Gene 93793.m00218 (T.vaginalis)

93793.m00218

Species: T.vaginalis
Alias: 93793.m00218, TvagK0499
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
93793.m00218.AA Protein None 345 None Fasta, JSON
93793.m00218.kin_dom Protein Kinase Domain None 188 None Fasta, JSON

Protein domain

Protein domains of 93793.m00218.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 93793.m00218.AA CK1 19-273 30 2.5e-78 266.51 In-house 1-339 (339) Show / Hide 
Range on Protein: 19-273
Range on HMM: 1-339/339
Sequence Identity: 30% (105 aa)

YQVNDLIGQGGYG-EIYTV-----HTLTDS-----TMYAMKVEALDCEKQG--LVCEIETLLKLQD--------------------SPHFPKINGYGVTD
..|  .||.||.| .|| |       ....     . ||||||  . ..|.  | .|.. ..|||.                    .||....  .| .|
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

TFR-YLVMTLCGLSISNTRR--LLPNRRMSLLTVTRIGLYMLDCIEDFHRHGFIHRDIKPGNFIFND-------------NNEIP-LVLIDFGLSK-CYI
 .  |.||||.| ...  |.   ..||..|. |. .|.. ||. .|. |..|||||||||.|| .               |||   ...||||...  |.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DP-----------KTHQHLPERP---KSGFRG-TSKYASMNAHSYKDQSQRDDLISWMYSLIELYNGR--LIWSKAKDNAS-----TRKIKQSTPDTELL
|.           ||.|| | |.   | |||| | .|.|.|.|  |.|. |||| ||.| |||.  |   | |.. ||.        .| |.   |. ..
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

SG------------LPTGYAEVWYYINALGFAEMPDFDKI
|             .|  . ... ||..| . . || ..|
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 93793.m00218.AA Worm6 19-273 30 1.2e-72 247.67 In-house 1-279 (279) Show / Hide 
Range on Protein: 19-273
Range on HMM: 1-279/279
Sequence Identity: 30% (86 aa)

YQVNDLIGQGGYGEIYTVHTLTDST--MYAMKVEA--LDCEKQGLVCEIETLLKL--QDSPHFPKINGYGVTDT--FRYLVMTLCGLSISNTRRLLPNRR
..|. .||.||.| .| |   .| .  ..|||.|.    ...| |  |. .|...  . ..||.||  .| .|   |.|.||||.| . .. |. .|.|.
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

MSLLTVTRIGLYMLDCIEDFHRHGFIHRDIKPGNFIFND------NNEIPLVLIDFGLSK-CYIDPKTHQHLPER-PKSGFRGTSKYASMNAHSYKDQSQ
.|. |  .|.. .|. ||| |..||||||.||||| ...      |..  . ..|||...  . . |  .  . | .. ||||| .||. ..|. ..|. 
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

RDDLISWMYSLIELYNGRLIWSKAKDNASTRKIKQS---TPD----TELLSGLPT-GYAEVWYYINALGFAEMPDFDKI
.||. ||.| ..|.  |.| | . ||  .  |.|     . .    .... . |. .. ..  ||  . . . || ..|
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 93793.m00218.AA TTBKL 19-277 31 1.7e-72 244.1 In-house 1-288 (288) Show / Hide 
Range on Protein: 19-277
Range on HMM: 1-288/288
Sequence Identity: 31% (90 aa)

YQVNDLIGQGGYGEIYTVHTLTD-STMYAMKVEALDCEKQG--LVCEIETLLKLQ--DSPHFPKINGYGVTDTFRYLVMTLCGLSISNTRRLLPNRR-MS
...  .||.||.|..| |  ..|  ...|||.|    |. .  .  |.. |.|||  .||||||. ..| .. ....|||||| ...  |. .||.. .|
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LLTVTRIGLYMLDCIEDFHRHGFIHRDIKPGNFIFNDNN------EIPLVLIDFGLSKCYIDP----------KTHQHLPERP---KSGFRGTSKYASMN
  |. |||   |... . |..||||||.||.|. . ...      .  . |||||... |...          .. .. ..|.   |..|||| .|.|.|
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCW-GYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPN

AHSYKDQSQRDDLISWMYSLIELYNGRLIWSKAKDNASTRKIKQSTPDTELLSG------LPTGYAEVWYYINALGFAEMPDFDKIRKIL
.|  |.|.  ||| ||||..|||. | | |.  .|   . . |... |. | ..      .|   ...  .. .| ... || ..|....
MHDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 93793.m00218.AA TTBK 19-273 36 1e-52 181.47 In-house 1-257 (257) Show / Hide 
Range on Protein: 19-273
Range on HMM: 1-257/257
Sequence Identity: 36% (94 aa)

YQVNDLIGQGGYGEIYTVHTLTDS-TMYAMKVEALDCEKQGLVCEIETLLKLQDSPHFPKINGYGVTDTFRYLVMTLCGLSISNTRRLLPNRRMSLLTVT
 .|   ||.||.||||    .       |.|||  .  || |  |.  | |||  .|  .  | |  | | |.||.| | . .. ||  |    || |  
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

RIGLYMLDCIEDFHRHGFIHRDIKPGNFIF--NDNNEIPLVLIDFGLSKCYIDPKTHQHLPERPKSGFRGTSKYASMNAHSYKDQSQRDDLISWMYSLIE
|.|. .|. ||  |  || |||||| ||    |  .     ..||||   |.  .     | |.  |||||  ||| |||  ..   .||| |  | |.|
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPP-REVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

LYNGRLIWSKAKDNASTRKIKQSTPDTELLSGLPTGYAEVWYYINALGFAEMPDFDKI
  .| | | | ||     ..|.      ||  .|         |. |.... ||.  |
FVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 93793.m00218.AA CK1-A 19-273 33 1.5e-43 151.03 In-house 1-261 (261) Show / Hide 
Range on Protein: 19-273
Range on HMM: 1-261/261
Sequence Identity: 33% (89 aa)

YQVNDLIGQGGYGEIYTVHTLTDSTMYAMKVEALDCEKQGLVCEIETLLKLQDSPHFPKINGYGVTDTFRYLVMTLCGLSISNTRRLLPNRRMSLLTVTR
|..   || | .|.||   ..|.    |.|.|  .     |. |      ||  . .|..  ||    .  .|| | | |. .   .  .|| .. ||  
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFC-KRRFTMKTVLM

IGLYMLDCIEDFHRHGFIHRDIKPGNFIFN-DNNEIPLVLIDFGLSKCYIDPKTHQHLPERPKSGFRGTSKYASMNAHSYKDQSQRDDLISWMYSLIELY
.   |.  ||  | ..|||||||| ||.   .     | ||||||.| | |..|.||.| |      || .|||.|||   .|| |||. |  | ..   
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

NGRLIWSKAKDNASTRKI------KQSTPDTELLSGLPTGYAEVWYYINALGFAEMPDFDKI
 |.| |   | ..   |       | |||  .|  | |. ..    |. .|.| | ||.  .
RGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 93793.m00218.AA CK1-Unclassified 19-223 38 6.3e-41 118.54 In-house 1-216 (244) Show / Hide 
Range on Protein: 19-223
Range on HMM: 1-216/244
Sequence Identity: 38% (83 aa)

YQVNDLIGQGGYGEIYTVHTLTDSTMYAMKVEALDCEKQGLVCEIETLLKLQDSP-------HFPKINGYGVTDT--FRYLVMTLCGLSISNTRRLLPNR
|.| . ||||  |||| .  . . . .|.|.|  . .   |. |.  .  ||.         ..||.  .|  .   . ..||.| | |.     .  ||
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMC-NR

RMSLLTVTRIGLYMLDCIEDFHRHGFIHRDIKPGNFIFN--DNNEIPLVLIDFGLSKCYIDP-KTHQHLPERPKSGFRGTSKYASMNAHSYKDQSQRDDL
. || ||  |.  |.. || .|...|||||||| ||      .|   . .||||||| |||. ||..| | | . .. ||  ||| |||  . || ||||
KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDL

ISWMYSLIELYNGRLIW
 | .| || .  |.| |
ESLGYVLIYFLKGSLPW
Kinase 93793.m00218.AA CK1-D 19-273 33 7.6e-40 138.22 In-house 1-261 (261) Show / Hide 
Range on Protein: 19-273
Range on HMM: 1-261/261
Sequence Identity: 33% (87 aa)

YQVNDLIGQGGYGEIYTVHTLTDSTMYAMKVEALDCEKQGLVCEIETLLKLQDSPHFPKINGYGVTDTFRYLVMTLCGLSISNTRRLLPNRRMSLLTVTR
| .   || | .|.||   ...     |.|.|..  .   |  |      .|     |.|  .|    .  .|| | | |.        .|. || ||  
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYC-HRKFSLKTVLM

IGLYMLDCIEDFHRHGFIHRDIKPGNFIFNDNNEIPLV-LIDFGLSKCYIDPKTHQHLPERPKSGFRGTSKYASMNAHSYKDQSQRDDLISWMYSLIELY
... |.  ||  | . |||||||| ||.        .| .|||||.| | |..||||.| | .    || .|||.| |   .|| |||| |  | |.   
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN

NGRLIWSKAKDNASTRKI------KQSTPDTELLSGLPTGYAEVWYYINALGFAEMPDFDKI
 | | |   |  .   |       | ||.  .| .|.|  ...   |   | | . ||.  .
RGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 93793.m00218.AA CK1 19-214 35 1.1e-37 127.34 In-house 1-207 (271) Show / Hide 
Range on Protein: 19-214
Range on HMM: 1-207/271
Sequence Identity: 35% (75 aa)

YQVNDLIGQGGYGEIYTVHTLTDSTM---YAMKVEALDCEKQGLVCEIETLLKLQD------SPHFPKINGYGVT--DTFRYLVMTLCGLSIS---NTRR
|.|   ||||  |.|| .  . ...    .|.|.|  . . . |. |.  .  ||.      ....|..  .|      . ..||.| | |     |   
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFN---

LLPNRRMSLLTVTRIGLYMLDCIEDFHRHGFIHRDIKPGNFIFN--DNNEIPLVLIDFGLSKCYIDPKTHQHLPERPKSGFRGTSKYASMNAHSYKDQSQ
 . ||. || ||  |.  |.. || .| ..|||||||| ||      ...  . .|||||.| |.|.||||| | | . .. ||  ||| |.|  . || 
-FCNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSR

RDDLISWMYSLI
|||. | .| |.
RDDMESLGYVLM
Kinase 93793.m00218.AA CK1-Unique 19-216 25 1.8e-34 116.95 In-house 1-223 (337) Show / Hide 
Range on Protein: 19-216
Range on HMM: 1-223/337
Sequence Identity: 25% (56 aa)

YQVNDLIGQGGYGEIYTVHTLTDS------TMYAMKVEALDCEKQ--------GLVCEIETLL-KLQDSPHFPKINGYGVTDTFRYLVMTLCGLSISNTR
..|  .|| ||||  . |  . .        ||.|| |     |             .| ..  ..... ||...   ....   ..|||. | |.   .
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

RLLPNRRMSLL------TVTRIGLYMLDCIEDFHRHGFIHRDIKPGNFIFNDNN---EIPLVLIDFGLSKC-YIDPKTHQHLPERPKSGFRGTSKYASMN
... |  . |       .. . |.  |. ||  | |||.||..||.|.   ...   .  .  .|.| ..   .  . ||  . ||.  |||. .|..  
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS

AHSYKDQSQRDDLISWMYSLIEL
 |  .... |||. || |.|. |
CHQCREHGRRDDMESWFYMLYHL
Kinase 93793.m00218.AA CK1-G 19-206 31 2.1e-27 89.85 In-house 1-191 (266) Show / Hide 
Range on Protein: 19-206
Range on HMM: 1-191/266
Sequence Identity: 31% (61 aa)

YQVNDLIGQGGYGEIYTVHTLTDSTMYAMKVEALDCEKQGLVCEIETLLKLQDSP-HFPKINGYGVTDTFRYLVMTLCGLSISNTRRLLPNRRMSLLTVT
|.|   || | .||..    .      | | |    .   |  |  .   |   |   |..  .|    .  .|| | | |      .  .|. |. || 
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWC-DRKFSVKTVC

RIGLYMLDCIEDFHRHGFIHRDIKPGNFIF---NDNNEIPLVLIDFGLSKCYIDPKTHQHLPERPKSGFRGTSKYASMNAHSYKDQSQRDDL
 .   |.. .|. | |  | ||.|| ||       ...  . .||||. | ||||.| || | | .    ||  | | | |  . || |||.
MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDM
Kinase 93793.m00218.AA Pkinase 19-191 21 1.5e-19 70.18 Pfam 1-179 (293) Show / Hide 
Range on Protein: 19-191
Range on HMM: 1-179/293
Sequence Identity: 21% (40 aa)

YQVNDLIGQGGYGEIYTVHTLTDSTMYAMKVEALDCEKQGLVC-------EIETLLKLQDSPHFPKINGYGVTDTFRYLVMTLCGLS---ISNTRRLL--
|..   ||.|..|. |  |   .. ..|.|.  .. ..   ..       ||. ...| ..|.  .. ..  ...  |.|| .|.     ..  ...   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

PNRRM--SLLTVTRIGLYMLDCIEDFHRHGFIHRDIKPGNFIFNDNNEI--PLVLIDFGLSKCYIDPKTHQHLPERPKSGFRGTSKYAS
 ....  |  .. .. . .|  .|  |..|.||||.|| |. ...|..|  .. ..||||.|..       . . .  ..| ||. |..
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMA
Kinase 93793.m00218.AA S_TKc 19-334 13 9.2e-15 39.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-334
Range on HMM: 1-231/231
Sequence Identity: 13% (47 aa)

YQVNDLIGQGGYGEIYTVHTLTDSTMYAMKVEALDCEKQGLVCEIETLLKLQDSPHFPKINGYGVTDTFRYLVMTLCGLSISNTRRLLPNRR-------M
|.. ..||.|..|. | ..   .   .|.|.       . .  ||. | |  . |.  |. .. .. .. |.|| .|. .  . .... .|.       .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLLTVTRIGLYMLDCIEDFHRHGFIHRDIKPGNFIFNDNNEIPLVLIDFGLSKCYIDPKTHQHLPERPKSGFRGTSKYASMNAHSYKDQSQRDDLISWMY
.  .. ..   ... .|  |.||.||||.|| |  ...     . ..||||.. .              . | ||  | .                   |
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL--------------GY

SL------------IELYNGRLIWSKAKDNASTRKIKQSTPDTELLSGLPTGYAEVWYYINALGFAEMPDFDKIRKILLQIIFDSNHSFSDPFDWESIPE
.             .|.. |.  ..   ...  .||.                                                               
GKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG---------------------------------------------------------------

SKVSRVSPFVPLPKAANLVQNYFEKYGI------TGK-------HKAV
            | | ..... ..|           .       |  .
-----------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase 93793.m00218.AA CK1 235-271 36 3e-06 17.78 In-house 234-271 (271) Show / Hide 
Range on Protein: 235-271
Range on HMM: 234-271/271
Sequence Identity: 36% (14 aa)

IKQSTPDTELLSG-LPTGYAEVWYYINALGFAEMPDFD
.|.|||  .| .| .|   |.   |.. |.|.| ||..
KKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase 93793.m00218.AA CK1-G 236-273 30 6.7e-05 12.44 In-house 227-266 (266) Show / Hide 
Range on Protein: 236-273
Range on HMM: 227-266/266
Sequence Identity: 30% (12 aa)

KQSTPDTELLSG--LPTGYAEVWYYINALGFAEMPDFDKI
|..|.   |. .  .|  .|    |.  | | | ||.| .
KRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 93793.m00218.AA TyrKc 19-277 12 0.000697 -159.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-277
Range on HMM: 1-280/280
Sequence Identity: 12% (39 aa)

YQVNDLIGQGGYGEIYTVHTLTDSTMYAMKVEALDCEKQGLVCEIETLLKL-QDSPHFPKINGYGVTD-------TFRYLVMTLCGLSISNTRRLLPNRR
 . .. .| | .||.|  .     .. | |.   |. .. .  |.. . ||  . |.  .. |. ...          ..|| .. .   . .  | ..|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH--GDLKDYLRKHR

--MSLLTVTRIGLYMLDCIEDFHRHGFIHRDIKPGNFIFNDNNEIPLVLI-DFGLSKCYIDPK-THQHLPERPKSGFRGTSKYASMNAHSYKDQSQRDDL
   .. .   . .   .  |  |....||||.   |   ..|.    | | |||||. .|. . ..                     ...|........ 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSR-DIYDDDQQG-------------------ESKDYYRKKEHKGG

I-----------SW--------------------MYSLIELYNGR-----LIWSKAKDNASTRKIKQSTPD-----TELLSGLPTGYAEVWYYINALGFA
            ..                    .... .          . .. .  .  ...     |.          . |.   ..     .   .
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPE

EMPDFDKIRKIL
. | |  |....
DRPTFSEIHECF