Gene 90524.m00030 (T.vaginalis)

90524.m00030

Species: T.vaginalis
Alias: 90524.m00030, TvagK0484
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
90524.m00030.AA Protein None 358 None Fasta, JSON
90524.m00030.kin_dom Protein Kinase Domain None 241 None Fasta, JSON

Protein domain

Protein domains of 90524.m00030.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 90524.m00030.AA CK1 19-273 27 1.4e-78 267.4 In-house 1-339 (339) Show / Hide 
Range on Protein: 19-273
Range on HMM: 1-339/339
Sequence Identity: 27% (94 aa)

YTIIKCIGQGGFG-DIYLV-----CDSESD-----QAFAMKLEISEARKQS--LHQEYTFMCGLQG--------------------SPHFPHMIEYGEDA
....| ||.|||| .||.|      |....     . .|||.|  ....|.  |. || ..  |||                    .||..... .||. 
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

R-NRYLVQELLGPSLSALRR--CFPGGKLSLPTVLCIAQEMLRILKEFHGRGFIHNDVKPSNFLIRL--------------GSPNFLVLIDFGLSK-TYI
. ..|.| .||||.|. ||.  .....|.|..|.| ||. ||  |.. | .|||| |.||.||.. .              .  . ...||||...  |.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DP-----------KTGQPIKVRQ---FSGFKG-TKKYASPNAHIGFDLTVRDDMYSWFYTIVELAYGV--LPWSHEKEKVA-----IMKGKRGIRNSPAF
|.           ||.|..  |      || | | .|.|.|.| | ... |||..||||...|.  |   |||.. |..       ..| |. ... . .
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

QI------------LPPRLQNLHAKIEDLGLFTKPDYDGW
.             .|. .  .   |. |  ...|||.  
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 90524.m00030.AA TTBKL 19-277 30 3.9e-59 198.32 In-house 1-288 (288) Show / Hide 
Range on Protein: 19-277
Range on HMM: 1-288/288
Sequence Identity: 30% (87 aa)

YTIIKCIGQGGFGDIYLVCDSES-DQAFAMKLEISE-ARK-QSLHQEYTFMCGLQ--GSPHFPHMIEYGEDARNRYLVQELLGPSLSALRRCFPGGK-LS
..|.| ||.|||| .|.| |... .. .||| |  . ... . .. |   .  ||  ||||||.....|.  . ...| .|.||.|..||.  | .| .|
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LPTVLCIAQEMLRILKEFHGRGFIHNDVKPSNFLIRLG---SPN--FLVLIDFGLSKTYIDPKTGQP----------IKVRQ---FSGFKGTKKYASPNA
  |.. |.   |  ||. |  |||| ||||.|. . .    ...   . |||||... |...  ...           . |     ..| || .|.|||.
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HIGFDLTVRDDMYSWFYTIVELAYGVLPWSHEKEKVAIMKGKRGIRNSPAFQI------LPPRLQNLHAKIEDLGLFTKPDYDGWIEEI
| . ...  ||..||.|.|.||. | |||.....|  |.. |.       |.       .|. .   .  .. |     |||.  .| .
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 90524.m00030.AA Worm6 19-229 33 5.6e-56 192.28 In-house 1-227 (279) Show / Hide 
Range on Protein: 19-229
Range on HMM: 1-227/279
Sequence Identity: 33% (77 aa)

YTIIKCIGQGGFGDIYLVCDSESDQ--AFAMKLEI--SEARKQSLHQEYTFMCGL--QGSPHFPHMIEYG-EDAR-NRYLVQELLGPSLSALRRCFPGGK
... | ||.||||..|.| |..      ||||.|    .. .| | .|.  .  .  ....||. ....|  | |  .|.| .|.|..|. ||. .|..|
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

LSLPTVLCIAQEMLRILKEFHGRGFIHNDVKPSNFLIRL------GSPNFLVLIDFGLSK-TYIDPKTGQPIKVR-QFSGFKGTKKYASPNAHIGFDLTV
.|..| | ||...|. . . |  |||| ||||.|| |        .    . ..|||...  . . | .. .. | .  ||.|| .||. ..| | ..  
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

RDDMYSWFYTIVELAYGVLPWSHEKEK
.||. |||| .||.  | ||| | |..
KDDCESWFYMMVEMIVGCLPWRHMKDH
Kinase 90524.m00030.AA CK1-Unclassified 19-223 38 5e-52 151.85 In-house 1-216 (244) Show / Hide 
Range on Protein: 19-223
Range on HMM: 1-216/244
Sequence Identity: 38% (84 aa)

YTIIKCIGQGGFGDIYLVCDSESDQAFAMKLEISEARKQSLHQEYTFMCGLQGSP-------HFPHMIEYGED--ARNRYLVQELLGPSLSALRRCFPGG
| .|. |||| ||.||.. ...... .|.||| . ..   |  |  .|  ||.         ..|.|...| .   .  ..| .||||||  |  .. ..
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDL-FNMCNR

KLSLPTVLCIAQEMLRILKEFHGRGFIHNDVKPSNFLIR-LG-SPNFLVLIDFGLSKTYIDP-KTGQPIKVRQFSGFKGTKKYASPNAHIGFDLTVRDDM
|.|| ||| ||  |.  .  .| ..||| | || |||.  ||   ... .||||||| |||. |||. |  |   .. ||  ||| |||.|     |||.
KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDL

YSWFYTIVELAYGVLPW
 |  |... .. | |||
ESLGYVLIYFLKGSLPW
Kinase 90524.m00030.AA CK1 19-223 38 9.4e-49 165.97 In-house 1-216 (271) Show / Hide 
Range on Protein: 19-223
Range on HMM: 1-216/271
Sequence Identity: 38% (84 aa)

YTIIKCIGQGGFGDIYLVCDSESDQAF---AMKLEISEARKQSLHQEYTFMCGLQG------SPHFPHMIEYGED--ARNRYLVQELLGPSLSALRRCFP
| ... |||| ||||||. .  ... .   |.||| . .. . || |. ..  |||      ....|||. .| .      ..| .||||||  |  .| 
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDL-FNFC

GGKLSLPTVLCIAQEMLRILKEFHGRGFIHNDVKPSNFLIRL--GSPNFLVLIDFGLSKTYIDPKTGQPIKVRQFSGFKGTKKYASPNAHIGFDLTVRDD
..|.|| ||| ||  |.. .  .| ..||| |.|| |||. .     . . .|||||.| |.|.||.| |  |   .. ||  ||| |.|.|     |||
NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDD

MYSWFYTIVELAYGVLPW
| |  | .. .. | |||
MESLGYVLMYFLRGSLPW
Kinase 90524.m00030.AA CK1-A 19-223 40 6.1e-48 165.58 In-house 1-205 (261) Show / Hide 
Range on Protein: 19-223
Range on HMM: 1-205/261
Sequence Identity: 40% (84 aa)

YTIIKCIGQGGFGDIYLVCDSESDQAFAMKLEISEARKQSLHQEYTFMCGLQGSPHFPHMIEYGEDARNRYLVQELLGPSLSALRRCFPGGKLSLPTVLC
| ... || | ||||||    .. .  |.|.|  .||   |  |      ||| . .|||  ||..  .  .| .||||||  |   |   . .. ||| 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDL-FNFCKRRFTMKTVLM

IAQEMLRILKEFHGRGFIHNDVKPSNFLIRLGS-PNFLVLIDFGLSKTYIDPKTGQPIKVRQFSGFKGTKKYASPNAHIGFDLTVRDDMYSWFYTIVELA
.|  |.  .   | ..||| |.|| |||. .|   | | ||||||.| | |..| | |. |.     || .||| |||.| . . |||| |  | ..   
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

YGVLPW
 |.|||
RGKLPW
Kinase 90524.m00030.AA TTBK 19-273 32 7.5e-48 165.3 In-house 1-257 (257) Show / Hide 
Range on Protein: 19-273
Range on HMM: 1-257/257
Sequence Identity: 32% (85 aa)

YTIIKCIGQGGFGDIYLVCDSESD-QAFAMKLEISEARKQSLHQEYTFMCGLQGSPHFPHMIEYGEDARNRYLVQELLGPSLSALRRCFPGGKLSLPTVL
 ...| ||.|||| ||   |   .    |.|.| ... || |  |   .  ||| .|    |  | . .  |.| .|.| .|. |||  | |. || | |
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

CIAQEMLRILKEFHGRGFIHNDVKPSNFLIRLGSPNF--LVLIDFGLSKTYIDPKTGQPIKVRQFSGFKGTKKYASPNAHIGFDLTVRDDMYSWFYTIVE
 .   .|  ... |  || | |.||||| . . . .     ..||||   |.   .|.    |.  || ||  ||| |||   ..  .||. | ||  ||
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTN-ACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

LAYGVLPWSHEKEKVAIMKGKRGIRNSPAFQILPPRLQNLHAKIEDLGLFTKPDYDGW
 . | |||   | |  . . |         . .|. ..   . |. |. ...|||   
FVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 90524.m00030.AA CK1-D 19-223 39 4.2e-43 149.53 In-house 1-205 (261) Show / Hide 
Range on Protein: 19-223
Range on HMM: 1-205/261
Sequence Identity: 39% (81 aa)

YTIIKCIGQGGFGDIYLVCDSESDQAFAMKLEISEARKQSLHQEYTFMCGLQGSPHFPHMIEYGEDARNRYLVQELLGPSLSALRRCFPGGKLSLPTVLC
| | . || | |||||.  . ...   |.|||   ..   || |  |   .||    |..  .|..     .| .||||||  |   . . | || ||| 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDL-FNYCHRKFSLKTVLM

IAQEMLRILKEFHGRGFIHNDVKPSNFLIRLGSPNFLV-LIDFGLSKTYIDPKTGQPIKVRQFSGFKGTKKYASPNAHIGFDLTVRDDMYSWFYTIVELA
.|. |.. ..  |.| ||| |.|| |||. ||    .| .|||||.| | |..| | |  |      || .||| | | | .   |||. |  | ..  .
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN

YGVLPW
 | |||
RGSLPW
Kinase 90524.m00030.AA CK1-G 19-206 36 1.8e-29 97.01 In-house 1-191 (266) Show / Hide 
Range on Protein: 19-206
Range on HMM: 1-191/266
Sequence Identity: 36% (71 aa)

YTIIKCIGQGGFGDIYLVCDSESDQAFAMKLEISEARKQSLHQEYTFMCGLQGSP-HFPHMIEYGEDARNRYLVQELLGPSLSAL-RRCFPGGKLSLPTV
| . | || | || ...          | |.|    |   || || |   | | |   |.   .|       .| .||||||  |   |  . | |. ||
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWC--DRKFSVKTV

LCIAQEMLRILKEFHGRGFIHNDVKPSNFLI-RLGSP--NFLVLIDFGLSKTYIDPKTGQPIKVRQFSGFKGTKKYASPNAHIGFDLTVRDDM
. .|  |.. ... | .  |  |||| |||| | ...  . . .||||. | ||||.|.| |  |      ||  | | | |.|     ||||
CMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDM
Kinase 90524.m00030.AA Pkinase 19-255 20 7.7e-24 85.38 Pfam 1-269 (293) Show / Hide 
Range on Protein: 19-255
Range on HMM: 1-269/293
Sequence Identity: 20% (56 aa)

YTIIKCIGQGGFGDIYLVCDSESDQAFAMKLEISEARKQSLHQ------EYTFMCGLQGSPHFPHMIEYGEDARNRYLVQELLGPSLSALRRCF------
|.|...||.|.||  |. ..  . . .|.|    . .| . .|      |   |  | ..|.   .... || .. |.|.|...  |. .   |      
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTW

PGGKL--SLPTVLCIAQEMLRILKEFHGRGFIHNDVKPSNFLIRLGSPNF---LVLIDFGLSKTYIDPKTGQPIKVRQFSGFKGTKKYASPNAHI-GFDL
 .|..  |  .. ... ..|| |.  | .|.|| |.||.|.||    ..    . ..||||.| .         . . ...| ||  |..|  .  | . 
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYY

TVRDDMYSWFYTIVELAYGVLPWSHE------KEKVAIMKGKRGIRNSPAFQILP-------------------PRLQNL
. . ||.|   .. |.. | .|....       ... | . ....  .. ..  .                   . .. .
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDF
Kinase 90524.m00030.AA Ciliate-E2 19-169 22 2.8e-18 59.34 In-house 1-209 (365) Show / Hide 
Range on Protein: 19-169
Range on HMM: 1-209/365
Sequence Identity: 22% (49 aa)

YTIIKCIGQGGFGDIYLVCDSESDQAFAMK----------------------LEISEARKQSLHQEYTFM---------------CGLQGSPHFPHMIEY
| .||.||||.||..|.... . .. ||.|                        ...  .... ||   |               . .  .|.   |.|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

GE--DARNRYLVQELL-GPSLSALRR--CFPGGKLSL----PTVLCIAQEMLRIL------------------KEFHGRG-FIHNDVKPSNFLIRLGSPN
 .  |  | ||| |.. | .|  . .  .   ..       .|   |.. |  ||                  .. | ..  || | ||.| |.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

FLVLIDFGLSKTYIDP
 . .||||||| | |.
-IKIIDFGLSKKYDDD
Kinase 90524.m00030.AA S_TKc 19-282 16 5.3e-16 57.77 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-282
Range on HMM: 1-231/231
Sequence Identity: 16% (46 aa)

YTIIKCIGQGGFGDIYLVCDSESDQAFAMKLEISEARKQSLHQEYTFMCGLQGSPHFPHMIEYGEDARNRYLVQELLGP---SLSALRRCFPGGK----L
|.|.. ||.|.||  |.. . .... .|.|        ... .|   .    . |.  ..... .|  . |.| |...    .|  . .  ....    .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLPTVLCIAQEMLRILKEFHGRGFIHNDVKPSNFLIRLGSPNFLVLIDFGLSKTYIDPKTGQPIKVRQFSGFKGTKKYASPNAHIGFDLTV-RDDMYSWF
.  .. ........ |.  | .|.|| |.||.| |.       . ..||||.. .              . | ||  | .|        .  . |..|  
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

YTIVELAYGVLPWSHEKEKVAIMKGKRGIRNSPAFQILPPRLQNLHAKIEDLGLFTKPDYD---GWIEEIE-------KSFE
 .. |...|  |..   .  ...|  .                   ||   .    . | .   .  |  .         . 
CILYEMLCGYPPFP---QMQMMFKKIG----------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF