Gene 92712.m00087 (T.vaginalis)

92712.m00087

Species: T.vaginalis
Alias: 92712.m00087, TvagK0099
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
92712.m00087.AA Protein None 390 None Fasta, JSON
92712.m00087.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of 92712.m00087.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 92712.m00087.AA CAMKL 9-262 36 3.3e-114 365.91 In-house 1-297 (297) Show / Hide 
Range on Protein: 9-262
Range on HMM: 1-297/297
Sequence Identity: 36% (111 aa)

YQIKYNIGKGGFAQVYYAIH-KLTGTKVAIKIIPKSKFSDDTDSKIR-----------IQREIEILRKIR---HPFVAELFDVVETDDN------ICIIM
|.|   .|||.|..|  |.| ..||.||||||| |.| ..|. .| .           |.|||.|.....   || .  |..|.||...      |...|
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYAQNGT--LLNYLNEF----GPFTEENAKLIFAQLIIVMKYLFSNFQIVHRDIKAENILLDSNN--NIRVIDFGLSSYQL-G----GQLFKTQSGSPCY
||...|   |..|. .     |...|. |. .| |..  ..|. |.  |||||||.||||||.|.  || .||||.| ..  .    ||..||. |||.|
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG-IVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

ASPELLLC--KEYT-IAADIWSAGVLLYALVSGNLPFQDQNM-------TKLVQKIAFKELDYPDNF---SDQLIDLLKKILQRDQSKRITLDEIMAHPW
..||...   |.|   ..||||.||.|||.| |.||| |...       . .  ..  .   ||. .   | ...||..|.||.. .||.|...|| |||
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW

V
.
M
Kinase 92712.m00087.AA CAMK 14-262 25 2.8e-106 343.52 In-house 1-425 (425) Show / Hide 
Range on Protein: 14-262
Range on HMM: 1-425/425
Sequence Identity: 25% (108 aa)

NIGKGGFAQVYYAIHKLTG------------TKVAIKIIPKSKFSDD------------------------TDSKIRIQREIEILRK-------IRHPFV
 .|.|.|..|. .|||.|.            .|||||||.|.| .|.                          .. ...|||||..|       ..|| .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

AELFDVVE------------TDDN--------ICIIM---EYAQNG----TLLNYLNEFGP---------------FTEENAKLIFAQLIIVMKYLFSNF
  |..| |            | ..        ....|   ||...|     |..|. | |.               |||. |. .| |..  ..|. |. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

QIVHRDIKAENILLDSN-----------------NNIRVIDFGLSSYQLG------------------------GQLFKTQSGSPCYAS-PELLLCKE--
 |||||.| ||||||.|                 ||| .||||.. .  .                        ||..||. |.|.|.. ||.|. |   
-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

------------YTIAADIWSAGVLLYALVSGNLPFQDQ-------------NMTKLVQKIAFKELDYPDNF----------------SDQ--------L
            |. ..|.||.||.||....| .||..              |. .| .||   . |.|. .                ||.         
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

IDLLKKILQRDQSKRITLDEIMAHPWV
.||..|.||.| .||.|......|||.
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 92712.m00087.AA AMPK 9-262 45 4.7e-104 309.81 In-house 1-254 (254) Show / Hide 
Range on Protein: 9-262
Range on HMM: 1-254/254
Sequence Identity: 45% (116 aa)

YQIKYNIGKGGFAQVYYAIHKLTGTKVAIKIIPKSKFSDDTDSKIRIQREIEILRKIRHPFVAELFDVV-ETDDNICIIMEYAQNGTLLNYLNEFGPFTE
|.|. .||.| |  |  ..|.|||.||||||. | |  |... . ||||||.||...||| .  |..|. || . | ..|||...| |  |    |  .|
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDM-VERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQE

ENAKLIFAQLIIVMKYLFSNFQIVHRDIKAENILLDSNNNIRVIDFGLSSYQLGGQLFKTQSGSPCYASPELLLCKEYT-IAADIWSAGVLLYALVSGNL
. |.  |.| |    |. ..  ||||| | ||.||| |.|| . ||||| .   |.. ||  ||||||.||.   | |     |||| || |||.. | |
REACRFFQQIISGVEYC-HRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYL

PFQDQNMTKLVQKIAFKELDYPDNFSDQLIDLLKKILQRDQSKRITLDEIMAHPWV
|| |.| ..| .||   |   |...|..  ||.|..|| |  |||| ..|..||| 
PFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase 92712.m00087.AA MARK 9-262 41 2.1e-101 332.17 In-house 1-262 (262) Show / Hide 
Range on Protein: 9-262
Range on HMM: 1-262/262
Sequence Identity: 41% (110 aa)

YQIKYNIGKGGFAQVYYAIHKLTGTKVAIKIIPKSKFSD-DTDSKIRIQREIEILRKIRHPFVAELFDVVE--TDDN-ICIIMEYAQNGTLLNYLNEF--
| ..  ||.|..|.|. |.||.||.||||||..| | .|  . ..  ..|||||..|. || . .||.|.|  |  . |..||||| .| |..|. ..  
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKN--VMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPN

GPFTEENAKLIFAQLIIVMKYLFSNFQIVHRDIKAENILLDSNN--NIRVIDFGLSSYQLGGQLFKTQSGSPCYASPELLLCKEYT-IAADIWSAGVLLY
|. .|| |. || |..  ..|. |.  |||||||.||||.|.|.  ||  ||||.|     ||. .|  |.| |..||..| |.|.  ..|||| ||.||
GRLHEEEARRIFRQIVSAVNYCHSKN-IVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLY

ALVSGNLPFQDQN--MTKLVQKIAFKELDYPDNFSDQLIDLLKKILQRDQSKRITLDEIMAHPWV
..|.|..|| ...  . .| .||   . |.|.. |... .|....|. . ..|.|..||| |||.
FMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 92712.m00087.AA S_TKc 9-262 34 1.3e-94 321.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-262
Range on HMM: 1-231/231
Sequence Identity: 34% (94 aa)

YQIKYNIGKGGFAQVYYAIHKLTGTKVAIKIIPKSKFSDDTDSKIRIQREIEILRKIRHPFVAELFDVVETDDNICIIMEYAQN--GTLLNYLNEFGP--
|.|   ||||.|..|| ..|| || .||||||.           ..|.|||.||.| .||..  |.|| .. |.....|||. .  |.|. |. . |.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FTEENAKLIFAQLIIVMKYLFSNFQIVHRDIKAENILLDSNNNIRVIDFGLSSYQLGGQLFKTQSGSPCYASPELLLCKEYTI-AADIWSAGVLLY
    |.|  |. ...|..  ..|. |. .|.|||.| ||||||.  .| ..||||.         .|. |.| | .||.|    |.  ..|.|| |..||
LRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ALVSGNLPFQDQNMTKLVQKIAFKELDYPDNFSDQLIDLLKKILQRDQSKRITLDEIMA-------HPWV
 ...|  ||.  .| .. .||           |....|...|.||.| .||.|  |...       |||.
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 92712.m00087.AA AGC 9-262 22 1.6e-91 236.18 In-house 1-395 (395) Show / Hide 
Range on Protein: 9-262
Range on HMM: 1-395/395
Sequence Identity: 22% (91 aa)

YQIKYNIGKGGFAQVYYAIHK------LTGTKVAIKIIPKSK-FSDDTD-SKIRIQRE------------IEILRKIR----------HPFVAE-LFDVV
....  ||||.| .|| . .|       ||   |.|.. |..   ..      ....|             .|| |..          |||.   |.   
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETDDN--ICIIMEYAQ---------NG-TLLNYLN---EFGPFTEENAKLIFAQ-------LIIVMKYLFSNFQIVHRD-IKAENILLDSNNNIRVIDFG
...|.  ....|||..          |  |. .|      | |.|| |. ..|.       ..  . || |.  |.||| .| ||||||.. .|.  |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSSYQL---------------------------------------------------GGQLFKTQSG--SPCYASPELLLCKEYTIAADIWS--AGVLLY
|.                                                       .... .|  |  .| | .|| |    |. |.|.||   |.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ALVSGNLPFQDQNMT----------KLVQKIA------FKELDYP----------DNFSDQLIDLLKKILQRDQSKRIT----------LDEIMAHPWV
 ...|  ||...|            .. |||       .... .|          ..||... ||.|| |..| .||..           .||..||| 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 92712.m00087.AA QIK 9-262 38 1e-85 291.08 In-house 1-272 (272) Show / Hide 
Range on Protein: 9-262
Range on HMM: 1-272/272
Sequence Identity: 38% (107 aa)

YQIKYNIGKGGFAQVYYAIHKLTGTKVAIKIIPKSKFSDDTDSKIRIQREIEILRKIRHPFVAELFDVVETDDNICIIMEYAQNGTLLNYLNEFGP----
| |   |||| || |  | |. | |||||||| ||.   | .  ... ||..|.  ..||..  |..| |||| . |..||..|| .  ||...|     
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQL--DEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVK

----------------FTEENAKLIFAQLIIVMKYLFSNFQIVHRDIKAENILLDSNNNIRVIDFGLSSYQLGGQLFKTQSGSPCYASPELLLCKEYT-I
                 .|. |. .| |..   .|. .  .|||||.||||||||.| || ..|||.| .. .||| .|  ||| || ||... |||.  
MVNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKR-NIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGP

AADIWSAGVLLYALVSGNLPFQDQNMTKLVQKIAFKELDYPDNFSDQLIDLLKKILQRDQSKRITLDEIMAHPWV
 .|||| ||.||.||.| |||  .....| |..       |   |  . .| .. |  | ..|.| . |. |.| 
KVDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase 92712.m00087.AA Pkinase 9-262 29 1.4e-85 295.45 Pfam 1-293 (293) Show / Hide 
Range on Protein: 9-262
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

YQIKYNIGKGGFAQVYYAIHKLTGTKVAIKIIPKSKFSDDTD-SKIRIQREIEILRKIRHPFVAELFDVVETDDNICIIMEYAQNG----TLLNYLN--E
|.|.  ||.|.|..|| ..|| || .||.|||.|.. ... | ...|. .||.|.....||.. .|.|..|..|.|...|||...|     |  |.   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

FGPF--TEENAKLIFAQLIIVMKYLFSNFQIVHRDIKAENILLDSNNNI----RVIDFGLSSY--QLGGQLFKTQSGSPCYASPELLL-CKEYTIAADIW
 |.|  .|. .| .. |..  ..|. |.  |.|||.| ||||.|.|..|    ...||||.       .. ..|  |.| |..||... ...|. ..|.|
HGCFYFSEWECKFYMYQILRGLEYCHSM-GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SAGVLLYALVSGNLPFQDQ------NMTKLVQKIAFKELDYPDNFS---------------------DQLIDLLKKILQRDQSKRITLDEIMAHPWV
|.|..|| ...|..||...      .. .....|  ..|...   .                     . ..|..|..|..| .||.| ..|. |||.
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 92712.m00087.AA ULK 9-262 27 2.9e-85 289.56 In-house 1-324 (324) Show / Hide 
Range on Protein: 9-262
Range on HMM: 1-324/324
Sequence Identity: 27% (90 aa)

YQIKYNIGKGGFA-QVYYAIHKLT---GTKVAIKIIPKSKFSDDTDS------KIRIQREIEILRKIR---HPF--VAELFDVVETD--DNICIIMEYAQ
|...  .||| |. .|| ...| |   . .||.|.|.|.|....         .  ...||.|..|.    ||.  . .|.|. ||.  .||.||||| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

NGTLLNYLNEFGP---------FTEENAKLIFAQLIIVMKYLFSNFQIVHRDIKAENILLDSNNN------------IRVIDFGLSSY-QLGG---QLFK
 |.| .|... ..         ..|. |. .| |..  .|.| .. .|.||||| .|||.  ..             . . |||..   . ..   |...
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKH-NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

TQS------GSPCYASPELLL----CKEYT-IAADIWSAGVLLYALVSGNLP----FQDQN--MTKLVQK-------IAFKELDYPD-----NFSDQLID
|.       |.| | .|..|     .|.|. . .|||| |...| .. |  |    |.||.  . ||...       |  . ...|.     ..|....|
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LLKKILQRDQSKRITLDEIMAHPWV
|... ||.|...||. .|| .|||.
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 92712.m00087.AA ULK 9-262 27 3.8e-83 282.53 In-house 1-329 (329) Show / Hide 
Range on Protein: 9-262
Range on HMM: 1-329/329
Sequence Identity: 27% (91 aa)

YQIKYNIGKGGFAQVYYAIHKLT----GTKVAIKIIPKSKFSDDTDS------KIRIQREIEILRKIR--------HPFVAELFDVVETD--DNICIIME
|...  .||| |..|| ...| |    . |||.|.|.|.|.. . .       .  ...||.|..|.         || . .|.|. ||.  .|| ||||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YAQNGTLLNYLNEFGP----------FTEENAKLIFAQLIIVMKYLFSNFQIVHRDIKAENILLDSNNN------------IRVIDFGLSSY-QLG---G
| . |.| .|... ..          ..|. |. .| |..  .|.| .. .|.||||| .|||.. ..             . . |||..   . .    
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKH-NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQ

QLFKTQS------GSPCYASPELLL----CKEYT-IAADIWSAGVLLYALVSGNLP----FQDQN---MTKLVQK-------IAFKELDYP-----DNFS
|...|..      |.| | .|..|     .|.|.   .|||| |...| .. |  |    |.||.   ..||...       |  . |..|     ...|
QMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

DQLIDLLKKILQRDQSKRITLDEIMAHPWV
....||... ||.|...||. .|. .|||.
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 92712.m00087.AA Ciliate-E2 9-262 25 1.2e-77 264.32 In-house 1-365 (365) Show / Hide 
Range on Protein: 9-262
Range on HMM: 1-365/365
Sequence Identity: 25% (98 aa)

YQIKYNIGKGGFAQVYYAIHKLTGT------------------KVAIKIIPKSKFSDD----TDSKIRIQREIE----------ILRKIRHPFVAELFDV
| .   ||.|.|..||.. .....                   ||.|||. .  .. .    . ..|.| |||.          ||... ||.. .....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

VE--TDDNICIIMEYAQNGTLLNYLNEF-----------GPFTEENAKLIFAQLI---------------IVMKYLFSNFQIVHRDIKAENILLDSNNNI
 .  .|.|| ..|||.| |.|. |....           ..|||. .| |..|..                 ..|| |.  |.||||| ||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

RVIDFGLSSYQLGG--------------------------------QLFKTQSGSPCYASPELLLCKE---------YTIAADIWSAGVLLYALVSGNLP
 .|||||| ..                                   ..|.|. |.| | .|| |  |.         |. ..||||.||.|| ...|..|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FQDQNMTKLVQKIAFKELDYP------------------DNFSDQLIDLLKK----ILQRDQSKRIT-LDEIMAHPWV
|         |.|  ...|.|                  .. |.. .||.||    .||.|..||||  ..|. ||| 
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 92712.m00087.AA Ciliate-E2-Unclassified 9-262 26 1.2e-74 254.34 In-house 1-352 (352) Show / Hide 
Range on Protein: 9-262
Range on HMM: 1-352/352
Sequence Identity: 26% (95 aa)

YQIKYNIGKGGFAQVYYAIHKLTGTKV-----AIKIIPKSKFSDDTDSKIRIQREIEILRK------------------IRHPFVAELFDVVETDDNICI
| | . ||.|||..|| ..|| .. ..     ..||. ... .  .   . .. ..|. .|                  . |||.  .|.. ....||.|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

IMEYAQNGTLLNYLNEFGP-----------------FTEENAK-----LIFAQLIIVMKYLFSNFQIVHRDIKAENILLDSNN---NIRVIDFGLSSYQL
.|||...|.|..|.....                  |||..||      .|||..   .|| ..  |.||||| ||||.|.|.   .|..||||.|... 
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

----------------GGQLFKTQSGSPCYA----SPELLLCKEYT----IAADIWSAGVLLYALVSGNLPFQDQNMTK----------------LVQKI
                  |...|..|.|.|     .||.|  ..|     ...|||| ||.||... |..||.|.| ..                | |.|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

AFKELDYP--------DNFSDQLIDLLK----KILQRDQSKRITLDEIMAHPWV
  |....|        .. |.. .|...    |.|. ...||||...|. ||| 
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 92712.m00087.AA TyrKc 9-266 21 1.2e-16 46.27 SMART 1-280 (280) Show / Hide 
Range on Protein: 9-266
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

YQIKYNIGKGGFAQVYYAIHKLTGTKVAIKIIPKSKFSDDTDSKIRIQREIEILRKI--RHPFVAELFDVVETD-------DNICIIMEYAQNGTLLNYL
 . .  .| | | .|| .. |   ..||.| . ...       .  . ||..|..|.  .|| .  |. |. ..       . ..|.|||. .| |..||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

NEFGPFTEENAKLIFAQLIIV-------MKYLFSNFQIVHRDIKAENILLDSNNNIRVIDFGLSSYQLGG-------QLFKTQS--GSP--C---YASPE
 . .|       |  ..|.         | || |. ...|||. | |.|...|. ... ||||| .   .       .  ....  |.         .||
RKHRPK------LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

LLLCKEYTIAADIWSAGVLLYALVS-GNLPFQD-----QNMTKLVQKIAFK-ELDYPDN--------FSDQLIDLLKKILQRDQSKRITLDEIMAHPWVK
 .  ...|.. |.|| ||... . . |  |  .      . . .....     .. |.|         .| . .. |.  ..| ..| |  ||      .
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI------H

DSI
. .
ECF
Kinase 92712.m00087.AA Pkinase_Tyr 9-99 27 4.8e-16 54.96 Pfam 1-98 (270) Show / Hide 
Range on Protein: 9-99
Range on HMM: 1-98/270
Sequence Identity: 27% (28 aa)

YQIKYNIGKGGFAQVYYAIHK----LTGTKVAIKIIPKSKFSDDTDS---KIRIQREIEILRKI-RHPFVAELFDVVE-TDDN--ICIIMEYAQNGTLLN
 ..   .|.| | .|| .. |     |...||.|.. |    . ...   .    ||..|.... .|| .  |  |.   ..   |.|.|||...| ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE---GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

YL
||
YL
Kinase 92712.m00087.AA Pkinase_Tyr 129-220 25 4e-06 21.3 Pfam 131-228 (270) Show / Hide 
Range on Protein: 129-220
Range on HMM: 131-228/270
Sequence Identity: 25% (25 aa)

QIVHRDIKAENILLDSNNNIRVIDFGLSSYQ-LGGQLFKTQSG----SPCYASPELLLCKEYTIAADIWSAGVLLYALVS-GNLP-FQDQNMTKLVQKI
...|||. | |.|...|| ... ||||. .    ..   ...|         .|| .  ...|.. |.|| |||.. ... |  | ...   . ....|
NCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI