Gene 88546.m00288 (T.vaginalis)

88546.m00288

Species: T.vaginalis
Alias: 88546.m00288, TvagK0957
External Links:
Annotation:

Classification

Group: CMGC
Family: CLK

Sequence

Name Sequence Type Origin Length Description Download
88546.m00288.AA Protein None 335 None Fasta, JSON
88546.m00288.kin_dom Protein Kinase Domain None 310 None Fasta, JSON

Protein domain

Protein domains of 88546.m00288.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 88546.m00288.AA CLK 24-333 30 4.5e-75 224.34 In-house 1-350 (350) Show / Hide 
Range on Protein: 24-333
Range on HMM: 1-350/350
Sequence Identity: 30% (106 aa)

YRVIGMVGEGTFSNVYKCVNIQT-QATVVIKICRSSKAFDEAADNEID-FMHFLRRI-DPFGTYF---VKFIESFQF-QHHECIVLEKLGLSLYENLRYL
| ..  .|||||. |..|.  .   . |..|| |. . . |||  ||.  |  .  . || ..|    .| ...| .   | ||| |..|||.|. ..  
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

K------YKPFNTNIVRQLMRQIIGAVDLLHRNEKIHTDLKLENILLTGNLIDRDGIDIKTNRNGA------------------YVKLVDFGSID---TG
.      |.|.  . .|.. .|.. ||  || .. .||||| |||...   . ..   .|.|  .                    ....||||       
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKINKKSNNCVCHYWHVKNTHICVIDFGSATKIRFD

KVWHTHLATTRHYRAPEILLGLKWGYEADIWSLGCILVELAIGNIPFDSRDTLEHLFLIQYVIG-KIPYDMWDRCTDREIVSRVRY--GKLSSDVVFEEN
.  |. .  ||||||||. ||| | .  |.|| ||||.|| .|   |.  | .||| ... . |  ||. |  | |.|. |..  .  ..|  |.     
HEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQR-TRRFKVKQKYFYHNRLDWDWHNSDG

RQAFLAKPPLREILGYNHD----IADLACYILRPDPRNRPKASEILRHPFF
|  .    ||.. . ....      ||.  .|  ||  |......| ||||
RYVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase 88546.m00288.AA CMGC 24-333 17 1e-61 201.23 In-house 1-513 (513) Show / Hide 
Range on Protein: 24-333
Range on HMM: 1-513/513
Sequence Identity: 17% (94 aa)

YRVIGMVGEGTFSNVYKCVN--------------IQTQATVVIKICRSSKAFDEAAD-------------NEIDFMHFLR-RIDPFG-----------TY
| .|. .||||...||||..              ..|.  | ||. .. . ..| |               || ..  |. . || .             
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

-FVKFIESFQFQH-----------------HECIVLEKLGLSLYENLRYLK--YKP-----FNTNI------------VRQLM------RQIIGAVD--L
  || ...|.. .                 | ..| | .. .||. ..  .  |..     ..               .. .|      .||. ...   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHRNE--KIHTDLKLENILLT--GNLIDRDGIDIKTNRNGAY-------------VKLVDFGS---IDTGKVW---------------------HTHLAT
.|..    ||.||| ||||..  . || |  .         .             .|. |||.   ... .                       .||   
CHSHWGNIIHRDLKPENILINHNCELITRM-M---------WKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVV

TRHYRAPEILLGLK----------WGYEADIWSLGCILVELAIG--------NIPFD-----------SRDTLEHLFLIQYVIGKIPYDMWDRCT-----
||.||||||||| |          .... |.||.|||. |.  |         . |             ......||.|  |.|...  | .. .     
TRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNF

---DREIVSRVR-------------------YGKLSSDVVFEENRQAFLAKPPLREILGY------------------------------------NHDI
   ..|. ...                    . .     ..  ||     ..|....                                       ... 
CKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQA

ADLACYILRPDPRNRPKASEILRHPFF
 || . .|. || .|..|...|.||.|
IDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 88546.m00288.AA S_TKc 24-333 24 5.5e-59 203.19 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-333
Range on HMM: 1-231/231
Sequence Identity: 24% (80 aa)

YRVIGMVGEGTFSNVYKCVNIQTQATVVIKICRSSKAFDEAADNEIDFMHFLRRIDPFGTYFVKFIESFQFQHHECIVLEKLGL---SLYENLRYLKY--
|...  .|.|.|. ||||... |.  | ||| .      | . .||. ..      |.    ||....||  .| ..|.| ..    .|.. ..  ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK---HHPN---IVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--KPFNTNIVRQLMRQIIGAVDLLHRNEKIHTDLKLENILLTGNLIDRDGIDIKTNRNGAYVKLVDFGSIDTGKVWHTHLATTRHYRAPEILLGLKWGY-
  .||.   .| .|.||. |.. .|..  || ||| |||||.                   .|. |||.    ..  |..  |..|.|||.|   ..|. 
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----------------HIKICDFGL---ARQL-TTFCGTPWYMAPEVL---GYGKC

EADIWSLGCILVELAIGNIPFDSRDTLEHLFLIQYVIGKIPYDMWDRCTDREIVSRVRYGKLSSDVVFEENRQAFLAKPPLREILGYNHDIADLACYILR
..|.||.|||| |.. |  ||.      .....  .||                                                  ..  |. . .|.
KCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------------------SPEAKDFIRKCLQ

PDPRNRPKASEILR-------HPFF
 ||..|| | |.|.       ||.|
KDPEKRPTA-EALQDEWDIKCHPWF
Kinase 88546.m00288.AA Pkinase 24-333 23 1.1e-50 179.46 Pfam 1-293 (293) Show / Hide 
Range on Protein: 24-333
Range on HMM: 1-293/293
Sequence Identity: 23% (79 aa)

YRVIGMVGEGTFSNVYKCVNIQTQATVVIKICRSSKAFDEAADN-----EIDFMHFLRRIDPFGTYFVKFIESFQFQHHECIVLEKL--GLSLYENLRYL
|.... .|.|.|. ||||... |. .|..|| . ... ..   .     ||  |. |.       . |.....|.   | ..|.| .  ||.. .  .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-----HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

K---YKPF--NTNIVRQLMRQIIGAVDLLHRNEKIHTDLKLENILLTGNLIDRDGIDIKTNRNGAYVKLVDFGS--I--DTGKVWHTHLATTRHYRAPEI
.   ...|    . ..  |.||. ... .|..  || |||.||||.  |    .            ||. |||.        ..  |... |..|.|||.
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-----------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV

LL-GLKWGYEADIWSLGCILVELAIGNIPFDSR----DTLEHLFLIQYVIGKIPYDMWDRCTDREIVSRVRYGKLSSDVVFEENRQAFLAKPPLREILGY
.. | ..|...|.||.|||| |.. |. ||...    . ......|. . |...   |.   ..   . .|. . .               . ...    
IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---------------F-HWTFHNW

NHDIADLACYILRPDPRNRPKASEILRHPFF
. .  |. ...|..||  || | .|| ||.|
SEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 88546.m00288.AA DYRK 24-259 35 2.3e-50 173.66 In-house 1-227 (320) Show / Hide 
Range on Protein: 24-259
Range on HMM: 1-227/320
Sequence Identity: 35% (86 aa)

YRVIGMVGEGTFSNVYKCVNIQTQATVVIKICRSSKAFDEAADNEIDFMHFLRRIDPFGTY-FVKFIESFQFQHHECIVLEKLGLSLYENLRYLKYKPF-
|..... | |.|..| || . .|.  | ||| |. |.|   | .||   . |.. ||  .| .|.. ..|... | ||| | |  .||| |.  . ..| 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

NTNIVRQLMRQIIGAVDLLHRN-EKIHTDLKLENILLTGNLIDRDGIDIKTNRNGAYVKLVDFGSIDTGKVWHTHLAT---TRHYRAPEILLGLKWGYEA
. | ||.  .||  . ..||.| . || ||| |||.|    ... .|           |..||||   . . . .. |    |.|||||..||.. .|. 
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQP-RNKSTI-----------KVIDFGS--SCFEHQ-RIYTYIQSRFYRAPEVILGCPYCYAI

DIWSLGCILVELAIGNIPFDSRDTLEHLFLIQYVIGKIPYDM
|.|||||||.|| .|.. |   .  . | .|. |.|..| .|
DMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWM
Kinase 88546.m00288.AA HIPK 24-232 34 6.8e-38 116.58 In-house 1-199 (329) Show / Hide 
Range on Protein: 24-232
Range on HMM: 1-199/329
Sequence Identity: 34% (72 aa)

YRVIGMVGEGTFSNVYKCVNIQTQATVVIKICRSSKAFDEAADNEIDFMHFLRRIDPFGTYFVKFIESFQFQHHECIVLEKLGLSLYENLRYLKYKPFNT
| |. . | |||  | ||    |.  | ||| .    .     .|.  .| |.  ..    ||.. | |. . | |.| | |   ||. ..  |. |   
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLPL

NIVRQLMRQIIGAVDLLHRNEKIHTDLKLENILLTGNLIDRDGIDIKTNRNGAYVKLVDFG--SIDTGKVWHTHLATTRHYRAPEILLGLKWGYEADIWS
. .| .. |.. |   |     || ||| |||.|           .   |    || .|||  |.    |  | |   |.||||||.|||.   . |.||
KHIRPILQQVLTALMKLKELGLIHADLKPENIML-----------VDPTRCPYRVKVIDFGSASHVSKVVCNTYLQ-SRYYRAPEIILGLPFCENHDMWS

LGCILVELAIG
|||.. ||  |
LGCVIAELFLG
Kinase 88546.m00288.AA Ciliate-E2 24-333 17 2.5e-36 122.21 In-house 1-365 (365) Show / Hide 
Range on Protein: 24-333
Range on HMM: 1-365/365
Sequence Identity: 17% (79 aa)

YRVIGMVGEGTFSNVYKCVNIQTQATV-----------------VIKICRSSKAFDEAADNEI-DFMHFLRRIDPFG---------------TYFVKFIE
| .| . |.|.|. |||| ....|  .                 | .     | . .   ..|    | .|.|.. .                . .|..|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

SFQ--FQHHECIVLEKL-GLSLYENLRYL----------KYKPFNTNIVRQLMRQIIG---------------AVDLLHRNE-KIHTDLKLENILLTGNL
.||   ...  .|.| . | .|.. ..            . |.|. . ....|.||.                |.  || .   || |.|.||||.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

IDRDGIDIKTNRNGAYVKLVDFGS------------------IDTGKV-----------------WHTHLATTRHYRAPEILLGLK---------WGYEA
                .|..|||                   . .                    ..  .. | .| ||||| | |         ..|..
----------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKC

DIWSLGCILVELAIGNIPFDSRDTLEHLFLIQYVIGKIPYDMWDRCTDREIVSRVRYGKLSSDVVFEENRQAFLAKPPLREILGYNHDIA----------
||||||.|| |.  |. ||                                                           ...|.  . |.           
DIWSLGVILYEMLFGKPPF-----------------------------------------------------------QQQIKQCKIDFPCPEWQKDTQC

----------------DLACY----ILRPDPRNRPK-ASEILRHPFF
                ||       .|  || .|.  ...|| ||.|
IQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 88546.m00288.AA DYRK1 24-261 32 1.3e-33 115.19 In-house 1-228 (321) Show / Hide 
Range on Protein: 24-261
Range on HMM: 1-228/321
Sequence Identity: 32% (78 aa)

YRVIGMVGEGTFSNVYKCVNIQTQATVVIKICRSSKAFDEAADNEIDFMHFLRRIDPFGTY-FVKFIESFQFQHHECIVLEKLGLSLYENLRYLKYKPFN
| .. ..| | |  | |    |.|  | ||| .  |.| . |  ||  . .. . |.   |  |.  . | |  | |.|.| |   ||. ||  ...   
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

TNIVRQLMRQIIGAVDLLHRNEK--IHTDLKLENILLTGNLIDRDGIDIKTNRNGAYVKLVDFGSIDTGKVWHTHLATTRHYRAPEILLGLKWGYEADIW
 |..|.. .|.. |.  .   |   || ||| |||||              |   . .|..||||         .    | ||.||.|||...  . |.|
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILL-------------CNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMW

SLGCILVELAIGNIPFDSRDTLEHLFLIQYVIGKIPYDMWD
||||||||. .|   |   . .. .  |  |.|  | .| |
SLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMID
Kinase 88546.m00288.AA YAK 24-229 33 3.2e-32 106.5 In-house 1-198 (347) Show / Hide 
Range on Protein: 24-229
Range on HMM: 1-198/347
Sequence Identity: 33% (70 aa)

YRVIGMVGEGTFSNVYKCVNIQTQATVVIKICRSSKAFDEAADNEIDFMHFL-RRIDPFGTY----FVKFIESFQFQHHECIVLEKLGLSLYENLRYLKY
| |  | | |||  | || |  |   . .|.  .  |.   | |||     |  ..|| .      ... . .| .  | |.| | | ..||| |   |.
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

KPFNTNIVRQLMRQIIGAVDLLHRNEKIHTDLKLENILLTGNLIDRDGIDIKTNRNGAYVKLVDFGSIDTGKVWHTHLATTRHYRAPEILLGLKWGYEAD
. | ....||   ||  .   |     || ||| |||.|              . |   .|..||||    |   .     ||||.|||...       |
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIML-------------CKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSID

IWSLGCILVEL
 ||||||..||
MWSLGCIVAEL
Kinase 88546.m00288.AA Ciliate-E2-Unclassified 24-333 20 6.7e-30 100.9 In-house 1-352 (352) Show / Hide 
Range on Protein: 24-333
Range on HMM: 1-352/352
Sequence Identity: 20% (80 aa)

YRVIGMVGEGTFSNVYKCVNIQTQATVVIKICRSSKAFDEAADNEIDFMHFLRRIDPFGT----------------------YFVKFIESFQFQHHECIV
|..|   |.| |. ||||......   ..|.  ... ..    .. |  . .  .  .                        . ||... || . . .||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LEKL-GLSLYENLRYLKY---------------KPFNTNIVR-----QLMRQIIGAVDLLHRNEKI-HTDLKLENILLTGNLIDRDGIDIKTNRNGAYVK
.|.. |..| . ..  |                | |  . ..     ....||. . . ||.. .| | |.|.||||.. |                |.|
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK------------NYYIK

LVDFGSI---------DTGK------VW----HTHLATTRHYR----APEILLGLKWG----YEADIWSLGCILVELAIGNIPFDSRDTLEHLFLIQYVI
. |||..         | ..      .|     .. . |  |     |||.| | . .    |..||||||.|| |.  |. ||....  .| .||.  |
IIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI

GKIPYDMWDRCTDREIVSRVRYGKLSSDVVFEENRQAFLAKPPLREILGY------NHDIA-----DLACYILRPDPRNRPKASEILRHPFF
  .                        . .... .| ...|..              .. |     || . .|  .| .|. ...|| ||.|
-NN------------------------A-YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 88546.m00288.AA DYRK2 24-185 35 3.7e-27 85.08 In-house 1-150 (318) Show / Hide 
Range on Protein: 24-185
Range on HMM: 1-150/318
Sequence Identity: 35% (58 aa)

YRVIGMVGEGTFSNVYKCVNIQTQATVVIKICRSSKAFDEAADNEIDFMHFLRRIDPFGTY-FVKFIESFQFQHHECIVLEKLGLSLYENLRYLKYKPFN
| .  . | | |  | ||    |.  | ||. |  | | . |  ||  .| .||.|. .|.  |.  ..| |  | ||..| |...||| ..  ... |.
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

TNIVRQLMRQIIGAVDLLHRNEKIHTDLKLENILLTGNLIDRDGIDIKTNRNGAYVKLVDFGS
 ..||   ..|. . ..||.|  || ||| |||||            . ||.|  .|..||||
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLK-----------QWNRSG--IKVIDFGS
Kinase 88546.m00288.AA STE 24-236 18 4.8e-25 85.44 In-house 1-268 (359) Show / Hide 
Range on Protein: 24-236
Range on HMM: 1-268/359
Sequence Identity: 18% (55 aa)

YRVIGMVGEGTFSNVYKCVNI------QTQAT---------VVIKICRSSK------------------AFDEAADNEIDFMHFLRRIDPFGTYF---VK
.. |...|.|.|  |||..|.      .|. .         . ||. . ..                     .   .||..|. ..      .     ||
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNH-----M-HPNIVK

FIESFQFQ-------HHECIVLEKLGLSLYENLRYLKYKPFNT-------------NIVRQLMRQIIGA-VDLLHRNEKIHTDLKLENILLTGNLIDRDG
.. ..          .. .|..| ..    . .   ||.....             ....   |||. .  ..||.. .|| |.|  ||||         
YYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------

IDIKTNRNGAYVKLVDFGSID-------------------TGKVWHTHLATTRHYRAPEILLG------LKWGYEADIWSLGCILVELAIGNIPF
           |||.|||                      |..   .... |  . |||....       . .. .||||||| ..|.| |. |.
-----------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW
Kinase 88546.m00288.AA DYRK2 199-234 52 3.6e-16 48.76 In-house 165-200 (318) Show / Hide 
Range on Protein: 199-234
Range on HMM: 165-200/318
Sequence Identity: 52% (19 aa)

TRHYRAPEILLGLKWGYEADIWSLGCILVELAIGNI
.| |||||. ||.| | . |.||.|||..|| .| .
SRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP
Kinase 88546.m00288.AA TyrKc 24-333 18 3.1e-07 -105.65 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-333
Range on HMM: 1-280/280
Sequence Identity: 18% (63 aa)

YRVIGMVGEGTFSNVYKCVNIQTQATVVIKICRSSKAFDEAADNEIDFMHFL----RRIDPFGTYFVKFIESFQFQ-------HHECIVLEKLGL-SLYE
 . . . ||| |  |||.. .    .| .| .....   |.  .|.  |. |      |       |...     |       .  .||.|   . .| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNI-------VRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

NLRYLKYKPFNTNIVRQLMRQIIGAVDLLHRNEKIHTDLKLENILLTGNLIDRDGIDIKTNRNGAYVKLVDFG-SIDTGKV-------WHTHLATTRHYR
 ||. . | ...    . . ||    . ||..  || ||   |.|.. |.                ||  ||| | | .            . ..... .
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

--------APEILLGLKWGYEADIWSLGCILVELAIGNIPFDSRDTLEHLFLIQYVIGKIPYDMWDRCTDR--EIVSRVRYGKLSSDVVFEENRQAFLAK
        ||| .   |   . |.|| |  . |.     .  . ....     | || ..   .  .. .   . .|                       
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYP-MS-----------------------

PPLREILGYNHDIADLACYILRPDPRNRPKASEILRHPFF
       .   .. ..     . || .||  |||  | .|
-----FVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 88546.m00288.AA STE 314-333 50 2e-06 19.0 In-house 338-359 (359) Show / Hide 
Range on Protein: 314-333
Range on HMM: 338-359/359
Sequence Identity: 50% (11 aa)

LRPDPRNRPKASEILR--HPFF
|. ||..||.||. |.  |||.
LQKDPNKRPTASQLLKSEHPFI
Kinase 88546.m00288.AA DYRK 317-333 47 1.2e-05 17.44 In-house 304-320 (320) Show / Hide 
Range on Protein: 317-333
Range on HMM: 304-320/320
Sequence Identity: 47% (8 aa)

DPRNRPKASEILRHPFF
||..|...|. |.||.|
DPHKRITPSQALQHPWF
Kinase 88546.m00288.AA DYRK2 317-333 41 0.000164 10.22 In-house 302-318 (318) Show / Hide 
Range on Protein: 317-333
Range on HMM: 302-318/318
Sequence Identity: 41% (7 aa)

DPRNRPKASEILRHPFF
||  | ..|..|.||..
DPSERMTPSQALKHPWI
Kinase 88546.m00288.AA DYRK1 308-333 38 0.006447 5.51 In-house 296-321 (321) Show / Hide 
Range on Protein: 308-333
Range on HMM: 296-321/321
Sequence Identity: 38% (10 aa)

DLACYILRPDPRNRPKASEILRHPFF
||   .|. ||..| .  ..|.|.||
DLIKRMLQYDPKQRITPYYALQHSFF
Kinase 88546.m00288.AA YAK 308-333 34 0.012096 4.36 In-house 322-347 (347) Show / Hide 
Range on Protein: 308-333
Range on HMM: 322-347/347
Sequence Identity: 34% (9 aa)

DLACYILRPDPRNRPKASEILRHPFF
|..  .|  .|| | |..    ||| 
DFINQLLQLNPRERWKPMQAMQHPFI