Gene 87150.m00250 (T.vaginalis)

87150.m00250

Species: T.vaginalis
Alias: TvagK0590, 87150.m00250
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2

Sequence

Name Sequence Type Origin Length Description Download
87150.m00250.AA Protein None 297 None Fasta, JSON
87150.m00250.kin_dom Protein Kinase Domain None 279 None Fasta, JSON

Protein domain

Protein domains of 87150.m00250.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 87150.m00250.AA CDC2 6-284 41 3.3e-110 340.01 In-house 1-301 (301) Show / Hide 
Range on Protein: 6-284
Range on HMM: 1-301/301
Sequence Identity: 41% (126 aa)

YHKDMKLGEGTYGSVFRATHIPTDQPVVLKLVRMDLEEDG--IPPSSVREVCILKSLN-HPNILHFREVICKDSKIIMVCEFMDMDLKNFLS----K-RR
| |  |.|||||| |... .  |.| |.|| .| . |..|  .| ...|| ..|| |. ||||   ..|| . .|. || |..|||||...     |   
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

MNPNLLRSYAFQLLCGTYYLHRIGIVHRDIKPENILIDRDGLLKLGDFGTA-AYCFHPIPYDIE-EIKTPWYLAPEILINAPAHGTEIDIWSIGCVIAEM
| |.|..||..|.| |  ..|. .|.|||.|| |||||..| .|..||| | | ..   .|  | |. | || |||||  .    |..|.|||||..|||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

----ARGNLFMGDSQVDQLIKITEVLGIPSEEDYPDFYKYK--INNIPCMKKEKPDFNSFFPG---------VDPELVDLISKMLQMNPEHRINAQSALN
     .  ||.|||. ||| || ..|| |.|...|. ....   |  |. |.   |. . .|          .||| .||...||| .|..||.|..||.
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQ--DLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQ

HPYF
||||
HPYF
Kinase 87150.m00250.AA CMGC 6-284 21 2e-101 334.07 In-house 1-513 (513) Show / Hide 
Range on Protein: 6-284
Range on HMM: 1-513/513
Sequence Identity: 21% (109 aa)

YHKDMKLGEGTYGSVFRATH--------------IPTDQPVVLKLVR---MDL------EEDGIPPSSVREVCILKSLN-----------------HPNI
|... |.|||||| |.....              . |.. | .| ..   ..       |.||.| .. ||. ||| ||                 |.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

LHFREVICKDS-----------------KIIMVCEFMDMDLKNFLSKRR----------MNPNL------------LRSYA------FQLLCGTY--YLH
.. ....  .                  .. .| |.||.||.... . .          ...               ...       .|.|.|    |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

RIG--IVHRDIKPENILIDRDGLL--------------------KLGDFGTAAYCFHP---------------------IPYDIEEIKTPWYLAPEILIN
. .  |.|||.|||||||. .. |                    |..||| | .  ..                          ... | || |||||..
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

A---------PAHGTEIDIWSIGCVIAEMAR---------GNLFMGDSQ-----------VDQLIKITEVLGIPS---------------EE--------
.            .|.||.||.||..||| .           || |.|            .||| || .||| |.               ||        
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

-----------------DYPDFYKYKINNIP-CMKKEKPDFNSFFPG-----------------------------------VDPELVDLISKMLQMNPE
                 ....|.. .|.. .   .. .......||.                                    ||...||..||||..|.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

HRINAQSALNHPYF
 || |. ||.||||
KRITAEQALQHPYF
Kinase 87150.m00250.AA CDK 6-284 36 9.4e-100 319.84 In-house 1-284 (284) Show / Hide 
Range on Protein: 6-284
Range on HMM: 1-284/284
Sequence Identity: 36% (116 aa)

YHKDMKLGEGTYGSVFRATHIPTD-----QPVVLKLVRMDL-----EEDGIPPSSVREVCILKSLNHPNILHFREVICKD-----------SKIIMVCEF
| |  |.|||||| |..| .  |.     | | || .||.      |..|.| ...||...|| | ||||   ..|.  .           .|. || |.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MDMDLKNFLSKRRMNPNLLRSYAFQLLCGTYYLHRIGIVHRDIKPENILIDRDGL-----LKLGDFGTA-AYCFH-----PI-PYDIEEIKTPWYLAPEI
||.||| ...         ..| .||| | .|.|. .|.|||.|| ||||...|      ||..||| | |.        |. .|.  |. | || |||.
MDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTH-EVVTLWYRAPEL

LINAPAHG--TEIDIWSIGCVIAEMA----RGNLFMGDSQVDQLIKITEVLGIPSEEDYPDFYKYKINNIPCMKKEKPDFNSFFPGVDPELVDLISKMLQ
|  .   .  |.||.||.||..|||.    |  ||.|||  ||| || ...| |.|.. |.. |.                           ||..|||.
LLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------DLLNKMLC

MNPEHRINAQSALNHPYF
..|..||.|. ||.||||
YDPKKRISAEQALQHPYF
Kinase 87150.m00250.AA S_TKc 6-284 28 2.2e-91 310.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 6-284
Range on HMM: 1-231/231
Sequence Identity: 28% (86 aa)

YHKDMKLGEGTYGSVFRATHIPTDQPVVLKLVRMDLEEDGIPPSSVREVCILKSLNHPNILHFREVICKDSKIIMVCEFMDM---DLKNFLSKRR-----
|..  |.|.|..|.|....|. |.. | .| ..          .  ||. |||. .|||| .. .|.   ... || |..|    ||. .. ||.     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--MNPNLLRSYAFQLLCGTYYLHRIGIVHRDIKPENILIDRDGLLKLGDFGTAAYCFHPIPYDIEEIKTPWYLAPEILINAPAHGT-EIDIWSIGCVIAE
  ...   |.|. |..|.  |.|. ||.|||.||||||.|.   .|..||| |.            . ||||.|||.|     .|. ..|.||.||...|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

MARGNLFMGDSQVDQLIKITEVLGIPSEEDYPDFYKYKINNIPCMKKEKPDFNSFFPGVDPELVDLISKMLQMNPEHRINAQSALN-------HPYF
|. |       |.....|.                                        .||. |.|.|.||..||.|. |  ||.       ||.|
MLCGYPPFP--QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 87150.m00250.AA CDK5 6-284 39 7.8e-91 287.21 In-house 1-287 (287) Show / Hide 
Range on Protein: 6-284
Range on HMM: 1-287/287
Sequence Identity: 39% (115 aa)

YHKDMKLGEGTYGSVFRATHIPTDQPVVLKLVRMDLEEDGIPPSSVREVCILKSLNHPNILHFREVICKDSKIIMVCEFMDMDLKNFLSKRR--MNPNLL
| |  |.|||||| |..|    |   | || ||.| |  |.| . .||.|.|| | |.||     ||  . |...| ||.| ||| .. ..   |.... 
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

RSYAFQLLCGTYYLHRIGIVHRDIKPENILIDRDGLLKLGDFGTAAYCFHPIPYDIEEIKTPWYLAPEILINAPAHGTEIDIWSIGCVIAEMA-RGN-LF
.|. .||| |  . |   . ||| || | || . | |||.||| |     |.     |. | || .| .|. .    | ||.||.||..||||  |  ||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

MGDSQVDQLIKITEVLGIPSEEDYP---DFYKYK--INNIPCMKKEKPDFNSFFPGVDPELVDLISKMLQMNPEHRINAQSALNHPYF
 | .. ||| .| ...| |.|.  |   .  .||  ... |    ... . .  |. | .. || .||||.||..|| |. ||.||||
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQS-WQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 87150.m00250.AA Pkinase 6-284 30 7.8e-86 296.26 Pfam 1-293 (293) Show / Hide 
Range on Protein: 6-284
Range on HMM: 1-293/293
Sequence Identity: 30% (92 aa)

YHKDMKLGEGTYGSVFRATHIPTDQPVVLKLVRMDLEEDGIPPSSVR--EVCILKSLNHPNILHFREVICKDSKIIMVCEFMDM-----DLKNFLS---K
||.  |.|.|..|.|....|. | . |..| .. . |... . . .|  |..|.|.||||||. ....   ...| || |....     ||. ..|   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RRM--NPNLLRSYAFQLLCGTYYLHRIGIVHRDIKPENILIDRDGLL----KLGDFGTAA---YCFHPIPYDIEEIKTPWYLAPEILINAPAHGTEIDIW
...   .. ...|. |.|.| .|.|. ||.|||.||||||||..| .    |..||| |.   |   . ....    ||||.|||..  .. .|...|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTF--CGTPWYMAPEVIRGGQYYGPKVDMW

SIGCVIAEMARG-NLFMGD----SQVDQLIKITEVLGIPSEEDYPDFYK-YKINNIPCMKKEKPDFNSFFPGVDPELVDLISKMLQMNPEHRINAQSALN
|.||...||. |  .| |.    . .||. .| ...| | ..|.|  .  .  . ..  . . . .  | . ...|. |.|...|...|. |..|. .|.
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQ

HPYF
||.|
HPWF
Kinase 87150.m00250.AA CDK7 6-284 33 1.1e-82 219.97 In-house 1-288 (288) Show / Hide 
Range on Protein: 6-284
Range on HMM: 1-288/288
Sequence Identity: 33% (99 aa)

YHKDMKLGEGTYGSVFRATHIPTDQPVVLKLVR----MDLEEDGIPPSSVREVCILKSLNHPNILHFREVICKDSKIIMVCEFMDMDLKNFLSKRR--MN
| |  ..|||... |..|.   |.| |  | ..     .  .|||  . .||. ||. . |.|.   . .. . | | .| .||| ||          . 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

PNLLRSYAFQLLCGTYYLHRIGIVHRDIKPENILIDRDGLLKLGDFGTAAYCFHPIPYDI--EEIKTPWYLAPEILINAPAHGTEIDIWSIGCVIAE-MA
|    .|. ..| | .|.||  | |||.|| | |.. .| ||..||| |   | . |  |    . | || ||| |  |   || .|.||.||..|| | 
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLAR--FYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELML

RGNLFMGDSQVDQLIKITEVLGIPSEEDYPDFYKYKINNIPCMKKEKP----DFNSFFPGVDPELVDLISKMLQMNPEHRINAQSALNHPYF
|   . ||| .||| .| . || |.||. |.    ....   .|.  .     ..  |     .|.||...|. |||  |. .  .|..|||
RVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNM--CCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase 87150.m00250.AA PFTAIRE 6-284 36 3.3e-60 206.33 In-house 1-287 (287) Show / Hide 
Range on Protein: 6-284
Range on HMM: 1-287/287
Sequence Identity: 36% (106 aa)

YHKDMKLGEGTYGSVFRATHIPTDQPVVLKLVRMDLEEDGIPPSSVREVCILKSLNHPNILHFREVICKDSKIIMVCEFMDMDLKNFLSKRR--MNPNLL
| |  |||||.|  |...  . . | | || .|.. || | |   .||.  || | | ||     .|  .    .| |... ||. ...|    |.||  
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQEE-GTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNV

RSYAFQLLCGTYYLHRIGIVHRDIKPENILIDRDGLLKLGDFGTAAYCFHPIPYDIEEIKTPWYLAPEILINAPAHGTEIDIWSIGCVIAEMARGN-LFM
| . |||| |  | |.  . |||.|| | ||   | ||| ||| |     |     .|. | ||  | .|. .    |..|.| .||.  ||  |  .| 
RLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAFP

GD-SQVDQLIKITEVLGIPSEEDYP---DFYKYKINNIPCMKKEKPDFNSFFPGVD--PELVDLISKMLQMNPEHRINAQSALNHPYF
|     ||| || .||| | |. .|    . .||   ..    .       .| ..  |.  ||..||||..|. |. || |. ||||
GMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase 87150.m00250.AA MAPK 166-284 37 3.1e-42 143.75 In-house 196-328 (328) Show / Hide 
Range on Protein: 166-284
Range on HMM: 196-328/328
Sequence Identity: 37% (50 aa)

WYLAPEILIN--APAHGTEIDIWSIGCVIAEMA--RGNLFMGDSQVDQLIKITEVLGIPSEEDY-----PDFYKYKINNIP-CMKKEKPDFNSFFPG---
|| ||||. |  .  . . .|.||.||  |||   |  || |.. .||. .|.|||| ||||..     .. ..  | . .   |. | .. . ||.   
WYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF

-VDPELVDLISKMLQMNPEHRINAQSALNHPYF
 ..|. .||..|||...|..||... ||.||||
NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 87150.m00250.AA GSK 169-284 33 3.7e-35 104.38 In-house 186-328 (328) Show / Hide 
Range on Protein: 169-284
Range on HMM: 186-328/328
Sequence Identity: 33% (48 aa)

APEILINAPAHGTEIDIWSIGCVIAEMARGN-LFMGDSQVDQLIKITEVLGIPSEEDY----PDF--YKYK------INNIPCMK-------------KE
||| ....   .. ||.||.|||.|||  |  || ||| ||||. |...|| |..|.     |.   .|..      |...|  |             | 
APELIFGCTNYTCQIDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKY

KPDFNSFFP-GVDPE-LVDLISKMLQMNPEHRINAQSALNHPYF
.   . |.  . |.. ..|||||.|...|. |...  |. ||.|
R-TVYMFKWCHTDMQDWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase 87150.m00250.AA RCK 166-284 37 1.5e-34 106.8 In-house 178-298 (298) Show / Hide 
Range on Protein: 166-284
Range on HMM: 178-298/298
Sequence Identity: 37% (45 aa)

WYLAPEILINAPAHGTEIDIWSIGCVIAEMARGN-LFMGDSQVDQLIKITEVLGIPSEEDYPDFY-KYKINNIPCMKKEKPDFNSFFPGVDPELVDLISK
|| |||.|  .    . .|||..||...|    . || | | .||. ||..|.|.|. .|.||.| .    |.   ....   .. .|   .....|. |
WYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEK

MLQMNPEHRINAQSALNHPYF
||| .|. ||.|| ||.||||
MLQWDPQKRITAQQALQHPYF
Kinase 87150.m00250.AA CDK4 6-146 40 9.1e-33 109.6 In-house 1-155 (290) Show / Hide 
Range on Protein: 6-146
Range on HMM: 1-155/290
Sequence Identity: 40% (62 aa)

YHKDMKLGEGTYGSVFRATHIPTDQPVVLKLVRMDLEED--GIPPSSVREVCILKSL---NHPNILHFREV---ICKDS---KIIMVCEFMDMDLKNFLS
| .   .||| || |.||  . | . | || ||  ..|.  |.| | .||. ... |   .||||    .|   .  |    || || |  | ||. .| 
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

KR-R--MNPNLLRSYAFQLLCGTYYLHRIGIVHRDIKPENILIDRDGLLKLGDFG
|  .  | |   .   .||| |  .||   |.||| ||.|||. .|| .|| |||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFG
Kinase 87150.m00250.AA GSK 6-150 30 2.3e-32 95.71 In-house 1-166 (328) Show / Hide 
Range on Protein: 6-150
Range on HMM: 1-166/328
Sequence Identity: 30% (53 aa)

YHKDMKLGEGTYGSVFRATHI----PTDQP----VVLKLVRMDLEEDGIPPSSVREVCILKSL---NHPNILHF-----REVICKDS--KIIM--VCEFM
|. . . | |. | |..|. .     |..     |. | |  | .         ||. |.| |   .|||| .      .    ||   ...   | |.|
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYK-----CNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYM

DMDLKNFLS-----KRRMNPNLLRSYAFQLLCGTYYLHRIGIVHRDIKPENILID-RDGLLKLGDFGTAAY
 ..| ...      |..|  .... |..|...|  ||| .||.||||||.|||.| ..| ||. ||| | .
PQTLYQVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQ
Kinase 87150.m00250.AA RCK 50-148 33 1.1e-27 84.64 In-house 44-161 (298) Show / Hide 
Range on Protein: 50-148
Range on HMM: 44-161/298
Sequence Identity: 33% (39 aa)

SVREVCILKSLN-HPNILHFREVICKDS--KIIMVCEFMDMDL----KNFLSKRR-MNPNL--LRSYAFQLLCGTYYLHRIGIVHRDIKPENILIDR---
..||.  |. || ||||.  .|||  .       |.|.|||.|    |.|  .|. .. |   .... .|.| |  ..|. |. |||.|||||..     
NLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQ

------DGLLKLGDFGTA
      ....|..||| .
YFEDQDQDHIKIADFGLC
Kinase 87150.m00250.AA CDK4 166-284 39 4.1e-27 89.92 In-house 174-290 (290) Show / Hide 
Range on Protein: 166-284
Range on HMM: 174-290/290
Sequence Identity: 39% (48 aa)

WYLAPEILINAPAHGTEIDIWSIGCVIAEM-ARGNLFMGDSQVDQLIKITEVLGIPSEEDYP-DFYKYKINNIPCMKKEKPDFNSFFPGVDPELVDLISK
|| |||.|  ..   | .|.||.||..|||  |  || | | .||| || .| | | |.| | |     .       .    | .| |  .    ||. |
WYRAPEVLLQSY-YNTPVDMWSVGCIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVS---LPWDHFPQRHPRPFKDFCPHMCKQGDDLLQK

MLQMNPEHRINAQSALNHPYF
||  |...|. | ..|.||||
MLCYNHHKRMSAYQCLQHPYF
Kinase 87150.m00250.AA MAPK 6-146 25 5.2e-27 90.28 In-house 1-162 (328) Show / Hide 
Range on Protein: 6-146
Range on HMM: 1-162/328
Sequence Identity: 25% (42 aa)

YHKDMKLGEGTYGSVFRATHIPTDQP------VVLKLVR--MDLEEDGIPPSSVREVCILKSL-NHPNILHFREVICK------DS-----KIIMVCEFM
|  . ..|.| || |. |.. .|.|       |..| .    . . .       ||. .|. . .|.||   ....        .|      | .| |.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCK--RTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELM

DMDLKNFLSKRR-MNPNLLRSYAFQLLCG--TYYLHRIGIVHRDIKPENILIDRDGLLKLGDFG
. || . .  .. ..    ..  .|.|.|    |.|  ...|||.||.|||.. ...||..|||
ETDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFG
Kinase 87150.m00250.AA Pkinase_Tyr 6-146 27 7.4e-18 61.11 Pfam 1-156 (270) Show / Hide 
Range on Protein: 6-146
Range on HMM: 1-156/270
Sequence Identity: 27% (45 aa)

YHKDMKLGEGTYGSVFRATHI----PTDQPVVLKLVRMDLEEDGIPPSS------VREVCILKSL-NHPNILHFREVIC-KDSK--IIMVCEFMDM-DLK
 ... ||||| .|.|...|       |..||  | ..      |  ..        ||. |.|.| .||||. .  |.  ..    |..| |.|   ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

NFLSKR-----RMNPNLLRSYAFQLLCGTYYLHRIGIVHRDIKPENILIDRDGLLKLGDFG
..| |.     . ..  | ....|  .|  ||......|||.   |.|.....  | .|||
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 87150.m00250.AA TyrKc 6-284 22 3.1e-14 7.49 SMART 1-280 (280) Show / Hide 
Range on Protein: 6-284
Range on HMM: 1-280/280
Sequence Identity: 22% (71 aa)

YHKDMKLGEGTYGSVFRATHIPTDQPVVLKLVRMDLEEDGIPPSSVREVCILKSL--NHPNILHFREVICKD-------SKIIMVCEFMDM-DLKNFLSK
 ... ||||| .| |...| .   ..|  | .. |  .  .     ||  |...|  .||||. .  |. ..         . .| |.|.  |||..| |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDF----MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RR--MNPNLLRSYAFQLLCGTYYLHRIGIVHRDIKPENILIDRDGLLKLGDFGTAAYCFHP-------IPYDIEEIKTPW------YLAPEILINAPAHG
.|   ..  | |...|  ||  |||. ...|||.   |.|.....  | .||| . .  .          |.  | |          .||| .     .|
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NYG

---TEIDIWSIGCVIAEMARGNLFMGDSQVDQL----IKITEVLGIPSEEDYPDFYKYKINNIPCMKKEKPDFNSFFPGVDPELVDLISKMLQMNPEHRI
   |. |.|| | .. |.    .  |..         .. .||.    . ....  ..     | |         | ..  .|. .....  . .|| | 
KFTTKSDVWSFGVCMWEI----FTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---P-MS--------F-VCCPDEMYQIMKQCWHEDPEDRP

NAQSALNHPYF
. .    | .|
TFSEI--HECF
Kinase 87150.m00250.AA RCK 6-23 50 0.000859 7.59 In-house 1-18 (298) Show / Hide 
Range on Protein: 6-23
Range on HMM: 1-18/298
Sequence Identity: 50% (9 aa)

YHKDMKLGEGTYGSVFRA
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YQIIKQLGDGTYGCVMKA