Gene 84511.m00298 (T.vaginalis)

84511.m00298

Species: T.vaginalis
Alias: 84511.m00298, TvagK0584
External Links:
Annotation:

Classification

Group: CMGC
Family: RCK
Subfamily: MAK

Sequence

Name Sequence Type Origin Length Description Download
84511.m00298.AA Protein None 366 None Fasta, JSON
84511.m00298.kin_dom Protein Kinase Domain None 282 None Fasta, JSON

Protein domain

Protein domains of 84511.m00298.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 84511.m00298.AA RCK 5-286 50 1.6e-173 555.27 In-house 1-298 (298) Show / Hide 
Range on Protein: 5-286
Range on HMM: 1-298/298
Sequence Identity: 50% (150 aa)

YEEVCSIGDGGFGVVTKMRNIATGQIVAMKRMKQKTQSFAECLELKEVKSLRKIK-HENVVKLVEVFREKSDGTLYLAFEHCDGNLYKLIST---RKSPI
|  .  .||| .|.|.|..|. ||.|||.|.||||  |  || .|.|.|||||.. |.|..|| ||.|.. ...||. ||..| |||... .   |. ..
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYL

PEPV--IRNILFQLLSGVDAIHKAGFFHRDLKPENVLFVG----------DTLKIIDFGLAREIRSKPPYTNYVGTRYYRAPEILLHHDFYNTPVDIWAL
||..  |.||..|.| | . .|| ||||||||||| .  |          |..||.||||.|||||||||| ||.||.|||||.||.  .||.|.||||.
PENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAV

GCIMAELYLQKPLFPGTSETDEIYKICAVLGPPTEQNFPEGYKLAQKLGIRFQNTTGTGLNSLLPDISAEGLDLLKKMLTLDPHKRPSAKQALNHPFF
||||.|||  .|||||.|| |.|.||| |.| |. .  |.|||||......|..  |..|..|.|..| ....|..|||. || ||..|.|||.||.|
GCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 84511.m00298.AA MAK 5-286 41 5.3e-147 471.27 In-house 1-352 (352) Show / Hide 
Range on Protein: 5-286
Range on HMM: 1-352/352
Sequence Identity: 41% (147 aa)

YEEVCSIGDGGFGVVTKMRN------------------------------IATGQIVAMKRMKQKTQSFAECLELKEVKSLRKIK-HENVVKLVEVFREK
|  .  .||| .| |.. .                               | || .|| ||||.|  |. ||..| |||||.|.. | |.||| ||.|. 
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

SDGTLYLAFEHCDGNLYKLISTRKS-PIPEPVIRNILFQLLSGVDAIHKAGFFHRDLKPENVLFVG------------------DTLKIIDFGLAREIRS
 . .||. ||    ||| ..  |.    ||||||||..| | |   .|| ||||||.||||.. .|                  . .|| ||||||||||
ENDHLYFVFEYMKENLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRS

KPPYTNYVGTRYYRAPEILLHHDFYNTPVDIWALGCIMAELYLQKPLFPGTSETDEIYKICAVLGPPTEQN----------------FPEGYKLAQKLGI
||||| || || |||||.||.   |. |.|.||.||||||||  .|||||.|| |.|.||| ||| |. .                  |.||.|| ... 
KPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAHMMNF

RFQNTTG---TGLNSLLPDISA-EGLDLLKKMLTLDPHKRPSAKQALNHPFF
||..  .   . | .|.| .|  ....|.|.||  || ||| |.|.. .|.|
RFPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase 84511.m00298.AA CMGC 5-286 24 6.7e-124 409.33 In-house 1-513 (513) Show / Hide 
Range on Protein: 5-286
Range on HMM: 1-513/513
Sequence Identity: 24% (128 aa)

YEEVCSIGDGGFGVVTKMRN--------------IATGQIVAMKRMKQKTQSFAECL-----------ELKEVKSLRKIK-----------------HEN
|| .  || | .||| | |.              . |..|||.|..|..     ...            | |.| |....                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVKLVEVFREKS---------------DGTLYLAFEHCDGNLYKLISTRKS--------PIPEPV------------IRNIL------FQLLSGVD--AI
.||| ..|. |                .  ||| ||..| .||..|   .         | .| .            |....      .|.| |..   .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HKAG--FFHRDLKPENVLFVGDT---------------------LKIIDFGLAR--EIRSKP--------------------PYTNYVGTRYYRAPEILL
|...  ..||||||||.|.  ..                     |||.||||||  ...|..                    |||.|| ||.||||||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

HH---------DFYNTPVDIWALGCIMAELYLQ--------KPLFPGTSE-----------TDEIYKICAVLGPPT---------------EQNFPE---
           . |.||.|.|..|||.||.|.         |||||| ||            | ..||. |||.||               |...|.   
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

----------------------GYKLAQKLGIRFQNTTGTGLNSLLPD-----------------------------------ISAEGLDLLKKMLTLDP
                      ....... ..||..  .  ...| |.                                   .. ...|||||||..||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

HKRPSAKQALNHPFF
.||..|.|||.||.|
DKRITAEQALQHPYF
Kinase 84511.m00298.AA CDK 5-286 35 3.9e-106 340.58 In-house 1-284 (284) Show / Hide 
Range on Protein: 5-286
Range on HMM: 1-284/284
Sequence Identity: 35% (114 aa)

YEEVCSIGDGGFGVVTKMRNIATG-----QIVAMKRMK------QKTQSFAECLELKEVKSLRKIKHENVVKLVEVFREKS---------DGTLYLAFEH
|| .. || | .||| | |.  ||     ||||.|. .      ..      .  . |.. |... |.|.||| .|.  |.         . .||. ||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

CDGNLYKLISTRKSPIPEPVIRNILFQLLSGVDAIHKAGFFHRDLKPENVLFVGDT------LKIIDFGLAREIRS-------KPPYTNYVGTRYYRAPE
.|  |.|...          |.....|||.|.. .|. .. |||||| | |   .       ||| ||||||.  .         .||. | |. |||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

ILLHHDFYN--TPVDIWALGCIMAELYL---QKPLFPGTSETDEIYKICAVLGPPTEQNFPEGYKLAQKLGIRFQNTTGTGLNSLLPDISAEGLDLLKKM
.||    |.  ||.|.|..|||.||...    ||||||.||.| . ||. ..| |||.| |.  ||                            ||| ||
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNKM

LTLDPHKRPSAKQALNHPFF
|..||.|| ||.|||.||.|
LCYDPKKRISAEQALQHPYF
Kinase 84511.m00298.AA S_TKc 5-286 31 6.5e-103 349.11 SMART 1-231 (231) Show / Hide 
Range on Protein: 5-286
Range on HMM: 1-231/231
Sequence Identity: 31% (94 aa)

YEEVCSIGDGGFGVVTKMRNIATGQIVAMKRMKQKTQSFAECLELKEVKSLRKIKHENVVKLVEVFREKSDGTLYLAFEHCDG---NLYKLISTRKSP--
|| .  || |.||.| | |.. ||.|||.|..|        .  ..|.. |.| .|.|.||| .||..   . ||. .|.|||   .|...|  |...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---IPEPVIRNILFQLLSGVDAIHKAGFFHRDLKPENVLFVGDTLKIIDFGLAREIRSKPPYTNYVGTRYYRAPEILLHHDFYNT-PVDIWALGCIMAEL
   .|| ..| .. |...... .|. |. ||||||||.|.   ..||.||||||..      | ..||..|.|||.|     |.. ..|.|..|||..|.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

YLQKPLFPGTSETDEIYKICAVLGPPTEQNFPEGYKLAQKLGIRFQNTTGTGLNSLLPDISAEGLDLLKKMLTLDPHKRPSAKQALN-------HPFF
.  .|.||   . ....|..                                        | |..|...|.|. || |||.| .||.       ||.|
LCGYPPFP---QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 84511.m00298.AA Pkinase 5-286 31 4.8e-100 343.46 Pfam 1-293 (293) Show / Hide 
Range on Protein: 5-286
Range on HMM: 1-293/293
Sequence Identity: 31% (95 aa)

YEEVCSIGDGGFGVVTKMRNIATGQIVAMKRMKQKTQSFAECLELK---EVKSLRKIKHENVVKLVEVFREKSDGTLYLAFEHCDG-----NLYKLIS-T
|. .  || |.||.| | ... ||.|||.|..| ....  .. ..    |.. .....|.|.|.| ..|..  .. .|. .|.|.|      |. .||  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

RKSPI--PEPVIRNILFQLLSGVDAIHKAGFFHRDLKPENVLFV--GDT---LKIIDFGLARE--IRSKPPYTNYVGTRYYRAPEILLHHDFYNTPVDIW
|. ..  .| ...... |.|.|.. .|. |. ||||||||.|..  |..   .||.|||||.   . ... .| ..||..|.|||.....  | ..||.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

ALGCIMAELYLQKPLFPGT----SETDEIYKICAVLGPPTEQNFPEGYKLAQKLGIRFQNTTGTGLNSLLPDISAEGLDLLKKMLTLDPHKRPSAKQALN
..|||..|... .|.|||     .  |....|| ..|||.. ..|. .       .|.   . . .  . . .| |..|..|..|..||.|||.|.|.|.
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQ

HPFF
||.|
HPWF
Kinase 84511.m00298.AA CDC2 5-286 37 9.4e-92 282.23 In-house 1-301 (301) Show / Hide 
Range on Protein: 5-286
Range on HMM: 1-301/301
Sequence Identity: 37% (114 aa)

YEEVCSIGDGGFGVVTKMRNIATGQIVAMKRMKQKTQSFAE---CLELKEVKSLRKIK-HENVVKLVEVFREKSDGTLYLAFEHCDGNLYKLIS---TRK
|. .  || | .|||.| ..  |.||||.|. . ....  .      ..|   | ..| |.|.||| .|. .     ||. || .| .| |.       .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

SPIPEPVIRNILFQLLSGVDAIHKAGFFHRDLKPENVLFVGD-TLKIIDFGLAREIRS-KPPYT--NYVGTRYYRAPEILLHHDFYNTPVDIWALGCIMA
...|. .......|.|.||.  |  . .|||||| | |   . ..|| |||||| .   . .||    | |. ||||||||   .|.||||.|..|||.|
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

EL---YLQKPLFPGTSETDEIYKICAVLGPPTEQNFPEGYKLAQKLGIRFQNTTGTGLNSLLPD---------ISAEGLDLLKKMLTLDPHKRPSAKQAL
|.      ||||.| || |...||  .|| |.||..|. ..| .     | . . ..| ...|.         .  ||.|||..|| .|| || |||.||
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQL-PDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEAL

NHPFF
.||.|
QHPYF
Kinase 84511.m00298.AA MOK 5-286 37 1.1e-86 271.67 In-house 1-283 (283) Show / Hide 
Range on Protein: 5-286
Range on HMM: 1-283/283
Sequence Identity: 37% (107 aa)

YEEVCSIGDGGFGVVTKMRNIATGQIVAMKRMKQKTQSFAECLELKEVKSLRKIK-HENVVKLVEVFREKSDGTLYLAFEHCDGNLYKLISTRKSPIPEP
|  .  ||.| |  | ||. .  |.  | |.|||. .|  .  .|.|.. .|..  | |...| ||  ..  | | |  |  | |.| ||  |. ..|. 
YKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNNLREIQAMRRLNPHPNILMLHEVVFDRKTGNLALICELMDMNIYELIRGRRHYLPQK

VIRNILFQLLSGVDAIHKAGFFHRDLKPENVLFVGDTLKIIDFGLAREIRSKPPYTNYVGTRYYRAPEILLHHDFYNTPVDIWALGCIMAELYLQKPLFP
 |.. ..||.  .| .|. | |||| ||||.|   | ||. |||  | . || ||| |. ||.||||| ||   .|   .|.|. ||.  |.   .||||
KIMHYMYQLCKSLDHMHRNGIFHRDVKPENILIKQDHLKLADFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGYYTYQMDMWSVGCVFYEIASLHPLFP

GTSETDEIYKICAVLGPPTEQNFPEGYKLAQKLGIRFQNTTGTGLNSLLPDISAEGLDLLKKMLTLDPHKRPSAKQALNHPFF
|  | | | ||  |.| | ..      . .  .   |    | |.. |.| ..   |....|| | ||  | .|.|.. ||.|
GVNEVDQISKIHDVMGTPCQKILNKFKNQSRAMNYDFPFKKGSGIEKLTPNLTKQCLEIMHKMCTYDPDERITAHQVIQHPYF
Kinase 84511.m00298.AA MAPK 5-286 30 4.1e-77 262.51 In-house 1-328 (328) Show / Hide 
Range on Protein: 5-286
Range on HMM: 1-328/328
Sequence Identity: 30% (102 aa)

YEEVCSIGDGGFGVVTKMRNIA------TGQIVAMKRMK--QKTQSFAECLELKEVKSLRKI-KHENVVKLVEVFREK-----SD----GTLYLAFEHCD
|. .  || | .||| . .         .|..|| |..     .. .. .  . |.| || . .|||..|| ..|. .     ..     ..|. .| ..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRT-YREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELME

GNLYKLISTRKSPIPEPVIRNILFQLLSG--VDAIHKAGFFHRDLKPENVLFVGD-TLKIIDFGLAREIRSKPPY---------------TNYVGTRYYR
 .|...| ... |  .  |. ...|.| |  .  || |.  ||||||.|.|   . .||| |||||| | ..  .               | || ||.||
TDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYR

APEILLH--HDFYNTPVDIWALGCIMAELYL-QKPLFPGTSETDEIYKICAVLGPPTEQNF-PEG-YKLAQKLGIRF---QNTTGTGLNSLLPD----IS
||||.|    . |.. ||.|..|||.||..  .||||||..  | . .| .||| |.|.     . .. | ..  ..   .....  . ...|.     .
APEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNAN

AEGLDLLKKMLTLDPHKRPSAKQALNHPFF
 . .|||.|||..||.|| ....||.||.|
PQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 84511.m00298.AA CDK4 5-286 37 1.7e-75 257.14 In-house 1-290 (290) Show / Hide 
Range on Protein: 5-286
Range on HMM: 1-290/290
Sequence Identity: 37% (111 aa)

YEEVCSIGDGGFGVVTKMRNIATGQIVAMKRMKQKTQSF------AECLELKEVKSLRKIKHENVVKLVEVFREKSDGT----LYLAFEHCDGNLYKLIS
|..|  || | .| | . | . ||..|| |. .  ..            |    . | .  | |.|||..|.     .     . . |||||  |  .. 
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYL-

TRKSPI---PEPVIRNILFQLLSGVDAIHKAGFFHRDLKPENVLFVGD-TLKIIDFGLAREIRSKPPYTNYVGTRYYRAPEILLHHDFYNTPVDIWALGC
 .| |    |.. |. . .|||.|||  |     ||||||.|.|   | ..|. ||||||.  ..   |  | |  |||||.||    ||||||.|..||
-DKCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMALTPVVVTLWYRAPEVLLQS-YYNTPVDMWSVGC

IMAELYLQKPLFPGTSETDEIYKICAVLGPPTEQNFPEGYKLAQKLGIRFQNTTGTGLNSLLPDISAEGLDLLKKMLTLDPHKRPSAKQALNHPFF
|.||.|  .|||.|.|| |   ||  | | |.|.  |    |.      |. .  . . .. |...  |.|||.|||. ..|||.|| |.|.||.|
IFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLPWD---HFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase 84511.m00298.AA CDK5 5-286 35 2.2e-75 237.52 In-house 1-287 (287) Show / Hide 
Range on Protein: 5-286
Range on HMM: 1-287/287
Sequence Identity: 35% (104 aa)

YEEVCSIGDGGFGVVTKMRNIATGQIVAMKRMKQKTQ-SFAECLELKEVKSLRKIKHENVVKLVEVFREKSDGTLYLAFEHCDGNLYKLISTRKSPIPEP
|| .  ||.| .|.| | ||  |. |||.|| .         .  . |.  |. .||.|.| |  |    |.  | | ||.||  | | .  ..  .  .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIH--SEKKLTLVFEFCDQDLKKYMDSCNGEMDMH

VIRNILFQLLSGVDAIHKAGFFHRDLKPENVLFVGD-TLKIIDFGLARE----IRSKPPYTNYVGTRYYRAPEILLHHDFYNTPVDIWALGCIMAELY-L
.|. ...||| |.   |.    |||||| | |     .||  ||||||     .|    |.  | |  ||.| .|.    |.|..|.|  |||.||.   
IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRC---YSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANA

QKPLFPGTSETDEIYKICAVLGPPTEQNFPEGYKLAQ-K-LGIRFQNTTGTG-LNSLLPDISAEGLDLLKKMLTLDPHKRPSAKQALNHPFF
 .|||||....|.  .|  ..| |.| . |   || . | .   .    ..  . .. |  ...|.|||.||| ..|..| |||.||.||.|
GRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 84511.m00298.AA CDKL 5-220 43 4.7e-69 235.23 In-house 1-218 (286) Show / Hide 
Range on Protein: 5-220
Range on HMM: 1-218/286
Sequence Identity: 43% (96 aa)

YEEVCSIGDGGFGVVTKMRNIATGQIVAMKRMKQ-KTQSFAECLELKEVKSLRKIKHENVVKLVEVFREKSDGTLYLAFEHCDGNLYKLISTRKSPIPEP
||    .| |  ||| | ||  |||||| |. |  . .       . |.| |.  |||| | |.|||| |  . |.| || || ..  .   . . ..| 
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRK--RKLHLVFEYCDHTVLHELEEYPNGVDEH

VIRNILFQLLSGVDAIHKAGFFHRDLKPENVLFV--GDTLKIIDFGLAREIRSKPP--YTNYVGTRYYRAPEILLHHDFYNTPVDIWALGCIMAELYLQK
|.|....|.|....  ||    ||| |||| |     ...|. |||.|| . .||   || || || ||||| |.    | .||||||.||.|||.    
VVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQ

PLFPGTSETDEIYKICAVLGP
||.|| |. |  |.|  .|||
PLWPGQSDIDQLYHIQKCLGP
Kinase 84511.m00298.AA CDKL 252-286 38 2.8e-13 41.75 In-house 251-286 (286) Show / Hide 
Range on Protein: 252-286
Range on HMM: 251-286/286
Sequence Identity: 38% (14 aa)

LPDIS-AEGLDLLKKMLTLDPHKRPSAKQALNHPFF
.|..| .. ||..||.| .|| .|....|...||.|
YPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 84511.m00298.AA TyrKc 5-286 19 3.2e-13 -8.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 5-286
Range on HMM: 1-280/280
Sequence Identity: 19% (63 aa)

YEEVCSIGDGGFGVVTKMRNIATGQIVAMKRMKQKTQSFAECLE-LKEVKSLRKI--KHENVVKLVEVFREK-----SDGTLYLAFEHCD-GNLYKLIST
 .    .| | ||.| | . .   . || | .|  .       . ..| . ..|.  .|.|.|.|. | ...     ... |.. .|... |.| . .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RKSPIPEPVIRNILFQLLSGVDAIHKAGFFHRDLKPENVLFVGDT-LKIIDFGLAREIRSK------PPYTNY---VGTR-----YYRAPEILLHHDFYN
..  .. .   .. .|  .| . .|. .. ||||   |.|   .   || ||||.|.| ..        |       |..        ||| .  .  ..
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT

TPVDIWALGCIMAELY-LQKPLFPG-----TSETDEIYKICAVLGPPTEQN----FPEGYKLAQKLGIRFQNTTGTGLNSLLPDISAEGLDLLKKMLTLD
|  |.|. |  | |.. . ..  ||      | .. | .. .   .|  .|                            .  .  ..|  .. |.    |
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------F--VCCPDEMYQIMKQCWHED

PHKRPSAKQALNHPFF
|..||. ..   | .|
PEDRPTFSEI--HECF