.|||.| |...|||||||||| ..||... .|| ||.||| || .||.. ||. ...||| YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
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| Kinase | 88200.m00261.AA | PI3_PI4_kinase | 1859-2109 | 24 | 1.3e-61 | 215.84 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 1859-2109 Range on HMM: 1-300/300 Sequence Identity: 24% (73 aa) KYTFLLKAHEDTR--LDERVMQLF-----------------------GFINTLVEHSDIPMKNHLDITTYKVIPLTTSVGLIGWVQGCSTVYDQIKQRRE | |..| ..| | |.|.||.. ...|.. . .. ...|..||. . |.|.|| | | .. .. WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV KAG-IPLELECQTTYKAAPNYEQLPLDDKLFAFKRGLNATKGDDLKILLLAQANDS-NHWIERRTAYSTSLAMTSMAGYILGLGDRHLCNIMI--KQKSA | . .... | .| .|....| . .|. | . .. |....| ... . | | |.|. . .|.| ....||||.||||. |||. . .. KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG KLVHIDFGDCFE-VAQHREKAPEKVPFRLTR------ILSNAL------EVSRIEGTFRSCCENVMNLMRSNSETINGIL-------EVFVYDPLQQWIE .|.|||||.||. ....... ||.||||.|. ...|. ..|. .|.||..|. .....|.... . | | .|.|.| | . HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
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| Kinase | 88200.m00261.AA | PI3Kc | 1861-2160 | 24 | 2.4e-60 | 207.73 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 1861-2160
Range on HMM: 1-336/336
Sequence Identity: 24% (83 aa)
TFLLKAHEDTRLDERVMQLFGFINTLVEHSDIPMKNHLDITTYKVIPLTTSVGLIGWVQGCSTVYDQIKQRREKAGIPLELE------------------
...|...| | |.|.||.|. .|.. . .| ...||.||. |.|.|| | |. | .......|. ..
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
---CQTTYKAAPNYEQLPLDDKLFAFKRGLNATKGDDLKILLLAQANDSN-HWIERRTAYSTSLAMTSMAGYILGLGDRHLCNIMIKQKSAKLVHIDFGD
|. .... |... .. .| | ....|...|. .. . |.| | |.|. . |.| .|..||||.||||. |||.. |. ...|||||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
CFEVAQHREKAP----EKVPFRLTRILSNALE----VSRIEGTFRSCCENVMNLMRSNSETINGILEVFVYDPL-QQWIEESKDEHGGDAKVIINRIKDK
.|. .. ... . |.||||||. . .. . .| .| ||.||. ....||..|..| ..|..||||. .| . . | |.. .|.
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-----EKDIKYLRQRFRLD
-LSGRDFPEK---------EKLTYQDQVDRLIQEATDANNL
|| .. .. . . . . |..... . ...
HLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| Kinase | 88200.m00261.AA | ATM | 1991-2107 | 51 | 3.5e-43 | 135.59 | In-house | 133-248 (304) | Show / Hide |
Range on Protein: 1991-2107 Range on HMM: 133-248/304 Sequence Identity: 51% (60 aa) WIERRTAYSTSLAMTSMAGYILGLGDRHLCNIMIKQKSAKLVHIDFGDCFEVAQHREKAPEKVPFRLTRILSNALEVSRIEGTFRSCCENVMNLMRSNSE | |.| || | | |. |||||||||| ||.| .|| ||||| | || . || ||||||| . . . .|| || ||| | || | WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILP-TPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE TINGILEVFVYDPLQQW |. | || .|||| | TLLTIVEVLLYDPLFDW |
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| Kinase | 88200.m00261.AA | ATR | 1829-2099 | 27 | 4e-41 | 137.6 | In-house | 1-267 (267) | Show / Hide |
Range on Protein: 1829-2099 Range on HMM: 1-267/267 Sequence Identity: 27% (74 aa) VTLSSIAPELTVMKSKQRPRRMIMFGDDGKKYTFLLKAHEDTRLDERVMQLFGFINTLVEHSDIPMKNHLDITTYKVIPLTTSVGLIGWVQ---GCSTVY .. . . .. | |.|... . | ||| | . | ..| | | | |. || . . ... || |||| ..| ||. . .. AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL DQIKQRREKAGIPLELECQTTYKAAPNYEQLPLDDKLFAFKRGLNATKGDDLKILLLAQANDSNHWIERRTAYSTSLAMTSMAGYILGLGDRHLCNIMIK |.. . ... .| |.. .| |. .|. | . . . . |. | | .| | | .| |||.|||||| ||.|. DKLWKEKKQYMQFYQLRQCMDKKSREEWE------KQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILID QKSAKLVHIDFGDCFEVAQHREKAPEKVPFRLTRILSNALEVSRIEGTFRSCCENVMNLMRSNSETINGILEVF . .||.|. | . | || ||||||. . ... . .| || || .| .|| . . | .... | KINGECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | 88200.m00261.AA | FATC | 2139-2171 | 69 | 2.2e-20 | 68.33 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 2139-2171 Range on HMM: 1-33/33 Sequence Identity: 69% (23 aa) EKLTYQDQVDRLIQEATDANNLCQMFKGWHPWW |.|. ..||||||||||| .|||||. || ||| EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
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| Kinase | 88200.m00261.AA | DNAPK | 1829-1923 | 35 | 8.2e-18 | 61.25 | In-house | 2-96 (301) | Show / Hide |
Range on Protein: 1829-1923 Range on HMM: 2-96/301 Sequence Identity: 35% (34 aa) VTLSSIAPELTVMKSKQRPRRMIMFGDDGKKYTFLLKAHEDTRLDERVMQLFGFINTLVEHSDIPMKNHLDITTYKVIPLTTSVGLIGWVQGCST | . ||| | ||.|.|. | | . |. | || |.| |. ||| | | |. || .||.| ||| || .. VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVV |
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| Kinase | 88200.m00261.AA | SMG1 | 1838-1935 | 36 | 8.3e-18 | 55.43 | In-house | 1-100 (242) | Show / Hide |
Range on Protein: 1838-1935 Range on HMM: 1-100/242 Sequence Identity: 36% (36 aa) LTVMKSKQRPRRMIMFGDDGKKYTFLLKAHEDTRLDERVMQLFGFINTLVEHSDIPMKNHLDITTYKVIPLTTSVGLIGWVQGCSTVYDQIK--QRREKA .|.. | .|.... | ||| | .| | || ||||.|| .||. . | | || | ||| || | .. | | || | ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAA |
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| Kinase | 88200.m00261.AA | DNAPK | 2009-2109 | 33 | 2.5e-17 | 59.48 | In-house | 201-301 (301) | Show / Hide |
Range on Protein: 2009-2109 Range on HMM: 201-301/301 Sequence Identity: 33% (34 aa) GYILGLGDRHLCNIMIKQKSAKLVHIDFGDCFEVAQHREKAPEKVPFRLTRILSNALEVSRIEGTFRSCCENVMNLMRSNSETINGILEVFVYDPLQQWI ..||| ||||| | |. . |||| | | || |||||| | . | | ... | .|. .||. ||. | HWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWK E N |
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| Kinase | 88200.m00261.AA | SMG1 | 1997-2051 | 47 | 5.3e-13 | 39.26 | In-house | 189-242 (242) | Show / Hide |
Range on Protein: 1997-2051 Range on HMM: 189-242/242 Sequence Identity: 47% (26 aa) AYSTSLAMTSMAGYILGLGDRHLCNIMIKQKSAKLVHIDFGDCFEVAQHREKAPE .| | |. || |||.||||||| |..| ||||. ||| . ..|| SYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGK-KLNVPE |
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| Kinase | 88200.m00261.AA | ATM | 1863-1920 | 37 | 1.7e-08 | 22.8 | In-house | 3-60 (304) | Show / Hide |
Range on Protein: 1863-1920 Range on HMM: 3-60/304 Sequence Identity: 37% (22 aa) LLKAHEDTRLDERVMQLFGFINTLVEHSDIPMKNHLDITTYKVIPLTTSVGLIGWVQG | | .| | | . | | |||. | | | ||||.|| | . | | LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTG |
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