Gene 86739.m00037 (T.vaginalis)

86739.m00037

Species: T.vaginalis
Alias: TvagK0866, 86739.m00037
External Links:
Annotation:

Classification

Group: Other
Family: WNK

Sequence

Name Sequence Type Origin Length Description Download
86739.m00037.AA Protein None 320 None Fasta, JSON
86739.m00037.kin_dom Protein Kinase Domain None 261 None Fasta, JSON

Protein domain

Protein domains of 86739.m00037.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 86739.m00037.AA NRBP 18-146 28 7.6e-17 55.51 In-house 2-138 (261) Show / Hide 
Range on Protein: 18-146
Range on HMM: 2-138/261
Sequence Identity: 28% (40 aa)

KQTQSRTKVYKCLDQEESIEAEWYEISLEG-----IAPEKLTRMQNSLIAYSGIKNAHLLQIFRAWVDSDRNT--LIFIKELFSNKTLRTYIKEV----S
..      .|  .|.|| .|  | |.            ||.  . . ||    ..  .. .. . |.|. ..   .||| |  |   .. ..| .    .
RDVPGIDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQ---LDHQNIVKFHKYWTDTKEEKPRVIFITEYMSSGSMKQFLKKTKKNHK

QIPAKACAQWCAQIMSGLTALHALNPPIIHNNISCDTIYI
....||  .|| ||.| |  ||. .||||| |. ||||.|
NMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFI
Kinase 86739.m00037.AA WNK 91-154 43 2.6e-13 39.29 In-house 82-146 (261) Show / Hide 
Range on Protein: 91-154
Range on HMM: 82-146/261
Sequence Identity: 43% (28 aa)

ELFSNKTLRTYIKEVSQIPAKACAQWCAQIMSGLTALHALNP-PIIHNNISCDTIYIDASVGAVK
||    ||.|| |   ..  |   .|| || .||  ||  .| ||||  . || |.|    |.||
ELMTSGTLKTYLKRFKKMKPKVLRSWCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVK
Kinase 86739.m00037.AA S_TKc 25-257 17 1.6e-07 -66.52 SMART 14-231 (231) Show / Hide 
Range on Protein: 25-257
Range on HMM: 14-231/231
Sequence Identity: 17% (45 aa)

KVYKCLDQEESIEAEWY---EISLEGIAPEKLTRMQNSLIAYSGIKNAHLLQIFRAWVDSDRNTLIFIKELFSN--KTLRTYIKEVSQ------IPAKAC
||||| . .     . .   .|.       . .|   ..      .  .. ... ...|   . | .. |. ..   .|..|||.         .|   .
KVYKCRHKK---TGRIVAIKIIK-------EHIRREIQILKK---HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HA

AQWCAQIMSGLTALHALNPPIIHNNISCDTIYIDASVGAVKL-------DTPSFESILFDWIQPTAALEAQQKISTPKSDVWSLGLAVIEISTGVIPYSD
. ...|| ..|  .| ..  |||  .  . | .|     .|.                |       | |   . ...|.|.||.|  ..|  .|  |.. 
RFYMYQICCALEYCHSHG--IIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP-

KTNPHDNILKGELPTALGQISDPSIADFATTCLL-SFEQRPCVNQLYE-------YALI
    .. ..|  .        .|.  ||   ||    |.|| . .. .          .
---QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 86739.m00037.AA STE 184-257 22 6.3e-07 20.62 In-house 248-359 (359) Show / Hide 
Range on Protein: 184-257
Range on HMM: 248-359/359
Sequence Identity: 22% (25 aa)

KSDVWSLGLAVIEISTGVIPYSDKTNP----HDNILK-------------GELPTALGQISD------------------PSIADFATTCL-LSFEQRPC
|.|.||||. .||  ||  |..| ...    . .. .             |. |.    .|.                  |.  ||   ||    ..|| 
KCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPT

VNQLYE--YALI
..|| .     |
ASQLLKSEHPFI
Kinase 86739.m00037.AA MEK3 184-204 61 1e-06 18.32 In-house 186-206 (264) Show / Hide 
Range on Protein: 184-204
Range on HMM: 186-206/264
Sequence Identity: 61% (13 aa)

KSDVWSLGLAVIEISTGVIPY
||||||||  .||. .|  ||
KSDVWSLGITMIEMAIGRYPY
Kinase 86739.m00037.AA MEK4 184-204 57 1e-06 17.41 In-house 192-212 (275) Show / Hide 
Range on Protein: 184-204
Range on HMM: 192-212/275
Sequence Identity: 57% (12 aa)

KSDVWSLGLAVIEISTGVIPY
.|||||||   .|. ||. ||
RSDVWSLGITMYEVATGKFPY
Kinase 86739.m00037.AA Ciliate-E2-Unclassified 78-142 20 2e-06 18.49 In-house 88-173 (352) Show / Hide 
Range on Protein: 78-142
Range on HMM: 88-173/352
Sequence Identity: 20% (18 aa)

WVDSDRNTLIFIKELFSNKTLRTYIKEVSQ-----------------IPAKACA-----QWCAQIMSGLTALHALNPPIIHNNISCD
... |....... |.. ...|. |||. ..                 .. ....     ...||| .||  ||  |  ||| .| ..
YCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPE
Kinase 86739.m00037.AA NZAK 181-207 40 1e-05 14.65 In-house 249-278 (329) Show / Hide 
Range on Protein: 181-207
Range on HMM: 249-278/329
Sequence Identity: 40% (12 aa)

STPKSDVWSLGLAVIEISTGVIP---YSDK
.. ||||||.|. |...  .  |   || |
INEKSDVWSFGCTVWQMFGYNPPNTIYSPK
Kinase 86739.m00037.AA Ciliate-E2 66-139 19 1.1e-05 15.46 In-house 89-187 (365) Show / Hide 
Range on Protein: 66-139
Range on HMM: 89-187/365
Sequence Identity: 19% (19 aa)

IKNAHLLQIFRAWVDSDRNTLIFIKELFSNKTLRTYIK-------------------EVSQIPAKACA-------QWCAQIMSGLTALHALNPPIIHNNI
... ...... .. . |.|.. .. |... ..|. |||                   |...| .. .         ..|.|...|  ||  |. ||| .|
LNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDI
Kinase 86739.m00037.AA STE7 184-204 59 1.1e-05 17.02 In-house 193-214 (288) Show / Hide 
Range on Protein: 184-204
Range on HMM: 193-214/288
Sequence Identity: 59% (13 aa)

KSDVWSLGLAV-IEISTGVIPY
.|||||||.   ||..||  ||
RSDVWSLGITMGIEMATGRYPY
Kinase 86739.m00037.AA Src-Echino1 167-209 43 1.5e-05 14.66 In-house 163-203 (252) Show / Hide 
Range on Protein: 167-209
Range on HMM: 163-203/252
Sequence Identity: 43% (19 aa)

WIQPTAALEAQQKISTPKSDVWSLGLAVIEIST-GVIPYSDKTN
|  | |||  .  |   |||||| |. . |. | | .|| . .|
WTAPEAALYGRFTI---KSDVWSFGILMTEMVTFGRYPYPGMMN
TyrKc 86739.m00037.AA TyrKc 6-255 15 0.000135 -148.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 6-255
Range on HMM: 1-280/280
Sequence Identity: 15% (49 aa)

LDAGKRY--------LRCELKQTQSRTKVY-KCLDQEESIEAEWYEISLEGIAPEKLTRMQNSLIAYSGI--KNAHLLQIFRAWVDSDR-----NTLIFI
.  ||           ....|     ..|  |.|  .                   .  . . .   . .  .. ...... . ... |       |  .
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIV

KELFSNKTLRTYIKEVSQ-IPAKACAQWCAQIMSGLTALHALNPPIIH------------NN---IS----CDTIYID------ASVGAVKL--DTP---
 |. ..  |. |...    .. |   ..| || .|   ||    ..||            |.   ||    .  || |       ..  .|   ..    
MEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTML

-----SFESILFDWIQPTAALEAQQKISTPKSDVWSLGLAVIEI-STGVIPYSD-----KTNP--HDNILKGELPTALGQ-------ISDPSIADFATTC
     . |.|             . .. |.|||||| |    || . |  ||..     ..|   . .. .|. .            .  . . .  ..|
PIRWMAPECI-------------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQC

LLS-FEQRPCVNQLYEYA
     |.||. ....|. 
WHEDPEDRPTFSEIHECF
Kinase 86739.m00037.AA WNK 186-257 23 0.000262 9.72 In-house 186-261 (261) Show / Hide 
Range on Protein: 186-257
Range on HMM: 186-261/261
Sequence Identity: 23% (18 aa)

DVWSLGLAVIEISTGVIPYSDKTNPHD---NILKGELPTALGQISDPSIADFATTCLLSFE-QRPCVNQLYEYALI
|| . |  . |  |. .|||  .|.      .  | .| ..  | .|.. ..   |.   .  || ..|| . .  
DVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTQGIKPNSFQKIQNPEVKEIIEKCIRHNKEERPSIQQLLNHDFF
Kinase 86739.m00037.AA Ciliate-E2-Unclassified 177-219 20 0.287204 0.18 In-house 240-303 (352) Show / Hide 
Range on Protein: 177-219
Range on HMM: 240-303/352
Sequence Identity: 20% (13 aa)

QQKISTP---KSDVWSLGLAVIEISTGVIPYSDKT------------------NPHDNILKGEL
.|. ...   |.|.||||    |. .|  |..|..                  . ..||.....
GQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNI