84626.m00053

Species: T.vaginalis
Alias: TvagK0380, 84626.m00053
External Links:
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
84626.m00053.AA Protein None 417 None Fasta, JSON
84626.m00053.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of 84626.m00053.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH 84626.m00053.AA PH 1-95 25 5.9e-07 30.36 SMART 3-82 (82) Show / Hide
Range on Protein: 1-95
Range on HMM: 3-82/82
Sequence Identity: 25% (24 aa)

MEGWLVKRSGIPHFWHKRYCVIESNCFYIYLDQQRQKMTNWFSITPKSQVALMESKKGLRFKITQPEGKDFAFQAKDEKEFHAWLNHILLLSIPE
.|||| |.|     |.||..|. ..|.|.| |    |    ....   .|   .      |.|.  ..  . ||...|.|.. |...|  .. . 
KEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK---KPKGSIPLSDC-TVRE-P-----CFEIHH-DR-TYYFQCESEEEMQEWMQAIQKAIHNN

PH 84626.m00053.AA PH 1-93 25 1e-06 26.5 Pfam 3-92 (92) Show / Hide
Range on Protein: 1-93
Range on HMM: 3-92/92
Sequence Identity: 25% (24 aa)

MEGWLVKRSGIPHFWHKRYCVIESNCFYIYLDQQRQKMTNWFSITPKSQVALMESKKGLRFKITQPEGKDFAFQAKDEKEFHAWLNHILLLSI
.|||| |..     |.||..|. .|| |.| | .  .    ...   . . . ..|.   |.|.  ... . |||..|.|.. |...|  .. 
KEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDK-YRPKGSIPLSDCQVTKVPDNKRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQSACR

Kinase 84626.m00053.AA AGC 103-356 30 1.4e-148 387.13 In-house 1-395 (395) Show / Hide
Range on Protein: 103-356
Range on HMM: 1-395/395
Sequence Identity: 30% (121 aa)

YEIISVLGRGFYGKVVLAKHK------KTGKFCAIKSIHKKV-LLDMK--KVDTIMVE------------RDILKSTK----------SPFIVS-LLSSF
.|.. |.|.| .||| |...|       |||..|.| . ||.  ...|  .|. .|.|            |.||.  .          .||||. | .||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTPSK--FYLVLEYVS---------GG-DLFMHLTN--NNNEISVDQIKLYIAE-------LAVALEQLHK-DHIIYRD-LKPENVLICEDGHIKLTDFG
|....   |.|.||..         || .||.|| .  ..   . .... |.||       .. ||| ||.  .||.|| |||||.|. |||||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

ISKMLN--------------------------------------------------EKQSTTNTLCG--TGEYLAPEVISDKGYTEAIDWWQ--LGILMY
 .|...                                                  .|. .|.|.||  | ||.|||..    |. | |||   ||.|||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMVVGKTPFADTN----------KSIMYSNIMN-----KNPNFFPIE-----------DENARNLIAHLLRKDPAKRAG----------FEEIKNSKFF
||..|..|| . |          .  |. .|||     ...  ||             ...|..|| .|| |||.|| |          .||||| ..|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF

Kinase 84626.m00053.AA SGK 103-356 41 9.5e-111 343.32 In-house 1-283 (283) Show / Hide
Range on Protein: 103-356
Range on HMM: 1-283/283
Sequence Identity: 41% (118 aa)

YEIISVLGRGFYGKVVLAKHKKT------------------GKFCAIKSIHKKVLL-------DMKKVDTIMVER-DILKSTKSPFIVSLLSSFQTPSKF
 ....|.| | .||| ..|||..                  .|| |.| . |.  .         |..  || || .|||  |.||||.|  .|||. | 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLVLEYVSGGDLFMHLTNNNNEISVDQIKLYIAELAVALEQLHKDHIIYRDLKPENVLICEDGHIKLTDFGISKMLNEKQSTTNTLCGTGEYLAPEVISD
|.|..|| ||..| || .  .  . |. . | ||.. ||| ||.  ||||||||||.|   .||..||||| .|   ... || | ||| |||||||.  
YFVMDYVNGGEMFYHL-QREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRK

KGYTEAIDWWQLGILMYEMVVGKTPFADTNKSIMYSNIMNKNPNFFPIEDENARNLIAHLLRKDPAKR----AGFEEIKNSKFF
...  . ||| ||...||| .|. || . ||..|| ||.|.  .. |     |. ||  || ||| ||    ..|.||||  ||
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF

Kinase 84626.m00053.AA Akt 103-356 42 2.2e-108 347.59 In-house 1-264 (264) Show / Hide
Range on Protein: 103-356
Range on HMM: 1-264/264
Sequence Identity: 42% (113 aa)

YEIISVLGRGFYGKVVLAKHKKTGKFC-AIKSIHKKVLLDMKKVDTIMVERDILKSTKSPFIVSLLSSFQTPSKFYLVLEYVSGGDLFMHLTNNNNEISV
 ... |||.| .|||.|.| |.|.|.  |.|.. |........|  .. || ||. ...||||.|  ||||. | |.|..|..||.|| ||    . .| 
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHL-QRKRRFSE

DQIKLYIAELAVALEQLHKDHIIYRD-LKPENVLICEDGHIKLTDFGISKML-NEKQSTTNTLCGTGEYLAPEVISDKGYTEAIDWWQ-LGILMYEMVVG
|... |.||.  |.| ||.  ||||| |||||.|. .||||.||||| .|.     . .|.|.||| ||||||.....|.| | |||  ||..||||  |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

KTPFADTNKSIMYSNIMNKNPNFF--PIEDENARNLIAHLLRKDPAKRAG-----FEEIKNSKFF
  || . ..  |. .|.|.. .|   .  . ....||  || ||| || |      .|||.  .|
RPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF

Kinase 84626.m00053.AA AktR 103-356 39 6.3e-100 338.29 In-house 1-268 (268) Show / Hide
Range on Protein: 103-356
Range on HMM: 1-268/268
Sequence Identity: 39% (106 aa)

YEIISVLGRGFYGKVVLAKHK-KTGKFCAIKSIHKKVLLDMKKVDTIMVERDILK-STKSPFIVSLLSSFQTPSKFYLVLEYVSGGDLFMHLTNNNNEIS
.... .||.| .|||.|...| ...|. |.|.|.|| . . .. . .  ||.|..   . |||| |  .||| .| ....||. ||.|| || .... .|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHL-KKKKKFS

VDQIKLYIAELAVALEQLHKD-HIIYRDLKPENVLICEDGHIKLTDFGISK--MLNEKQSTTNTLCGTGEYLAPEVISD-KGYTEAIDWWQLGILMYEMV
 .|.. |.|.   ||| ||.  .|||||||||| |. ||||.|.|||| ||    ...  .....||| ||.|||.|   ||.. ..|||..||. ||||
EEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMV

VGKTPFADTNKSIMYSNIMNKNPNFFPIED----ENARNLIA-HLLRKDPAKRAG-----FEEIKNSKFF
.| .|| . |. .|. .| .|. .... .     .....||   || |.| || |     .||||. ..|
TGCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF

Kinase 84626.m00053.AA S_TKc 103-356 34 3.3e-98 333.49 SMART 1-231 (231) Show / Hide
Range on Protein: 103-356
Range on HMM: 1-231/231
Sequence Identity: 34% (93 aa)

YEIISVLGRGFYGKVVLAKHKKTGKFCAIKSIHKKVLLDMKKVDTIMVERDILKSTKSPFIVSLLSSFQTPSKFYLVLEYVSG--GDLFMHLTNNNNE--
|||. ..|.| .||| ...|||||. .||| |.          ..|. |..|||. . |.|| |. .||. ...|.|.||..|  |||| .. ... .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---ISVDQIKLYIAELAVALEQLHKDHIIYRDLKPENVLICEDGHIKLTDFGISKMLNEKQSTTNTLCGTGEYLAPEVISDKGYTE-AIDWWQLGILMYE
   ..  ... |..... ||| .|. .||.|||||||.|..|  |||..|||... |       .|.||| .|.||||.   ||.  ..||| .|...||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MVVGKTPFADTNKSIMYSNIMNKNPNFFPIEDENARNLIAHLLRKDPAKRAGFEEIKN-------SKFF
|..|..||   .   |. .|.          .. |...| ..|.|||.|| .  |. .         .|
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 84626.m00053.AA PKA 103-356 42 1.2e-97 330.77 In-house 1-263 (263) Show / Hide
Range on Protein: 103-356
Range on HMM: 1-263/263
Sequence Identity: 42% (114 aa)

YEIISVLGRGFYGKVVLAKHKKTGKFCAIKSIHKKVLLDMKKVDTIMVERDILKSTKSPFIV-SLLSSFQTPSKFYLVLEYVSGGDLFMHLTNNNNEISV
.||| .||.| .|.| |..||..|...|.| . |    ..| |. .. |. ||...|.|||| .. ..||.... |.|.|||.||..| .|  ..   | 
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYL-RKSGRFSN

DQIKLYIA-ELAVALEQLHKDHIIYRDLKPENVLICEDGHIKLTDFGISKMLNEKQSTTNTLCGTGEYLAPEVISDK-GYTEAIDWWQLGILMYEMVVGK
.. |.|.| .   ||| ||. .|||||||||| || ..||||.|||| .| . .    | ||||| ||||||.|. | |.  ..||| |||| |||..|.
PHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD---RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGY

TPFADT--NKSIMYSNIMNKNPNFFPIEDENA---RNLIAHLLRKDPAKRA-----GFEEIKNSKFF
.|| |.  ..  .|  | |   .| .  | .|   . || .|| .|. ||      | . ||| |.|
PPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF

Kinase 84626.m00053.AA MAST 103-356 32 8e-92 296.27 In-house 1-334 (334) Show / Hide
Range on Protein: 103-356
Range on HMM: 1-334/334
Sequence Identity: 32% (110 aa)

YEIISVLGRGFYGKVVLAKHKKTGKFCAIKSIHKKVLLDMKKVDTIMVERDILKSTKSPFIVSLLSSFQTPSKFYLVLEYVSGGDLFMHLTNNNNEISVD
.|.| ....| |||| |.|||||... |.| | |  ... . ||. .|||.||. ...||.|.. .|||| .. ..|.||..|||.. .| . .    ..
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYG-YFDEW

QIKLYIAELAVALEQLHKDHIIYRDLKPENVLICEDGHIKLTDFGISKM-----------L------------------NEKQSTT--------------
  |.||||.. .|| ||.  |. |||||.|.||  .||||||||| ||.           .                  .. ....              
MAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQI

----------------------NTLCGTGEYLAPEVISDKG-YTEAIDWWQLGILMYEMVVGKTPFADTNKSIMYSNIMNKN---PNFFPIEDEN-----
                      . .||| .|.||||| ..| .  ..||| .|| |||  || .|| | .  . ..|| |.|     . . .| |     
QQQQEQPQCQQQNMRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAM

---ARNLIAHLLRKDPAKRAGFE----EIKNSKFF
   |. ||  ||  || || |.     |.|. .||
SPEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF

Kinase 84626.m00053.AA RSK 106-356 38 1.3e-91 310.71 In-house 1-278 (278) Show / Hide
Range on Protein: 106-356
Range on HMM: 1-278/278
Sequence Identity: 38% (108 aa)

ISVLGRGFYGKVVLAKHK---KTGKFCAIKSIHKKVLLDMKK-VDTIMVERDILKSTK-SPFIVSLLSSFQTPSKFYLVLEYVSGGDLFMHLTNNNNE--
..|||.| |||| | . .   .||.  | | ..|...   .| . . | ||.||. .. .||||.|  .|||..|.||..||..||.||.|| .      
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

ISVDQIKLYIAELAVALEQLHKDHIIYRDLKPENVLICE---DGHIKLTDFGISKM-LNEKQSTTNTLCGTGEYLAPEVIS----DKGYTEAIDWWQLGI
.| |  . |.||...|.| ||. .||.|||||||.|  .   .||||||||| .|   ... . |.| |.| ||.|||..     ..|...| ||| ||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMYEMVVGKTPFAD---TNKSIMYSNIMNKN--PNFF--PIEDENARNLIAHLLRKDPAKRAG-----FEEIKNSKFF
||||| .|..||.     |..    .|....  ...   .   ..|..|| ..| .||.|| |      ||||....|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase 84626.m00053.AA Pkinase 103-356 32 1.7e-85 295.13 Pfam 1-293 (293) Show / Hide
Range on Protein: 103-356
Range on HMM: 1-293/293
Sequence Identity: 32% (95 aa)

YEIISVLGRGFYGKVVLAKHKKTGKFCAIKSIHKKVLLDMKKVDTIMV--ERDILKSTKSPFIVSLLSSFQTPSKFYLVLEYVSGG----DLFMHLT-NN
|.|....|.| .|.| ...||.|||  |.| | |.   ...|  |     |  |.|. ..|.|| |. .|..... |.|.||. ||    ||| ...  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

NNEI--SVDQIKLYIAELAVALEQLHKDHIIYRDLKPENVLICEDGHI----KLTDFGISKML-NEKQSTTNTLCGTGEYLAPEVIS-DKGYTEAIDWWQ
.. .  | ...| |. ... .|| .|.  ||.|||||||.|| ..|||    |..|||..| . . ..| ..|.||| .|.|||||  ...|. ..|.| 
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGILMYEMVVGKTPFADT------NKSIMYSNIMNKNPNFFPIED---------------------ENARNLIAHLLRKDPAKRAGFEEIKNSKFF
.|...|||. |..|| .       ..  |. .|| . . |   ..                     |... .|  .|.|||.|| ..|.|.....|
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 84626.m00053.AA Ciliate-E2-Unclassified 103-356 28 1.4e-84 287.26 In-house 1-352 (352) Show / Hide
Range on Protein: 103-356
Range on HMM: 1-352/352
Sequence Identity: 28% (102 aa)

YEIISVLGRGFYGKVVLAKHKKTGKFC-----AIKSIHKKVLLDMKKVDTIMVERDILKSTK-------------------SPFIVSLLSSFQTPSKFYL
|.|| ..|.| .||| ...|||.. .      ..|....|... |.|   || | ..... |                   .|||| ..  ||.  ..|.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VLEYVSGGDLFMHLTNNNN----------------EISVDQIK-----LYIAELAVALEQLHKDH-IIYRDLKPENVLICEDG---HIKLTDFGISK---
|.||. ||||. .......                ...  |.|      |.|.. ..||.||. . ||.||.||||.|. ..|   .||..||||||   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

------------MLNEKQSTTNTLCGTGEYL----APEVISDKGYT----EAIDWWQLGILMYEMVVGKTPFADTNKSI----------------MYSNI
            | . ||  ..| ||| .|.    ||||.  ..|     ...|.| ||...|||. |. || |.|. .                .|.||
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

MNKNPNFFPIE--------DENARNLIA----HLLRKDPAKRAGFEEIKNSKFF
..||..|.. .        ...| ..|      .| |.| || .||.|.|  .|
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase 84626.m00053.AA Ciliate-E2 103-356 25 2.8e-82 279.66 In-house 1-365 (365) Show / Hide
Range on Protein: 103-356
Range on HMM: 1-365/365
Sequence Identity: 25% (97 aa)

YEIISVLGRGFYGKVVLAKHKKTG-----------------------KFCAIKSIHKKVLLDMKKVDTIM----------VERDILKSTKSPFIVSLLSS
|..| ..|.| .|.| ..|..|..                       |. |.|...|. .  .|... ||           |. ||.. ..|.|. .  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TPSKFYLVLEYVSGGDLFMHLTNN----NNE------ISVDQIKLYIAELAV---------------ALEQLHKDH-IIYRDLKPENVLICEDGHI
||  . ...|||.||..||||| .. ||    |.|      ..  .|| ......                ||| ||. . ||.||.||||.|.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLTDFGISKMLNEK-------------------------------QSTTNTLCGTGEYLAPEVISDKG---------YTEAIDWWQLGILMYEMVVGKTP
|..|||.|| ....                               | ..||.||| .|.|||... |.         |....|.| ||...|||. ||.|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FADTNKSIMYSNIMNKNPNFFPIE------------------DENARNLIAH----LLRKDPAKRAG-FEEIKNSKFF
|        . .|.... .|.. |                  .... .||      .| ||| || . .|.|.| ..|
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase 84626.m00053.AA MAST 103-256 43 1e-66 202.59 In-house 1-157 (337) Show / Hide
Range on Protein: 103-256
Range on HMM: 1-157/337
Sequence Identity: 43% (68 aa)

YEIISVLGRGFYGKVVLAKHKKTGKFCAIKSIHKKVLLDMKKVDTIMVERDILKSTKSPFIVSLLSSFQT--PSKFYLVLEYVSGGDLFMHLTNNNNEIS
.|.| ....| ||.| |.|||||... |.|.| .  ..| . ||...|||.||. .. ||.|.. .||||    . ..|.||..||| . .| . .|   
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

VDQIKLYIAELAVALEQLHKDHIIYRDLKPENVLICEDGHIKLTDFGISKM-LNEKQ
..  |.||||.  .|| ||.  |. |||||.|.||  .||||||||| ||. .. |.
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKT

Kinase 84626.m00053.AA MAST 263-356 38 4e-30 88.72 In-house 229-337 (337) Show / Hide
Range on Protein: 263-356
Range on HMM: 229-337/337
Sequence Identity: 38% (42 aa)

CGTGEYLAPEVISDKG-YTEAIDWWQLGILMYEMVVGKTPFADTNKS-IMYSNIMN--KNPNFFPIEDEN--------ARNLIAHLLRKDPAKRAGFE--
||| .|.|||||  .| |  ..||| .|| |||  || .|| . .   .  .|| |  .. .. ...| |        |. ||  ||...| || |.   
CGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGANGA

-EIKNSKFF
 |||. .||
DEIKQHPFF

Kinase 84626.m00053.AA TyrKc 103-356 20 5.3e-17 52.18 SMART 1-280 (280) Show / Hide
Range on Protein: 103-356
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

YEIISVLGRGFYGKVVLAKHKKTGKFCAIKSIHKKVLLDMKKVDTIMVERDILKST--KSPFIVSLLSSFQTP-------SKFYLVLEYVSGGDLFMHLT
 . . .||.|..|.|.... |     .|.|....        .  .| |  |...   . | || |.    ..          ..|.||...|||  .| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NNNNEISVDQIKLYIAELAVALEQLHKDHIIYRDLKPENVLICEDGHIKLTDFGISKMLNEK-------QSTTNTLCGTGE------YLAPEVISDKGYT
.. .......   .    |   | ||. ..| |||   |.|. |....| .||| |. . ..       .  . .  . |        .|||.| .. .|
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

EAIDWWQLGILMYEMV-VGKTPFAD-----TNKSIMYSNIMNKNPNFFPIE---------DENARNLIAHLLRKDPAKRAGFEEIKNSKFF
.. | |  |..|.|.   |..|  .      . . .. .... .    | .          .   ...    . ||..|  |.||   ..|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase 84626.m00053.AA Pkinase_Tyr 103-304 24 1.5e-13 46.47 Pfam 1-218 (270) Show / Hide
Range on Protein: 103-304
Range on HMM: 1-218/270
Sequence Identity: 24% (55 aa)

YEIISVLGRGFYGKVVLAKHK----KTGKFCAIKSIHKKVLLDMKK---VDTIMVERDILKST-KSPFIVSLLSSFQ-TPSK--FYLVLEYVSGGDLFMH
 ... .||.| .|.|.... |    .|.  .|.|.. |     |..    .  | |  |.|.  . | ||.|.            |.|.||. .|||  .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LTNN---NNEISVDQIKLYIAELAVALEQLHKDHIIYRDLKPENVLICEDGHIKLTDFGISKMLNEKQSTT-NTLCGTGE---YLAPEVISDKGYTEAID
| ..   .. ... ..  . .. | ..| |.  ..| |||   |.|. |....| .||| .. . .. ..   .  |.      .|||.|... .|.. |
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSD

WWQLGILMYEMVV-GKTP-FAD
 |  |.||.|..  |..| ...
VWSFGVLMWEIFTYGEQPTYPG