Gene 95937.m00107 (T.vaginalis)
95937.m00107
Species: T.vaginalis
Alias: TvagK0708, 95937.m00107
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 95937.m00107.AA | Protein | None | 306 | None | Fasta, JSON |
| 95937.m00107.kin_dom | Protein Kinase Domain | None | 247 | None | Fasta, JSON |
Protein domains of 95937.m00107.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| S_TKc | 95937.m00107.AA | S_TKc | 13-260 | 25 | 9.2e-46 | 159.27 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 13-260 Range on HMM: 1-231/231 Sequence Identity: 25% (67 aa) YEFVKVLYNGHSSQILLIKCLNYHQTYICKVTHDNPKDRSINESYSREVDALLALDHPNIVRIFDAFRKDLYLFLIIEYCSQ--GTLNQFIGSTQK---- ||..... | .. . . . .. . .|. . |. ||.. | .|||||...|.|. .|... |||.. |.| ..| . .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --LRDTQLMTYARDLISALCAMHSRGYSHGNIQPSNILLDETGSIKLRDFGSARGTSSVETDQNLIVKFYSAPEISYSSIYDPFKADVWSLGVTLYSIAS . . |.. ...|| .||.| | . |.|||||| ||. |||.|| . .| |||. |...|.|.||.|..|| .. FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC GRSVFSSKNINYCIHELRNGRDHLIYISRTMRTVINACLTKNPAERPTIYEVKR---------ML |. |. ... .. .. |. .. |. ||.|.|..|||. |. . . GYPPFP--QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Pkinase | 95937.m00107.AA | Pkinase | 13-260 | 21 | 1.1e-37 | 134.35 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 13-260 Range on HMM: 1-293/293 Sequence Identity: 21% (64 aa) YEFVKVLYNGHSSQILLIKCLNYHQTYICKVTHDNPKDRSINESYSR--EVDALLALDHPNIVRIFDAFRKDLYLFLIIEYCSQG----TLNQFIG--ST |...... | ... . . .. ... .|. .. . ... | |. .. |.||||||..|.|. . .. .. ||| | | .| . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH QKL--RDTQLMTYARDLISALCAMHSRGYSHGNIQPSNILLDETGSI----KLRDFGSAR---GTSSVETDQNLIVKFYSAPEISYSSIYDPFKADVWSL .. . .. |.. ....| .||.| | . |.|||.|..| | |. |||.|. ... .. .| |||. .. |.. |.|.||. GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC GVTLYSIASGRSVFSSK------NINYCIHELRNGRDHLIYI----------------------SRTMRTVINACLTKNPAERPTIYEVKRM--L |..|| ..|| |... . ...| . . .. | . |.... .|. ||.|.|..|||. ... . GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 95937.m00107.AA | Ciliate-E2-Unclassified | 13-257 | 19 | 1.9e-35 | 120.39 | In-house | 1-347 (352) | Show / Hide |
Range on Protein: 13-257
Range on HMM: 1-347/352
Sequence Identity: 19% (68 aa)
YEFVKVLYNGHSSQILLIKCLN----YHQTYICKVTHDNPKD--------RSINESYSRE---VD--------ALLALDHPNIVRIFDAFRKDLYLFLII
|...|.. .| ... . .. . |.. |..|. ... | ....| ... .. || ..||.||. |..|... .....
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM
EYCSQGTLNQFIGSTQK-----------------LRDTQLM-----TYARDLISALCAMHSRG-YSHGNIQPSNILLDETG---SIKLRDFGSAR-----
||| .|.| |.| . | . . | .|.. ....|. .|. . | .|.|.|||.|. | ||. |||...
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN
------------------GTSSVETDQNLIVKFYSAPEISYSSIYDP---FKADVWSLGVTLYSIASGRSVFS--SKNINYC-------------IHELR
.. . | . .. . | |||. . || .|.|.||||| || . |. |. ....... ...
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q-YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI
NGRDHLIY----------ISRTMRTVIN----ACLTKNPAERPTIYEVK
. .. . .| . || .| ||| .|.|. ...
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQIL
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| Kinase | 95937.m00107.AA | Ciliate-E2 | 13-257 | 19 | 4.8e-32 | 107.27 | In-house | 1-360 (365) | Show / Hide |
Range on Protein: 13-257 Range on HMM: 1-360/365 Sequence Identity: 19% (71 aa) YEFVKVLYNGHSSQILLIKC-LNYH----------------------QTYICKVTHDNPKDRSINESY-SREVD----------ALLALDHPNIVRIFDA |.|.|.. .| ... . | .. . . | |. . | . .| . ||.. | |.||||...... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FR--KDLYLFLIIEYCSQGTLNQFIGSTQKLR-----------DTQLMTYARDLIS---------------ALCAMHSRG-YSHGNIQPSNILLDETGSI | .| ...|. |||..|.| ..| . .| | . . .. . ... || .||.. | .| |.|||. | FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I KLRDFGSAR---------------------GTSSVETD-------QNLI-----VKFYSAPEISYS--------SIYDPFKADVWSLGVTLYSIASGRSV |. ||| .. . |. . ||.. | |||| . . . .|.|.|||||.|| .|. KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP FSSKNINYCIHELRNGRDH------------LIYISRTMRTVINA----CLTKNPAERPT-IYEVK | ..| | .... ..| . |. .| |.| .|.| . ... F-QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL |
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| Kinase | 95937.m00107.AA | CAMK | 59-258 | 17 | 1.3e-31 | 98.55 | In-house | 80-421 (425) | Show / Hide |
Range on Protein: 59-258
Range on HMM: 80-421/425
Sequence Identity: 17% (61 aa)
REVDALLA-------LDHPNIVRIFDAFR--------KDLY------------LFLII---EYCSQG----TLNQFIGST---------------QKLRD
||.. . ||||||....... | | .... |||| | | ..| . ..
REIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTE
TQLMTYARDLISALCAMHSRGYSHGNIQPSNILLDET-----------------GSIKLRDFGSA--RGTSSVET-------------------DQNLIV
. .| | ..||. .||.. | . | |||||. . ||. ||| | .. .. .| .
REARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKT
KF----YSA-PEISYS-------------SIYDPFKADVWSLGVTLYSIASGRSVFSSK-------------NINYCIHELRNGRDHLI-----------
. | | ||. . |...|.|.||.|| || .|.. | .. |.. . ..|. . .
FCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNY
--------------YISRTMRTVINACLTKNPAERPTIYEVKR
..| . |. .|...| .|.|| ....
GPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLN
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| Kinase | 95937.m00107.AA | ULK | 37-250 | 20 | 7.9e-29 | 97.82 | In-house | 29-317 (329) | Show / Hide |
Range on Protein: 37-250 Range on HMM: 29-317/329 Sequence Identity: 20% (58 aa) QTYICKVTHDNPKDRSINE--------SYSREVDALLALD--------HPNIVRIFDAFRKD--LYLFLIIEYCSQGTLNQFIGSTQK----------LR . ..||. . .... || . .|.. . |. |||||. .| |. . ....| ||| .|.| |.| .| | EKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLS DTQLMTYARDLISALCAMHSRGYSHGNIQPSNILLDET------------GSIKLRDFGSARG-TSS-VETDQNLIVK---------FYSAPEISY---- . . ....... ..|.... | | |.|||... | .|. ||| |. ... .| .... . | ||.| EQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGE SSIYDPFKADVWSLGVTLYSIASGR-----SVFSSKNINYCIHELRNGRDHL--IY--------------ISRTMRTVINACLTKNPAER |. .|.|.||||. .| . |. . |.. ...... ...|. . | || .. | .|.... .| QKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDR |
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| Kinase | 95937.m00107.AA | ULK | 53-200 | 24 | 5.1e-27 | 92.95 | In-house | 53-243 (324) | Show / Hide |
Range on Protein: 53-200 Range on HMM: 53-243/324 Sequence Identity: 24% (46 aa) INESYSREVDALLALD---HPN--IVRIFDAFRKDLY--LFLIIEYCSQGTLNQFIGSTQK---------LRDTQLMTYARDLISALCAMHSRGYSHGNI . .. .|. . |. ||| ||. .| |. . . ...| ||| .|.| |.| .| | . . ....... ..|.... | | MWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDI QPSNILLDET------------GSIKLRDFGSARGTSSVETDQNLI--------VK---FYSAPEISY----SSIYDPFKADVWSLGVTLY |.|||. . | .|. ||| |. . . .|... .| | ||.| |. .|.|.||||. .| KPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFY |
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| Kinase | 95937.m00107.AA | Ciliate-E2c | 49-200 | 35 | 4.1e-26 | 88.57 | In-house | 53-210 (310) | Show / Hide |
Range on Protein: 49-200 Range on HMM: 53-210/310 Sequence Identity: 35% (57 aa) KDRSINESYSREVDALLALDHPNIVRIFDAFRKDLYLFLIIEYCSQGTLNQFIGSTQKLRDTQLMTYARDLISALCAMHSR-GYSHGNIQPSNILLDETG ....| || .||.. . ..||.|... ||. | ..|| |||..||| |.| . |. | .| .|||. |. . |. | |.|||. . | NEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGTLEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHN-G SIKLRDFGSARGTSSVETD--Q--NLIV--KFYSAPEISYSSIYDPFKADVWSLGVTLY ||. ||| .. . | | .. .|.||.| .. |. |.|.|||||||| MIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEKSDIWSLGVTLY |
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| Kinase | 95937.m00107.AA | MELK | 60-265 | 27 | 8.3e-26 | 84.92 | In-house | 47-254 (254) | Show / Hide |
Range on Protein: 60-265 Range on HMM: 47-254/254 Sequence Identity: 27% (58 aa) EVDALLALDHPNIVRIFDAFRKDLYLFLIIEYCSQGTLNQFIGSTQKLRDTQLMTYARDLISALCAMHSRGYSHGNIQPSNILLDETGSIKLRDFGSARG |.||| .| | .| ... . .|...|||. | . .| . ..| . . . | ..||. .||.||.| ...| |.|.|| .|| ||| EMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAK TSSVETDQNLIV----KFYSAPEISYSSIYDPFKADVWSLGVTLYSIASGRSVFSSKNINYCIHELRNGR-DHLIYISRTMRTVINACLTKNPAERPTIY | || | |||. | |||||.|. || . | | |. . . | . ..| . .. . | .| | TKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKR---I EVKRMLETVRL ..|..|. . SMKNLLNHPWV |
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| Kinase | 95937.m00107.AA | MSK | 59-207 | 32 | 1.9e-23 | 76.14 | In-house | 49-208 (277) | Show / Hide |
Range on Protein: 59-207 Range on HMM: 49-208/277 Sequence Identity: 32% (53 aa) REVDALLAL-DHPNIVRIFDAFRKDLYLFLIIEYCSQGTLNQFIGSTQKLRDTQLMTYARDLISALCAMHSRGYSHGNIQPSNILLDET---GSIKLRDF .|. .|... ||||| ..||. .. ..|. |||. | | | . .. . . . | |..|. ||..| |. . | |||.|. | .|| || TERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDF GSARGTSSVETDQNLIVKF---YSAPEISY----SSI-YDPFKADVWSLGVTLYSIASGRS |.|| . . |... | | |||. . ||. |.|||||.|| .|.. GFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDE-ACDWWSLGVILYTMLTGQV |
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| Kinase | 95937.m00107.AA | TKL | 17-260 | 14 | 5.5e-23 | 79.6 | In-house | 11-364 (364) | Show / Hide |
Range on Protein: 17-260
Range on HMM: 11-364/364
Sequence Identity: 14% (54 aa)
KVLYNGHS-------SQILLIKCLNYHQ-TYICKVTHD-------------NPKDRSINESYSREVDALLALDHPNIVRIFD-AFRKDL-----------
| ..|.. .. .| .. |. | . .|. . ... .|. .. |.|||||.. ... .
KGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPW
-YLFLIIEYCSQGT-LNQFIGSTQKLRDTQL-MTYARDLISALCAMHS--------RGYSHGNIQPSNILLDETGS--------------IKLRDFGSAR
.|... |||. |. |.... .. . |.| .... .|| .. | .. ..|||.|| . .|. ||| .|
GQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSR
------GTSSVETD-------------QNLIV--KFYSAPEISYSSIYDP---------------FKADVWSLGVTLYSIASGRSVFS-SKNI-------
. . .|. . .. . . |||. ..... |.||.| |. |. |.... ... ...
FMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDP
-----NYCIH-ELRNGRD----------HLIYISRTMRTVINACLTKNPAERPTIYEVKRML
.... || .. . .. . |. . | .| .||. |.. |
FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | 95937.m00107.AA | CAMKL | 59-157 | 31 | 1.1e-20 | 62.66 | In-house | 61-176 (297) | Show / Hide |
Range on Protein: 59-157 Range on HMM: 61-176/297 Sequence Identity: 31% (37 aa) REVDALLALD---HPNIVRIFDAFRKDLY------LFLIIEYCSQGT--LNQFIGST----QKLRDTQLMTYARDLISALCAMHSRGYSHGNIQPSNILL ||. . |. ||||..... . . . ..|. |||| | | ..| . ... . | | ..||. .||.| | | | |||| REIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILL DETGS--IKLRDFGSA || |. ||. ||| . DENGNNNIKIIDFGFS |
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| Kinase | 95937.m00107.AA | CAMKL | 174-258 | 32 | 5.1e-14 | 40.99 | In-house | 199-293 (297) | Show / Hide |
Range on Protein: 174-258 Range on HMM: 199-293/297 Sequence Identity: 32% (32 aa) YSAPEISYS-SI-YDPFKADVWSLGVTLYSIASGRSVFSSK--------NINYCIHELRNGRDHL-IY--ISRTMRTVINACLTKNPAERPTIYEVKR | |||| . || .|.|.||.||.|| . |. | || | .. . | . |. .| | | |..|| .|||| .... YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN |
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| Kinase | 95937.m00107.AA | TyrKc | 13-260 | 18 | 3e-12 | -24.72 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 13-260 Range on HMM: 1-280/280 Sequence Identity: 18% (54 aa) YEFVKVLYNGHSSQILLIKCLNYHQTYICKVTHDNPKDRSINESYSREVDALLAL--DHPNIVRIFDAFRKD-------LYLFLIIEYCSQGTLNQFIGS .. |.| .|. .. . . .. |. ... | || . | .||||||.. . ... |... ||.. | |.... . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK TQK-LRDTQLMTYARDLISALCAMHSRGYSHGNIQPSNILLDETGSIKLRDFGSARGTSSV-------ETD-------QN--LIVKFYSAPEISYSSIYD ... | .| .. . . ||... | . |.|..| . .| ||| .| . .. . | .. . ||| ... HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECINYGKFT PFKADVWSLGVTLYSIAS-GRSVFSS-----KNINYCIHELRNG--RDHLIY--------ISRTMRTVINACLTKNPAERPTIYEVKRML .| |||| ||... | . | . . .. |. ...| .. . . | ... | .|..||| |... . -TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 95937.m00107.AA | MSK | 231-257 | 28 | 0.17882 | 0.74 | In-house | 246-277 (277) | Show / Hide |
Range on Protein: 231-257 Range on HMM: 246-277/277 Sequence Identity: 28% (9 aa) ISRTMRTVINACLTKNPAERPTIY-----EVK .| . | .|||.|. |.. |.| MSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK |
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