Gene 95045.m00065 (T.vaginalis)

95045.m00065

Species: T.vaginalis
Alias: 95045.m00065, TvagK0505
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
95045.m00065.AA Protein None 362 None Fasta, JSON
95045.m00065.kin_dom Protein Kinase Domain None 188 None Fasta, JSON

Protein domain

Protein domains of 95045.m00065.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 95045.m00065.AA CK1 11-265 23 1.6e-81 277.1 In-house 1-339 (339) Show / Hide 
Range on Protein: 11-265
Range on HMM: 1-339/339
Sequence Identity: 23% (81 aa)

YQIGPLLGKGSYG-DIYAA-----RNTEDG-----TFVAIKIESL-TSERKVLETEAYIMRKISKFT---------------------FFPKYITFGKTQ
.... ..|.|..| .|| .     ......     ...|.|.|.  .  .. .. |.|.| |. ..                      ....|.  |...
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

NNT-FLVMELCGPSLSYVIK--NLPEHKLSLSTGIRTMYIVMQGLEQLHHAGIIHRDVKPSNVLLRT--------------SISNPIAIIDFGLSR-VFI
..  ..||.|.||.|. . |   .. .|.|..|... ..  ...||..| .|.||||.||.|...                . .. . .||||..|  ..
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DK---W--------TKKQLPPRQ---NPGFRG-TTIFASPHAHLHQELSPRDDLISWYYMCIDLIVEP--LPWRNIKNRA------DILEKKLSTNLMEL
||   .        |..  |||    . |||| |. ..|...||..|...|||| || || |....    |||.|.|          . .|. ... ...
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

GT-----------EIAPQFQLIWRHITTLNYEDTPDYNYI
 |           .. ..|  |. .| .|.|.|.||| .|
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 95045.m00065.AA TTBKL 11-269 30 9.1e-72 241.56 In-house 1-288 (288) Show / Hide 
Range on Protein: 11-269
Range on HMM: 1-288/288
Sequence Identity: 30% (87 aa)

YQIGPLLGKGSYGDIYAARNTED-GTFVAIKIESLTSE--RKVLETEAYIMRKIS--KFTFFPKYITFGKTQNNTFLVMELCGPSLSYVIKNLPEHK-LS
..|  ..|.| .| .| .....| ... | |.|. . |   .... |.... | .  . ..||| .  ||... .|.||.||||.|. . | .|  | .|
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LSTGIRTMYIVMQGLEQLHHAGIIHRDVKPSNVLLRTSI-----SNPIAIIDFGLSRVFIDK---W-------TKKQLPPRQ---NPGFRGTTIFASPHA
 .|  | .. .  .| |.| .|.|||||||.|. .  .      .  . .||||..| ...|   |       ...  .||     ..||||| ..|| .
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HLHQELSPRDDLISWYYMCIDLIVEPLPWRNIKNRADILEKKLSTNLMELGTE------IAPQFQLIWRHITTLNYEDTPDYNYIYKLL
|...|... ||| ||.|| | | .. |||.|.... .| ..|.....  |  .      . ..|  . .|. .|.| |.||| .||...
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 95045.m00065.AA TTBK 11-265 33 6.4e-48 165.52 In-house 1-257 (257) Show / Hide 
Range on Protein: 11-265
Range on HMM: 1-257/257
Sequence Identity: 33% (86 aa)

YQIGPLLGKGSYGDIYAARNTEDG-TFVAIKIESLTSERKVLETEAYIMRKISKFTFFPKYITFGKTQNNTFLVMELCGPSLSYVIKNLPEHKLSLSTGI
 ..    | | .| || | .       ||||.||    . ||  |  ...|     .  ..|. |   .  ..||.| | .|.    . |. . |||| .
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

RTMYIVMQGLEQLHHAGIIHRDVKPSN--VLLRTSISNPIAIIDFGLSRVFIDKWTKKQL-PPRQNPGFRGTTIFASPHAHLHQELSPRDDLISWYYMCI
|    ..|..|. |  |  |||.||||  . .  |  . . ..|||| | ..   .. .  |||.  |||||  .||  ||. .|.  .||| | .|| .
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTN--ACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLV

DLIVEPLPWRNIKNRADILEKKLSTNLMELGTEIAPQFQLIWRHITTLNYEDTPDYNYI
  ..  |||| || . .. | |   ..  |  .. ..|..   ||  |||||.|||  |
EFVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 95045.m00065.AA CK1-A 11-265 31 1.1e-43 151.43 In-house 1-261 (261) Show / Hide 
Range on Protein: 11-265
Range on HMM: 1-261/261
Sequence Identity: 31% (83 aa)

YQIGPLLGKGSYGDIYAARNTEDGTFVAIKIESLTSERKVLETEAYIMRKISKFTFFPKYITFGKTQNNTFLVMELCGPSLSYVIKNLPEHKLSLSTGIR
|..   .| ||.|||| . |...|  ||||.||       |  || . | ...   .|.   .|. ...  .||.| ||||  .  |. . . .. | . 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLF-NFCKRRFTMKTVLM

TMYIVMQGLEQLHHAGIIHRDVKPSNVLLRTS-ISNPIAIIDFGLSRVFIDKWTKKQLPPRQNPGFRGTTIFASPHAHLHQELSPRDDLISWYYMCIDLI
    ..  .| .|. . ||||.|| | |. .    | . .|||||.. . |. |.. .| |.     ||  .|| .|||  | | |||. |  |. .   
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

VEPLPWRNIKNRAD------ILEKKLSTNLMELGTEIAPQFQLIWRHITTLNYEDTPDYNYI
   |||  .|  .       |.|||.|| . .|      .| ..  ..  | .|..||| |.
RGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 95045.m00065.AA CK1-D 11-265 32 8.4e-39 134.47 In-house 1-261 (261) Show / Hide 
Range on Protein: 11-265
Range on HMM: 1-261/261
Sequence Identity: 32% (86 aa)

YQIGPLLGKGSYGDIYAARNTEDGTFVAIKIESLTSERKVLETEAYIMRKISKFTFFPKYITFGKTQNNTFLVMELCGPSLSYVIKNLPEHKLSLSTGIR
| ||  .| ||.||||   | . .  ||||.|.. ..   |. |. . . ..     |.   .|.  .   .||.| ||||  .  |  . | || | . 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLF-NYCHRKFSLKTVLM

TMYIVMQGLEQLHHAGIIHRDVKPSNVLLRT-SISNPIAIIDFGLSRVFIDKWTKKQLPPRQNPGFRGTTIFASPHAHLHQELSPRDDLISWYYMCIDLI
    ... .| .|    ||||.|| | |.      | . ||||||.. . |  |.. .| | |    ||  .||   |.  | | |||| |  |. .   
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN

VEPLPWRNIKNRAD------ILEKKLSTNLMELGTEIAPQFQLIWRHITTLNYEDTPDYNYI
   |||  .|  .       | |||.||.. .|      .||    .  .| ..| ||| |.
RGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 95045.m00065.AA CK1-Unclassified 11-198 36 8.8e-35 100.09 In-house 1-199 (244) Show / Hide 
Range on Protein: 11-198
Range on HMM: 1-199/244
Sequence Identity: 36% (74 aa)

YQIGPLLGKGSYGDIYAARNTEDGTFVAIKIESLTSERKVLETEAYIMRKISKFT-------FFPKYITFGKT--QNNTFLVMELCGPSLSYVIKNLPEH
|...  .| || |.|| . |......||||.|. .|. . |  ||.||.   .          .|| ...|.   ..  ..||.| |||| . ..|.   
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLED-LFNMCNR

KLSLSTGIRTMYIVMQ---GLEQLHHAGIIHRDVKPSNVLL--RTSISNPIAIIDFGLSRVFIDK-WTKKQLPPRQNPGFRGTTIFASPHAHLHQELSPR
|.|| |   .. |. |    .|.||. ..|||| || | |   .   .. . |||||||  .||.  |.|  | | | .. ||. .||  |||  | | |
KFSLKT---VLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRR

DDL
|||
DDL
Kinase 95045.m00065.AA Worm6 11-136 29 1.3e-34 121.31 In-house 1-134 (279) Show / Hide 
Range on Protein: 11-136
Range on HMM: 1-134/279
Sequence Identity: 29% (40 aa)

YQIGPLLGKGSYGDIYAARNTEDGT--FVAIKIES--LTSERKVLETEAYIMRKISKFT--FFPKYITFGKTQN--NTFLVMELCGPSLSYVIKNLPEHK
.... ..|.|..|..| . ...|..  ..|.| |.   ...|..|  |.... .. .    .|.| .  ||..|    ..||.|.|..|.  .||.|. |
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

LSLSTGIRTMYIVMQGLEQLHHAGIIHRDVKPSN
.|..||..      ...|.||..| |||||||.|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGN
Kinase 95045.m00065.AA Worm6 149-265 32 1.3e-30 107.17 In-house 153-279 (279) Show / Hide 
Range on Protein: 149-265
Range on HMM: 153-279/279
Sequence Identity: 32% (42 aa)

IIDFGLSR--VFIDKWTKKQLPPR-QNPGFRGTTIFASPHAHLHQELSPRDDLISWYYMCIDLIVEPLPWRNIKNRADIL-EKKLS--TN---LMELGTE
..|||..|  ....| .. . .|| .. |||||. .|. ..| .||....||. || || ...||  ||||..| . .   .||    ..   .|..  .
MLDFGMCRRKKYCNKGNELR-TPRWTACGFRGTVRYAPLACHKGQEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFG

IAP--QFQLIWRHITTLNYEDTPDYNYI
. |  .|. |   |....|.|.|||..|
PCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 95045.m00065.AA Pkinase 11-178 27 1.9e-24 87.56 Pfam 1-174 (293) Show / Hide 
Range on Protein: 11-178
Range on HMM: 1-174/293
Sequence Identity: 27% (50 aa)

YQIGPLLGKGSYGDIYAARNTEDGTFVAIKIESLTSERKVLE------TEAYIMRKISKFTFFPKYITFGKTQNNTFLVMELCGPSLSYVIKNL------
|.||  .|.||.|  | ...  .|  ||.|| .. .|..  .      .|..||... .  .  ... .  . ..  .|||.|.  |. |.         
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTW

PEHKL--SLSTGIRTMYIVMQGLEQLHHAGIIHRDVKPSNVLLR--TSISNPIAIIDFGLSRVFIDKWTKKQLPPRQNPGFRGT
 . ..  |  . .. || . .||| .|  ||||||.||.|.|.     |. .. |.||||...|         . . . .| ||
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGT
Kinase 95045.m00065.AA CK1-G 11-265 29 2e-24 79.62 In-house 1-266 (266) Show / Hide 
Range on Protein: 11-265
Range on HMM: 1-266/266
Sequence Identity: 29% (79 aa)

YQIGPLLGKGSYGDIYAARNTEDGTFVAIKIESLTSERKVLETEAYIMRKISKFT-FFPKYITFGKTQNNTFLVMELCGPSLSYVIKNLPEHKLSLSTGI
|..|.  | |..| ..  .|   . .||||.|   |.   |  |    .  .      |.   ||       .||.| ||||     .. . | |. | .
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLF-DWCDRKFSVKTVC

RTMYIVMQGLEQLHHAGIIHRDVKPSNVLL---RTSISNPIAIIDFGLSRVFIDKWTKKQLPPRQNPGFRGTTIFASPHAHLHQELSPRDDLISWYYMCI
      .. .|..|    | ||||| | |     .   . | |||||. . .||  ||.  | |      ||  . |   || .| | |||. .   | .
MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFM

DLIVEPLPWR-----NIKNRAD-ILEKKLSTNLMELGTE--IAPQFQLIWRHITTLNYEDTPDYNYI
      |||      | | | . | ..| .||   |     .  ||    | .  |.....|||.|.
YFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 95045.m00065.AA Ciliate-E2-Unclassified 11-156 23 5.9e-23 76.47 In-house 1-195 (352) Show / Hide 
Range on Protein: 11-156
Range on HMM: 1-195/352
Sequence Identity: 23% (46 aa)

YQIGPLLGKGSYGDIYAARNTEDGTFV-----AIKIESLT-----------SERKVLET--EAYIMR----------KISKFTFFPKYITFGKTQNNTFL
| |.  .|.|..|..| ... ... ..     ..|| .              | | ..   . |..|          . ..  |  |..   ....| ..
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VMELC-GPSLSYVIKNLPE---------------HKLSLSTGI-----RTMYIVMQGLEQLHHAG-IIHRDVKPSNVLLRTSIS-NPIAIIDFGLSR
|||.| | .|.. ||. .                ....    .     . .. . ||||.||| . ||||| ||.|.|.  . . . | |||||.|.
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISK
Kinase 95045.m00065.AA CK1 11-91 32 7.4e-21 68.69 In-house 1-91 (271) Show / Hide 
Range on Protein: 11-91
Range on HMM: 1-91/271
Sequence Identity: 32% (30 aa)

YQIGPLLGKGSYGDIYAARNTEDGTF--VAIKIESLTSERKVLETEAYIMRKISK------FTFFPKYITFGKT--QNNTFLVMELCGPSL
|..|  .| || |||| . |. .| .  ||||.|. .|.   |  ||.|..   .         .|. ...|.   ..  ..||.| ||||
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSL
Kinase 95045.m00065.AA S_TKc 11-284 19 4.4e-19 70.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-284
Range on HMM: 1-231/231
Sequence Identity: 19% (60 aa)

YQIGPLLGKGSYGDIYAARNTEDGTFVAIKIESLTSERKVLETEAYIMRKISKFTFFPKYITFGKTQNNTFLVMELCGP---SLSYVIKNLPEHK----L
|.|. ..|||..|  | .|....|  ||||| .     . .. |  |..|  .  .  |.. .  . .. ..|||.|.    .|  .||. . |.    .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLSTGIRTMYIVMQGLEQLHHAGIIHRDVKPSNVLLRTSISNPIAIIDFGLSRVFIDKWTKKQLPPRQNPGFRGTTIFASPHAHLHQELSPRDDLISWYY
.  .  . || . ..|| .|  ||||||.||.|.|| .     | |.||||.|..                | ||  . .|               .. .
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL------------GYGK

----------MCIDLIVEPLPWRNIKNRADILEKKLSTNLMELGTEIAPQFQLIWRHITTLNYEDTPDYNYIYKLLEEVMR----ANNINM-------MD
          . . ...   |..   . . ...| .                            . .  . | |.|.   .    |  .         . 
CKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

PF
 |
WF
Kinase 95045.m00065.AA CK1 117-263 33 1e-16 54.21 In-house 116-271 (271) Show / Hide 
Range on Protein: 117-263
Range on HMM: 116-271/271
Sequence Identity: 33% (53 aa)

QGLEQLHHAGIIHRDVKPSNVLL-R-TSISNPIAIIDFGLSRVFIDKWTKKQLPPRQNPGFRGTTIFASPHAHLHQELSPRDDLISWYYMCIDLIVEPLP
| .| .|. ..||||.|| | |  |    .. . ||||||.  ..|  |..  | | | .. ||. .||  .||  | | |||. |  |. . ..   ||
QRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDMESLGYVLMYFLRGSLP

WRNIK--NRAD----ILEKKLSTNLMELGTE-IAPQFQLIWRHITTLNYEDTPDYN
| ..|  .. .    |.|||.||.. .|    .  .|.   ...  |..|..||| 
WQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase 95045.m00065.AA TyrKc 11-213 17 1e-06 -114.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-213
Range on HMM: 1-280/280
Sequence Identity: 17% (49 aa)

YQIGPLLGKGSYGDIYAARNTEDGTFVAIKIESLTSERKVLETEAYIMRKI-SKFTFFPKYITFGKTQ-------NNTFLVMELC--GPSLSYVIKNLPE
 . |  || | .| .| .. .   . ||.|     . |. .  || ||.|.  .     . .    .|          ..|||..  |  ..|  |. |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

HKLSLSTGIRTMYIVMQGLEQLHHAGIIHRDVKPSNVLLRTSISNPIAIIDFGLSRVFIDK-------WTKKQ----LPP--------------------
  |.... .  .. . .| | ||. ..||||    |.|.       . | ||||||   |.        ....                           
--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

-------------------RQNPG-----FRGTTIFASPHAH--LHQELS--------PRDDLISWYYMCIDL----------IVEPL
                      ||        . ...   .   . |  .          |.. .   .| .           |.| .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF