Gene 80892.m00270 (T.vaginalis)

80892.m00270

Species: T.vaginalis
Alias: TvagK0898, 80892.m00270
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: ATR

Sequence

Name Sequence Type Origin Length Description Download
80892.m00270.AA Protein None 2006 None Fasta, JSON
80892.m00270.kin_dom Protein Kinase Domain None 272 None Fasta, JSON

Protein domain

Protein domains of 80892.m00270.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 80892.m00270.AA ATR 256-272 23 0.138044 0.68 In-house 251-267 (267) Show / Hide 
Range on Protein: 256-272
Range on HMM: 251-267/267
Sequence Identity: 23% (4 aa)

RSISTYREPIISYYKSF
. ..  |..|.|... |
MCMRDHRDDIMSVWDCF
Kinase 80892.m00270.AA ATR 1688-1944 28 5.1e-38 126.87 In-house 2-267 (267) Show / Hide 
Range on Protein: 1688-1944
Range on HMM: 2-267/267
Sequence Identity: 28% (76 aa)

YMKRIDKVKATRIFGSKCKPMELEFTSDIGDKYLFLLKEGKDLEMRKDMRIMDIFTFINSVFNLDAFCKNRHLNITTYAVIILNKNFSLIELVPDSIEMK
|.  .| .    |. |  ||  . .    |  |. . |   ||  ||| | |..   || .   |.  . | ... ||||| || .  .|| | . . ..
YIAGFDDM--VEILASLQKPKKISLKGSDGKFYIMMCKPKDDL--RKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLR

NVYTELYTNFVNIRNEYQKRIKNEQSFAVNSENFKNQ-----FSHP--LKEWFCLQFKEPKKWFSAQKEYTMSCAVLSWVGSIFQIDDRHLGNILLKRET
 . ..|.         || |   ..  .  .|  |         ||   ..||  .| .|..|.|... |  | ||.. || |  . |||  |||... .
PILDKLWKEKKQYMQFYQLRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKIN

GTVFHIDFEEILES------KIAADFRLTHIILDGLGICGVNGSFTKCCIITANNLKANRDALVSLMEGF
| . |.|.  |  |           ||||| .  |.|  . .| | . |. .   .. .|| ..|... |
GECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase 80892.m00270.AA PI3_PI4_kinase 1719-1946 19 3e-37 134.89 Pfam 1-292 (300) Show / Hide 
Range on Protein: 1719-1946
Range on HMM: 1-292/300
Sequence Identity: 19% (56 aa)

KYLFLLKEGKDLEMRKDMRIMDIF-----------------------TFINSVFNLDAFCKNRHLNITTYAVIILNKNFSLIELVPDSIEMKNVYTELYT
 | |..| | ||  |.|||.| ..                       ...| .   |. . .|......| .| ....  .||.||.. .....  . ..
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

NFVNIRNEYQKRIK-----------NEQSFAVNSENFKNQFSHPLKEWFCLQFKEP-KKWFSAQKEYTMSCAVLSWVGSIFQIDDRHLGNILL--KRETG
.   . ...... .            .|   |.... .... . | .||  .....   |..| . .. |||... |. |... |||..||..  ...||
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

TVFHIDFEEILE--------SKIAADFRLTH----------IILDG--LGICGVNGSFTKCCIITANNLKANRDALVSLM-------EGFID
 .|||||  ...           . .||.||           ....  |.  |  | | ..|  . . |  . .....|.       | ...
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVH
Kinase 80892.m00270.AA PI3Kc 1721-1992 20 1.1e-26 95.95 SMART 1-336 (336) Show / Hide 
Range on Protein: 1721-1992
Range on HMM: 1-336/336
Sequence Identity: 20% (70 aa)

LFLLKEGKDLEMRKDMRIMDIFTFINSVFNLDAFCKNRHLNITTYAVIILNKNFSLIELVPDSIEMKNVYTELYTNFV----------------------
 ...| | ||  |.|||.| .|  .| .   |. | .|.| ...|..| ....  .||.||..  . ..  .....                        
AVIFKCGDDL--RQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNM

------------NIRNEYQKRIKNEQSFAVNSENFKNQFSHPLKEWFCLQFKEP-KKWFSAQKEYTMSCAVLSWVGSIFQIDDRHLGNILLKRETGTVFH
            ... .  ........|    .. .... ..|..||  .|..|  .|..|.. .| |||. . |. |..| |||..||.|...|| .||
YMMIWHQQACHWMMMYQHMTHMEWLKYF---EGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFH

IDFEEILES-----KI------AADFRLTHIILDGLG----ICGVNGSFTKCCIITANNLKANRDALVSLMEGFIDVEFEPEKSQE--------ILDQLK
|||  |...     ..      .. ||||| .... |    . |. | | .||  . . .. .......|.| ... .  |. . .        .  .| 
IDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLD

-----KRVDMIAD------DGHSSISPEQLVYSKISYCQQL
     ..  ....      ..||  |    .|  . . .|.
HLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 80892.m00270.AA PIKK 1829-1944 34 1.1e-26 94.28 In-house 168-290 (290) Show / Hide 
Range on Protein: 1829-1944
Range on HMM: 168-290/290
Sequence Identity: 34% (42 aa)

LKEWFCLQFKEPKKWFSAQKEYTMSCAVLSWVGSIFQIDDRHLGNILLKRETGTVFHIDFEEILESKIA-------ADFRLTHIILDGLGICGVNGSFTK
.|.|| . |  |  |... . || | || . || |  . |||. ||.....|| . ||||  . ||.           ||||. . ...|..||.| |..
FKKWFWRKFPDPEIWWERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRR

CCIITANNLKANRDALVSLMEGF
||. ..  .. .|. | ...| |
CCEHVMMCMRQHRETLMTVCEVF
Kinase 80892.m00270.AA ATM 1828-1942 37 1.2e-17 52.63 In-house 117-238 (304) Show / Hide 
Range on Protein: 1828-1942
Range on HMM: 117-238/304
Sequence Identity: 37% (46 aa)

PLKEWFCL-QFKEPKKWFSAQKEYTMSCAVLSWVGSIFQIDDRHLGNILLKRETGTVFHID----FEE--ILESKIAADFRLTHIILDGLGICGVNGSFT
|   .||. .| .|  ||     || | |  | || |  . |||  |||.      . |||    ||   ||       ||||  | ||.|| || | | 
PVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFR

KCCIITANNLKANRDALVSLME
.||  |   ..   . |. ..|
RCCEKTMEVMRNSQETLLTIVE
Kinase 80892.m00270.AA FRAP 1843-1945 30 3e-13 45.15 In-house 133-242 (251) Show / Hide 
Range on Protein: 1843-1945
Range on HMM: 133-242/251
Sequence Identity: 30% (33 aa)

WFSAQKEYTMSCAVLSWVGSIFQIDDRHLGNILLKRETGTVFHIDFEEILESKIAAD-------FRLTHIILDGLGICGVNGSFTKCCIITANNLKANRD
||     || | |..| .| |  . |||. ||.| | || . ||||    |  .  .       |||| ..   . .||..| .   | .  . .. ...
WFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKE

ALVSLMEGFI
 ..  .| |.
SVMAVLEAFV
Kinase 80892.m00270.AA PIKK 1720-1794 34 4.5e-12 40.59 In-house 31-103 (290) Show / Hide 
Range on Protein: 1720-1794
Range on HMM: 31-103/290
Sequence Identity: 34% (26 aa)

YLFLLKEGKDLEMRKDMRIMDIFTFINSVFNLDAFCKNRHLNITTYAVIILNKNFSLIELVPDSIEMKNVYTELY
| .|.| |.. . |.| |.|  | ..|  .  |. |  |||.|.||.|| .. .  ||| |...   |  |....
YPYLCK-GHE-DLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYKQWC
Kinase 80892.m00270.AA SMG1 1840-1888 44 1.9e-09 27.31 In-house 180-228 (242) Show / Hide 
Range on Protein: 1840-1888
Range on HMM: 180-228/242
Sequence Identity: 44% (22 aa)

PKKWFSAQKEYTMSCAVLSWVGSIFQIDDRHLGNILLKRETGTVFHIDF
|  |.   . |  | ||.| || |  . |||| |.|.   || | |||.
PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY
Kinase 80892.m00270.AA FRAP 1719-1782 34 7.3e-09 28.84 In-house 1-62 (251) Show / Hide 
Range on Protein: 1719-1782
Range on HMM: 1-62/251
Sequence Identity: 34% (22 aa)

KYLFLLKEGKDLEMRKDMRIMDIFTFINSVFNLDAFCKNRHLNITTYAVIILNKNFSLIELVPD
 | ||||   |.  | | |.| .|  ||   . ..  . . |.|. |..| |  |  ||  |..
EYHFLLKGHEDI--RQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHH
Kinase 80892.m00270.AA DNAPK 1722-1768 38 2.8e-05 14.97 In-house 35-79 (301) Show / Hide 
Range on Protein: 1722-1768
Range on HMM: 35-79/301
Sequence Identity: 38% (18 aa)

FLLKEGKDLEMRKDMRIMDIFTFINSVFNLDAFCKNRHLNITTYAVI
|. | . ||  | | ||   |   | .|  |  |  | |.  || .|
FCYKGIEDL--RQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNII
Kinase 80892.m00270.AA SMG1 1699-1749 35 0.00202 7.02 In-house 2-50 (242) Show / Hide 
Range on Protein: 1699-1749
Range on HMM: 2-50/242
Sequence Identity: 35% (18 aa)

RIFGSKCKPMELEFTSDIGDKYLFLLKEGKDLEMRKDMRIMDIFTFINSVF
 |   | ||  | |    |  | .| |   || .  | |||     .| .|
TILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHL--DERIMQFLSIVNTMF
Kinase 80892.m00270.AA DNAPK 1866-1888 47 0.006508 6.22 In-house 206-228 (301) Show / Hide 
Range on Protein: 1866-1888
Range on HMM: 206-228/301
Sequence Identity: 47% (11 aa)

IDDRHLGNILLKRETGTVFHIDF
| |||| | .   |.| .  |||
IGDRHLNNFMVNMENGDIISIDF