Gene 92747.m00194 (T.vaginalis)

92747.m00194

Species: T.vaginalis
Alias: 92747.m00194, TvagK0491
External Links:
Annotation:

Classification

Group: CK1
Family: CK1
Subfamily: CK1-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
92747.m00194.AA Protein None 410 None Fasta, JSON
92747.m00194.kin_dom Protein Kinase Domain None 244 None Fasta, JSON

Protein domain

Protein domains of 92747.m00194.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 92747.m00194.AA CK1 10-268 52 3.1e-158 532.0 In-house 1-271 (271) Show / Hide 
Range on Protein: 10-268
Range on HMM: 1-271/271
Sequence Identity: 52% (143 aa)

YRIKKKRGSGSFGDIYAGEHIITLEE--VAVKFESVDNIPPQLLCESKIYKTLRG------GVGIPDIKWYGVE--GDYNVMVIELLSSTLENLLDECQR
||. .| |.||||||| |... . ||  ||.|.|. ..  |||. |.|||| |.|      ..||| ..|.| |  ||||.||..||   || |.. |.|
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCNR

SFSLKTVLMIADQMLSRIQYIHNNGILHRDIKPENFMLGT-DKDQNIIYSIDFGLSKRYIDPKTGKHIPQIDGRTLLGTARYASLNTHRGIEQSRRDDLE
 |||||||||||||..||.|.||....||||||.||. |.  |.....| |||||.|||.|.||..|||. ... | |||||||.||| |||||||||.|
KFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDME

SIAYVLIYLLKGSLPWQGFKEENRTRKHQLIYDCKLKTTPEELCSG-LPVEFCNFLTSVRALGFKDDPDYV
|..|||.|.|.||||||| | ...  | . | . |..|..|.||.| .|.||...|. .| |.|...||| 
SLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase 92747.m00194.AA CK1-Unclassified 10-242 55 7.4e-155 460.44 In-house 1-244 (244) Show / Hide 
Range on Protein: 10-242
Range on HMM: 1-244/244
Sequence Identity: 55% (135 aa)

YRIKKKRGSGSFGDIYAGEHIITLEEVAVKFESVDNIPPQLLCESKIYKTLRGGV-------GIPDIKWYGVE--GDYNVMVIELLSSTLENLLDECQRS
||...| |.||||.|| . .. | ||||.|.|. ..  |||. | ||.. |..|        ||| . |.| |  ||||.|| .|| . || |.  |.| 
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK

FSLKTVLMIADQMLSRIQYIHNNGILHRDIKPENFMLG-TDKDQNIIYSIDFGLSKRYIDP-KTGKHIPQIDGRTLLGTARYASLNTHRGIEQSRRDDLE
|||||||||||||..||.|.||....||||||.||. | . | ....| |||||||||||. |||||||. ... | |||||||.|.|.|||||||||||
FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLE

SIAYVLIYLLKGSLPWQGFKEENRTRKHQLIYDCKLKTTPEELC
|..|||||.||||||||. | .|.  | . | . |. |..|.||
SLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase 92747.m00194.AA CK1-D 10-270 56 1.7e-133 449.79 In-house 1-261 (261) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-261/261
Sequence Identity: 56% (147 aa)

YRIKKKRGSGSFGDIYAGEHIITLEEVAVKFESVDNIPPQLLCESKIYKTLRGGVGIPDIKWYGVEGDYNVMVIELLSSTLENLLDECQRSFSLKTVLMI
||| .| ||||||||| |. |.| ||||.| |..  . |||  |||.||...||.||| |.|.| ||||||||..||   || |   |.| ||||||||.
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLML

ADQMLSRIQYIHNNGILHRDIKPENFMLGTDKDQNIIYSIDFGLSKRYIDPKTGKHIPQIDGRTLLGTARYASLNTHRGIEQSRRDDLESIAYVLIYLLK
||||..||.||| .  .||||||.||..|  |  |..| |||||.||| |..| .|||  . . | |||||||.|||.||||||||||||. |||.|  .
ADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNR

GSLPWQGFKEENRTRKHQLIYDCKLKTTPEELCSGLPVEFCNFLTSVRALGFKDDPDYVKY
||||||| |  ..  | . | . |..|  ..||.|.| || ...  .| | | | |||.  
GSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 92747.m00194.AA CK1-A 10-270 51 5.3e-120 404.96 In-house 1-261 (261) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-261/261
Sequence Identity: 51% (135 aa)

YRIKKKRGSGSFGDIYAGEHIITLEEVAVKFESVDNIPPQLLCESKIYKTLRGGVGIPDIKWYGVEGDYNVMVIELLSSTLENLLDECQRSFSLKTVLMI
||. .| ||||||||| |  |   ||||.| || .   |||. |.|.|. |.|.|||| ..||| | ||||||..||   ||.|   |.| |..|||||.
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLML

ADQMLSRIQYIHNNGILHRDIKPENFMLGTDKDQNIIYSIDFGLSKRYIDPKTGKHIPQIDGRTLLGTARYASLNTHRGIEQSRRDDLESIAYVLIYLLK
||||..|| |.|. . .||||||.||..|...  | .. |||||.|.| |..| .|||  . . | |||||||.| | |||||||||.||..||..|  .
ADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNR

GSLPWQGFKEENRTRKHQLIYDCKLKTTPEELCSGLPVEFCNFLTSVRALGFKDDPDYVKY
|.|||||.|  ..  |   | . |. |. |.|| | | ||| ... .|.|.|.. |||.  
GKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 92747.m00194.AA CK1 10-270 34 2.1e-109 369.76 In-house 1-339 (339) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-339/339
Sequence Identity: 34% (116 aa)

YRIKKKRGSGSFG-DIYAG-----EHIITL-----EEVAVKFESVDNI--PPQLLCESKIYKTLRGG-------------------VGIPDIKWYGVEGD
....|| |.|.|| .|| .     . . .      ||.|.| |....   .|||..|...|| |.||                   ...| . ||. |.|
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

--YNVMVIELLSSTLENLLD---ECQRSFSLKTVLMIADQMLSRIQYIHNNGILHRDIKPENFMLGT-------------DKDQNIIYSIDFGLSK-RYI
  ||.||..||  .|| |..    |.| ||.||.||||.|||....|.|..|..||||||.||..|              ... ...| ||||... .|.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DP-----------KTGKHIPQID---GRTLLG-TARYASLNTHRGIEQSRRDDLESIAYVLIYLLKGS--LPWQGFKEENR-------TRKHQLIYDCKL
|.           ||..|.|. .    . . | ||||.|.|.|.|.||.|||||.| .|.||..|||.  ||||. |.|..         | . | . |.
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

KTTPEELCSG-----LPVEFCNFLTSVRALGFKDDPDYVKY
.|... || .     .| ||  ... .|.| ..| ||| . 
STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 92747.m00194.AA CK1-G 10-270 46 8e-109 367.84 In-house 1-266 (266) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-266/266
Sequence Identity: 46% (125 aa)

YRIKKKRGSGSFGDIYAGEHIITLEEVAVKFESVDNIPPQLLCESKIYKTLRGGV-GIPDIKWYGVEGDYNVMVIELLSSTLENLLDECQRSFSLKTVLM
||. || | |.|| .. |. ... | ||.||| .    |||  | . || | | . ||| . ..| .| ||.||..||   || | | | | ||.|||.|
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCM

IADQMLSRIQYIHNNGILHRDIKPENFMLG--TDKDQNIIYSIDFGLSKRYIDPKTGKHIPQIDGRTLLGTARYASLNTHRGIEQSRRDDLESIAYVLIY
.| ||..|..|.|    . ||.||.||. |    |||..|. ||||. | ||||.|..|||    . | ||||| | ||| | |||||||.|..  . .|
VAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMY

LLKGSLPWQGFKEENRTRKHQLIYDCKLKTTPEELCSG--LPVEFCNFLTSVRALGFKDDPDYVKY
 | ||||||| | .|   . | | | | || .| || .  .|..|  .|  || | | ..|||   
FLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 92747.m00194.AA TTBKL 10-274 27 7.4e-49 163.1 In-house 1-288 (288) Show / Hide 
Range on Protein: 10-274
Range on HMM: 1-288/288
Sequence Identity: 27% (81 aa)

YRIKKKRGSGSFGDIYAGEHIIT-LEEVAVKFESV--DNIPPQLLCESKIYKTLR--GGVGIPDIKWYGVEGDYNVMVIELLSSTLENLL-DECQRS-FS
..|.|. |.| || .| .. . .  .. |.| |.   ....  .  | .. . |   |   .| ....| ..||| || .|..  |  |  . ...  ||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LKTVLMIADQMLSRIQYIHNNGILHRDIKPENFMLGTDKD----QNIIYSIDFGLSKRYIDPKTG----------KHIPQID---GRTLLGTARYASLNT
  |.. |. | |  ....| .|..|||.|| |...|  ..    . ..| ||||....|...  .          .. .. .      . || ||.|.| 
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HRGIEQSRRDDLESIAYVLIYLLKGSLPWQGFKEENRTRKHQLIYDCKLKTTPEELCSG------LPVEFCNFLTSVRALGFKDDPDYVKYRADF
|.. ||.| ||| |  |..|.|..| |||.. ... .      |.  |.... | |...      .| ||| | . .|.| ..| ||| . .. |
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKME------IEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 92747.m00194.AA Worm6 10-270 28 2.9e-48 166.68 In-house 1-279 (279) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-279/279
Sequence Identity: 28% (79 aa)

YRIKKKRGSGSFGDIYAGEHIITLE--EVAVKFES--VDNIPPQLLCESKIYKTL--RGGVGIPDIKWYG-VEGD-YNVMVIELLSSTLENLLDEC-QRS
. . || |.|.||..|  |.  . .  ..|.| |.    .  ..|  |  . |..  ... . ..|  .| |. . .| .|..|.   |..|  .. .| 
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FSLKTVLMIADQMLSRIQYIHNNGILHRDIKPENFMLGT-----DKDQNIIYSIDFGLSK--RYIDPKTGKHIPQIDGRTLLGTARYASLNTHRGIEQSR
||. | | || |.| .|.  ||.| .|||.|| ||  |      |... .|| .|||...  .|.. ..  . |  .     || |||.|. |.|.||.|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

RDDLESIAYVLIYLLKGSLPWQGFKEENRTR-KHQLIYDCKLKTTPEELCSGLPV-EFCNFLTSVRALGFKDDPDYVKY
.||.||  |... ...| |||...|....    .  ..... ..  ...  . |  ||   .. .  . . |.||| . 
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 92747.m00194.AA TTBK 10-270 35 1.4e-43 151.15 In-house 1-257 (257) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-257/257
Sequence Identity: 35% (93 aa)

YRIKKKRGSGSFGDIYAGEHIITL-EEVAVKFESVDNIPPQLLCESKIYKTLRGGVGIPDIKWYGVEGDYNVMVIELLSSTLENLLDECQR-SFSLKTVL
 ...|| | | || || .. .|.  |.||.| ||..     |  |  . | | |   .      | . ..| || .|.   | .|  .  |  ||| | |
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

MIADQMLSRIQYIHNNGILHRDIKPENFMLG-TDKDQNIIYSIDFGLSKRYIDPKTGKHIPQIDGRTLLGTARYASLNTHRGIEQSRRDDLESIAYVLIY
 .  |.|  |. ||. | ||||||| || .| . .  ...| .||||  .|.   .|   |        ||.|||| | ||  |  |.||| |. |.|. 
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTN-ACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

LLKGSLPWQGFKEENRTRKHQLIYDCKLKTTPEELCSGLPVEFCNFLTSVRALGFKDDPDYVKY
 ..| |||   |      | | .   | |     |   .| ||  |.  .. |...| |||.  
FVQGQLPWRKIKD-----KDQ-VGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 92747.m00194.AA Pkinase 10-216 26 7.9e-31 110.08 Pfam 1-214 (293) Show / Hide 
Range on Protein: 10-216
Range on HMM: 1-214/293
Sequence Identity: 26% (60 aa)

YRIKKKRGSGSFGDIYAGEHIITLEEVAVKFESVDNIPPQLL------CESKIYKTLRGGVGIPDIKWYGVEGDYNVMVIELLSSTLENLLDEC------
|.|..| ||||||  | . |. | ..||||  ..... .. .       | .| | |.    .  . |.   .|.  || |..  .|. ..| .      
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLY-VMDLFDYISTW

-QRSF--SLKTVLMIADQMLSRIQYIHNNGILHRDIKPENFMLGTDKDQN--IIYSIDFGLSKRYIDPKTGKHIPQIDGRTLLGTARYASLNTHR-GIEQ
 ...|  | ... ... |.|. ..|.|..||.|||.||||...  .....  ..  .||||.| .       . ..    |. || .|..   .| | . 
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYY

SRRDDLESIAYVLIYLLKGSLPWQG
... |  |.  .|...| | .|..|
GPKVDMWSCGCILYEMLCGRPPFPG
Kinase 92747.m00194.AA Dual 94-214 34 6.9e-26 83.93 In-house 98-225 (282) Show / Hide 
Range on Protein: 94-214
Range on HMM: 98-225/282
Sequence Identity: 34% (44 aa)

LDECQR-----SFSLKTVLMIADQMLSRIQYIHNNGILHRDIKPENFMLGTDKDQNIIYSIDFGLSKRYIDPKTGKHIPQIDGRTLLGTARYASLNTHRG
|.|. |     ..|  .   .| |||  ||. |. | |||.||| ||  | . |   .|  ||.. . ||||...|| .   .   .|..|||.      
LQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQ

IEQSRRDDLESIAYVLIYLL-KGS-LPW
 .| | ||||.  | . .|.  .. ..|
KDQGRKDDLECWIYMVFDLMDPEHGMSW
Kinase 92747.m00194.AA S_TKc 10-317 17 9.1e-15 39.62 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-317
Range on HMM: 1-231/231
Sequence Identity: 17% (58 aa)

YRIKKKRGSGSFGDIYAGEHIITLEEVAVKFESVDNIPPQLLCESKIYKTLRGGVGIPDIKWYGVEGDYNVMVIELLSS---TLENLLDECQRS-----F
|.| .| |.|.||  | . |. | ..||.|  .      ... | .| |   .   |  .. . .. |.  || |...    .|  ......|      |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLKTVLMIADQMLSRIQYIHNNGILHRDIKPENFMLGTDKDQNIIYSIDFGLSKRYIDPKTGKHIPQIDGRTLLGTARYASLNTHRGIEQSR-RDDLESI
.  ..  .. |... ..|.|..||.|||.|||| .| .      |  .||||....              .|. ||  | .         .. . |  |.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

AYVLIYLLKGSLPWQGFKEENRTRKHQLIYDCKLKTTPEELCSGLPVEFCNFLTSVRALGFKDDPDYVKYRADFRALFERQGFVYDYKYDWVLKAELVRA
  .|. .| |  |..          .|....  .                                                   .   |  ..  |.. 
GCILYEMLCGYPPFP---------QMQMMFKKIG--------------------------------------------------SPEAKD-FIRKCLQKD

SDTRSMSTDTLV------TTPLM
 . |    . |         | .
PEKRPTA-EALQDEWDIKCHPWF
Kinase 92747.m00194.AA TyrKc 10-234 18 1.4e-05 -132.63 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-234
Range on HMM: 1-280/280
Sequence Identity: 18% (54 aa)

YRIKKKRGSGSFGDIYAGEHIITLEEVAVKFESVDNIPPQLLCESKIYKTL-RGGVGIPDIKWYGV--EG-------DYNVMVIELLSS-TLENLLDECQ
 . .|| |.| || .| |. .   ..||||    |     .. | .| . |      |  .. |||  ..       .   .| |. .   | . | ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNI--VRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

RSFSLKTVLMIADQMLSRIQYIHNNGILHRDIKPENFMLGTDKDQNIIYSI---DFGLSKRYIDPK-----TGKHIPQ---IDGRTLLGTARYA--SLNT
. ...|. | .. |  .  .|.| ... |||.   | ..| ..       .   ||||| |.|. .      .. . .    .|.|.|    .|  ..|.
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------TVKISDFGLS-RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

H--------------------RGIEQSRRDDL--ESIAYVLIYLLKGSLPWQGFK------------------------EENRTRKHQLIYDCKL
.                    .| .    . .   | . |. |. .|  . |                            |.| .  ..    ..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF