Gene 97190.m00037 (T.vaginalis)
97190.m00037
Species: T.vaginalis
Alias: 97190.m00037, TvagK0513
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 97190.m00037.AA | Protein | None | 358 | None | Fasta, JSON |
| 97190.m00037.kin_dom | Protein Kinase Domain | None | 218 | None | Fasta, JSON |
Protein domains of 97190.m00037.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 97190.m00037.AA | CK1 | 13-267 | 25 | 9.7e-72 | 244.65 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 13-267
Range on HMM: 1-339/339
Sequence Identity: 25% (86 aa)
YRLVQCVGHGAFG-SVWSA-----KKEQEEQ----AIYAIKFEFPTVS--KPILASEALINQDLSNL--------------------GTFTKFYESGTLQ
...|. | |.|| .. . | .. ||.| | . .| | |... . | .. . . ... .| .
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED
GLS-YMVIEMLGMSVRIFQE--NHPGGILPLSEVGRLGDAMLTAIHKFHDAGYVHRDIKPSNFVFR-------GRPAD-------LDVCLIDFGLAK-RW
. |||...||.. . . ... . .. . .... || |. ||.|..||||||.||.. |. . | .||||.|. .
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKH-HHEWNNEHRQVYMIDFGMARRKY
RNKDGT------------IEPERP---NVGFRG-TSRYASINSHDGADLGRRDDLWSLFYLLIELFAPP--LPWKAQTSKDA-----VAQIKRR------
|.|||. . | |. ..|||| | ||.|||.|.| ..||||||||.||.|||.. . |||. .... | . |.
RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKK
---GVAKLCVG-----LPPQFNDFAQHLSTLGFADEPNYEHL
. || . .|..| ........| . |.|.|| .
MSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
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| Kinase | 97190.m00037.AA | TTBKL | 13-271 | 27 | 4.1e-65 | 218.78 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 13-271 Range on HMM: 1-288/288 Sequence Identity: 27% (80 aa) YRLVQCVGHGAFGSVWSAKKEQEEQAIYAIKFEFPTVSK--PILASEALINQDLS--NLGTFTKFYESGTLQGLSYMVIEMLGMSVRIFQENHPGG--IL .. |. .| |.||.| .. . . .| | |. . .. .. |. . |. . | |...|| .. ..|| ...|.... .| . . WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS PLSEVGRLGDAMLTAIHKFHDAGYVHRDIKPSNFVFRGRPAD-----LDVCLIDFGLAKRWRNKDG-----------TIEPERP---NVGFRGTSRYASI . . ..|.| | |. ||.|..|||.||.|... | .. | |||||.|.....||| .. ..|. ..|||| ||.|. DGT-WSRIGIQCLYALKQMHDCGFIHRDVKPCNCCW-GYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSP NSHDGADLGRRDDLWSLFYLLIELFAPPLPWKAQTSKDAVAQIKRRGVAKLCVG-------LPPQFNDFAQHLSTLGFADEPNYEHLHDLL | ||....|| |||||..| .|||... |||. ..|. ... |. .. . .|..| .|..||..| ..|.|.|| . .. NMHDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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| Kinase | 97190.m00037.AA | TTBK | 13-267 | 35 | 3e-60 | 206.47 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 13-267
Range on HMM: 1-257/257
Sequence Identity: 35% (92 aa)
YRLVQCVGHGAFGSVWSAKKEQEEQAIYAIKFEFPTVSKPILASEALINQDLSNLGTFTKFYESGTLQGLSYMVIEMLGMSVRIFQENHPGGILPLSEVG
. |. .| |.|| ...|| . .. ||| | | .| | . . | .|. | ||| ...| . . | | ||
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL
RLGDAMLTAIHKFHDAGYVHRDIKPSNFVFRGRPADLDVC-LIDFGLAKRWRNKDGTIEPERPNVGFRGTSRYASINSHDGADLGRRDDLWSLFYLLIEL
||| .| .| |. |. ||||||||| |. | ..||||| .. | | . | |. ||||| ||||||.| ..||.||||||||.|.|
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEF
FAPPLPWKAQTSKDAVAQIKRR-GVAKLCVGLPPQFNDFAQHLSTLGFADEPNYEHL
||| || | ..| . | .|..| | .|.. |...| |.| .
VQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
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| Kinase | 97190.m00037.AA | Worm6 | 13-267 | 24 | 6.1e-52 | 178.87 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 13-267 Range on HMM: 1-279/279 Sequence Identity: 24% (69 aa) YRLVQCVGHGAFGSVWSAKKEQEEQA-IYAIKFEF--PTVSKPILASEALINQDLSNLG--TFTKFYESGTLQG--LSYMVIEMLGMSVRIFQENHPGGI . ... .| |.||.| ...... .|.| | .. ... | |. . . . . . |.|. . |. . |.|....|.. . .| |.. WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK LPLSEVGRLGDAMLTAIHKFHDAGYVHRDIKPSNFVFRGR------PADLDVCLIDFGLAK--RWRNKDGTIEPER-PNVGFRGTSRYASINSHDGADLG . .. ... .| || | .|..|||.||.|| . || ....|||... . .||.... . | ...||||| |||....|.| ... FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCI-GRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQC RRDDLWSLFYLLIELFAPPLPWKAQTSKDAVAQIKRR----G---VAKLCVG-LPP-QFNDFAQHLSTLGFADEPNYEHL |.||. | ||...|.. . |||. . .|.|...|.. ... | |. .||| . . .. . |.|.|... RKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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| Kinase | 97190.m00037.AA | CK1-D | 13-267 | 32 | 9.3e-35 | 119.99 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 13-267
Range on HMM: 1-261/261
Sequence Identity: 32% (87 aa)
YRLVQCVGHGAFGSVWSAKKEQEEQAIYAIKFEFPTVSKPILASEALINQDLSNLGTFTKFYESGTLQGLSYMVIEMLGMSVRIFQENHPGGILPLSEVG
||. .| |.|| .. .. | . . ||| | | | |. . . .. . | ||...|| |. |. . | |
YRIGRKIGSGSFGDIYHGTNIQTNEEV-AIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLF-NYCHRKFSLKTVL
RLGDAMLTAIHKFHDAGYVHRDIKPSNFVFR-GRPADLDVCLIDFGLAKRWRNKD-GTIEPERPNVGFRGTSRYASINSHDGADLGRRDDLWSLFYLLIE
|.| |.. |. | ..|||||| ||. |. .. | .||||||||.| | | | || |||||| | | . ||||| || |.|.
MLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNM-VYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMY
LFAPPLPW---KAQTSKDAVAQIKRR----GVAKLCVGLPPQFNDFAQHLSTLGFADEPNYEHL
||| || | .. .| . . .|| |.| .| .. . .| | | |.| .|
FNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
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| Kinase | 97190.m00037.AA | CK1-A | 13-267 | 31 | 2.1e-34 | 118.89 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 13-267
Range on HMM: 1-261/261
Sequence Identity: 31% (83 aa)
YRLVQCVGHGAFGSVWSAKKEQEEQAIYAIKFEFPTVSKPILASEALINQDLSNLGTFTKFYESGTLQGLSYMVIEMLGMSVRIFQENHPGGILPLSEVG
||||. .| |.|| .. . . .. . . ||| | . | | || . . |. . . |. . ||...|| |. | . |
YRLVRKIGSGSFGDIYLGINITNGEEV-AIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLF-NFCKRRFTMKTVL
RLGDAMLTAIHKFHDAGYVHRDIKPSNFVFRGRPADLDVCLIDFGLAKRWRNKDGTIE-PERPNVGFRGTSRYASINSHDGADLGRRDDLWSLFYLLIEL
| | |.. | | ...|||||| ||. . ||||||||..| . . | | || |||||| | | . ||||. |. | ..
MLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYF
FAPPLPW---KAQTSKDAVAQIKRR----GVAKLCVGLPPQFNDFAQHLSTLGFADEPNYEHL
||| ||.| | .| . ...|| | | .| . .. |.| ..|.| .|
NRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
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| Kinase | 97190.m00037.AA | CK1-Unclassified | 114-209 | 45 | 1.2e-29 | 84.66 | In-house | 109-207 (244) | Show / Hide |
Range on Protein: 114-209 Range on HMM: 109-207/244 Sequence Identity: 45% (45 aa) LGDAMLTAIHKFHDAGYVHRDIKPSNFVFRG-RPADLDVC-LIDFGLAKRWR--NKDGTIEPERPNVGFRGTSRYASINSHDGADLGRRDDLWSLFYLLI ..| |.. | .| ...|||||| ||. | . ... .|||||.|| . |.|. | | | .. || ||||||.| | .||||| || |.|| IADQMIQRIEYLHNKNFIHRDIKPDNFLM-GKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLESLGYVLI |
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| Kinase | 97190.m00037.AA | CK1 | 118-209 | 47 | 1.8e-23 | 77.76 | In-house | 114-207 (271) | Show / Hide |
Range on Protein: 118-209 Range on HMM: 114-207/271 Sequence Identity: 47% (45 aa) MLTAIHKFHDAGYVHRDIKPSNFVF-R-GRPADLDVCLIDFGLAKRWR-NKDGTIEPERPNVGFRGTSRYASINSHDGADLGRRDDLWSLFYLLI |.. | .| ...|||||| ||. | |. .. | .|||||||| | |... | | | .. || ||||||.| | .||||. || | |. MIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQ-VYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDMESLGYVLM |
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| Kinase | 97190.m00037.AA | CK1-Unique | 13-219 | 21 | 1.1e-18 | 61.49 | In-house | 1-233 (337) | Show / Hide |
Range on Protein: 13-219 Range on HMM: 1-233/337 Sequence Identity: 21% (50 aa) YRLVQCVGHGAFGSVWSAKKEQEE-----QAIYAIKFEFPTVSKP--ILASEALINQDLSNLG-------TFTKFYESGTLQGLSYMVIEMLGMSVRIFQ . | | .| | .. .. . |. | | ..|. .| | .. .. . | . .. . ...| |.| | WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC ENHPGGILPLS------EVGRLGDAMLTAIHKFHDAGYVHRDIKPSNFVFRGRP-ADLDVC-LIDFGLAKR--WRNKDGTIEPERPNVGFRGTSRYASIN . . .|. ....| . | .| | .|. ||..|| |.. . ... . .|.| .| . . | . || . |||. .|... MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS SHDGADLGRRDDLWSLFYLLIELFAPP--LPWK .| ..|||||. |.||.|. |. | || CHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK |
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| Kinase | 97190.m00037.AA | CK1-G | 118-267 | 29 | 7.1e-18 | 57.08 | In-house | 105-266 (266) | Show / Hide |
Range on Protein: 118-267 Range on HMM: 105-266/266 Sequence Identity: 29% (47 aa) MLTAIHKFHDAGYVHRDIKPSNFVF--RGRPADLDVCLIDFGLAKRWRNKDGTIE-PERPNVGFRGTSRYASINSHDGADLGRRDDLWSLFYLLIELFAP |.. . |. . ||.|| || . . . . .||||.|| .. . | | || || ||| | | ||||. .| . . MIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMYFLRG PLPW---KAQTSKDAVAQI----KRRGVAKLCVG--LPPQFNDFAQHLSTLGFADEPNYEHL ||| || . | | .. . || . .| || . . | | ..| |..| SLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL |
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| Kinase | 97190.m00037.AA | Pkinase | 13-225 | 22 | 1.1e-17 | 63.66 | Pfam | 1-222 (293) | Show / Hide |
Range on Protein: 13-225 Range on HMM: 1-222/293 Sequence Identity: 22% (53 aa) YRLVQCVGHGAFGSVWSAKKEQEEQAIYAIKFEFPTVSKPILA------SEALINQDLSNLGTFTKFYESGTLQGLSYMVIEMLGMSVRIFQENH----- |......| |.||.|. ... ... |.|.| |. ||. | . | | ..|.. . . ||| | ... . .. . YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYIST -PGGIL--PLSEVGRLGDAMLTAIHKFHDAGYVHRDIKPSNFVFR--GRPADLDVCLIDFGLAKRWRNKDGTIEPERPNVGFRGTSRYAS---INSHDGA .| . . |. . .| .. |. | .|||.||.|. . | ... .|...|||||| . . . . . .| ||..|.. |. .| WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIR--GGQ DLGRRDDLWSLFYLLIELFAPPLPWKAQ----TSKD . |.. | ||. .|.|.. .|.. . . | YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HD |
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| Kinase | 97190.m00037.AA | S_TKc | 13-271 | 18 | 1.8e-13 | 20.55 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 13-271 Range on HMM: 1-231/231 Sequence Identity: 18% (52 aa) YRLVQCVGHGAFGSVWSAKKEQEEQAIYAIKFEFPTVSKPILASEALINQDLSNLGTFTKFYESGTLQGLSYMVIEMLGM---SVRIFQENHPG----GI |.... .|.||||.|. ... . |.||| . .| | . . |.|.. . ||| |... ... . ..... YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP LPLSEVGRLGDAMLTAIHKFHDAGYVHRDIKPSNFVFRGRPADLDVCLIDFGLAKRWRNKDGTIEPERPNVGFRGTSRYASINSHDGADLGR-RDDLWSL .| .. .. .. |. |. | .|||.||.| . . ..|||||.. | || | . |. . | ||. FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC FYLLIELFA--PPLPWKAQTSKDAVAQIKRRGVAKLCVGLPPQFNDFAQHLST------LGFADEPNYEHL---HDLL .|.|... || | ... .. . .|.. || ... . .. . ..| . | . GCILYEMLCGYPPFP-----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 97190.m00037.AA | CK1-Unclassified | 13-93 | 30 | 1.2e-10 | 27.64 | In-house | 1-89 (244) | Show / Hide |
Range on Protein: 13-93 Range on HMM: 1-89/244 Sequence Identity: 30% (27 aa) YRLVQCVGHGAFGSVWSAKKEQEEQAIYAIKFEFPTVSKPILASEALINQDLSNLG-------TFTKFYESGTL--QGLSYMVIEMLGMS ||... .| |.|| . .. |.. .|||.| .. | | || | |.| | ..| |..|. .. .|| . || | YRVIEKIGQGSFGEIYKCINMQTN-EEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPS |
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| Kinase | 97190.m00037.AA | CK1 | 13-93 | 25 | 1.8e-09 | 28.98 | In-house | 1-90 (271) | Show / Hide |
Range on Protein: 13-93 Range on HMM: 1-90/271 Sequence Identity: 25% (23 aa) YRLVQCVGHGAFGSVWSAKKEQEEQA-IYAIKFEFPTVSKPILASEALINQDLSN------LGTFTKFYESGTL--QGLSYMVIEMLGMS ||... .| |.|| . .. ..... ..|||.| . | | || | . | . . . | .|. . .||.. || | YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPS |
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| Kinase | 97190.m00037.AA | CK1 | 235-265 | 31 | 1.1e-07 | 22.68 | In-house | 240-271 (271) | Show / Hide |
Range on Protein: 235-265 Range on HMM: 240-271/271 Sequence Identity: 31% (10 aa) VAKLCVG-LPPQFNDFAQHLSTLGFADEPNYE | || | .| .|... .. |.|...|.|. VEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
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