Gene 91566.m00180 (T.vaginalis)

91566.m00180

Species: T.vaginalis
Alias: TvagK0763, 91566.m00180
External Links:
Annotation:

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
91566.m00180.AA Protein None 341 None Fasta, JSON
91566.m00180.kin_dom Protein Kinase Domain None 283 None Fasta, JSON

Protein domain

Protein domains of 91566.m00180.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 91566.m00180.AA CMGC 38-320 21 9.8e-100 328.45 In-house 1-513 (513) Show / Hide 
Range on Protein: 38-320
Range on HMM: 1-513/513
Sequence Identity: 21% (113 aa)

YRVVQHIGSGAFGTVFQSIS---------------PTGNIVAVKKVFQNPHFKN----------------RELEVLKALK-----------------SPN
| ... ||.|..|.|.. .                 |..|||.||..... ...                ||.. || |.                  .|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

CLSLHDYYTEKESGTD-----------NTYLFLVIEFLPMSLRHCIKESR----------L-------------FSNKFDPILHKLYSYQILTGLR--DI
...|.|... |.| ..           . .|.|| |.....| . ||. .          |              . |. .|. . |.||||.||    .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIR-YMYQILRGLKLKYC

HALG--IAHRDIKPENILVNPL-------------------HGEIKICDFGSAKFILND----------------------RNSVPEVGSLNYRAPELLL
|  .  | |||.||||||.|.                     |..||||||.|... .                       |   ..| .. |||||.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GNRTYS---------TEIDIWAAGCVIAEMVLD-------NISMFP-----------GTNDTNQMEGIVKVLGQPT---------------PE---EDKS
| . |.         |.||.|..||..|||..           .||           |... .|.. |.|||| ||               .|   . ..
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

FPHPIP---------------------------FPNEEKIADISIILPYK---------------------------------CDPLLIDLLKSIFVYNP
 |. ..                           ||.  ..   ... ...                                 |||..||||| ...|.|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

SKRPTAAQLMKHPYF
.||.||.| ..||||
DKRITAEQALQHPYF
Kinase 91566.m00180.AA GSK 38-320 32 8.1e-96 293.13 In-house 1-328 (328) Show / Hide 
Range on Protein: 38-320
Range on HMM: 1-328/328
Sequence Identity: 32% (109 aa)

YRVVQHIGSGAFGTVFQSISP-----TGNI----VAVKKVFQNPHFK-NRELEVLKAL---KSPNCLSLHDYYTEKESGTDN--TYLF-LVIEFLPMSLR
|.  . ||.|.||.|.| .       |. |    ||.|||.|....| ||||. .| |   . ||. .|  .. .. ...|.   |.  || |..|. | 
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLY

HCIKESRLFSNKFDPILHKLYSYQILTGLRDIHALGIAHRDIKPENILVNPLHGEIKICDFGSAKFILN--DRNSVPEVGSLNYRAPELLLGNRTYSTEI
  |.. .    ... |. |||.||.. ||. .| .||.||||||.||||.|  |. ||||||||| .    .  ...   |  ||||||..|   |.. |
QVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQI

DIWAAGCVIAEMVLDNISMFPGTNDTNQMEGIVKVLGQPTP-------EEDKSFPHP------IPFPNEEK-------------------IADI-SIILP
|.| .|||.|||..  . .||| .  .| . |.|.|| ||        .. . | .|      |  ... |                   .  .   . .
DVWSCGCVMAEMLKGQP-LFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQ

YKCDPLLIDLLKSIFVYNPSKRPTAAQLMKHPYF
      .|||.....||.|.||... ....||.|
-----DWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase 91566.m00180.AA S_TKc 38-320 27 5.4e-80 272.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 38-320
Range on HMM: 1-231/231
Sequence Identity: 27% (83 aa)

YRVVQHIGSGAFGTVFQSISPT-GNIVAVKKVFQNPHFKNRELEVLKALKSPNCLSLHDYYTEKESGTDNTYLFLVIEFLPM---SLRHCIKESRLFSNK
|.....||.||||.|.. .    | |||.|..        ||...||  . ||   |.|.. .       ..|..| |...    .|.. ||. .   ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FDPILHKLYSYQILTGLRDIHALGIAHRDIKPENILVNPLHGEIKICDFGSAKFILNDRNSVPEVGSLNYRAPELLLGNRTYST-EIDIWAAGCVIAE
  |..   . | |||. .|  .| .|| |||.||||||..    .|||||||.|...         .|...|.|||.|     |.. ..|.|. ||...|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

MVLDNISMFPGTNDTNQMEGIVKVLGQPTPEEDKSFPHPIPFPNEEKIADISIILPYKCDPLLIDLLKSIFVYNPSKRPTAAQLMK-------HPYF
|.      ||      ||. . |..|                                 .| ..|... .....|.||||| ....       ||.|
MLC-GYPPFP------QMQMMFKKIG---------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 91566.m00180.AA CDK 38-320 31 1.2e-74 238.25 In-house 1-284 (284) Show / Hide 
Range on Protein: 38-320
Range on HMM: 1-284/284
Sequence Identity: 31% (101 aa)

YRVVQHIGSGAFGTVFQSISPT-G-----NIVAVKKVFQNP--------HFKN---RELEVLKALKSPNCLSLHDYYTEKESGTDN-----TYLFLVIEF
|  .. || |..|.|.  ..   |     .||| ||.             |     ||   || |  ||  .||| .. |.. ..|     . |..| |.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LPMSLRHCIKESRLFSNKFDPILHKLYSYQILTGLRDIHALGIAHRDIKPENILVNPLHGE-----IKICDFGSAKFIL-------NDRNSVPEVGSLNY
... | . ..              | | .|.| ||  .|  .| |||.|| |||.|   ||     .|| ||| |.          . |   .||  | |
MDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINN-NGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RAPELLLGNRTYS--TEIDIWAAGCVIAEMVLD--NISMFPGTNDTNQMEGIVKVLGQPTPE---EDKSFPHPIPFPNEEKIADISIILPYKCDPLLIDL
|||||||| ..||  |.||.|..||..|||..|  .  .|||.....|.. | ...| ||..   . ...|.                          ||
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DL

LKSIFVYNPSKRPTAAQLMKHPYF
| . ..|.|.|| .| | ..||||
LNKMLCYDPKKRISAEQALQHPYF
Kinase 91566.m00180.AA Pkinase 38-320 28 2e-73 255.06 Pfam 1-293 (293) Show / Hide 
Range on Protein: 38-320
Range on HMM: 1-293/293
Sequence Identity: 28% (90 aa)

YRVVQHIGSGAFGTVFQSISPTGNI-VAVKKVFQNPHFKNR--------ELEVLKALKSPNCLSLHDYYTEKESGTDNTYLFLVIEFLPM-----SLRHC
|.... ||||.||.|.. .    .. ||||..      ..         |....| |..|| . |.|....      .... .| |....     .| . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDY

IK--ESRLFSNKFDPILHKLYSYQILTGLRDIHALGIAHRDIKPENILVNPLHGEI----KICDFGSAKF--ILNDRNSVPEVGSLNYRAPELLLGNRTY
|.  ... |.  |..   | | |||| ||  .|. || |||.||||||..  .|.|    ||||||.||.  . |..     .|...|.|||...|.. |
ISTWRHGCFY--FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYY

STEIDIWAAGCVIAEMVLDNISMFPGT----NDTNQMEGIVKVLGQPTPEEDKSF---------PHPIPFPNEEKIADISIILPYKCDPLLIDLLKSIFV
....|.|..||...||..     |||     |  .||. |....| |....             . . .        .    . .. .. ..|..|... 
GPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H--------F-HWTF-HNWSEECKDFIKWCLC

YNPSKRPTAAQLMKHPYF
..|.|||||.|...||.|
KDPKKRPTAEQILQHPWF
Kinase 91566.m00180.AA MAPK 38-320 29 6.8e-57 195.26 In-house 1-328 (328) Show / Hide 
Range on Protein: 38-320
Range on HMM: 1-328/328
Sequence Identity: 29% (99 aa)

YRVVQHIGSGAFGTVFQSISP-------TGNIVAVKKV---FQNPHFKN---RELEVLKAL-KSPNCLSLHDYYTEK-----ESGTDNTYLFLVIEFLPM
|. .. ||.||.|.|.  |         .|..||.||.   ||||..     ||.  |. . . .|  .| | .| .     .|  .   . .| |.   
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

SLRHCIKESRLFSNKFDPILHKLYSYQILTG--LRDIHALGIAHRDIKPENILVNPLHGEIKICDFGSAKFILNDRNSV---------------PEVGSL
 |.. ||  .    . . .  .   |||| |  |  ||  .. |||.||.|||||   .. |||||| |  | .. .                 . |   
DLHQIIKSQQ----PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVN-ENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATR

NYRAPELLLG--NRTYSTEIDIWAAGCVIAEMVLDNISMFPGTNDTNQMEGIVKVLGQPTPEEDKSFP-HPIP---------FPNEEKIADISIILPY--
 |||||..|.   . |.. .|.|..||  |||. |.  .|||..  .|.. |..||| |..|  .  .  . .         .|.  |. . . ..|   
WYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKK-PWEKMFPNAN

-KCDPLLIDLLKSIFVYNPSKRPTAAQLMKHPYF
 ...|. ||||.   | .|.|| |... . ||||
FNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 91566.m00180.AA CDK5 38-320 34 7.2e-50 155.49 In-house 1-287 (287) Show / Hide 
Range on Protein: 38-320
Range on HMM: 1-287/287
Sequence Identity: 34% (104 aa)

YRVVQHIGSGAFGTVFQSIS-PTGNIVAVKKVF--QN----PHFKNRELEVLKALKSPNCLSLHD-YYTEKESGTDNTYLFLVIEFLPMSLRHCIKESRL
|  .  || | .|||.      |. ||| |.|   ..    |    ||  .|| || .|   |||   .||        | || ||.   |.  . .   
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKK-------LTLVFEFCDQDLKKYMDSCNG

FSNKFDPILHKLYSYQILTGLRDIHALGIAHRDIKPENILVNPLHGEIKICDFGSAK-FILNDRNSVPEVGSLNYRAPELLLGNRTYSTEIDIWAAGCVI
   . |. . | . || | ||   |.  . ||| || | |.|  .|| |  ||| |  |    |.   ||  | ||.|  |.| ..||| ||.| .||..
---EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLIN-KNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIF

AEMVLDNISMFPGTNDTNQMEGIVKVLGQPTPEEDK-----SFPHPI----PFPNEEKIADISIILPYKCDPLLIDLLKSIFVYNPSKRPTAAQLMKHPY
|||.     .|||.....|.  | |..|  || |||       |       ..|  .     . | |   |  . |||. . ..|| .| .|.. ..|||
AEMANAGRPLFPGNDVEDQLKRIFKIMG--TPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK-LDEKGMDLLQKMLQCNPNQRISAKAALHHPY

F
|
F
Kinase 91566.m00180.AA CDC2 38-241 37 3e-49 149.23 In-house 1-211 (301) Show / Hide 
Range on Protein: 38-241
Range on HMM: 1-211/301
Sequence Identity: 37% (83 aa)

YRVVQHIGSGAFGTVFQSIS-PTGNIVAVKKVFQNPHFKN--------RELEVLKALK-SPNCLSLHDYYTEKESGTDNTYLFLVIEFLPMSLRHCIKES
|  .. || | .| |.. .   |. |||.||.                ||.  ||.||  ||  .||| . .         |..| |.| | |.   ..|
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-------NKLYMVFEYLDMDLKKYMDMS

RLFSNKFDPILHKLYSYQILTGLRDIHALGIAHRDIKPENILVNPLHGEIKICDFGSAK-FILNDRNSV--PEVGSLNYRAPELLLGNRTYSTEIDIWAA
     ...|.| | | |||| |.   |. .| |||.|| |||..   |.||| ||| |. |  . |.     ||  | |||||.||| ..|||..|.|. 
IPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILID-KKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSI

GCVIAEMVLD--NISMFPG
||..||| .|  .  .|.|
GCIFAEMFMDVTKKPLFHG
Kinase 91566.m00180.AA Ciliate-E2 38-320 19 1e-47 161.9 In-house 1-365 (365) Show / Hide 
Range on Protein: 38-320
Range on HMM: 1-365/365
Sequence Identity: 19% (78 aa)

YRVVQHIGSGAFGTVFQSIS------------------------PTGNIVAVKKV-FQNPHFKNRELEVLKALK----------------SPNCLSLHDY
| ... ||.|.||.|..                            ...|.|.| .  ..  ....|. ... ..                .|| . ....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YTEKESGTDNTYLFLVIEFLPM-SLRHCIKESRLFS-------NKFDPILHKLYSYQILT---------------GLRDIHALG-IAHRDIKPENILVNP
. ||    |.....|| |..   .|...||......       ..|.    | ...|||                .|. .|  . | ||||||||||.  
FQEK----DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

LHGEIKICDFGSAKFILND---------RNSVPEVG------------------------SLNYRAPELLLG--------NRTYSTEIDIWAAGCVIAEM
    |||.||| .|.. .|         ..  .. .                        ...| ||| | |           |....|||..|... ||
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM

VLDNISMFPGTNDTNQMEGIVKVLGQPTPEEDKSFPHPIPFPNEEKIADISII-----LPYKCDPLLIDLLKS----IFVYNPSKRPT-AAQLMKHPYF
.  .                         .. |  .  .|.|. .|  .  .|      . |...  .||.|     .....|.||.| . |...||.|
LFGKPPF---------------------QQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 91566.m00180.AA Ciliate-E2-Unclassified 38-320 21 2.4e-47 162.29 In-house 1-352 (352) Show / Hide 
Range on Protein: 38-320
Range on HMM: 1-352/352
Sequence Identity: 21% (80 aa)

YRVVQHIGSGAFGTVFQSISPTGN------------IVAVKKVFQNPHFKNRELEVLKALKSPNCLS------------------LHDYYTEKESGTDNT
|.... ||.|.||.|.. .    .            |...|.. ..   ...|.. .. .|. .  .                  ....|...    |  
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQ----DKQ

YLFLVIEFLPM-SLRHCIKE------------SRLFSNK-FDPILHK-----LYSYQILTGLRDIHALG-IAHRDIKPENILVNPLHG--EIKICDFGSA
....| |...  .|. .||.             .. ..| |.    |      | .||| ||  .|  . | ||||||||||..  ..  .|||.|||..
NIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS

KFILND----------------RNSVPEVGSLNYR----APELLLG-NRTYS--TEIDIWAAGCVIAEMVLDNISMFPGTNDTN---------------Q
|.. ..                 ..   .|..||     |||.| | |   |   ..|||. |... ||.  .   |...|..                |
KKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY-YPFYDNNCEQHQQLITQWINNAYRKQ

MEGIVK---VLGQPTPEEDKSFPHPIPFPNEEKIADISIILPYKCDPLLIDLLKSIFVYNPSKRPTAAQLMKHPYF
.. . |   .  .. |.                   |. ... ..  .. |||......||.||.|. |...||.|
LYQNIKQKNIQFPKFPWQQ-----------------IPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 91566.m00180.AA CDKL 38-320 34 7.7e-47 158.16 In-house 1-286 (286) Show / Hide 
Range on Protein: 38-320
Range on HMM: 1-286/286
Sequence Identity: 34% (103 aa)

YRVVQHIGSGAFGTVFQSIS-PTGNIVAVKKVFQ---NPHFK---NRELEVLKALKSPNCLSLHDYYTEKESGTDNTYLFLVIEFLPMSLRHCIKESRLF
|     .| |. |.|.      || |||.||      .|. |    ||.  || || .|  .|      |        |.|| |.   .. |  .|   .
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKR------KLHLVFEYCDHTVLHELEE---Y

SNKFDPILHKLYSYQILTGLRDIHALGIAHRDIKPENILVNPLHGEIKICDFGSAKFILNDRN-SVPE-VGSLNYRAPELLLGNRTYSTEIDIWAAGCVI
 |  |. . . | .||| ..   |   . ||||||||||..| .|..|.|||| |. .|.  .  . . |    |||||||.| . |....||||.|||.
PNGVDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVM

AEMVLDNISMFPGTNDTNQMEGIVKVLGQPTPEEDKSFPHP-----IPFPNEEKIADISIILPYKCDPLLIDLLKSIFVYNPSKRPTAAQLMKHPYF
||| .|   ..|| .|  |.  |.|.||  .|.  . |        . ||  |.   .   .| | .....|..|. .  .|..|.|..|||.||||
AEM-IDGQPLWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 91566.m00180.AA STE 38-232 23 7.7e-37 127.65 In-house 1-262 (359) Show / Hide 
Range on Protein: 38-232
Range on HMM: 1-262/359
Sequence Identity: 23% (64 aa)

YRVVQHIGSGAFGTVFQSISP----------------TGNIVAVKKV-FQNP----------------HFKN----RELEVLKALK--SPNCLSLHDYYT
.. .. ||.||||||.. .                  ||.|.|.|.. ..|                 | .     .|....| ..  .||    ...| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EKESGTDN-TYLFLVIEFLP-MSLRHCIKE--SRLFSNK--------FDPILHKLYSYQILTG-LRDIHALGIAHRDIKPENILVNPLHGEIKICDFGSA
 .   ..| ..|... |...  ||.  ||.  .......        |.  . . . .||| | |  .| ..| |||||| |||.      .|.|||| .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

KFILN-----------------DRNSVPEVGSLNYRAPELLLG-----NRTYSTEIDIWAAGCVIAEMV
. . .                 . ..   ||.  . ||| ...     .  |.|  |||  ||.| ||.
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA
Kinase 91566.m00180.AA TyrKc 38-320 20 4.9e-13 -11.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 38-320
Range on HMM: 1-280/280
Sequence Identity: 20% (66 aa)

YRVVQHIGSGAFGTVFQSISPTGNIVAVKKVFQNPHFKN---RELEVLKAL--KSPNCLSLHDYYTEKESGTDN---TYLFLVIEFLPM-SLRHCIKESR
 .  . .|.||||.|.. .      ||||..  .   .    ||..... |  . || . |. . |...          |..| |. |  .|.. ....|
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDYLRKHR

LFSNKFDPILHKLYSYQILTGLRDIHALGIAHRDIKPENILVNPLHGEIKICDFGSAKFILND--------RNSVPE--VGS--LNYR--APELLLGNRT
     . .     ...||  | . .|  .. |||.   |.||.  |  .||.||| ...| .|          .. |   |   | .|  ||| .   ..
PK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGK

YSTEIDIWAAGCVIAEMVLDNISMFPG-----TNDTNQMEGIVKVLGQPTPEE----DKSFPHPIPFPNEEKIADISIILPYKCDPLLIDLLKSIFVYNP
..|. |.|. | .. |.  .  .  ||      ...  .| . .    | |..                       .      | . . .. |.   ..|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------F----VCCPDEMYQIMKQCWHEDP

SKRPTAAQLMKHPYF
..||| ...  | .|
EDRPTFSEI--HECF
Kinase 91566.m00180.AA CDC2 280-320 38 3e-10 27.16 In-house 253-301 (301) Show / Hide 
Range on Protein: 280-320
Range on HMM: 253-301/301
Sequence Identity: 38% (19 aa)

DISIILPYK--------CDPLLIDLLKSIFVYNPSKRPTAAQLMKHPYF
|.|.|.| .        .||  ||||... .|.|.|| .| . ..||||
DLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase 91566.m00180.AA STE 285-320 39 4.7e-10 31.82 In-house 322-359 (359) Show / Hide 
Range on Protein: 285-320
Range on HMM: 322-359/359
Sequence Identity: 39% (15 aa)

LPYKCDPLLIDLLKSIFVYNPSKRPTAAQLMK--HPYF
.| |. | ..| ..  ....|.||||| ||.|  || .
YPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI