81616.m00138

Species: T.vaginalis
Alias: TvagK0727, 81616.m00138
External Links:
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: CDC15

Sequence

Name Sequence Type Origin Length Description Download
81616.m00138.AA Protein None 1048 None Fasta, JSON
81616.m00138.kin_dom Protein Kinase Domain None 232 None Fasta, JSON

Protein domain

Protein domains of 81616.m00138.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 81616.m00138.AA STE 22-255 23 6.4e-60 205.38 In-house 15-359 (359) Show / Hide
Range on Protein: 22-255
Range on HMM: 15-359/359
Sequence Identity: 23% (81 aa)

VVKALSKT---------------SGKFFAMKYFPAES------------LKNI---EKKTIYRLINVLSSLY--HPHITYINEIMYKANP-----DEAFI
|.||. .                .|...|.|  . |.            |.|.   |.. | . |.... .   ||.|       .| ..     || .|
VYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWI

ALEWCDGSSVKNTLD-RFST-------------LPEKLVGRYTYEIIKG-LEFLHSQGQVHKNLKAANLLLASGVLKLSDFGLSAEVST-----------
..|..|| |.   .. ....             .||.........|.|| |..|||.. .|  .|.|| ||     ||.|||... ..            
CMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQLTDSMANIQSNNII

---CSISEH-------PYWAAPEVIES------RTFSNKSDIWSMGATIIELLTGKPPFAELPPEEARIKIL----------------NETPPIP-----
    .....       | | |||||.          . |.|||| | ||||..|||||.....| .|   |.                .. ||.|     
DCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQ

--------------AKASAHLQDFLCACFAKNPDERPSTEECYN--FFFV
               | | ...||.  |. |.|..||....  .    |.
NEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase 81616.m00138.AA S_TKc 22-255 26 1.5e-47 165.19 SMART 15-231 (231) Show / Hide
Range on Protein: 22-255
Range on HMM: 15-231/231
Sequence Identity: 26% (65 aa)

VVKALSKTSGKFFAMKYFPAESLKNIEKKTIYRLINVLSSLYHPHITYINEIMYKANPDEAFIALEWCDG--SSVKNTLDRFST------LPEKLVGRYT
| |.  | .|. .|.|  .         ..|.| |..|..  ||.|  . ....    |. .. .| |||   ...  ...  .      .||  . .|.
VYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYM

YEIIKGLEFLHSQGQVHKNLKAANLLLASGVLKLSDFGLSAEVSTCSISEHPYWAAPEVIESRTFSN-KSDIWSMGATIIELLTGKPPFAELPPEEARIK
|.|...||..||.| .|  || .|.|| . ..|..||||....   ..   |.. ||||.    ..  |.|.|| | ...|.|.|.|||     ... .|
YQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFK

ILNETPPIPAKASAHLQDFLCACFAKNPDERPSTEECYN-------FFFV
..          |  . ||.. |. |.|..||.  |. .         ..
KIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 81616.m00138.AA STE11 86-248 32 6.3e-46 158.9 In-house 92-296 (303) Show / Hide
Range on Protein: 86-248
Range on HMM: 92-296/303
Sequence Identity: 32% (67 aa)

LEWCDGSSVKNTLD-RFST--LPEKLVGRYTYEIIKGLEFLHSQGQVHKNLKAANLLLAS-GV-LKLSDFGLSAEVS-TCSISEH--------------P
.|.| | |..  |. .. .  ..|... .||  | .|| .|||.| .|. .|.||.|| | |. .||.||| .  ..  |. ...              |
MEYCPGGSLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTP

Y--------WAAPEVIESRT---FSNKSDIWSMGATIIELLTGKPPFAELP--PEEARIKIL---NETPPIPAKAS------AHLQDFLCACFAKNPDER
|        | |||||   .    . |.|||| |.|.|| .|||||....   .  |  ||    . .|||| . |      ....|||  || ..| .|
YNSMMGTPMWMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKR

PSTEE
|.  .
PTANQ

Kinase 81616.m00138.AA STE20 56-255 28 5.6e-42 145.78 In-house 55-288 (288) Show / Hide
Range on Protein: 56-255
Range on HMM: 55-288/288
Sequence Identity: 28% (67 aa)

INVLSSLYHPHITYINEIMYKANP--DEAFIALEWCDGSSVKNTLDRFS---------TLPEKLVGRYTYEIIKGLEFLHSQGQVHKNLKAANLLLASG-
|.... . ||.|.   .  .| ..  || .|. | |.| |.   ....          .. |. .   ..|. .||..|||....|  .||.| || .  
ISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDG

VLKLSDFGLSAEVST------C----SISEHPYWAAPEVIES-----RTFSNKSDIWSMGATIIELLTGKPPFAELPPEEARIKIL--NETPP---I--P
  ||.|||..| ...           ..   ||| |||||.          .|.|||| | |.||...|.||.....|  |  .|.  .. ||      |
EVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKP

AKASAHLQDFLCACFAKNPDERPSTEECYNFFFV
 | | ...||.  |  |.|..||....  .  |.
HKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI

Kinase 81616.m00138.AA Dicty2 22-245 35 1.3e-40 139.2 In-house 16-254 (264) Show / Hide
Range on Protein: 22-245
Range on HMM: 16-254/264
Sequence Identity: 35% (85 aa)

VVKALSKTSGKFFAMKYFP-AESLKNIEKKTI---YRLINVLSSLYHPHI-TYINEIMYKANPDEAFIALEWCDGSSVKNTLDRFSTLPEKLVGRYTYEI
| |.| ...| | | | .     ...| .. .      |. |  | |. | .||  |  ...     |.||   . |    . .| ..|| |. .| | .
VYKGLHIETGDFVAIKQINIMKKKTKISEEQHQSIMQEIHLLKKLNHHNIVKYIEHIETENH---LYIILEYIENGSLSKIIKKFGCFPESLCCIYIYQV

IKGLEFLHSQGQVHKNLKAANLLLA----SGVLKLSDFGLSAEVS------TCSISEHPYWAAPEVIESRT--FSNKSDIWSMGATIIELLTGKPPFAEL
 |||. ||.|| .|   ||||.|      ||| ||.|||   ...        ..   ||| |||||.      . ..|||| | |||||||| ||   |
LKGLVYLHRQGVIHRDIKAANILITKEGKSGVIKLADFGVATHIDYSDDDSRYTVVGTPYWMAPEVIQMSGNHCCTACDIWSLGCTIIELLTGNPPYWDL

PPEEARIKILNE-TPPIPAKASAHLQDFLCACFAKNPDERPS
 |  |  .. ..  ||.|   |. . ||| .|| | | .|..
NPMHAMFRMVQDDHPPLPNDISPECKDFLMQCFCKDPNQRMT

Kinase 81616.m00138.AA Pkinase 22-253 24 2.2e-40 143.87 Pfam 15-293 (293) Show / Hide
Range on Protein: 22-253
Range on HMM: 15-293/293
Sequence Identity: 24% (69 aa)

VVKALSKTSGKFFAMKYFPAESLKNIEKKTIYR--LINVLSSLYHPHITYINEIMYKANPDEAFIALEWCDGS----SVKNTLD-----RFSTLPEKLVG
| |.  | .|| .|.| .. .. |  ...|  |   | .. .| ||.|  . ....   .|.  . .|.|.|     . .  .      .|. ..|. . 
VYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECK

RYTYEIIKGLEFLHSQGQVHKNLKAANLLLA-SGVL----KLSDFGLSAEVSTCSISEH------PYWAAPEVIE-SRTFSNKSDIWSMGATIIELLTGK
.| |.|..|||..||.| .|  || .|.|.   |..    |..||||.. ... . |        |...|||||  ..  . |.|.||.| ...|.|.|.
FYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR

PPFAEL---PPEEARIKILNETPPIPAKAS-------------------------AHLQDFLCACFAKNPDERPSTEECYNF--F
||| .    ..    ....... . | . .                           ..||.. |..|.| .||. |.. .   |
PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 81616.m00138.AA STE-Unique 84-255 22 5.4e-40 139.18 In-house 371-616 (616) Show / Hide
Range on Protein: 84-255
Range on HMM: 371-616/616
Sequence Identity: 22% (56 aa)

IALEWCDGSSVKNTLDRFST---------LPEKLVGRYTYEIIKGLEFLHSQG--QVHKNLKAANLLLAS-G-----VLKLSDFGLSAEVSTC-------
| .| |......  ..| ..         .|| .| .|||.| .|||.||||.   .| .||..| .... |       |..|||.. . .         
IFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNN

------------------------------------SISEHPYWAAPEVIESR-----TFSNKSDIWSMGATIIELLTGKPPFAELPPEEA--RIKILNE
                                    ..   | . .||||. |      .. |.|||| |........| ||. .. . .|   . |.. 
SKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIH

TPPI-------PAKASAHLQDFLCACFAKNPDERPSTEECYNFFFV
..|        | | .  .|.|. .|. .||  |||...    |. 
CQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL

Kinase 81616.m00138.AA CAMK 22-255 14 4.7e-38 119.7 In-house 10-425 (425) Show / Hide
Range on Protein: 22-255
Range on HMM: 10-425/425
Sequence Identity: 14% (62 aa)

VVKALSK-TSG-----------KFFAMKYFPAESLKNIE--------------------------KKTIYRLINVLSS-------LYHPHITYINEIMYK
| ..  | | |           . .|.|  . . ||. .                          .| ..| |.....       | ||.|  . |..  
VKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYED

AN-----------------PDEAFIAL---EWCDGS----SVKNTLDRF---------------STLPEKLVGRYTYEIIKGLEFLHSQGQVHKNLKAAN
..                 ... .. .   | |.|      . . . .                  ..|. . ||   |. .....||.. ||  ||  |
PHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPEN

LLLAS------------------GVLKLSDFGLSAEVS----------------------------TCSISEHPYWAA-PEVIES-------------RT
.|| .                  . .|..|||.....                                    |. .| |||...             ..
ILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKP

F-SNKSDIWSMGATIIELLTGKPPFAELPPEEARI-------------KILNETPP-IPAK-----------------------ASAHLQDFLCACFAKN
  . |.|.||.|     .|.|.||| .   .| .              ||..     .| .                        |.  .|... .  ..
YYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVD

PDERPSTEECYNFFFV
|..|.. |.| |  ..
PEKRMTIEQCLNHPWM

Kinase 81616.m00138.AA TKL 27-253 18 1.9e-36 127.42 In-house 23-364 (364) Show / Hide
Range on Protein: 27-253
Range on HMM: 23-364/364
Sequence Identity: 18% (64 aa)

SKTSGKFFAMKYFPAESLKNIEK-------------------------KTIYRLINVLSSLYHPHITYINE---------IMYK--ANPDEAFIALEWCD
|  .||  |.| |. .. .. .|                         ... . |...|.| ||.|  .           ....   .. . .|  |.|.
S-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCP

GSS-VKNTLDRFSTLPEKLVGRYTYEIIKGLEFLHSQG--------QVHKNLKAANLLLAS-GV--------------LKLSDFGLSAEVS---------
| |   . .         .  |  ..| .|...|||..         .| .|| .|.|. . .               .|..||||| ..|         
GGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTM

---------------TCSISEHPYWAAPEVIESR----------------TFSNKSDIWSMGATIIELLTGKPPFAELPPE---------EARIKIL--N
               |...  .|.| ||||..                  ..| |.|..|.|  . |.||...|....|..         |  ...   .
TTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKG

ETPPIP------------AKASAHLQDFLCACFAKNPDERPSTEECYNFF
. ||||              .  .. . .  | . .|..||| .|.   .
LRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase 81616.m00138.AA MEKK2 84-255 38 5.6e-36 125.86 In-house 80-262 (262) Show / Hide
Range on Protein: 84-255
Range on HMM: 80-262/262
Sequence Identity: 38% (71 aa)

IALEWCDGSSVKNTLDRFSTLPEKLVGRYTYEIIKGLEFLHSQGQVHKNLKAANLLL-ASGVLKLSDFGLSAEVSTC--------SISEHPYWAAPEVIE
| .|.  | |||  |  .  | |.   .||  |. |...||..  ||. .| ||.|  .|| .||.||| |  . |         |.   ||| .||||.
IFMEYMPGGSVKDQLKAYGALTETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICMHITGMKSVTGTPYWMSPEVIN

SRTFSNKSDIWSMGATIIELLTGKPPFAELPPEEARIKILNET--PPIPAKASAHLQDFLCACFAKNPDERPSTEECYNFFFV
   .  | |.||.| |..|.|| |||.||     |  ||  .   | .| . | |  |||  || .   .||| ||     ||
GEGYGRKADVWSIGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV

Kinase 81616.m00138.AA MEKK15 84-255 31 5.7e-36 125.82 In-house 78-264 (264) Show / Hide
Range on Protein: 84-255
Range on HMM: 78-264/264
Sequence Identity: 31% (59 aa)

IALEWCDGSSVKNTLDRFSTLPEKLVGRYTYEIIKGLEFLHSQGQVHKNLKAANLLLAS-GVLKLSDFGLSAEVSTC-----------SISEHPYWAAPE
| ...  | |.   . ||  |.|    .||  |..| ..||    ||. .| .|..| . |..|| |||    ..             |.   ||| |||
IFMQFVPGGSISSIINRFGPLDEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPE

VIESRTFSNKSDIWSMGATIIELLTGKPPFAELPPEEARIKILNE---TPPIPAKASAHLQDFLCACFAKNPDERPSTEECYNFFFV
||    .  ||||||.| |. |. |.|||.|....  |   |  .    |..|.| |   ..|  .|  .  .|||.  .     |.
VIMETGYGRKSDIWSIGCTVFEMATRKPPWADMDRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI

Kinase 81616.m00138.AA STE11-Unclassified 84-248 28 4.6e-35 121.72 In-house 84-301 (308) Show / Hide
Range on Protein: 84-248
Range on HMM: 84-301/308
Sequence Identity: 28% (63 aa)

IALEWCDGSSVKNTLDRFSTLPEKLVGRYTYEIIKGLEFLHSQGQVHKNLKAANLLL-ASGVLKLSDFGLSAEVS----------------TCSIS-EH-
| .| . | |.   |...  . |..   || .|..||..|||.| .|. .|.||.|. . |. ||.|||..  ..                  .|. .  
IFMEYMPGGSIWSMLNKYGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHIN

------------PY---WAAPEVIE---SRTFSNKSDIWSMGATIIELLTGKPPFAEL----PPEEAR-IKILNETPPIPAKAS-----------AHLQD
            ||   | |||||.   .   . |||||| | |.||  |||.|.. .    .. ... | . |..|.|| . |           . ..|
SQQNHCKSMQGTPYQPFWMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKD

FLCACFAKNPDERPSTEE
|| .||  .| .||.. .
FLRKCFQIDPKKRPTANQ

Kinase 81616.m00138.AA Pkinase_Tyr 118-253 29 1.8e-23 80.14 Pfam 122-270 (270) Show / Hide
Range on Protein: 118-253
Range on HMM: 122-270/270
Sequence Identity: 29% (44 aa)

KGLEFLHSQGQVHKNLKAANLLLA-SGVLKLSDFGLSAEV-------STCSISEHPY-WAAPEVIESRTFSNKSDIWSMGATIIELLT-GKPP-FAELPP
||.|.|.|.. .|  | | | |.. ..| | .||||.  .        . . .  |  | |||.|  . |. |||.|| | .. |..| |. | ......
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSN

EEARIKIL--NETPPIPAKASAHLQDFLCACFAKNPDERPSTEECYNFF
||   .|   ..  |.| .... . | .. | ...|..||. .|.....
EEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

TyrKc 81616.m00138.AA TyrKc 7-253 20 3.2e-15 23.38 SMART 1-280 (280) Show / Hide
Range on Protein: 7-253
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

YVFSEKIPEDCNRPMVVKALSKTSGKFFAMKYFPAESLKNIEKKTIYRLINVLSSL--YHPHITYINEIMYKANP-------DEAFIALEWCDGSSVKNT
 .. .|.   ..   |.|.  |      | |   ...     .. ..| ......|   ||.|  .. . .   .       .  .| .| ... . |. 
ITLGKKL-GEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNI--VRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

L-DRFSTLPEKLVGRYTYEIIKGLEFLHSQGQVHKNLKAANLLLASGV-LKLSDFGLSAEVSTC--------SISE-----HP-----YWAAPEVIESRT
| ..  .|. |    . . | .| |.|||.. .|  | | | |....   | |||||| ..            ..              | |||.|  ..
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

FSNKSDIWSMGATIIELLT-GKPPFAE-----LPPEEARIKILNE-TPPIPAK--------ASAHLQDFLCACFAKNPDERPSTEECYNFF
|. |||.|| | .. |..| |..|  .     ....|.. .. .   .|.|.         ... . .    | . .|..||. .|.. .|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF