Gene 82012.m00114 (T.vaginalis)

82012.m00114

Species: T.vaginalis
Alias: TvagK0678, 82012.m00114
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
82012.m00114.AA Protein None 307 None Fasta, JSON
82012.m00114.kin_dom Protein Kinase Domain None 255 None Fasta, JSON

Protein domain

Protein domains of 82012.m00114.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 82012.m00114.AA NEK 5-259 39 3.3e-115 389.06 In-house 1-286 (286) Show / Hide 
Range on Protein: 5-259
Range on HMM: 1-286/286
Sequence Identity: 39% (113 aa)

YEIIERLGQGSFGSVCKAIRKSDQKV-----VAIKEISYSQMDNKKKQMLI-NEVNALRNIQNEHVVGYYDRIVVREKKLMYIVMEYCE-KGDLQQL---
||||. .||||||.| |. ||||.|.     ...|.|... |. |.||... |||. |. ......|.|||... ...  ..||||||| .|||.|.   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IRKTRADNDRIPESAIWQVLTDMCIALDSCH--P----KMIHRDIKPGNIFISGNGH----VKLGDFGLAREIEDG--AAST-YAGTPPYMSPELISHQP
| | .  .. ..|. || ... ||.||. .|  .    | .|||||| |||.. |.     ||.||||.... ...  .|.| . ||| |||||.....|
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YDEKSDIWALGCVLFELADL--HLPFNGS--N-EVITQLIQTG-PLRRIPAM--YSDDLFEVIQSMMMKKPQERPTVKQLLENKYV
|..|||||.|||||.|.. |    ||...  | .     |. |    .|| .  ||.|| ..|..|  | |..||...|.||. ..
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 82012.m00114.AA NEK2 5-259 36 8.70000000001e-111 374.33 In-house 1-319 (319) Show / Hide 
Range on Protein: 5-259
Range on HMM: 1-319/319
Sequence Identity: 36% (116 aa)

YEIIERLGQGSFGSVCKAIRKSDQKVVAIKEISYSQMDNKKKQMLINEVNALRNIQNEHVVGYYDRIVVREKKLMYIVMEYCEKGDLQQLIRKTRADNDR
||. . .|.||||.. | .|||| |. . ||| | .|. |..|||..|.| ||  . . .| |||.|. |...  |||||||| ||| |.| | | .  .
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

IPESAIWQVLTDMCIALDSCHP------------------KM----IHRDIKPGNIFISGNGH-------------------------------------
..|. || ... .|.||  ||                   .     .||||||.||| . ..                                      
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--VKLGDFGLAREIE-DGA-ASTYAGTPPYMSPELISHQPYDEKSDIWALGCVLFELADLHLPFNGSN-EVITQLIQTGPLRRIPAMYSDDLFEVIQSMM
  ||||||||||  . |   | |. ||| |||||... |.|.||||||..||...|.. || || . |    .  |. |  ||||. ||..| |.| .|.
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

MKKPQERPTVKQLLENKYV
  ... || .  .|..  .
NVDHYHRPSIEEILQHPQI
Kinase 82012.m00114.AA S_TKc 5-259 30 3.5e-85 290.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 5-259
Range on HMM: 1-231/231
Sequence Identity: 30% (82 aa)

YEIIERLGQGSFGSVCKAIRKSDQKVVAIKEISYSQMDNKKKQMLINEVNALRNIQNEHVVGYYDRIVVREKKLMYIVMEYCEK--GDLQQLIRKTRADN
|||.. .|.|.||.|.|.. |.....||||.|.         .....|.. |.. . ...| .|| ..    . .|.|||||.   ||| ..|.| .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

DR--IPESAIWQVLTDMCIALDSCHPK-MIHRDIKPGNIFISGNGHVKLGDFGLAREIEDGAASTYAGTPPYMSPELISHQPYDE-KSDIWALGCVLFEL
 |  .||  .. ..  .| ||. || .  ||||.|| ||...   |.|..||||||..     .|. ||| ||.||..   .|.  |.|.|..||.|.|.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

ADLHLPFNGSNEVITQLIQTGPLRRIPAMYSDDLFEVIQSMMMKKPQERPTVKQLLE-------NKYV
.    ||    ... ..|            |... . |. .. | |..|||. ..|.         ..
LCGYPPFP-QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 82012.m00114.AA NEK1 5-259 36 1.5e-73 250.7 In-house 1-276 (276) Show / Hide 
Range on Protein: 5-259
Range on HMM: 1-276/276
Sequence Identity: 36% (101 aa)

YEIIERLGQGSFGSVCKAIRKSDQKVVAIKEISYSQMDNKKKQMLINEVNALRNIQNEHVVGYYDRIVVREKKLMYIVMEYCEKGDLQQLIRKTRADNDR
|..|  .|.|||| . .. .|.| .. .||||. ..|  | ..   |||. |..   . .|.|..  . . . . |||||||. ||| | | . .  .  
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

IPESAIWQVLTDMCIALDSCHP-KMIHRDIKPGNIFIS--GNG---------------HVKLGDFGLAREIEDGA--ASTYAGTPPYMSPELISHQPYDE
..|  | .  . .|.||   |  | .|||||. ||| .   ||                ||||||| ||   .    |.|..||| | |||..  .||. 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDIWALGCVLFELADLHLPFNGSNEVITQLIQT-GPLRRIPAMYSDDLFEVIQSMMMKKPQERPTVKQLLENKYV
|||||.||||| ||  | .||.. |.    |... |.   ||. || .| . . .|  . |. || | |.||   .
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 82012.m00114.AA Pkinase 5-259 29 2.6e-73 254.67 Pfam 1-293 (293) Show / Hide 
Range on Protein: 5-259
Range on HMM: 1-293/293
Sequence Identity: 29% (87 aa)

YEIIERLGQGSFGSVCKAIRKSDQKVVAIKEISYSQMDNKKKQMLIN--EVNALRNIQNEHVVGYYDRIVVREKKLMYIVMEYCEKG----DLQQLIRKT
|.|....|.||||.|.|...|...|.||.|.|...  . .|.| ...  |.  ..... ...| .||  ....|. .|.||||||.|    ||  .|.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYD--WFEDKDHIYMVMEYCEGGLYVMDLFDYIST-

RADNDRI--PESAIWQVLTDMCIALDSCHPKMI-HRDIKPGNIFISGNGHV----KLGDFGLAR---EIEDGAASTYAGTPPYMSPELIS-HQPYDEKSD
  .. ..  .|  .  ... .. .|. || . | |||.|| ||.|. |||.    |..|||||.   .  .. ..|..|||.||.||.|  .|.|. |.|
-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

IWALGCVLFELADLHLPFNGS--------NEVITQLIQTGPLRRIPAMYS-------------------DDLFEVIQSMMMKKPQERPTVKQLLENKYV
.|..||.|.|..  ..|| |.        ...| .  .. . . .|  .|                   ... ..| ..  |.|..||| .|.|. ...
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 82012.m00114.AA STE 5-259 23 7.4e-72 245.04 In-house 1-359 (359) Show / Hide 
Range on Protein: 5-259
Range on HMM: 1-359/359
Sequence Identity: 23% (85 aa)

YEIIERLGQGSFGSVCKAIRK------SDQKV---------VAIKEISYSQMDN---------------KKKQMLINEVNALRNIQ--NEHVVGYYDRIV
.|.||..|.|.||.|.||...      . ..|         .|||...... .|               ...| ...|.. ... .   ...| ||.  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VR---EKK--LMYIVMEYCEKGDLQQLIR---KTRADND-------RIPESAIWQVLTDMCIA-LDSCH-PKMIHRDIKPGNIFISGNGHVKLGDFGLAR
.    .|     .|.|||.. | | ..|.   ..  ...       |.||| |  .. . . . |.  |  . |||||||.||..     ||| |||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

EIEDGAA--------------S----TYAGTPPYMSPELISH------QPYDEKSDIWALGCVLFELADLHLPF-NGSNE-VITQLIQT-----------
 ..|  |              .    | .||| .|.|| |.       ..||.|.||| |||.. |.|. . |. ....  .. . ..            
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---GPLRRIP-------------------AMYSDDLFEVIQSMMMKKPQERPTVKQLLE--NKYV
   ||  ..|                     .|... . |.    | |..|||..|||.   . .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 82012.m00114.AA CAMK 10-259 18 2.1e-63 202.9 In-house 1-425 (425) Show / Hide 
Range on Protein: 10-259
Range on HMM: 1-425/425
Sequence Identity: 18% (78 aa)

RLGQGSFGSVCKAIRKSDQ------------KVVAIKEISYSQMDNK--------------------------KKQMLINEVNALRN-------IQNEHV
 ||.|||| | ..|.|...            . |||| |. .....|                          ..... .|.. ...       .. ...
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VGYYD-----------RI------VVRE-KKLMYIVM---EYCEKG----DLQQLIRKT-----------RADND-RIPESAIWQVLTDMCIALDSCHPK
.  |.           ..      |. . .| ||.||   |||. |    || . |..             . .. |..|.   ..   .| |.. || .
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH

M-IHRDIKPGNIFISGN-----------------GHVKLGDFGLAREIEDGA-------------------------ASTYAGTPPYMS-PELISH----
  .|||.|| || .. |                 . .|. |||.|.....|                           .|. |||.||. ||...     
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

----------QPYDEKSDIWALGCVLFELADLHLPFNGSN--------------EVITQLIQTGPLRRIPAMYSD-----------------------DL
          ..|..|.|.|..|..|. .   ..||.|..              . . . |..|  . .| . |.                       . 
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

FEVIQSMMMKKPQERPTVKQLLENKYV
   |..|. . |..|.|..| |. . .
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 82012.m00114.AA ULK 5-259 24 4.3e-63 215.91 In-house 1-324 (324) Show / Hide 
Range on Protein: 5-259
Range on HMM: 1-324/324
Sequence Identity: 24% (81 aa)

YEIIERLGQGSFG-SVCKAI-RKSD--QKVVAIKEISYSQMDNKKKQ--------MLINEVNALRNIQ---NEH--VVGYYDRIVVREK--KLMYIVMEY
|.....||.||||  |.|..  |..  ...||.| |. ..| .||..        .|.||.. .. .    ...  .| .||  . ...  .  ||.|||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYD--WFETSNHNNIYIIMEY

CEKGDLQQLIRKTRA-----DNDRIPESAIWQVLTDMCIALDSCHPK-MIHRDIKPGNIFISGN------------GHVKLGDFGLAREIEDG-----AA
|. |||.|.| | .       . |..|. . |.. . | ..   | .  ||||||| || |. .            |..|..|||.|. ....       
CNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMC

STYA------GTPPYMSPELIS----HQPYD-EKSDIWALGCVLFELADLHLPFNGSNEVITQ---------------LIQTGPLRRIPAM----YSDDL
 |.       ||| ||.|....    ..||.  |.||| |||...|.     ||...    ..               .|.. |..  .       |...
QTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPEC

FEVIQSMMMKKPQERPTVKQLLENKYV
 . |. |. ... .| .  ...... .
KDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 82012.m00114.AA ULK 5-259 25 1.1e-62 214.6 In-house 1-329 (329) Show / Hide 
Range on Protein: 5-259
Range on HMM: 1-329/329
Sequence Identity: 25% (84 aa)

YEIIERLGQGSFGSVCKAI-RKSD---QKVVAIKEISYSQMDNKKKQ--------MLINEVNALRNI--------QNEHVVGYYDRIVVREK--KLMYIV
|.....||.|||| |.|..  |..   ...||.| |. ..|..|...        .|.||.  .. .        .....| .||  . ...  .  ||.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYD--WFETSNHNNIYII

MEYCEKGDLQQLIRKTRA------DNDRIPESAIWQVLTDMCIALDSCHPK-MIHRDIKPGNIFISGN------------GHVKLGDFGLAREIEDG---
||||. |||.|.| | .        . |..|. . |.. . . ..   | .  ||||||| || |. .            |..|..|||.|. ....   
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

--AASTYA------GTPPYMSPELIS----HQPYD-EKSDIWALGCVLFELADLHLPFNGS-NE-V---ITQL----------IQTGPLRRIPAM----Y
   . |.       ||| ||.|....    ..||.  |.||| |||...|.     ||... |. .   |..|          |.. ||.  ..      
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQI

SDDLFEVIQSMMMKKPQERPTVKQLLENKYV
|... . |. |. ... .| .  .|.... .
SPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 82012.m00114.AA STE20 5-259 28 2.2e-62 213.58 In-house 1-288 (288) Show / Hide 
Range on Protein: 5-259
Range on HMM: 1-288/288
Sequence Identity: 28% (81 aa)

YEIIERLGQGSFGSVCKAIRKSDQKV----VAIKEISYSQMDN--KKKQMLINEVNALRNIQNEHVVGYYDRIVVREK--KLMYIVMEYCEKGDLQQLIR
||..|..||||.|.|.||. |. ...    |||| ..... ||  ........|.. ... .....| ||.  ..  .     .||||||. | |.....
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

KTRADND-----RIPESAIWQVLTDMCIALDSCHP-KMIHRDIKPGNIFISGNGHVKLGDFGLAREIED-------GAASTYAGTPPYMSPELISH----
..  ..      .. |. |  .. ... .||  |  ..|||||| .|| .. .| ||| |||..  ...       .   |  ||| .|.||.|.     
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-QPYDEKSDIWALGCVLFELADLHLPFNG--SNEVITQLI--QTGPLRRI---PAMYSDDLFEVIQSMMMKKPQERPTVKQLLENKYV
 ..||.|.|||.||  . |.|. . |.       .. . .  | .|..     |  .|... . . ..  | |..|||..|||. ...
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase 82012.m00114.AA Ciliate-E2 5-259 21 4e-59 201.6 In-house 1-365 (365) Show / Hide 
Range on Protein: 5-259
Range on HMM: 1-365/365
Sequence Identity: 21% (82 aa)

YEIIERLGQGSFGSVCKAIRKSDQKV------------------VAIKEISYSQMDNKKKQMLINEVNALRNIQ----------------NEHVVGYYDR
|..|. .|||.||||.|. ....||                   |.||..   .| ....... .| . .| |.                . ... .|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IVVREKKLMYIVMEYCEKGDLQQLIRKT---------RADNDRIPESAIWQVLTDMC---------------IALDSCHP-K-MIHRDIKPGNIFISGNG
     .. .|.|||||. |||...|..            |  .. |  | .. .  .                || ..|  .  ||||||| ||..    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

HVKLGDFGLAREIEDG---------------------------------AASTYAGTPPYMSPELISHQP---------YDEKSDIWALGCVLFELADLH
 .|. ||||.... |                                   . |..|||.||.|| .. ..         ||.|.|||.||..|.|.    
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

LPFNGSNEVITQLIQTGPLR-R----------------IPAMYSDDLFEVIQS----MMMKKPQERPT-VKQLLENKYV
.||        | |. .... .                ..   |..    |.     |. |.|..|.|  .|.|.... 
PPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 82012.m00114.AA WEE 5-259 30 8.2e-59 195.91 In-house 1-297 (297) Show / Hide 
Range on Protein: 5-259
Range on HMM: 1-297/297
Sequence Identity: 30% (90 aa)

YEIIERLGQGSFGSVCKAIRKSDQKVVAIKEISYSQMDNKKKQMLINEVNALRNIQ-------NEHVVGYYDRIVVREKKLMYIVMEYCEKGD--LQQLI
.......|.||||.| |.. ..| .. ||| .     ...  .. ..|| |. ..         .|.| ||   .  |.  |||.||||..|   ||..|
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYS--AWEEDDHMYIQMEYCNGGSNLLQFWI

RKTRADNDRIPESAIWQVLTDMCIALDSCHPK--MIHRDIKPGNIFISGNG--------------------HVKLGDFGLAREIE-DGAASTYA--GTPP
    . |...||. |||.| | | .|   | .  |.| ||||.||||| ..                      |.||||.. ... . . ....  | ..
QQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTDMNSNNNNPHQEQEGDSR

YMSPELIS---HQPYDEKSDIWALGCVLFELA-DLHLPFNGSN-EVITQL-----IQTGPLRRIPAMYSDDLFEVIQSMMMKKPQERPTVKQLLENKYV
||.||...   |  .. |.|| .||....||| ...|| ||   . | |       . .|  .... .|..| ..|..|| . |. |||  |||.. ..
YMAPEILQGYYHYTHLYKADIFSLGITIYELACNMDLPKNGDWWHQIRQGDLSFDKNQIPFPEFDNIISQELKQLIKWMMHPDPEQRPTCQQLLQHPVL
Kinase 82012.m00114.AA TyrKc 5-261 21 3.4e-28 100.89 SMART 1-280 (280) Show / Hide 
Range on Protein: 5-261
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

YEIIERLGQGSFGSVCKAIRKSDQKVVAIKEISYSQMDNKKKQMLINEVNALRNI--QNEHVVGYYDRIVVREK-------KLMYIVMEYCEKGDLQQLI
 . .. || | || |.|.. |     ||.| .  .      ......| . ....  .....|  |   |....       . ..|||||...|||.. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLY--GVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RKTRADNDRIPESAIWQVLTDMCIALD--SCHPKMIHRDIKPGNIFISGNGHVKLGDFGLAREIEDG-----AASTYA-----GTPP-----YMSPELIS
||.| .   .. .   .  .. .   .  . . . ||||.   |. .. |..|| .||||.|.|.|.     . ..|      |.        |.|| | 
RKHRPK---LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

HQPYDEKSDIWALGCVLFELADL-HLPFNG------SNEVITQLIQTGPLRRIPAM--------YSDDLFEVIQSMMMKKPQERPTVKQLLENKYVKL
.  . .|||.|. | ...|.  .   |  |      ||. . .....|  ...|.          .|........  . .| .||| ...    . ..
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI----HECF
Kinase 82012.m00114.AA Pkinase_Tyr 5-99 26 2.2e-17 59.5 Pfam 1-102 (270) Show / Hide 
Range on Protein: 5-99
Range on HMM: 1-102/270
Sequence Identity: 26% (27 aa)

YEIIERLGQGSFGSVCKAIRK----SDQKVVAIKEI--SYSQMDNKKKQMLINEVNALRNI-QNEHVVGYYDRIVVREKK-LMYIVMEYCEKGDLQQLIR
 .... ||.|.||.|.|.. |    ...  ||.| .  .... .| .......|.. .... .....| .|  .. ...   .||||||...|||    |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KTR
| |
KHR
Kinase 82012.m00114.AA Pkinase_Tyr 137-198 32 1e-12 43.71 Pfam 141-207 (270) Show / Hide 
Range on Protein: 137-198
Range on HMM: 141-207/270
Sequence Identity: 32% (22 aa)

NIFISGNGHVKLGDFGLAREI-EDGAASTYAGT-----PPYMSPELISHQPYDEKSDIWALGCVLFEL
|. .. |..|| .|||||| | .|.   .....      . |.|| |..  . .|||.|. | ...|.
NCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEI