Gene 91970.m00074 (T.vaginalis)

91970.m00074

Species: T.vaginalis
Alias: TvagK0603, 91970.m00074
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
91970.m00074.AA Protein None 365 None Fasta, JSON
91970.m00074.kin_dom Protein Kinase Domain None 292 None Fasta, JSON

Protein domain

Protein domains of 91970.m00074.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 91970.m00074.AA ERK 20-311 48 1.2e-158 533.34 In-house 1-307 (307) Show / Hide 
Range on Protein: 20-311
Range on HMM: 1-307/307
Sequence Identity: 48% (150 aa)

YEIKRRLGRGAYGVVFAAKDKK-----TKKMVAIKKVEHIFDTLLDAKRCLREVCILSHFN-HDNITNLIDVTSPSDYNKFNYLIIIMDLMETDLHRIIS
|.|  ..|.||||||..|.||.     | . |||||.| .||.....|| |||  .| ||. |.||..|.|.  |.  ...| . .. .|||||||.|| 
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

SNQPITVEHHRFFIYQILRGLKYIHSANVLHRDLKPANILVNANCDLKITDFGLARVSELNDDSD------FLSEYVATRYYRPPEVLLNYNTYGPALDV
| |... .|  .|.||||.||||||||||.|||||| ||||| |||||| ||||||. .   ..       |..||||||.||.||..|... |  | |.
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WSVGCILAEMILRRPLLPGKNTLDQIALIVNLIGSP-SEQDLEECPAQNAKKYVQSLGE--KKKVAWKTIFRGKLYIDEELDLLDRMLTWDPRKRITVDE
||.|||.|||. |.||.|||....|| .| ..||.| ||.||.. . .||.||. .|..  .... |..||     . . .|||..||..|| |||||.|
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

ALEHPFL
.||||..
CLEHPYF
Kinase 91970.m00074.AA MAPK 20-311 46 1.5e-157 529.68 In-house 1-328 (328) Show / Hide 
Range on Protein: 20-311
Range on HMM: 1-328/328
Sequence Identity: 46% (151 aa)

YEIKRRLGRGAYGVVFAAKDKK------TKKMVAIKKVEHIFDTLLDAKRCLREVCILSHF-NHDNITNLIDVTSP------SDYNKFNYLIIIMDLMET
|.| ...| ||||||..|.||.      ..| |||||... |......|| .||. .| || .|.|| .|.|.  |      ..  .|| . |.|.||||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHRIISSNQPITVEHHRFFIYQILRG--LKYIHSANVLHRDLKPANILVNANCDLKITDFGLARVSELNDDSD------------FLSEYVATRYYRPP
|||.|| |.|| . .| ..|.||||||  |||||||||.||||||.||||| |||||| ||||||. . ..  .            ...||||||.|| |
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EVLLN--YNTYGPALDVWSVGCILAEMIL-RRPLLPGKNTLDQIALIVNLIGSPSEQDLEECP-AQNAKKYVQSL---GEKKKVAWKTIFRGKL--YIDE
|..||  .. |  | |.||||||.|||.  |.||.|||...||. ||....|.|||....  .  ..|..|.|||     ..|. |...| . .    ..
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

ELDLLDRMLTWDPRKRITVDEALEHPFL
 .|||..||..|| |||||.|||.||..
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 91970.m00074.AA CMGC 20-311 25 2.2e-132 437.74 In-house 1-513 (513) Show / Hide 
Range on Protein: 20-311
Range on HMM: 1-513/513
Sequence Identity: 25% (131 aa)

YEIKRRLGRGAYGVVFAAKD--------------KKTKKMVAIKKVEHIFDTLLDAK----------RCLREVCILSHFN-----------------HDN
||| ...|.|.||||. ..|              ..|...|||||.   |    .||          |.|||. || |.|                 | |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

ITNLIDVTSPSDYN------------KFNYLIIIMDLMETDLHRIISSNQP----------------------------ITVEHHRFFIYQILRGLK--Y
| .|.|.  ... .            .||.| .....|..||...| .||.                            ... | | ..||||||||  |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

IHSAN--VLHRDLKPANILVNANCDL--------------------KITDFGLARVSELNDD-------------------SDFLSEYVATRYYRPPEVL
.||..  ..||||||.|||.| ||.|                    || ||||||  . ..|                   . ....||.||.||.||.|
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LNY---------NTYGPALDVWSVGCILAEMILR--------RPLLP-----------GKNTLDQIALIVNLIGSP----------------SEQDLEEC
|..         . |... |.||||||.|||...        .|| |           ||...||...|....|.|                .|.. .  
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

P--------------------AQNAKKYVQS---LGEKKKVAWKTIFRG---------------------------------KLYIDEELDLLDRMLTWD
.                       |..|.||   ......  || .| .                                 |.  .. .|||..||..|
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PRKRITVDEALEHPFL
| ||||...||.||..
PDKRITAEQALQHPYF
Kinase 91970.m00074.AA ERK5 20-311 47 1.8e-119 403.23 In-house 1-295 (295) Show / Hide 
Range on Protein: 20-311
Range on HMM: 1-295/295
Sequence Identity: 47% (142 aa)

YEIKRRLGRGAYGVVFAAKDKKTKKMVAIKKVEHIFDTLLDAKRCLREVCILSHFNHDNITNLIDVTSPSD-YNKFNYLIIIMDLMETDLHRIISSNQPI
|.|  ..| |||||| .|. .|. . |||||.   || .  ||| .||. || || ||||  . |.  |   |  .    ...|||| ||| || ||||.
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

TVEHHRFFIYQILRGLKYIHSANVLHRDLKPANILVNANCDLKITDFGLARVSEL---NDDSDFLSEYVATRYYRPPEVLLNYNTYGPALDVWSVGCILA
|.|| |.|.|||||||||.|||.|.||||||.|.||| ||.||| |||.||       ..   |. ||||||.|| ||...  . |  |.||||||||. 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

EMILRRPLLPGKNTLDQIALIVNLIGSPSEQDLEECPAQNAKKYVQS-LGEKKKVAWKTIFRGKLYIDEELDLLDRMLTWDPRKRITVDEALEHPFL
||| || . |||| ..|. ||.  .| |. . ..   |.  . |.|. . ... . |.... .       |||| ||| ..| .|||| .|| ||||
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKA--DRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase 91970.m00074.AA p38 20-311 41 6.2e-113 381.5 In-house 1-289 (289) Show / Hide 
Range on Protein: 20-311
Range on HMM: 1-289/289
Sequence Identity: 41% (123 aa)

YEIKRRLGRGAYGVVFAAKDKKTKKM---VAIKKVEHIFDTLLDAKRCLREVCILSHFNHDNITNLIDVTSP--SDYNKFNYLIIIMDLMETDLHRIISS
|.  . .| |||| | .| |..|..    |||||    | . ..|||  ||.  | | .|.|.  |.||  |  .. | |.   ... .|..||..|. .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

NQPITVEHHRFFIYQILRGLKYIHSANVLHRDLKPANILVNANCDLKITDFGLARVSELNDDSDFLSEYVATRYYRPPEVLLNYNTYGPALDVWSVGCIL
 . .. .| .| .|||||||||||||.. |||||| || || .|.|.| ||||||        | . .||||| || ||..||   |  . |.||||||.
QR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR-----HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIM

AEMILRRPLLPGKNTLDQIALIVNLIGSPSEQDLEECPAQNAKKYVQSLGEKKKVAWKTIFRGKLYIDEELDLLDRMLTWDPRKRITVDEALEHPFL
||.| .|.| ||.. .||.  |....|.|.|  ..    ..|. |.||. . ..   ...|.|  .   ..|||..||  || ||||. ||..||..
AELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMG--ANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase 91970.m00074.AA ERK1 20-311 49 3.5e-110 372.36 In-house 1-289 (289) Show / Hide 
Range on Protein: 20-311
Range on HMM: 1-289/289
Sequence Identity: 49% (146 aa)

YEIKRRLGRGAYGVVFAAKDKKTKKMVAIKKVEHIFDTLLDAKRCLREVCILSHFNHDNITNLIDVTSPSDYNKFNYLIIIMDLMETDLHRIISSNQPIT
|   . .| ||||.| .| |. .|. |||||.   |.     .| |||. ||  |.|.|| |. |.   .  ...  . |. .|||||| ... . |.. 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKT-QHLS

VEHHRFFIYQILRGLKYIHSANVLHRDLKPANILVNANCDLKITDFGLARVSELNDD-SDFLSEYVATRYYRPPEVLLNYNTYGPALDVWSVGCILAEMI
 .|  .|.||||||||||||||||||||||.|.|.|  ||||| ||||||... . |   || ||||||.|| ||..||   |  ..|.||||||||||.
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML

LRRPLLPGKNTLDQIALIVNLIGSPSEQDLEECPAQNAKKYVQSLGEKKKVAWKTIFRGKLYIDEELDLLDRMLTWDPRKRITVDEALEHPFL
  ||. |||  |||. .|. ..||||..||.    . |. |.|||  |.||.|. .| .       |||||.|||. | |||||.||| ||.|
SNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKA--DSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase 91970.m00074.AA ERK7 20-311 41 1e-106 360.84 In-house 1-292 (292) Show / Hide 
Range on Protein: 20-311
Range on HMM: 1-292/292
Sequence Identity: 41% (122 aa)

YEIKRRLGRGAYGVVFAAKDKKTKKMVAIKKVEHIFDTLLDAKRCLREVCILSHFN-HDNITNLIDVTSPSDYNKFNYLIIIMDLMETDLHRIISSNQPI
|||..|||.||||.|  | ||.||..||.||.   |    || |  ||. .|  |. |.||  ||.|  . | ..  ||  . . |||||| .|   . .
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVI-RADNDRDIYL--VFEFMETDLHAVIRKGNIL

TVEHHRFFIYQILRGLKYIHSANVLHRDLKPANILVNANCDLKITDFGLAR-VSELN---DDSDFLSEYVATRYYRPPEVLLNYNTYGPALDVWSVGCIL
   | .. .||.|| .||.||.||.||||||.|||....| .|. |||||| .....   ..   | |||||| || ||.||   .| .. | ||.||||
KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCIL

AEMILRRPLLPGKNTLDQIALIVNLIGSPSEQDLEECPAQNAKKYVQSLGEKKKVAWKTIFRGKLYIDEELDLLDRMLTWDPRKRITVDEALEHPFL
.||.  .|. ||  |..|| .|...|. |...|.|    . | . .......|.   . ...     |. .||| |.|   |.||.|...||.||. 
GEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMP--QCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 91970.m00074.AA nmo 21-311 42 5.4e-103 317.61 In-house 2-292 (292) Show / Hide 
Range on Protein: 21-311
Range on HMM: 2-292/292
Sequence Identity: 42% (125 aa)

EIKRRLGRGAYGVVFAAKDKKTKKMVAIKKVEHIFDTLLDAKRCLREVCILSHFNHDNITNLIDVTSPSDYNKFNYLIIIMDLMETDLHRIISSNQPITV
.  | .| ||.|||..  | .  | ||.||. ..|  |. .||  ||. .|. |.|||.  . |.  | . . |. . .. .||  |||.|| | |... 
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS

EHHRFFIYQILRGLKYIHSANVLHRDLKPANILVNANCDLKITDFGLARVSELNDDSDFLSEYVATRYYRPPEVLLNYNTYGPALDVWSVGCILAEMILR
.| . |.|||||||||.||||.||||.|| |.|||.|| ||| ||||||| |. |.|  . . | | ||| ||.|.    |  |.|.|||||| ||.. |
DHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQ-DQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGR

RPLLPGKNTLDQIALIVNLIGSPSEQDLEECPAQNAKKYVQSLGEKKKVAWK--TIFRGKLYIDEELDLLDRMLTWDPRKRITVDEALEHPFL
| |   .. ..|. .|..|.| ||  |.     . ||  .   ..|.    .  |.        |  .|| ||| .|| ||| . .||.||.|
RILFQAQSPIQQLQMITDLLGTPSMEDMKYA-CEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase 91970.m00074.AA CDK 20-311 32 8.60000000001e-101 323.22 In-house 1-284 (284) Show / Hide 
Range on Protein: 20-311
Range on HMM: 1-284/284
Sequence Identity: 32% (106 aa)

YEIKRRLGRGAYGVVFAAKDKKTK-----KMVAIKKV--EHI----FDTLLDAKRCLREVCILSHFNHDNITNLIDVTSPS---DYNKF---NYLIIIMD
||.  ..|.|.||||. |.||.|.     ..||.||.  |.      .. .     .||...| .  |.|| .|.||   .   ..||.   | | ....
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFP-ITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

LMETDLHRIISSNQPITVEHHRFFIYQILRGLKYIHSANVLHRDLKPANILVNANCD-----LKITDFGLARVSELNDD----SDFLSEYVATRYYRPPE
 |..||  ...          . ...|.|||| |.|| ...||||||.|||.| |       |||.||||||    . .    .  ..  | |. ||.||
YMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

VLLNYNTYG--PALDVWSVGCILAEMIL---RRPLLPGKNTLDQIALIVNLIGSPSEQDLE---ECPAQNAKKYVQSLGEKKKVAWKTIFRGKLYIDEEL
.||   .|.  .. |.||||||.|||..   |.||.||.. .||. .| ...|.|.|..     . |                                 
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------------

DLLDRMLTWDPRKRITVDEALEHPFL
|||..||. || |||. ..||.||..
DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 91970.m00074.AA S_TKc 20-311 30 3e-98 333.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-311
Range on HMM: 1-231/231
Sequence Identity: 30% (93 aa)

YEIKRRLGRGAYGVVFAAKDKKTKKMVAIKKVEHIFDTLLDAKRCLREVCILSHFNHDNITNLIDVTSPSDYNKFNYLIIIMDLMET---DLHRIISSNQ
||| | .|.||.|.|. ...|||.. ||||..          .. .||. ||.. .|.|| .|.||         ..| ..|.....   ||...| ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

P------ITVEHHRFFIYQILRGLKYIHSANVLHRDLKPANILVNANCDLKITDFGLARVSELNDDSDFLSEYVATRYYRPPEVLLNYNTYGP-ALDVWS
.      ..  | ||..|||...|.|.|| ...||||||.|||..    .||.||||||.          . .. |..|..||||     ||. . |.||
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKCKCDWWS

VGCILAEMILRRPLLPGKNTLDQIALIVNLIGSPSEQDLEECPAQNAKKYVQSLGEKKKVAWKTIFRGKLYIDEELDLLDRMLTWDPRKRITVDEALE--
.||||.||. ..|. |      |.... ..||                                        .| .|.....|..||.||.|. |||.  
CGCILYEMLCGYPPFP------QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

-----HPFL
     ||..
WDIKCHPWF
Kinase 91970.m00074.AA Pkinase 20-311 30 1.2e-90 312.27 Pfam 1-293 (293) Show / Hide 
Range on Protein: 20-311
Range on HMM: 1-293/293
Sequence Identity: 30% (95 aa)

YEIKRRLGRGAYGVVFAAKDKKTKKMVAIKKVEHIFDTLLDAKRCLR--EVCILSHFNHDNITNLIDVTSPSDYNKFNYLIIIMDLMET-----DLHRII
|.|.|..|.|..|.|. ...|.| |.||.|...   .     .. .|  |..|. ..||.||  |.|.         ... ..|...|      ||...|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

S--SNQPI--TVEHHRFFIYQILRGLKYIHSANVLHRDLKPANILVNANCDL----KITDFGLARVSELNDDSDFLSEYVATRYYRPPEVLLNYNTYGPA
|  .. ..  . .. .|..|||||||.|.|| ...||||||.|||.. |...    ||.|||||.. . .  .  .. .. |..|..|||.. .. |||.
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

LDVWSVGCILAEMILRRPLLPGK----NTLDQIALIVNLIG-SPSEQDLEECPAQNAKKYVQSLGEKKKVAWKTIFRGKLYIDEEL-DLLDRMLTWDPRK
 |.||.||||.||...||. ||.    | .||...|..  |  ....  ..|.  . .   .   .       . .. . ...||. |.....|..|| |
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------F-HWTFHNWSEECKDFIKWCLCKDPKK

RITVDEALEHPFL
|.| ...|.||..
RPTAEQILQHPWF
Kinase 91970.m00074.AA MAPK-Unclassified 20-169 49 3.4e-68 232.88 In-house 1-157 (575) Show / Hide 
Range on Protein: 20-169
Range on HMM: 1-157/575
Sequence Identity: 49% (77 aa)

YEIKRRLGRGAYGVVFAAKDKKT-KKMVAIKKVEHIFDTLLDAKRCLREVCILSHFNHDNITNLIDVTSPSDYNK--FNYLIIIMDLMET---DLHRIIS
|| .  .| ||||.|  |.|||. .. |||||| ||| .  |.|| |||. || . || || .. |.  . .     |  . | ||.|.|   ||| || 
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SNQ-PITVEHHRFFIYQILRGLKYIHSANVLHRDLKPANILVNANCDLKITDFGLAR
||| .   .| . |.|||||||||.|||...||||||.|.|.| .| ..| |||..|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase 91970.m00074.AA MAPK-Unclassified 180-311 32 6.5e-50 172.13 In-house 405-575 (575) Show / Hide 
Range on Protein: 180-311
Range on HMM: 405-575/575
Sequence Identity: 32% (55 aa)

LSEYVATRYYRPPEVLLNYNTYGPALDVWSVGCILAEMILR-----------RPLLPGKN--------------------TLDQIALIVNLIGSPSEQDL
...||.||.|| || .|    |. . | ||.|||.|||...           |||.||..                      ||| .|.   |.| |.|.
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

EECPAQNAKKYVQSLGEKKKVAWKTIFRGKLY--------IDEELDLLDRMLTWDPRKRITVDEALEHPFL
 .    .|.||.||.. |. | .. ..  | .          |..|... ||  .|.|||| |.|||||. 
NFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase 91970.m00074.AA Pkinase_Tyr 20-176 31 5.2e-19 65.02 Pfam 1-165 (270) Show / Hide 
Range on Protein: 20-176
Range on HMM: 1-165/270
Sequence Identity: 31% (54 aa)

YEIKRRLGRGAYGVVFAAKDK----KTKKMVAIKKVEHIFDTLLD--AKRCLREVCILSHF-NHDNITNLIDVTS-PSDYNKFNYLIIIMDLMET-DLHR
 .. . ||.||.|.|. .. |    .||  ||.|.. .   .  .   .  .||. |.... .|.|| .|. | .  .. |   ...|.| .|.  ||. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLLD

IISS----NQPITVEHHRFFIYQILRGLKYIHSANVLHRDLKPANILVNANCDLKITDFGLARVSELNDD
   .    .||.|...   . .|| .|. | .| |  ||||   |.||. |   ||.||||||    |||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDD
Kinase 91970.m00074.AA TyrKc 20-263 23 1.4e-14 13.25 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-263
Range on HMM: 1-280/280
Sequence Identity: 23% (67 aa)

YEIKRRLGRGAYGVVFAAKDKKTKKMVAIKKVEHIFDTLLDAKRCLREVCILSHF--NHDNITNLIDVTSPSDYNKF---NYLIIIMDLMET-DLHRIIS
 . .. ||.||.|.|. .. |    .||.|.. .        .  .||  |....  .|.|| .|. | . .  | |     | |.| .|.  ||.  . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLR

SNQP-ITVEHHRFFIYQILRGLKYIHSANVLHRDLKPANILVNANCDLKITDFGLARVSELN-------DDSDF----LSEY-VATRYYRPPEVLLNYNT
...| .....   | .|| .|  |.|| |. ||||   |.||..|   ||.||||.|  .         |  .      . . .  | . .||.. ||..
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGK

YGPALDVWSVGCILAEMI-LRRPLLPG-----KNTLDQIALIVNLIGSPSEQD----------------LEECPAQNAKK------YVQSL
. .. |||| |  . |.  .  .  ||     ..  . |... .    |  ..                 ..| . ....       .. .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF