Gene 85304.m00088 (T.vaginalis)

85304.m00088

Species: T.vaginalis
Alias: 85304.m00088, TvagK0908
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMK1

Sequence

Name Sequence Type Origin Length Description Download
85304.m00088.AA Protein None 307 None Fasta, JSON
85304.m00088.kin_dom Protein Kinase Domain None 253 None Fasta, JSON

Protein domain

Protein domains of 85304.m00088.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 85304.m00088.AA CAMK 20-267 21 2.3e-95 307.71 In-house 1-425 (425) Show / Hide 
Range on Protein: 20-267
Range on HMM: 1-425/425
Sequence Identity: 21% (92 aa)

KIFETEHAIVYESYHE-QKC-----------CKLAIKCIKKAKAN-----------------------------PQAIEDEVNIMRSLQ-------HQNI
.. .   ..|.. .|   ..            | ||| |.| |.                               . .. |..||..||       | ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IQAMDVFD--------IEFY------------YCVVM---PLATGG----DLFEIVYQN---------------GKMKEQTVCKIMYSMLQAIDYCHSIG
|.  .|..        .. |            .. ||    ...||    |||. . ..               |...|. .....  ...|..|||| .
IKLYEVYEDPHYFKNTND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IMHRDIKPENIFLQNGDLENP-------------LALLADFGFAKRFNP------------------------GQLLNDSVGTPIYAA-PEIYLH-----
|.|||.||||| |.. . ...                ..|||||..|.|                        ||......||| |.| ||. .      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------KPYGEKIDLWSLGVTMYVLLTAESPFPSG----------------DCHREIIEARYDFNSEAFDD------------VSDE--------AK
         ..||.|.| ||.|| .|..|. ..|| .                 . .. |....||| .. |..            .|||        .|
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLIRWLMEKDPDRRLSAQEALNHIWF
||||.....||..|......||| |.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 85304.m00088.AA CAMK1 42-267 35 2.6e-85 247.96 In-house 31-276 (276) Show / Hide 
Range on Protein: 42-267
Range on HMM: 31-276/276
Sequence Identity: 35% (88 aa)

AIKCIK-KAKANP------QAIEDEVNIMRS---LQHQNIIQAMDVFDIEFYYCVVMPLATGGDLFEIVYQNGKMKEQTVCKIMYSMLQAIDYCHSIGIM
|||||. |           .|.| |..||..   ..|.|||.  .... . ... || | |||.||. . ..|.  |.  ..||   |.|. |.|| ||.
AIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIVEKGNYTEKDARHIMKQILSAVEYMHSKGIV

HRDIKPENIFLQNGDLENPLA-LLADFGFAKRFNPGQ-LLNDSVGTPIYAAPEIYLH---KPYGEKIDLWSLGVTMYVLLTAESPFPSGDCH----REII
|||.||||. . . | . ... ..|||| .|.|...  |. . .||| | |||.      |||. ..|.|| ||  |.||.  .|| . . .    . |.
HRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIK

EARYDFNSEAFDDVSDE-AKDLIRWLMEKDPDRRLSAQEALNHIWF
.. |.| |  .|..||. |||.|. ..|.||  |......||| |.
KCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
S_TKc 85304.m00088.AA S_TKc 15-267 32 2.5e-80 274.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 15-267
Range on HMM: 1-231/231
Sequence Identity: 32% (88 aa)

YRLYTKIFETEHAIVYESYHEQKCCKLAIKCIKKAKANPQAIEDEVNIMRSLQHQNIIQAMDVFDIEFYYCVVMPLATG--GDLFEIVYQNGK------M
|..  || .   . ||  .|     . |||.||      . |. |..|... .| ||..  |||.   ....|| .. |  ||||..  ..|.      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

KEQTVCKIMYSMLQAIDYCHSIGIMHRDIKPENIFLQNGDLENPLALLADFGFAKRFNPGQLLNDSVGTPIYAAPEIYLHKPYGE-KIDLWSLGVTMYVL
 | .....|| ...|..|||| ||.|||.|||||.| .         ..|||.|...      .  .||| | |||.    .||  |.| ||.|...| .
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LTAESPFPSGDCHREIIEARYDFNSEAFDDVSDEAKDLIRWLMEKDPDRRLSAQEALN-------HIWF
|. . |||    . ....             |.||||.|| ...|||..|..| |||.       | ||
LCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 85304.m00088.AA Pkinase 29-267 30 1.3e-78 272.29 Pfam 15-293 (293) Show / Hide 
Range on Protein: 29-267
Range on HMM: 15-293/293
Sequence Identity: 30% (87 aa)

VYESYHEQKCCKLAIKCIKKAKANPQAIED-----EVNIMRSLQHQNIIQAMDVFDIEFYYCVVMPLATGG----DLFEIVY--QNGKM--KEQTVCKIM
||. .|   ... |.|.||| .....  .      |. ||..|.| ||..  |.|  . ....||... ||    |||...   ..|..   |......|
VYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYM

YSMLQAIDYCHSIGIMHRDIKPENIFLQ-NGDLENPLALLADFGFAKR--FNPGQLLNDSVGTPIYAAPEIYL-HKPYGEKIDLWSLGVTMYVLLTAESP
| .|....|||| ||.|||.|||||..  ||... ..  ..|||.||     ... ... .||| |.|||. . ...|| |.| ||.|...| .|. . |
YQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACV-KICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPP

FPSGD----------CHREIIEARYDFNSEAFDDVS-----------------DEAKDLIRWLMEKDPDRRLSAQEALNHIWF
|| |.          ....| .....|...  ...|                 .|.||.|.|. .||| .|..|...|.| ||
FP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 85304.m00088.AA Ciliate-E2a 42-267 35 1.4e-77 227.92 In-house 29-275 (275) Show / Hide 
Range on Protein: 42-267
Range on HMM: 29-275/275
Sequence Identity: 35% (87 aa)

AIKCIKKAKANP---QAIEDEVNIMRSLQHQNIIQAMDVFDIEFYYCVVMPLATGGDLFEIVYQNGKMKEQ--TVCKIMYSML-QAIDYCHSIGIMHRDI
..| |||.  .    .....|.||||.| | |||.  .|.  | .|  || .  ||.|..   |.....|    .|.||  .| |.. |.|. .|||||.
MKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDL

KPENIFLQ--NGDL-ENPLALLADFGFAKRF--NPGQLLNDSVGTPIYAAPEIYLHKP------YGEKIDLWSLGVTMYVLLTAESPFPS---GDCHREI
|||||..   . .  .|    ..|||.|...  . .. .   .||| | |||..  |       |..| |.||.|| .| ||. ..||.     .   ..
KPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQN

IEARYDFNSEA-FDDVSDEAKDLIRWLMEKDPDRRLSAQEALNHIWF
 .  .|||.   . ..|.|.|||.. . ||||  |..||.|||| ||
KKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 85304.m00088.AA Ciliate-E2 15-267 24 3.9e-74 252.6 In-house 1-365 (365) Show / Hide 
Range on Protein: 15-267
Range on HMM: 1-365/365
Sequence Identity: 24% (91 aa)

YRLYTKIFETEHAIVYESYH-EQKC-------------------CKLAIKCIKKA-KANPQAIEDEVNIMR----------------SLQHQNIIQAMDV
| .  || .  ...||.  . ....                   .|  |. .|   | . ..|. | .|||                .|.| |||.  ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FD--IEFYYCVVMPLATGGDLFEIVYQN-----------GKMKEQTVCKIMYSMLQ---------------AIDYCHSIG-IMHRDIKPENIFLQNGDLE
|    . ..  || .. |||||.. ..|           ....|. ...||.  ||               |. |.|| . |.|||||||||..      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

NPLALLADFGFAKRFNPG--------------------------------QLLNDSVGTPIYAAPEIYLHKP---------YGEKIDLWSLGVTMYVLLT
     ..|||..|....                                 .. |  .||| | ||||.  |.         |..|.|.|||||..| .|.
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

AESPFPSGDCHREIIEARYDFNSE--------------AFDDVSDEAKDLIRW----LMEKDPDRRLS-AQEALNHIWF
 . ||      ..|..  .||...               ....|.|.||||.     ...|||. |.. ....||| ||
GKPPF-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 85304.m00088.AA CAMKL 15-267 28 4.3e-73 232.55 In-house 1-297 (297) Show / Hide 
Range on Protein: 15-267
Range on HMM: 1-297/297
Sequence Identity: 28% (88 aa)

YRLYTKIFETEHAIVYESYHEQK-CCKLAIKCIKKAKAN-PQAIED---------------EVNIMRSLQ---HQNIIQAMDVFDIEFY------YCVVM
||.   . .   . |    |..   .| ||| |.| |..  . ...               |..||..|.   |.|||. ..|.. . .      .. ||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

PLATGGD--LFEIVYQN----GKMKEQTVCKIMYSMLQAIDYCHSIGIMHRDIKPENIFLQ-NGDLENPLALLADFGFAKRFNP-----GQLLNDSVGTP
 .. ||.  ||. . ..    |.|.|   ...   .. |..|||| || ||||||||| |  ||.     . ..||||.  . |     ||.|. . |.|
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN---NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

IYAAPEIYLH--KPYG-EKIDLWSLGVTMYVLLTAESPFP-----------SGDCHREIIEARYDFNSEAFDDVSDEAKDLIRWLMEKDPDRRLSAQEAL
 |.||||..   |||   |.| ||.||..|.... . ||                ...|..  | ..   . .|| ...||||......|..| .... .
PYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPP--IWYHVS-DCRDLIRKMLQVNPEKRPTIHQIM

NHIWF
|| |.
NHPWM
Kinase 85304.m00088.AA CDPK 41-267 37 2.3e-71 218.21 In-house 29-271 (271) Show / Hide 
Range on Protein: 41-267
Range on HMM: 29-271/271
Sequence Identity: 37% (93 aa)

LAIKCIKKA--KANPQ--AIEDEVNIMRSLQHQNIIQAMDVFDIEFYYCVVMP--LATGGDLFEIVYQNGKMKEQTVCKIMYSMLQAIDYCHSIGIMHRD
.|.| |.|   | . |      |..|...| | |||.   ..  | .| .||   . |||.||. . ..|. .|.  ..||.  |.|. |||| .|.|||
VAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHFTEKEAAYIMRQILSAVNYCHSNNIVHRD

IKPENIFLQNGDLEN----PLALLADFGFAKRFNP-----GQLLNDSVGTPIYAAPEIYLHKPYGEKIDLWSLGVTMYVLLTAESPFPSGDCHREIIEA-
.||||| ... .  .    ..  . |.| .|.|..     .. ... .||| | |||.. .| | || |.||.|| .|.||  . ||  |.   ||.|. 
LKPENILFDSKKDDSWVIYNIK-VIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWSCGVILYILLCGYPPF-YGKNDQEIMEKV

---RYDFNSEAFDDVSDEAKDLIRWLMEKDPDRRLSAQEALNHIWF
   .|.|. . .|..||||||||| . ..||. |.|||.||.| ||
KKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 85304.m00088.AA RAD53 27-267 31 8e-65 191.81 In-house 13-305 (305) Show / Hide 
Range on Protein: 27-267
Range on HMM: 13-305/305
Sequence Identity: 31% (93 aa)

AIVYESYHEQKCCKLAIKCIKKAK---------ANPQAIEDEVNIMRSLQHQNIIQAMDVFDI-EFYYCVVMPLATGGDLFEIVYQNGK----MKEQTVC
..|.. |    | | ||| |.| |         ...  ...||.|.. |.|..||.  |.||  . ||  |. |.|||.||. .  |..     .| |  
GTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNKRCQMGFDEDTCK

KIMYSMLQAIDYCHSIGIMHRDIKPENIFLQNGDLEN-------------PLAL-LADFGFAKRFNPGQLLNDSVGTPIYAAPEIYLHK-----------
 . | |. |. | |. || |||.||||| . . | |.              ... ..||| .|    |....   ||| | |||. . |           
YYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITSKGHNCYHENEER

----PYGEKIDLWSLGVTMYVLLTAESPFP-S-------GDCHREIIE-ARYDFNSEAFDDVSDEAKDLIRWLMEKDPDRRLSAQEALNHIWF
     |. | |.||.|.. |..|.   ||  .        .    |.  ..| | ..  |..|.||||||.|.   ||..|... ||||| |.
QVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEALNHPWM
Kinase 85304.m00088.AA CAMK-Unique 42-267 25 1.6e-64 211.86 In-house 28-363 (363) Show / Hide 
Range on Protein: 42-267
Range on HMM: 28-363/363
Sequence Identity: 25% (87 aa)

AIKCIKK--AKANPQAI-------------------EDEVNIMRSLQHQNIIQAMDV----FDIEF---------------YYCVVMPLATGGDLFEIVY
|.| .||  .. . | .                   . |..|.... |.|||. .|.    |  .                |.  || ...|||||... 
ACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQ

Q--------------------NGKMKE--QTVCKIMYSMLQAIDYCHSIGIMHRDIKPENIFLQNG------------DLENPLALLADFGFAKRFNPGQ
.                    .|.. |    .| || . |.|. | ||..| |||.|.||| ...             |. |    |.||| .. .|  .
KWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNK

LLN---DSVGTPIYAAP--------------EIYLHKPYGEKI----DLWSLGVTMYVLLTAESPFPSGDCHR-------EIIE----ARY-DFNSEAFD
        .|||.|.||              |.    .|...     |.|||||.|| .|. ..|| . .  |       ||.|    ..| .| .....
MCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWH

D---VSDEAKDLIRWLMEKDPDRRLSAQEALNHIWF
.   .|.||||..  .|. ||| |.|| |.| |.|.
GPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 85304.m00088.AA DCAMKL 15-267 33 2e-61 189.66 In-house 1-279 (279) Show / Hide 
Range on Protein: 15-267
Range on HMM: 1-279/279
Sequence Identity: 33% (94 aa)

YRLYTKIFETEHAIVYESYHEQKC-CKLAIKC-----------------IKKAKANP--QAIEDEVNIMRSLQHQNIIQAMDVFDIEFYYCVVMPLATGG
|..  .|     |.|.|  | .    | | |                  |.|.|       |. || ||....| .||| ....| |  |  || ...||
YQIGRIIGDGNFAVVHECRHRETGDHKYAMKIRYQSTLQFSFPSKFFQQIDKRKCKGKEHMIDNEVSIMQKIKHPHIIQLYEHWDTETHYYLVMEYVQGG

DLFEIVYQNGKMKEQTVCKIMYSMLQAIDYCHSIGIMHRDIKPENIFLQNGDLENPLAL-LADFGFAKRFNP-GQLLNDSVGTPIYAAPEIYLHKPYGEK
|||. . .|.|  |     .|. . .|. | |. .| ||||||||  ..  .    . | |.||| |.  |    .|    ||| | ||||   . || |
DLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDG-EKSLKLCDFGLACHVNGDFGPLYTVCGTPTYVAPEILMETGYGCK

IDLWSLGVTMYVLLTAESPFPSGDCHRE-----IIEARYDFNSEAFDDVSDEAKDLIRWLMEKDPDRRLSAQEALNHIWF
.| |..||  |.||    || | |   |     |... ..| .   |..|| |||||. ....||..| .|.. . | | 
VDIWAAGVILYILLCGFPPFRSPDNDQEELFDQIMQGKFEFPMPYWDNISDSAKDLISHMLQVDPEKRYTAEQIMQHPWV
Kinase 85304.m00088.AA Ciliate-E2-Unclassified 15-267 21 2.4e-57 196.82 In-house 1-352 (352) Show / Hide 
Range on Protein: 15-267
Range on HMM: 1-352/352
Sequence Identity: 21% (75 aa)

YRLYTKIFETEHAIVYESYHEQKCCKL-----AIKCIKKAKANPQA---------IEDEVN-------------IMRSLQHQNIIQAMDVFDIEFYYCVV
|..  .| .  ...||. .|...  ..     ..| ..... . .          .. . .             |.....| .|.  ...|  ... . |
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MPLATGGDLFEIVYQNGK-----------------MKEQTVC-----KIMYSMLQAIDYCHSIG-IMHRDIKPENIFLQNGDLENPLALLADFGFAK---
| .. ||||...  ...|                   || ..     ....  ||...|.|. . | |||||||||...|.   |    ..|||..|   
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISKKYQ

-------------RFNPGQLLNDSVGTPIYA----APEIYLHKPYG----EKIDLWSLGVTMYVLLTAESPFPSGD-------------------CHREI
              ... |.... .|||.|     |||..  . |.    .|.| ||||| .| .|. . ||.. .                    ...|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

IEARYDFNSEAF----DDVSDEAKDLIR----WLMEKDPDRRLSAQEALNHIWF
..  ..|... .    ...|.||||.|.     ...|.|. |......||| ||
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 85304.m00088.AA TyrKc 15-265 18 2.1e-12 -22.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 15-265
Range on HMM: 1-280/280
Sequence Identity: 18% (53 aa)

YRLYTKIFETEHAIVYESYHEQKCCKLAIKCIKKAKANPQAIEDEVNIMRSL--QHQNIIQAMDVFDIE-------FYYCVVMPLATGGDLFEIVYQNGK
 .|  |. | .  .||.        . |.|..|. .   ... .| .||..|  .|.||..   |   .         ...|| .. .||| .    ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-MKEQTVCKIMYSMLQAIDYCHSIGIMHRDIKPENIFLQNGDLENPLALLADFGFAKRFNPG-------QLLNDSV--GTP--I---YAAPEIYLHKPYG
  . .. .....   .  .| || .. |||.   |. . ..      .  .||| ..    .       .    .   |.   .     |||   .. . 
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

EKIDLWSLGVTMYVLLTAESPFPSG-----DCHREIIEA-RYDFNSEAFDD--------VSDEAKDLIRWLMEKDPDRRLSAQEALNHI
.| | || ||.|. ..|   . ..|        .|.||  .  .  .  ..         .||  .....  . ||. | . .|    .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF