Gene 84843.m00270 (T.vaginalis)

84843.m00270

Species: T.vaginalis
Alias: TvagK0774, 84843.m00270
External Links:
Annotation:

Classification

Group: Other
Family: PLK
Subfamily: PLK1

Sequence

Name Sequence Type Origin Length Description Download
84843.m00270.AA Protein None 265 None Fasta, JSON
84843.m00270.kin_dom Protein Kinase Domain None 251 None Fasta, JSON

Protein domain

Protein domains of 84843.m00270.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc 84843.m00270.AA S_TKc 13-263 31 3.5e-84 286.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 13-263
Range on HMM: 1-231/231
Sequence Identity: 31% (85 aa)

VTNLHEIGHGTFSIVYQGKLKDSGQGIAIKKITADITEEIFRREINNMCSSDHPNIVKIYDAFLQDKFPYIILQYCAN--GTLSQRLETLDN------YS
 . | .||.|.|. ||... |..|.  |||.|      | .||||. . . .||||||.||.|   .. |... || .  |.| ....          ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

DDDARLILKSVLEAVSYLHSHHIIHRDIKAENIYFDENDNVLLGDFGSSKFIANDTAQSLVGTMDYIAPEVIESNISGTNYNE-KADIWSIGILTFYLIE
  .|| ... ...|. |.|||.|||||.| ||| .||  .. ..|||.....      ...|| .|.||||.        |.  |.|.||.|.. . .. 
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCILYEMLC

KHFPFQVSNYRVSPDMTDGSYKNEFYLSHSDKILDFIDKCLQPNPDDRPDAAELLK-------HPYI
   ||.           .  .|.      |.  .|||.|||| .|..|| | |.|.       ||..
GYPPFP---------QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase 84843.m00270.AA Pkinase 13-263 26 1.3e-74 259.03 Pfam 1-293 (293) Show / Hide 
Range on Protein: 13-263
Range on HMM: 1-293/293
Sequence Identity: 26% (78 aa)

VTNLHEIGHGTFSIVYQGKLKDSGQGIAIKKITADITEEIFRR------EINNMCSSDHPNIVKIYDAFLQDKFPYIILQYCANG----TLSQRLE--TL
 . .  || |.|. ||... |..|.  |.|.|  . ... ...      ||  | . .|||||..||.|  .. .|... || .|     |. ...    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DNY--SDDDARLILKSVLEAVSYLHSHHIIHRDIKAENIYFDENDNV----LLGDFGSSKF--IANDTAQSLVGTMDYIAPEVIESNISGTNYNEKADIW
 ..  |..... ... .|... |.||. |||||.| ||| .|.|...     ..|||..|.  . |.......|| .|.|||||    .|. |  |.|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIR---GGQYYGPKVDMW

SIGILTFYLIEKHFPFQVS-------NYRVSPDMTDGSYKNEFYLSHS-------------------DKILDFIDKCLQPNPDDRPDAAELLKHPYI
|.|.. .... ...||. .        . .     .. .. ... ..|                   .  .|||..||...| .|| |...|.||..
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 84843.m00270.AA CAMK 18-263 19 1.9e-72 232.53 In-house 1-425 (425) Show / Hide 
Range on Protein: 18-263
Range on HMM: 1-425/425
Sequence Identity: 19% (82 aa)

EIGHGTFSIVYQGKLKDSG------------QGIAIKKIT------------------------------ADITEEIFRREINNMCSS-------DHPNI
..|.|.|..|. .. | ..            |  ||| |                                . ... .||||. | .        |||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKIYDAFLQ-------------------DKFPYIIL---QYCANG----TLSQRLETLDN---------------YSDDDARLILKSVLEAVSYLHSHHI
.|.|...                     ||. |...    || .|     | ...    .               .. ..|| . . ...|| |.|||.|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKAENIYFDEND-----------------NVLLGDFGSSKFIA-------------------------NDTAQSLVGTMDYIA-PEVIES------
.|||.| ||| .|.|.                 |. . ||| ....                          ..  .  .||  |.| |||...      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----NISGTNYNEKADIWSIGILTFYLIEKHFPFQVSNYRVSP--------------DMTDGSYK-NEFYLSH-------------SDK--------ILD
    .   . |..|.|.||.|.... .   ..||. ..    .                . | |   ..|.|.             ||           |
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FIDKCLQPNPDDRPDAAELLKHPYI
.| |.||..|..|. ... |.|| .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 84843.m00270.AA STE 13-263 23 2.8e-70 239.77 In-house 1-359 (359) Show / Hide 
Range on Protein: 13-263
Range on HMM: 1-359/359
Sequence Identity: 23% (86 aa)

VTNLHEIGHGTFSIVYQGKLKD---------------SGQGIAIKKIT----------------ADI---TEEIFRREINNMCSSD--HPNIVKIYDAFL
 ... .||.|.|  ||... ..               .|. .|||..                  ..    .. . .||. |  ..  |||||| |....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

QD-------KFPYIILQYCANGTLSQRLE-------TLDNYS-------DDDARLILKSVLEA-VSYLHSHHIIHRDIKAENIYFDENDNVLLGDFGSSK
..          .|.. |...|.|.. ..       .|.. .        .  . |....|..  .|||||||||||||. || .     | | ||| ..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

FIAND------------------TAQSLVGTMDYIAPEVIESNISG--TNYNEKADIWSIGILTFYLIEKHFPF-QVSNYRVSPDMT-------------
 ....                    ...|||  . |||||. | .|    |..|.||||.|..   ... . |.   .. |.   ..             
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---DGSYKNEFYLS-----------------HSDKILDFIDKCLQPNPDDRPDAAELLK--HPYI
   ... . .  ||                  |..  |||.|||| .|..||.| .|||  || |
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 84843.m00270.AA Ciliate-E2 13-263 19 8.5e-65 221.35 In-house 1-365 (365) Show / Hide 
Range on Protein: 13-263
Range on HMM: 1-365/365
Sequence Identity: 19% (75 aa)

VTNLHEIGHGTFSIVYQGKLKDSGQGIAIKKITADI----------------------TEEIFRREINNMC-----------------SSDHPNIVKIYD
   .  || |.|..||..| .  .. .|||.|. ..                       . ..   .....                 . .||||.|.|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

AFL--QDKFPYIILQYCANGTLSQRLE------------TLDNYSDDDARLILKSVLE---------------AVSYLHSHH-IIHRDIKAENIYFDEND
.|   .|.  |... ||  |.| ....               ....  .. | | .|.               |. |||| . ||||||| ||| |    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

NVLLGDFGSSKFIAND---------------------------------TAQSLVGTMDYIAPEVIES-----NISGTNYNEKADIWSIGILTFYLIEKH
 . . ||| ||.. .|                                 ......||  | |||....     .. .. |..|.||||.|.. .... . 
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

FPFQVSNYRVSPDMTDGSYKNEF------------------------YLSHSDKILDFIDK----CLQPNPDDRPD-AAELLKHPYI
.||               ...                          ....|..  |.| |    .|| .|. |.. . ..|.||..
PPF---------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 84843.m00270.AA Ciliate-E2-Unclassified 16-263 22 4e-55 189.45 In-house 4-352 (352) Show / Hide 
Range on Protein: 16-263
Range on HMM: 4-352/352
Sequence Identity: 22% (78 aa)

LHEIGHGTFSIVYQGKLKDSGQGI-----AI-------KKITADITEEIFR-REINNM----------------CSSDHPNIVKIYDAFLQDKFPYIILQ
.. ||.| |..||. . |. .  .     ..       |.|   . |...   |.||.                 ...||.||| ...| ... .||...
IKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVME

YCANGTLSQRLETLDN-----------------YSDDDAR-----LILKSVLEAVSYLHSHH-IIHRDIKAENIYFDEND---NVLLGDFGSSK------
|| .|.|.| ..   .                  ..  |.      ... .|.. .|||. . ||||||| ||| ||.|    .. . |||.||      
YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNN

-----------FIANDTAQSLVGTMDYI----APEVIES-NISGTNYNEKADIWSIGILTFYLIEKHFPFQVSNYRVSP-------------DMTDGSYK
           .. .. ... .||  |.    ||||... | ...   .|.|||| |.. ....   .||.  |.  .               . .  ..
NCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

NEFY----------LSHSDKILDFID----KCLQPNPDDRPDAAELLKHPYI
....             |..  |||     |.|. ||. |... ..|.||..
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 84843.m00270.AA CAMK1 14-199 34 1e-52 151.55 In-house 2-207 (276) Show / Hide 
Range on Protein: 14-199
Range on HMM: 2-207/276
Sequence Identity: 34% (71 aa)

TNLHEIGHGTFSIVYQGKLKDS---GQGIAIKKIT-ADITEE-------IFRREINNMCSS---DHPNIVKIYDAFLQDKFPYIILQYCANGTLSQRLET
 .  ||| |.||.||... |..   |. .||| |   . ...        ...||. | ..   |||||.|.|. .  |.. |...... .| |  |   
EFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIVE

LDNYSDDDARLILKSVLEAVSYLHSHHIIHRDIKAENIYFDENDNVL-----LGDFGSSKFIAND--TAQSLVGTMDYIAPEVIESNISGTNYNEKADIW
 .||. .|||.| | .|.|| |.||. | |||.| ||. .  .|.       . ||| ||.. .|  . .  .|| .|.||||.|     . |  . |.|
KGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKK-DKPYDKACDMW

SIGILTF
|||. |.
SIGVITY
Kinase 84843.m00270.AA ULK 13-263 24 5.1e-51 175.82 In-house 1-324 (324) Show / Hide 
Range on Protein: 13-263
Range on HMM: 1-324/324
Sequence Identity: 24% (80 aa)

VTNLHEIGHGTFS-IVYQGKLKDS---GQGIAIKKIT-----ADITE-------EIFRREINNMCSSD---HPN--IVKIYDAFLQD--KFPYIILQYCA
    |..|.|.|   ||.|. |..   .| .|.|.|       .  |       . ...||..|   .   |||  ||| || |  .  .. |||. || 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

NGTLSQRLETL---------DNYSDDDARLILKSVLEAVSYLHSHHIIHRDIKAENIYFDENDN------------VLLGDFGSSKFIANDT-----AQS
 |.|.| ...           . | . |. ..|  ...  .||.| ||||||| .||   ...             . ..||| .|.. |..      |.
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

LV------GTMDYIAPEVIESNISGTNYN-EKADIWSIGILTFYLIEKHFPFQVSNYRVSP----DMTDG---------SYKNEFYLSH-----SDKILD
.|      ||  | ||......  . .|.  |.||||.|.. ....    ||. . ..       .. .            . .|..       |... |
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

FIDKCLQPNPDDRPDAAELLKHPYI
.| ..|| ...|| .  |...|| .
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 84843.m00270.AA ULK 13-263 24 1.1e-50 174.67 In-house 1-329 (329) Show / Hide 
Range on Protein: 13-263
Range on HMM: 1-329/329
Sequence Identity: 24% (81 aa)

VTNLHEIGHGTFSIVYQGKLKDS----GQGIAIKKITAD-ITEEI-----------FRREINNMCSSD--------HPNIVKIYDAFLQD--KFPYIILQ
    |..|.|.|  ||.|. |..    .. .|.|.|  . . ..            ...|| .|   .        |||||| || |  .  .  |||. 
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCANGTLSQRLETLDNYSDDD----------ARLILKSVLEAVSYLHSHHIIHRDIKAENIYFDENDN------------VLLGDFGSSKFIAND-----
||  |.|.| ...  . . |           |. ..|  |..  .||.| ||||||| .||  ....             . ..||| .|.. ||     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

TAQSLV------GTMDYIAPEVIESNISGTNYN-EKADIWSIGILTFYLIEKHFPFQVSNYRVSPDMTDGSYKN--------------EFYLS-----HS
 ... |      ||  | ||......  . .|.  |.||||.|.. ....    ||. . ..   ..   . .|              .|. .      |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

DKILDFIDKCLQPNPDDRPDAAELLKHPYI
... |.| ..|| ...|| .  ||..|| .
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 84843.m00270.AA TKL 19-261 18 6.9e-49 168.74 In-house 1-364 (364) Show / Hide 
Range on Protein: 19-261
Range on HMM: 1-364/364
Sequence Identity: 18% (69 aa)

IGHGTFSIVYQGKLKD--------SGQGIAIKKITAD-----------------------------ITEEIFRREINNMCSSDHPNIVKIYDAFLQDKF-
|| |.|..||.||..         .|. .|.||.  .                               .. ...||. | . .|||||... . .. .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PYIILQYCANGT-LSQRLETLDNYSDDDARLILKSVLEAVSYLHSHH--------IIHRDIKAENIYFDENDN--------------V
            ..|. .|| .|. |.. .        .    . ...  ...||||..        |||||.| .||  ||| .              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

LLGDFGSSKFIAND---------------------TAQSLVGTMDYIAPEVIESNISGTN------------YNEKADIWSIGILTFYLIEKHFPFQ-VS
 ..||| |.|. ..                     |  . .||  . ||||.. ..  |.            |.||.|..| ||. . ..    |..   
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

NYRVSPD-------MTDGSYKNEFYLS------------HSD--KILDFIDKCLQPNPDDRPDAAELLKHP
.. . .        | ... ..   .             ..    . . . .| ...|..|| . |.||. 
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 84843.m00270.AA STE20 14-196 32 8.2e-40 138.59 In-house 2-215 (288) Show / Hide 
Range on Protein: 14-196
Range on HMM: 2-215/288
Sequence Identity: 32% (70 aa)

TNLHEIGHGTFSIVYQGKLKDSGQG----IAIKKITADIT------EEIFRREINNMCSSDHPNIVKIYDAFLQDKFP----YIILQYCANGTLSQRLE-
..|..||.|..  || .  |..|.     .||||.  .        .|    ||. |  ..|||||| |...| |. .    .|.  ||. |.|.. .. 
ELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKH

--TLDN------YSDDDARLILKSVLEAVSYLHSHHIIHRDIKAENIYFDENDNVLLGDFGSSKFIAN-------DTAQSLVGTMDYIAPEVIESNIS-G
  ....       . .    |.. ||.. .||||.||||||||| ||  .|. .| | ||| .  . .        . ...|||  . |||||. . .  
CMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPD

TNYNEKADIWSIGI
 .|..|.|||| ||
KGYDYKCDIWSLGI
Kinase 84843.m00270.AA STE11 13-195 30 5e-37 129.32 In-house 1-225 (303) Show / Hide 
Range on Protein: 13-195
Range on HMM: 1-225/303
Sequence Identity: 30% (70 aa)

VTNLHEIGHGTFSIVYQGKLKDSGQGIAIKKITADITE----------EI------FRREINNMCSSDHPNIVKIYDAFL---QDKFPYIILQYCANGTL
 .  . || |.|. ||..  .| |. .|.|.|  . ..          .       .. ||. |   .|.|||. |.. |   |... .|...||..|.|
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

SQRLETL---DNYSDDDARLILKSVLEAVSYLHSHHIIHRDIKAENIYFDENDN-VLLGDFGSSKFIANDT------------AQSLVGTMD--------
|. |..     . .    |   | .||...|||||.|||||||..||  | . | . |.|||..| .|...             .|. ||          
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

YIAPEVIESNISGTN---YNEKADIWSIG
. ||||    |...    |  ||||||.|
WMAPEV----IKQEGRDGYGRKADIWSLG
Kinase 84843.m00270.AA Pkinase_Tyr 13-197 27 3e-23 79.34 Pfam 1-203 (270) Show / Hide 
Range on Protein: 13-197
Range on HMM: 1-203/270
Sequence Identity: 27% (57 aa)

VTNLHEIGHGTFSIVYQGKLK----DSGQGIAIKKITADITEEI-----FRREINNMCSS-DHPNIVKIYDAFL-QDKF--PYIILQYCANGTLSQRLET
.| ....|.| |  ||.|..|    . ..  |.|..  . ..|      | ||.. |..  .|||||. | . . |..   .||.. |...| |   | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----LDNYSDDDARLILKSVLEAVSYLHSHHIIHRDIKAENIYFDENDNVLLGDFGSSKFI-ANDTA-QSLVGTMD---YIAPEVIESNISGTNYNEKAD
     .. .  |   .   . .. .||.|...||||. | |.  .||  |  .||| .. |   |.  ..  |..      |||.|  ..    ...| |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK----FTTKSD

IWSIGIL
.|| |.|
VWSFGVL
Kinase 84843.m00270.AA TyrKc 13-263 25 8.6e-18 64.92 SMART 1-280 (280) Show / Hide 
Range on Protein: 13-263
Range on HMM: 1-280/280
Sequence Identity: 25% (74 aa)

VTNLHEIGHGTFSIVYQGKLKDSGQGIAIKKITADITEEIFRREINNMCSS--DHPNIVKIYDAFLQD-------KFPYIILQYCANGTLSQRLETLDN-
.| ....|.| | .||.|..|   .  |.|.. .|  .| |.||.. ||.   .|||||..| . .|.       . ..|.. |...| | ..|    . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

YSDDDARLILKSVLEAVSYLHSHHIIHRDIKAENIYFDENDNVLLGDFGSSKFIAND------TAQSLV----GTMD-----YIAPEVIESNISGTNYNE
 . .|   .   . .  .||||...||||. | |.  .||  |  .||| |..| .|      .    .    |. .       |||.|  ..    ...
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK----FTT

KADIWSIGIL---TFYLIEKHFPFQ----VSNYRVSPDMTDGSYKNEFYLS--------HSDKILDFIDKCLQPNPDDRPDAAELLKHPYI
| |.|| |..    | . ..  | .    .||..|  .  .| |  .   .         .|.. . . .| . .|.|||  .|.  | ..
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG-YRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 84843.m00270.AA STE20 233-263 58 1.6e-12 42.37 In-house 258-288 (288) Show / Hide 
Range on Protein: 233-263
Range on HMM: 258-288/288
Sequence Identity: 58% (18 aa)

SDKILDFIDKCLQPNPDDRPDAAELLKHPYI
|..  ||.||||| .|..|| | .|||||.|
SPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase 84843.m00270.AA STE11 233-263 41 1.6e-12 41.88 In-house 273-303 (303) Show / Hide 
Range on Protein: 233-263
Range on HMM: 273-303/303
Sequence Identity: 41% (13 aa)

SDKILDFIDKCLQPNPDDRPDAAELLKHPYI
|..  ||...|....| .|| |..||.|| |
SEECRDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase 84843.m00270.AA CAMK1 238-263 38 2.7e-08 20.14 In-house 251-276 (276) Show / Hide 
Range on Protein: 238-263
Range on HMM: 251-276/276
Sequence Identity: 38% (10 aa)

DFIDKCLQPNPDDRPDAAELLKHPYI
||| . | ..|  |..... |.|| |
DFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 84843.m00270.AA Pkinase_Tyr 242-263 31 4.207931 0.97 Pfam 251-270 (270) Show / Hide 
Range on Protein: 242-263
Range on HMM: 251-270/270
Sequence Identity: 31% (7 aa)

KCLQPNPDDRPDAAELLKHPYI
.| ...|.|||  .|.  |  .
QCWHYDPEDRPTFSEI--HEQL