Gene 97466.m00060 (T.vaginalis)

97466.m00060

Species: T.vaginalis
Alias: 97466.m00060, TvagK0903
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMK-Tvag3

Sequence

Name Sequence Type Origin Length Description Download
97466.m00060.AA Protein None 261 None Fasta, JSON
97466.m00060.kin_dom Protein Kinase Domain None 252 None Fasta, JSON

Protein domain

Protein domains of 97466.m00060.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc 97466.m00060.AA S_TKc 7-258 24 1.2e-58 202.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 7-258
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

YIQQKILSSSQNSSTEICYDQMEKRTVVLKKFPKNVKPLDRFLEEVNAQAFISSTGVIQTYSAFEENDNYVLVMEAGKT---NLMDIIKHGC-------L
|   ... .   ..   |..   .| | .|. .      .... |..         ... | .|.. |.. .|||   .   .|.|.||.         .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SETLVKSLLPNVLVGLKDLHSNHIVHNDVKPENIVLCLDGKMKIIDFDLATIHDKEKCNYEHGVFGTWPYMSPEVVDGGDHTE-KVDVWSMGVVMYVALT
.|  .....  .. .|. .||..|.| |.||||| |.     ||.|| ||..         . . ||  ||.|||.    ..  |.|.|| |...|  |.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GVLPFKAPNQTTYLDNVKQQPFNKILLEKVHCSRQLIDLISTMLTKDPAKRPTISQCLK-------HEWF
|  ||   .. . .....              |....|.|. .|.|||.||||. ..|.       |.||
GYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 97466.m00060.AA CAMK 63-258 20 6.3e-56 178.35 In-house 100-425 (425) Show / Hide 
Range on Protein: 63-258
Range on HMM: 100-425/425
Sequence Identity: 20% (68 aa)

VIQTYSAFEE-------------------NDNYVLVM---EAGKTN------LMDIIKHGC---------------LSETLVKSLLPNVLVGLKDLHSNH
.|. | ..|                    ......||   |           .  |..|||               ..|  .. .   .. ... .||..
IIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHNDVKPENIVLCLD-----------------GKMKIIDFDLATIHDKEKCNY----------------------EHGVFGTWPYMS-PEVVDG-----
||| | ||||| |. .                 .. ||||| .|.. |. . |.                       . ..|| .||. |||. |     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------GDHTEKVDVWSMGVVMYVALTGVLPFKAP-------------NQTTYLDNVKQQPFNKILLE---------------------KVHCSRQL
           ...|.|.||.||..|. |.| .|| ..             |.   . ....  .. .  .                     . ..| . 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQEC

IDLISTMLTKDPAKRPTISQCLKHEWF
.|||. ||..|| ||.||.|||.|.|.
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 97466.m00060.AA Pkinase 63-258 31 1.8e-51 182.12 Pfam 62-293 (293) Show / Hide 
Range on Protein: 63-258
Range on HMM: 62-293/293
Sequence Identity: 31% (75 aa)

VIQTYSAFEENDNYVLVMEAGKT-----NLMDIIK---HGCL--SETLVKSLLPNVLVGLKDLHSNHIVHNDVKPENIVLCLDGKM----KIIDFDLATI
....| .||..|.. .|||          |.|.|.   |||.  ||  .|. .  .| ||. .||. |.| |.||||| .  .|      ||.|| ||  
IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQ

HDKEKCNYE-HGVFGTWPYMSPEVVD-GGDHTEKVDVWSMGVVMYVALTGVLPFKAPNQTTYLDNVKQQPFNKILLEKVHCS------------------
.|    |.. ... || .||.|||.  | ... |||.||.|...|  |.| .||.  . ..   . ..| ...|.  ..| .                  
FD--Y-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFH

-------RQLIDLISTMLTKDPAKRPTISQCLKHEWF
       . ..|.|. .|.|||.||||. |.|.|.||
WTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 97466.m00060.AA CAMKL 63-258 29 2.5e-50 158.72 In-house 77-297 (297) Show / Hide 
Range on Protein: 63-258
Range on HMM: 77-297/297
Sequence Identity: 29% (67 aa)

VIQTYSAFEENDN------YVLVME-AGKTN--LMDIIK-HGC----LSETLVKSLLPNVLVGLKDLHSNHIVHNDVKPENIVLCLDG--KMKIIDFDLA
.|. |  .|  ..      ..|||| ..  .  |.| |. ||.    ..|   . .   .. ... .||..||| | ||||| |  .|  . ||||| ..
IIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS

TIHD---KEKCNYEHGVFGTWPYMSPEVVDG---GDHTEKVDVWSMGVVMYVALTGVLPFKAP--------NQTTYLDNVKQQPFNKILLEKVHCSRQLI
....   . . .  .   |. |||.||.. |     .  |||.||.||..|. ..| |||...        |. ...  .... .       .| | ...
NMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-Y--YPPIWYHVS-DCR

DLISTMLTKDPAKRPTISQCLKHEWF
|||. ||...| ||||| | ..|.|.
DLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 97466.m00060.AA Ciliate-E2 63-258 25 7.7e-49 165.77 In-house 94-365 (365) Show / Hide 
Range on Protein: 63-258
Range on HMM: 94-365/365
Sequence Identity: 25% (72 aa)

VIQTYSAFE--ENDNYVLVME-AGKTNLMDIIKHG------------CLSETLVKSLLPNVLV---------------GLKDLHSNH-IVHNDVKPENIV
.|. | .|.   ..|. |||| .   .|.|.||.             ...|  .| .   .|                .|. |||.. |.| | |||||.
IIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENIL

LCLDGKMKIIDFDLATIHDKE-----------KCNYEHG--------------------VFGTWPYMSPEVVDGGD---------HTEKVDVWSMGVVMY
.      ||||| |... |..           .. . ..                    . || .||.||.. |..         ...|.|.||.||..|
F-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILY

VALTGVLPFKAPNQTTYLDNVKQQPFNKILLE--------------KVHCSRQLIDLIST----MLTKDPAKRPT-ISQCLKHEWF
  |.| .||        ... ||....    |              . ..| . .|||.     || ||| ||.| ..|.|.|.||
EMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 97466.m00060.AA Ciliate-E2-Unclassified 63-258 25 2.3e-48 165.87 In-house 83-352 (352) Show / Hide 
Range on Protein: 63-258
Range on HMM: 83-352/352
Sequence Identity: 25% (69 aa)

VIQTYSAFEENDNYVLVMEAGK-TNLMDIIKH------------------GCLSETLVK-----SLLPNVLVGLKDLHSNH-IVHNDVKPENIVLCLDG-
..  . .|.  .|  .|||  .  .|...||.                   ...|  .|      ..  .|.||. ||... |.| | |||||..  .| 
IVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK

--KMKIIDFDLATIHDKE--------------KCNYEHGVFGTWPYM----SPEVVDGGDHT----EKVDVWSMGVVMYVALTGVLPFKAPNQTT-----
  . ||||| ..   ..               | .  . . ||  ||    .||| .|  .     .|.|.||.||..|  |.| .||...|..      
NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLI

-----------YLDNVKQQPFNKILLEK----VHCSRQLIDLIS----TMLTKDPAKRPTISQCLKHEWF
           ...| ||.....   ..     | | . .|.|.     || |.| ||.|..| |.| ||
TQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 97466.m00060.AA AGC 48-258 19 7.2e-48 120.7 In-house 67-395 (395) Show / Hide 
Range on Protein: 48-258
Range on HMM: 67-395/395
Sequence Identity: 19% (65 aa)

FLEEVNAQAFIS----------STGVIQ-TYSAFEENDN--YVLVME-----------AGKTNLMDII----KHGCLSETLVKSLLPN-------VLVGL
. || |  . ..          .  ...  ...|. .|.    .|||            |   |. ..    | |...|  ..  .         .. .|
VWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLAL

KDLHS-NHIVHND-VKPENIVLCLDGKMKIIDFDLATIHDKE-------------------------------------------------KCNYEHGVF
  ||| ..|.| | .|||||.|  ||  |. || |...  ..                                                 | .  .   
EYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFC

G--TWPYMSPEVVDGGDHTEKVDVWS--MGVVMYVALTGVLPFKAPN---------QTTYLDNVKQQP----FNKILLEK---------VHCSRQLIDLI
|  |  ||.||..    ..  .| ||  .|..||  |||  || . |         .   . .  . .    ..|. .           .. | .. |||
GPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLI

STMLTKDPAKRPT----------ISQCLKHEWF
. .|.|||.||..          ...  .|.||
KKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 97466.m00060.AA Ciliate-E2a 63-258 34 2.2e-38 110.63 In-house 61-275 (275) Show / Hide 
Range on Protein: 63-258
Range on HMM: 61-275/275
Sequence Identity: 34% (74 aa)

VIQTYSAFEENDNYVLVME--AGKTNLM-DIIKHGCLSET--LVKSLLPNVL-VGLKDLHSNHIVHNDVKPENIVLC---LDG----KMKIIDFDLATIH
.|. |  .| ..|| ||||   |   |.  |...... |    ..... . |  ||  .|...|.| | ||||| .     ..    . ||||| |||  
IIKLYEVYEDENNYYLVMEYCEG-GELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFI

DKEKCNYEHGVFGTWPYMSPEVVDGGD------HTEKVDVWSMGVVMYVALTGVLPFKAPNQTTYLDNVKQQPFNKILLE-KVHCSRQLIDLISTMLTKD
|| . .| .   ||  |. |||    .       ..|.|.|| ||..|  |.| .|||. . .  | ..|.  ..    |    || . .||.. || ||
DKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKD

PAKRPTISQCLKHEWF
| ||.|. |.|.| ||
PKKRITAQQALNHPWF
Kinase 97466.m00060.AA RSK 92-258 29 2.5e-37 130.34 In-house 96-278 (278) Show / Hide 
Range on Protein: 92-258
Range on HMM: 96-278/278
Sequence Identity: 29% (56 aa)

KH-GCLSETLVKSLLPNVLVGLKDLHSNHIVHNDVKPENIVLCL---DGKMKIIDFDLATIHDKEKCNYEHGVFGTWPYMSPEVVD----GGDHTEKVDV
|| ||.||. ..  . .. . .. ||. .|.| | |||||..     .|  |..||... . . .. .  .   .|  || ||..     .| |.. .|.
KHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDW

WSMGVVMYVALTGVLPFKAPNQTTYLDNVKQQPFNKILLEK--VHCS------RQLIDLISTMLTKDPAKRPT-----ISQCLKHEWF
|| ||.||  ||| .||..||.     | ... ...|.  |  .         .   |||. ||..||.||..     ... ..|.||
WSLGVLMYEMLTGCPPFQGPND-----NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 97466.m00060.AA MARK 63-258 31 7.9e-37 118.03 In-house 61-262 (262) Show / Hide 
Range on Protein: 63-258
Range on HMM: 61-262/262
Sequence Identity: 31% (67 aa)

VIQTYSAFE--ENDN-YVLVME-AGKTNLMD-IIKH--GCLSETLVKSLLPNVLVGLKDLHSNHIVHNDVKPENIVLCLDG--KMKIIDFDLATIHDKEK
.|. . ..|  .. .  .|.|| |....|.| |..|  |.|.| . . .   .. ... .||..||| | ||||| .  .|  ..||||| .. |. .. 
IIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFS-ICIPPG

CNYEHGVFGTWPYMSPEVVDGGDHT-EKVDVWSMGVVMYVALTGVLPFKAPNQTTYLDNV--KQQPFNKILLEKVH----CSRQLIDLISTMLTKDPAKR
.  .    || |||.||.. . . .  |||.||.|||.|. ..| .||.        .      . . ||| .| .     |... .||. .|| .| .|
QKLN-TFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFD--------GDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEER

PTISQCLKHEWF
|||....||.|.
PTIEEIMKHPWM
Kinase 97466.m00060.AA STE 45-258 22 2.2e-35 122.42 In-house 72-359 (359) Show / Hide 
Range on Protein: 45-258
Range on HMM: 72-359/359
Sequence Identity: 22% (67 aa)

LDRFLEEVNAQAFIS--STGVIQTYSAFEEN-------DNYVLVMEAGK-TNLMDIIKH--GCLS-------------ETLVKSLLPNVLVG-LKDLHSN
....|.|..     .  .  ... | ... .       |.  ..||      | |||||  ||.              |....  .  .| | |. |||.
MQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSH

HIVHNDVKPENIVLCLDGKMKIIDFDLATIHDKE------------------KCNYEHGVFGTWPYMSPEVVDG------GDHTEKVDVWSMGVVMYVAL
||.| |.|| || |      |..|| .... ...                  |.|   |      .|.|||...      .....|.|.|| | ..   .
HIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP----WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA

TGVLPFKAPNQT----TYLDNVKQQP---------FNKILLEKV------------------HCSRQLIDLISTMLTKDPAKRPTISQCLK--HEWF
||  |.   . .      ..| . |.         ..   |.                    ..|  ..| |.  |.||| |||| || ||  |...
TGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 97466.m00060.AA CAMK-Unique 70-258 21 2.5e-33 107.24 In-house 89-363 (363) Show / Hide 
Range on Protein: 70-258
Range on HMM: 89-363/363
Sequence Identity: 21% (59 aa)

FEEND---------------NYVLVMEAGKTN-LMDIIKH---------------------GCLSE--TLVKSLLPNVLVGLKDLHSNHIVHNDVKPENI
|.  .               ....|||    . | |.| .                     | .||  ... ..   .|  .. .||. ||| | |.|||
FCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENI

VLCLDGK----------------MKIIDFDLATIHD-KEKCNYEHGVFGTWPYMSP--------------EVVDGGDHTEKV----DVWSMGVVMYVALT
..|  .|                 |..||.|..  . ...|   . . || .||.|              ||... .  ...    | ||.||.||  |.
MVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLC

GVLPFKAPNQTTYLDNVKQQPFNKILLEKV--------HC----SRQLIDLISTMLTKDPAKRPTISQCLKHEWF
| .|| ...     .| .   | .|.  ..        |     | ...|..   .| ||..| .... |.|.|.
GCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
TyrKc 97466.m00060.AA TyrKc 22-258 22 5.1e-09 -76.83 SMART 14-280 (280) Show / Hide 
Range on Protein: 22-258
Range on HMM: 14-280/280
Sequence Identity: 22% (60 aa)

EICYDQMEKRTVVLKKFPKNVKPLDRFLEEVNAQAFI--SSTGVIQTYSAFEEN-------DNYVLVME-AGKTNLMDII-KHGC-LSETLVKSLLPNVL
|..  ..  ..|  |.  ..   .  |..| .    .  .   ... | .  .        . . .||| . . .| | . ||.  |.     |    . 
EVYKGTWK-IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIA

VGLKDLHSNHIVHNDVKPENIVLCLDGKMKIIDFDLATIHDKE------KCNYEHGV--FGT--WPY--MSPEVVDGGDHTEKVDVWSMGVVMY-VALTG
 |   |||....| |    |. .  .. .|| || |.  .. .      |  | .     |   .|.  |.||. . |  |.| |||| ||.|. .   |
CGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYG

VLPFKA-----PNQTTYLDNVKQQPFNKILLE-----KVHCSRQLIDLISTMLTKDPAKRPTISQCLKHEWF
  |         . .  . .|||    ..  .      |.|.  . .....    ||..||| |..  || |
QQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF